unique and effective characterization of space groups in computer applications

... entry of drugs, thereby making many antibiotics ineffective Current TB drugs are mainly effective against growing mycobacteria and ineffective against latent bacilli20 As of 2010, the recommended ... minimum six months of a combination of four antibiotics containing rifampicin, isoniazid (INH), pyrazinamide (PZA) and ethambutol (EMB) for the first two months, followed by only rifampicin and ... formation is initiated by recruitment of immune cells to the site of infection by range of cytokines and chemokines that are released in response to the infection Among the cytokines, tumor necrosis...

Ngày tải lên: 09/09/2015, 10:07

... incorporate businessgovernment interplay into the research of business groups, our theory enriches scholarly understanding of the evolution of business groups In particular, we show how the institutional ... defined as loose constellations of firms operating in a wide variety of industries and being tied together through formal and informal ties, are key economic players in the landscape of emerging ... Business groups, consisting of legally-independent firms under common administrative and financial control (Khanna and Rivkin, 2001), are common in emerging economies such as Taiwan Business groups in...

Ngày tải lên: 11/09/2015, 10:16

... highlighting the advantages and promising prospect of SiNWs in the design and fabrication of third generation solar cells In previous works, SiNWs were fabricated using a variety of methods, which mainly ... (Jsc) comparing to Si planar device, owing to effective light trapping and anti-reflection property of SiNWs Core-shell SiNW device displays a higher increase of 52% in Jsc, as a result of larger ... data of SiNW surface and planar Si surface, measured using integrating sphere (b) Reflected spectral irradiance of SiNW surface comparing with that of planar Si surface; the inset shows incident...

Ngày tải lên: 12/10/2015, 17:35

... English Word Groups a) Word Groups Containing Xuân (WGCX) and Others Containing only Spring/Autumn The word groups containing xuân have four following senses a) Word Groups Containing only Spring - ... meaning, semantic properties, lexical field, definitions of metaphor sentence and in finding ways and means of building larger and more and classification of metaphor All serve investigating ... to find out the main similarities and differences of WGCWSs groups containing words denoting two seasons- spring and autumn- in Vietnamese and English in terms of syntactic, lexical-semantic in...

Ngày tải lên: 26/11/2013, 13:16

... pancreatic juice and intestine: inadequate for role in zinc absorption Am J Clin Nutr 35, 1–9 Evans GW & Johnson PE (1980) Characterization and quantitation of a zinc binding ligand in human milk ... splicing of exons and of the ACMSD gene (Fig 2A); the presence of exon in ACMSD II causes a shift in the open reading frame, resulting in the occurrence of the first available start codon in exon ... Residues involved in catalysis in the bacterial enzyme and the corresponding amino acids in the human protein are pointed with arrows The mean hydrophobicity values of residues within the window...

Ngày tải lên: 19/02/2014, 02:20

... goal of contributing to understanding of the metabolism of this pathogen and providing the enzyme for the identication and development of selective inhibitors, we cloned and expressed Rv2992c in ... the discriminating behaviour of Mt-GluRS in E coli Studies on Tt-GluRS indicated that discriminating and nondiscriminating GluRS can be distinguished on the basis of the presence of a specic ... exceptions in that activation of the amino acid requires the presence of the cognate tRNA [2,4] In these aaRS the binding of tRNA induces an ATP productive binding mode [5] GluRS are also distinguished...

Ngày tải lên: 07/03/2014, 03:20

... experiment, the indicated proteins were incubated together in NaCl ⁄ Pi containing 250 mM NaCl at °C for h, and then incubated with Talon beads The amount of protein present in the fraction bound ... role, such as in DNA replication, in living cells In contrast, mutants of AtRPA70b were viable but showed high sensitivity to UV and MMS, suggesting involvement of AtRPA70b in the repair of damaged ... region, and a third, DBD-C, in the C-terminal region DBD-A and DBD-B are the most important regions for binding of ssDNA, whereas DBD-C has only weak ssDNA-binding activity At the N-terminus of RPA70kDa...

