... non-competitive inhibitors and uncompetitive inhibitors In particular, a competitive inhibitor can bind to the corresponding substrate binding site; a mixed type inhibitor can bind to an allosteric ... binding sites may change, leading to decrease in their binding affinity There are several approaches to deal with the drug resistance problem In addition to inhibiting alternative targets, inhibiting ... both the thymidine and phosphate binding sites were also developed In the open conformation of E coli TP, the distance between the thymidine binding site and the phosphate binding site was approximately...
Ngày tải lên: 10/09/2015, 09:12
... dried and sprayed with 5% H2SO4 in 1-propanol followed by incubation at 120 8C for N-Terminal amino-acid sequencing was conducted using the Edman degradation and phenylisothiocyanate amino-acid ... (0.4 mL) containing mg of laminarin was preincubated at various temperatures in the range mentioned above Then 50 mL (0.005 U) of enzyme solution in the same buffer was added and incubated for ... buffer, pH 4.5, and contained 0.5 mg of laminarin and crude or purified enzyme extract corresponding to at least 0.2 mg of pure exo-1,3-b-glucanase Incubation was at 37 8C for 10 –30 and the reaction...
Ngày tải lên: 24/03/2014, 04:21
What a world 3 Amazing stories from around the globe
... UNDERSTANDING MAIN IDEAS Some of the following statements are main ideas, and some are supporting statements Some of them are stated directly in the reading Find the statements Write M for each main ... lights shining at every door and window so that she can find her way in easily Businesspeople put out all their accoun t books for Lakshmi to inspect Hindus pay their bills and leave money and jewelry ... orders, and the Incas obeyed them because they were used to obeying all their lives The Spaniards were only interested in the Inca gold and silver, so they made the people work in the mines and neglect...
Ngày tải lên: 15/10/2013, 17:42
What a world 3 amazing stories from around the globe
... UNDERSTANDING MAIN IDEAS Some of the following statements are main ideas, and some are supporting statements Some of them are stated directly in the reading Find the statements Write M for each main ... lights shining at every door and window so that she can find her way in easily Businesspeople put out all their accoun t books for Lakshmi to inspect Hindus pay their bills and leave money and jewelry ... orders, and the Incas obeyed them because they were used to obeying all their lives The Spaniards were only interested in the Inca gold and silver, so they made the people work in the mines and neglect...
Ngày tải lên: 15/09/2015, 16:45
G/A Lớp 3 Tuần 5 (buổi 1)
... gõ, băng nhạc máy nghe,một số tranh , ảnh minh hoạ III Các hoạt động dạy học chủ yếu Hoạt động 1: Dạy hát Đếm a) Giới thiệu - Cho học sinh xem tranh minh hoạ nghe hát mẫu b) Dạy hát - Đọc đồng ... động trò GV nêu nhiệm vụ tiết học Hớng dẫn kể chuyện theo tranh - HS quan sát tranh minh hoạ - GV treo tranh minh hoạ SGK - HS nối tiếp nhau, quan sát tranh - Sau lần HS kể, GV nhận xét nội dung, ... Trong trình hỏi - đáp trên, GV dùng hình phần nhau, phần vẽ, sơ đồ nh SGK để minh hoạ số kẹo cần tìm - Cho học sinh tự nêu giải toán (nh SGK) - HS tự nêu giải ? Muốn tìm 12 kẹo ta làm nh nào?...
Ngày tải lên: 19/09/2013, 14:10
Báo cáo khoa học: Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone A retrobiosynthetic NMR study with root cultures of Swertia chirata docx
... convenient to compress this information into a single icon (Fig 7A) in which the labelling patterns of each observed multiply 13 C-labelled isotopomer are indicated by lines connecting the respective ... of 13 In line with this interpretation, the experiment with [carboxy-13C1]shikimate shows that the carboxylic group, which is lost in the formation of phenylalanine and tyrosine (Fig 1) is in fact ... tyrosine (Fig 1) is in fact incorporated into ring B of 1,3,5,8tetrahydroxyxanthone (Figs 7C and 11) Phenylalanine, tyrosine and metabolites downstream from the amino acids would not have been...
Ngày tải lên: 08/03/2014, 02:21
English 6-Unit7- A 1,3,5,7
... new Introduction: Answer these questions: Is the any yard? Are there any big? ? flowers Are therehouse trees ? Is there a well ? ? Introduction: Minh Hoa Introduction: Is your house big ? Minh and ... it ? 1.Where are the mountains? -The mountains are behind the house 2.Where are some trees? -Some trees are behind the house 3.Where are the flowers? -The flowers are in front of the house ( b.) ... is it ? 1.Where are the mountains? -The mountains are behind the house 2.Where is the tree? -The tree is to the left of the house 3.Where is the lake? -The lake is in front of the house (c.) A5.Listen...
