the probabilistic longest path
The ubiquitin-proteasome pathway in cell cycle control
Ngày tải lên :
25/10/2013, 21:20
... and then effects the processive attachment of ubiqui-
tin monomers first to lysines on the targeted protein and then to lysines of
previously attached ubiquitins. The activation of ubiquitin by the ... down-regulated. The primary
mechanism whereby this requirement is met is via the APC/C-dependent
The ubiquitin-proteasome pathway in cell cycle control 157
minal to the F-box. In addition, some members of the ... domain
properly with respect to the catalytic site of the SCF core. The essentiality
of dimerization in the function of other Cdc4/Fbw7 homologs remains to be
determined.
The second class of SCF cofactor...
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Tài liệu Báo cáo khoa học: Isoprenoid biosynthesis via the methylerythritol phosphate pathway Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase ppt
Ngày tải lên :
21/02/2014, 03:20
... wasincubatedwithH-DXRinthe
presence of NADPH, consumption of the cofactor was
shown by the decrease in the absorption at 340 nm,
suggesting that the enzyme reduced the aldehyde 4.Forthe
identification of MEP, the ... triterpenoids of the
hopane series from Methylobacterium fujisawaense demon-
strated for the first time the presence of a rearrangement in
the MEP pathway [48]. By analogy with the biosynthesis of
the amino ... NADPH-dependent reduction of the oxo
group to give the final product. In the reactions catalyzed by
the two enzymes, the ketol-acid and the DXP isomero-
reductase, the formation of the expected intermediates,
3-hydroxy-3-methyl-2-oxo-butyrate...
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342
0
Your Guide to the Breast Cancer Pathology Report pptx
Ngày tải lên :
06/03/2014, 02:21
... is
removed from the body to check for
cancer. These are called pathology
reports. Each report has the results
of the studies done on the removed
tissue. The information in these
reports will ... Your Pathology Report
• The pathology report answers
questions about a breast abnormality 6
• Is the breast abnormality a cancer? 6
• Is the breast cancer invasive? 7
• How different are the ...
Your Guide
to the
Breast Cancer
Pathology Report
TABLE OF CONTENTS
Wait for the Whole Picture
• Waiting for test results 2
• Get all the information you need 3
• Parts of your pathology report...
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Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc
Ngày tải lên :
07/03/2014, 09:20
... in metabolic pathways are found visually
by looking at the connectivity between the enzyme genes on
the pathway map reflecting current pathway knowledge.
Suppose that there is a pathway hole between ... In this study the param-
eter h is set to 10
5
. This means that, the larger the distance
between two genes along the chromosome, the smaller the
value of the similarity score. The resulting ... by the number of nucleotides between the end of
the i-th gene and the start of the j-th gene along the chro-
mosomes. We then derived a distance kernel using the for-
mula K
position
(x
i
,x
j
)...
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Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx
Ngày tải lên :
07/03/2014, 17:20
... increase of synthesis of pyr-
idine nucleotide cofactors, as the total pool of these
increased. Whether the synthesis is regulated by the
NADPH concentration remains speculation. The
G6PDH overproducing ... 6-phosphate is a branching point to several
pathways. It leads to the pentose phosphate pathway,
glycolysis and the pathways for biosynthesis of cell
wall components. The Aspergillus niger gene encoding
G6PDH ... Figure 4B shows the X-loading weights of the
X-variables (measured variables other than NADPH)
and the Y-loading of NADPH on the two PCs. As
NADPH is in the first quadrant of Fig. 4B (the four
quadrants...
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Báo cáo khoa học: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin⁄26S proteasome-mediated proteolysis potx
Ngày tải lên :
15/03/2014, 09:20
... interaction with the DSK2 homolog
from the respective species, we decided to test the
hydrophobic patches within the UBLs of the DSK2
homologs for their involvement in the interaction with
RPN13. The potential ... abolished the
association with RPN10 (Fig. 2B). These results indi-
cate that the UBLs of the human RAD23 and DSK2
homologs and yeast DSK2 play a role in the associa-
tion with the RPN10 homolog. Furthermore, ... critical for the interaction. S5a in parentheses is the
designated name for the human RPN10 homolog.
d
IF, the interface regions on the UBL–UBA factors that are involved in binding with the docking...
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Báo cáo khoa học: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway potx
Ngày tải lên :
16/03/2014, 12:20
... whether the SLe
x
level of InR on insulin-responsive cells in diabetic
patients was changed. This may reveal the role of the
sugar chains on InR in the pathogenesis of diabetes.
In summary, the ... upregulating the phosphorylation and
expression of some signaling molecules involved in the InR-signaling path-
way. These effects are likely mediated by its product, SLe
x
, on the glycans
of the InR. ... receptor; IP, immunoprecipitation by the antibody to the protein indicated at the
right; WB, western immunoblot with the antibody to the compound indicated at the right. (A), (C) and (D) are representative...
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Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc
Ngày tải lên :
23/03/2014, 15:21
... expected, the
largest differences are found for the PPP split-ratio and
the fluxes of the nonoxidative branch of the PPP.
The minimized covariance-weighted sum of
squared residuals (SS
res
) in these ... normalized for the glucose-uptake rate.
Values outside parentheses denote the net
fluxes, while values inside parentheses
represent the exchange fluxes. Solid arrow-
heads denote the direction of the net ... of the traditional
model. The similarity of the flux estimates indicates
that the presence of isoenzymes reduces the difference
in
13
C-label distribution between the two models and
impedes their...
13
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0
Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
Ngày tải lên :
30/03/2014, 10:20
... in the mutant. First, there is an increase in the
negative charge in the active site and, second, breaking
the salt bridge would alter the quaternary structure of
the protein and therefore the ... catalysis. The
alignment of the small CMLEs from different members
of the Rhizobiales with these sequences demonstrated
that in A. radiobacter S2 (and the other member of the
Rhizobiales), the amino ... demonstrated that the mutation did not
alter the tetrameric behavior of the protein, indicating
that the mutation affected the catalytic machinery
directly, rather than the oligomeric state of the
enzyme.
Overall...
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