Ngày tải lên: 07/03/2014, 21:20

... VBARP and Vpr is specific The input panel represents the amount of protein used in this assay indicating that an equal amount of protein was used in all our samples and that the lack of interaction ... variant A Fig Interaction of Vpr and VBARP proteins in vitro and in vivo (A) In vitro translated 35S-labeled VBARP-His isoforms were incubated with Vpr or Nef and immunoprecipitated using a-His (lanes ... a role in promoting proliferation and preventing apoptosis [8] dMASK mediates receptor tyrosine kinase (RTK) signaling, independent of MAP kinase (MAPK) by either functioning downstream of MAPK...

Ngày tải lên: 07/03/2014, 21:20

... communities of indigenous minority groups The unique cases of selected minority groups are discussed in more detail later in this paper to show the patterns of injustice, waste dumping, ecocide, and ... genocide against members of minority groups in order to appropriate their lands and natural resources The subjugation of indigenous minority groups extends to the subjugation of nature and the Human ... justice and the need for international codification of norms pertaining to the rights of all people to clean air, water, and a safe and sound environment capable of sustaining life are offered in...

Ngày tải lên: 15/03/2014, 23:20

... motif of an adjacent subunit and thus contributes to stabilizing the intersubunit interface Indeed, the Arg297 and Gln304 side chains of the Ca8 helix make favorable interactions with the Glu422 and ... frequency varies in distinct populations and geographic areas [79] and a number of them have been analyzed and characterized in vitro [10,11] Identication of the mutations and subsequent in vitro expression ... neighborhood of Q301 were analyzed in the structure of the ternary complex of human PAH with BH4 and thienylalanine, which consists of only the catalytic domain and dimerization motif (Protein databank...

Ngày tải lên: 16/03/2014, 01:20

... referring to all of them as caveolae, was demonstrated by their content of both caveolin-1 and caveolin-2 The coexistence of caveolin-1 and caveolin-2 in all three caveolae subclasses is in line ... presence of additional specialized subgroups or classes of caveolin-containing membranes in the plasma membrane We now report the separation and biochemical characterization of three classes of caveolae, ... indicated protein or EZ-Link-sulfo-NHS-LC-biotin labelling by SDS ⁄ PAGE and immunoblotting or avidin-labelled HRP, respectively The amounts of indicated proteins are expressed in arbitrary densitometric...

Ngày tải lên: 16/03/2014, 13:20

... substrate and the cofactor in addition to hydrophobic interactions Important residues lining the cofactor binding pocket indicates that Gln11, Asp32, Thr76, Ala77, Val117 and M142 are involved in hydrogen ... green in the case of Pf LDH and red in the case of Pf MDH Comparative expression of Pf MDH, Pf LDH and Pf MQO and effect of gossypol The effect of gossypol on the expression of Pf LDH and Pf MDH in ... concentration of pyruvate and NADH, while MDHs were assayed in the presence of saturating concentrations of OAA and NADH For inhibition studies the reaction mixtures containing the enzyme and the inhibitors...

Ngày tải lên: 16/03/2014, 18:20

... important in the literature and have roles assigned [12–18,20]: *, CTP-binding residue of the P-loop; (*), CTP-binding residue; ^, Neu5Ac-binding residue; #, Neu5Ac-binding residue forming part of the ... pocket plays a role in substrate discrimination against binding of the 5-OH group of Kdo and in favour of the N-acetyl group of Neu5Ac and, although these residues are conserved in CNS enzymes, none ... release The increased mechanistic understanding gained from this study should allow incremental advances in the design and production of inhibitors and mimetics of CNS and other enzymes in the pathways...

Ngày tải lên: 22/03/2014, 21:21

... of bands in SDS/PAGE, each band corresponding to gain or loss of a glycose moiety due to the phase variable nature of H in uenzae LPS synthesis [3,21,22] In LPS from RM118 lgtC lic3A it was interesting ... two chains precludes coincident expression of both It is noteworthy that the majority of SiallNnT-containing glycoforms contain two PEtn residues In the inner core of H in uenzae LPS, one PEtn ... sialylated glycoform The structure of the sialylated glycoforms of the O-deacylated LPS of H in uenzae strain RM118 and mutants causing sequential truncations from Hep III are illustrated in Fig DISCUSSION...