Ngày tải lên: 18/07/2014, 02:00
Unit 5 A 1-3 Let''''s lear 1
... school A: 1, 2, 1.Look, listen and repeat 2.Look and say 3.Let’s talk This is _ Thursday,Noverber 3rd, 2011 Unit 5: My school A: 1, 2, 1.Look, listen and repeat 2.Look and say 3.Let’s talk * Sumarize ... 1, 2, 1.Look, listen and repeat This is my school This is my classroom And this is my school library Thursday,Noverber 3rd, 2011 Unit 5: My school A: 1, 2, 1.Look, listen and repeat *Tõ míi: ... n¬i chèn ®å vËt Thursday,Noverber 3rd, 2011 Unit 5: My school A: 1, 2, 1.Look, listen and repeat 2.Look and say This is my school school classroom • This is my _ classroom school library...
Ngày tải lên: 29/10/2014, 10:00
LỚP 5 UNIT 11 A 1-3
... 2011 UNIT 11: PLACES OF INTEREST SECTION A 1,2,3 Look and say Read and answer Friday,April st 2011 UNIT 11 : PLACES OF INTEREST SECTION A 1,2,3 Look and say Where are you going next weekend? I’m ... Friday,April 1st 2011 UNIT 11: PLACES OF INTEREST SECTION A 1,2,3 Look, listen and repeat Nam : Where are we going tomorrow? Mai:We’re going to Cuc Phuong National Park Linda:It sounds nice.I like to go ... 1st 2011 UNIT 11: PLACES OF INTEREST SECTION A 1,2,3 Look, listen and repeat Nam : Where are you going tomorrow? we Mai: We’re going to Cuc Phuong National Park I’m Linda:It sounds nice.I like...
Ngày tải lên: 26/05/2015, 16:00
Synthesis and biological investigation of pyrimido 1,2 a 1,3,5 triazine and its analogues 2
... compounds by using INVDOCK with their scores ELP (Ligand protein interaction energy in Kcal/mol) Targets Function 149b 149f 173b 173c 173f 173h Tyrosine-protein kinase JAK2 Involved in interleukin3 signal ... NADPH-flavin oxidoreductase Involved in oxidoreductase activity 2bkj, 2h0u, 1bkj 2.977 0.2857 32 Tyrosine-protein kinase JAK2 Plays a role in leptin signaling and control of body weight Tyrosine kinase ... 2.914 0.34 29 Casein kinase II subunit alpha Involved in protein kinase activity 1om1, 1oml, 3owl 2.901 0.39 30 Guanine nucleotide-binding protein G(i), alpha-1 subunit Involved in signal transducer...
Ngày tải lên: 10/09/2015, 15:49
Synthesis and biological investigation of pyrimido,1,2 a ,1,3,5,triazine and its analogues 1
... 2,4-bis(o-carbomethoxyanilino)-6-dimethylamino-1,3,5-triazine 21 in acidic condition for 16h yielded 2(4)-anilino-4(2)hydroxy-6H-1,3,5-triazino[2,1b]quinazolin-6-one (22) Cyclization-deamination and decarboxylation ... 1,3,5-triazine ring undergoes a hydrolytic ring opening step in preference to the pyrimidine ring in dimethyl formamide (DMF) Isomers 32 and 33 were not observed This is consistent with the mechanism and ... (where pyrimidine is fused to five-membered rings like pyrrole and pyrazole) scaffold have been reported as KDR kinase, Btk kinase and CDK-2 inhibitors Benzo[d]pyrimidine or quinazoline66-68 derivatives...
Ngày tải lên: 10/09/2015, 15:49
Quản trị chiến lược Chuong 1, 3, 4,5,6
... đáng tin cậy hệ thống thông tin - Việc áp dụng công nghệ thu thập, xử lý thông tin - Tính bảo mật thông tin - Đề hình thành hệ thống thông tin hữu hiệu khai thác lợi cạnh tranh thông tin cần ... tin môi trờng kinh doanh - Xử lý thông tin, chọn hội thách thức trọng yếu nhất, xắp sếp theo thứ tự u tiên (khoảng 20 nhân tố) - Đánh giá thông tin, yếu tố tác động, phơng thức xử lý thông tin ... tin công nghệ thông tin sử dụng Trong trình đánh giá cần sử dụng công nghệ thông tin để thu thập xử lý thông tin: thông tin thu thập từ nhiều nguồn khác nhau, sàng lọc thông tin có giá trị, kết...
Ngày tải lên: 16/09/2013, 12:30
DE TH + DAP AN CAC MON LOP 1,3,4,5
... 1(2 im): in cỏc t ng: thng li, c lp, lũng tin, nim t ho vo ch trng ca cỏc cõu sau cho thớch hp ? (Th t cỏc t cn in l: thng li, c lp, nim t ho, lũng tin - in ỳng mi t c 0,5 im) Cuc khỏng chin chng ... su, h tiờu, mn B Phn t lun: ( im) Cõu 1(2 im): in cỏc t ng: thng li, c lp, lũng tin, nim t ho vo ch trng ca cỏc cõu sau cho thớch hp ? Cuc khỏng chin chng quõn Tng xõm lc ó gi vng c nn ca nc ... ho , lũng tin sc mnh ca dõn tc Cõu 2: H Ni l trung tõm chớnh tr, hoỏ, khoa hc v kinh t ln ca nc ta : Vỡ: - H Ni l ni lm vic ca cỏc c quan lónh o cao nht ca t nc - H Ni ni trung nhiu vin nghiờn...