Ngày tải lên: 23/03/2014, 21:21

... biological process of interest, allows genes to be ordered into pathways, and can provide important and novel mechanistic insights into the molecular structure and function of proteins In addition to ... cytoplasm and functions as a chemical chaperone that aids in the refolding of misfolded proteins Loss of function of protein homeostasis genes also causes accumulation of damaged proteins and activation ... serine-threonine protein kinases that includes vertebrate oxidative-responsive (OSR1) and proline-alanine-rich Ste20-related kinase (PASK; also known as SPAK) [32] GCK-VI kinases are expressed in...

Ngày tải lên: 30/03/2014, 03:20

... volume and energetic properties of the binding of CO to hemoproteins Biophys J 66, 89–98 Tuckey RC & Kamin H (1983) Kinetics of O2 and CO Binding to adrenal cytochrome P-450scc Effect of cholesterol, ... was in the range of values determined in previous studies for the interaction between bovine Adx and bCYP11B1 Biacore measurements were performed to investigate the binding behavior between bovine ... formation of hydrogen peroxide, other NADPH consuming reactions probably involving the redox partners AdR and Adx are taking place Further studies will focus on investigating this interesting question...

Ngày tải lên: 30/03/2014, 04:20

... in intracellular cytoskeletal proteins, including titin, MyBP-Cm, MyBP-M, MyBPH, myotilin, and palladin [30–35] As Ig-C2 domains may serve as molecular spacers and bind to a diversity of ligands, ... domain in myosin light chain kinase A Fig Prediction for a conserved aggregation domain in the 4Ig region of L-MLCK and recombinant expression of MLCK variants (A) The sequences of the N-terminal ... barrier in intestinal disease Lab Invest 84, 282–291 12 Tran QK, Watanabe H, Zhang XX, Takahashi R & Ohno R (1999) Involvement of myosin light-chain kinase in chloride-sensitive Ca2+ in ux in porcine...

Ngày tải lên: 30/03/2014, 04:20

... to fragmented adhesion region in the cell center Vinculin staining on the whole cell surface in most of the cells (green, G); some cells still have vinculin staining similar to starved cells (arrow) ... chemiluminescence Equal loading of proteins was ensured by b-actin concentration Control: cells were growing in MEM containing 10% fetal bovine serum 24, 48, 72, 96 h: cells were cultivated in MEM ... was inhibited by  70%, returning to the level observed after the addition of fresh medium in the absence of agonist (Fig 6C, inset) Incubation in media containing specific receptor antagonists and...

Ngày tải lên: 30/03/2014, 08:20

... tail and the binding of H1.4 to chromatin, as arginine offers additional hydrogen-bonding abilities to DNA as compared to lysine Lysine 173 in H1.4 is situated in an SPKK motif, one of the known ... the binding of H1.2 to chromatin, may be affected A further nonsynonymous substitution prompted the replacement of lysine with arginine in the C-terminal tail (position 173) of histone H1.4 in ... believed to be involved in positioning of the globular domain on the nucleosome [32] The N- and C-terminal tails of histone H1 adopt a random coil in solution [33] On binding of histone H1° to DNA,...

Ngày tải lên: 30/03/2014, 20:20

... library using a combination of PCR amplification, mass sequencing and library screening as described in the Materials and methods The first clone was 1689 bp and contained an ORF of 1434 bp coding for ... selection on minimal medium agar plates without uracil or leucine, cells harbouring the yeast plasmid were cultivated in minimal medium lacking uracil or leucine but containing 2% (w/v) raffinose and 1% ... manufacturer’s instructions and submitted to random sequencing by the chain termination method using the ABI PRISM Big Dye Termination Cycle Sequencing Ready Reaction Kit (Perkin-Elmer, Weiterstadt,...

Ngày tải lên: 31/03/2014, 09:20