Ngày tải lên: 31/10/2013, 08:11
BO DE THI CAC LOP 1,3,4,5(CKTKN)
... học ngọc minh HD chM đề thi học kì I - Năm học: 2010 - 2011 Môn: Toán(lớp 4) A Phn I: Trc nghim (6 im) Khoanh trũn vo ch t trc cõu tr li ỳng t cõu n cõu 8: Cõu 1(0,5 im): S thớch hp in vo ch chm ... Cõu 7(0,5 im): Viết số thích hợp vào chỗ chấm: - Số Mt trm hai mi mt triu bn trm linh năm nghìn đợc viết là: Cõu 8(2im): ỳng thỡ ghi , sai thỡ ghi S vo ụ trng a t 60 kg = 460 kg ... 7(0,5 im): Viết số thích hợp vào chỗ chấm:(Đúng ý đợc 0,5 điểm) - Số Mt trm hai mi mt triu bn trm linh năm nghìn đợc viết là:121 405 000 Cõu 8(2im): ỳng thỡ ghi , sai thỡ ghi S vo ụ trng sau: a t...
Ngày tải lên: 31/10/2013, 08:11
Ðánh giá mức sẵn lòng trả (WTP) cho dịch vụ nhà vệ sinh công cộng chất lượng quận 1,3,5
... Vietnamese Rhino” Ph m Khánh Nam Tr n Võ Hùng Sơn, 2005: “Household Demand for Improved Water Services in Ho Chi Minh City: A Comparison of Contingent Valuation and Choice Modelling Estimates” ... Ecosystems in Phang Nga Bay, Thailand” Kevin J.Boyle, 2003: “Chapter 5: Contingent Valuation in Practice” in “A Primer on Nonmarket Valuation” Tri u Dương (2011, 27 Feb) TPHCM: Nh ch nhác nhà v sinh ... http://giadinh.net.vn/20090626083057588p0c1000/tp-hcm-thua-locot-thieu-nha-ve-sinh-cong-cong.htm Quang Kh i, Chí Qu c, T.C.Nghĩa (2008, Mar) Xây d ng n p s ng văn minh đô th : Đ m t tìm nhà v sinh công c ng Đư c l y v t : http://tuoitre.vn/Chinhtri-Xa-hoi/246118/Do-mat-tim-nha-ve-sinh-cong-cong.html...
Ngày tải lên: 26/12/2013, 15:29
Tài liệu Lab 5.1.3 Using the Boot System Command pptx
... steps, logoff by typing exit Turn the router off 3-5 CCNA 2: Routers and Routing Basics v 3.0 - Lab 5.1.3 Copyright 2003, Cisco Systems, Inc Erasing and reloading the router Enter into the privileged ... Copyright 2003, Cisco Systems, Inc Router Interface Summary Router Ethernet Ethernet Serial Serial Interface Model Interface #1 Interface #2 Interface #1 Interface #2 #5 800 (806) Ethernet ... of interface even though a specific router may contain one An example of this might be an ISDN BRI interface The string in parenthesis is the legal abbreviation that can be used in IOS command...
Ngày tải lên: 18/01/2014, 04:20
Tài liệu Lab 5.1.3 Using the Boot System Command doc
... steps, logoff by typing exit Turn the router off 3-5 CCNA 2: Routers and Routing Basics v 3.0 - Lab 5.1.3 Copyright 2003, Cisco Systems, Inc Erasing and reloading the router Enter into the privileged ... Copyright 2003, Cisco Systems, Inc Router Interface Summary Router Ethernet Ethernet Serial Serial Interface Model Interface #1 Interface #2 Interface #1 Interface #2 #5 800 (806) Ethernet ... of interface even though a specific router may contain one An example of this might be an ISDN BRI interface The string in parenthesis is the legal abbreviation that can be used in IOS command...
Ngày tải lên: 18/01/2014, 04:20
Tài liệu Lab 5.1.3 Connecting Router LAN Interfaces pdf
... computers, and hub or switch b To verify the router connections, insure that the link light on the router interface and the hub/switch interface are both lit c 2-2 To verify the computer connections, insure ... computer NIC and connect the other end to a port on the hub or switch Be sure to examine the cable ends carefully and select only straight-through cables Step Verifying the connection a Plug in and turn ... connections, insure that the link light on the NIC and the hub interface are both lit CCNA 1: Networking Basics v 3.0 - Lab 5.1.3 Copyright 2003, Cisco Systems, Inc ...
Ngày tải lên: 24/01/2014, 19:20