the epigenetic link between aging and cancer

... in the design of the study, acquisition, analysis and interpretation of data and drafting the manuscript BB and BL performed the histological and morphometrical analyses, and contributed to the ... analysis and contributed to the interpretation of data GL conceived and coordinated the study, participated in the design of the study, analysis and interpretation of data and drafting the manuscript ... emphysema and fibrosis may result from two distinct and apparent opposite processes, they may coexist either in different areas, or in a same area of the lung of humans and animals The development and...

Ngày tải lên: 12/08/2014, 18:21

... 48106-1346 The undersigned, appointed by the Dean of the Graduate School, have examined the thesis A FURTHER ANALYSIS OF THE CAUSAL LINK BETWEEN ABORTION AND CRIME Presented by Spencer Martin, a candidate ... state fixed effects and the differences in the five early-legalizing states, and across time, since the theory implies there is a time lag between the abortion decision and the crime impact For ... argument to the debate around this subject The original article and argument simply assumed the link between the typical aborting mother and the typical mother of a potentially criminal child; no...

Ngày tải lên: 01/10/2015, 16:59

... because the latter depends on (a) the structural integrity of the vascular bed of the penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium ... production Because androgen deficiency is linked to the development of IR and T2DM, and the latter contributes profoundly to endothelium dysfunction and ED [130,131], the concept of androgen deficiency ... contribute to endothelial dysfunction and microvascular disease and reduced androgen levels; (b) the insult on the endothelium resulting in endothelial injury and reduced NO synthase activity and NO production,...

Ngày tải lên: 18/02/2014, 06:20

... double-strand breaks (DSBs) A single-strand overhang is formed by exonuclease activity and invades the homologous doublestranded region of the other allele These steps of homology search and recombination ... CcCac1L and CcLim15 in the crude extracts of meiotic tissues (Fig 2E) Taken together, these results suggest that the interaction between CcLim15 and CcCac1L is related to specific events during the ... (Fig 3A) The FEBS Journal 275 (2008) 2032–2041 ª 2008 The Authors Journal compilation ª 2008 FEBS 2035 Link between Lim15/Dmc1 and the CAF-1–PCNA complex S Ishii et al phase together with the meiosis-specific...

Ngày tải lên: 07/03/2014, 05:20

... difference was between the group that improved by to letters and the no change group (p < 0.01) The association between visual acuity and HRQL Results of GLMs examining the link between best eye ... (0.50) following the guidelines proposed by Cohen [33] The primary analyses focused on the link between visual acuity (i.e., ETDRS) and HRQL (i.e., the VFQ-25 and to a lesser extent, the SF-36) over ... among the groups that improved in visual acuity The only statistically significant pairwise comparison between groups was between the no change group and the worsened by ≥ 10 letters group in the...

Ngày tải lên: 18/06/2014, 19:20

... autism according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders [30] The autistic group comprised 55 males and 15 females Their ages ranged between and 12 years (mean ... autism A more detailed understanding of the interactions between tachykinins and immune cells may provide the basis for the development of new therapies for inflammatory and immunemediated diseases ... USA) The data were non-parametric, thus they were presented as median and interquartile range (IQR), which are between the 25th and 75th percentiles Mann-Whitney test was used for comparison between...

Ngày tải lên: 19/06/2014, 22:20

... difference was between the group that improved by to letters and the no change group (p < 0.01) The association between visual acuity and HRQL Results of GLMs examining the link between best eye ... (0.50) following the guidelines proposed by Cohen [33] The primary analyses focused on the link between visual acuity (i.e., ETDRS) and HRQL (i.e., the VFQ-25 and to a lesser extent, the SF-36) over ... among the groups that improved in visual acuity The only statistically significant pairwise comparison between groups was between the no change group and the worsened by ≥ 10 letters group in the...

Ngày tải lên: 20/06/2014, 16:20

... market power and negatively correlated with debt ratio and R&D intensity The correlation between ROA and market power and the Correlation between ROA and R&D intensity are expected, as the activity ... with the regulator’s recommendations and are likely to disclose more on their governance status There is not necessarily a strong link between governance level and performance On the other hand, ... divide by the number of elements, and multiply this ratio by 20 Thus, each subindex has a value between and 20 We define the overall standardized score as the sum of all the five subindices As the...

Ngày tải lên: 06/01/2015, 19:48

...   The LIBOR Scandal: The Fix Is In the Bank of England Did It! No 125, 2012   2012/9 The Mediterranean Conundrum The Link between the State and the Macroeconomy, and the Disastrous ... the reversal of the sequester and the other spending cuts and tax hikes that made up the “fiscal cliff ” until the economy had time to recover We adopt the actual Fed target for the unemployment ... in the coming years, confounding the pessimism expressed by Hendrik Houthakker and Stephen Magee (1969) and others over the decades about the prospects for US export-led growth A solution to the...

Ngày tải lên: 23/09/2015, 08:52

... differentiate between normal and tumor breast tissues Furthermore, it is possible to differentiate between fibrocystic changes and carcinoma using this parameter The difference between adipose and tumors ... further highlighted and even though the fibroglandular and fibrocystic changes peaks are close, they are statistically separated Using the results in Table effective d-spacings have been found These ... and this is demonstrated in these results by the lack of any adipose peak in the carcinoma diffraction profile The peak positions for the adipose and fibrocystic changes were 1.09±0.03 nm-1 and...

Ngày tải lên: 02/11/2012, 11:08

... protection, and the effectiveness of compliance and enforcement This chapter examines the tensions between the principles of precaution and pollution prevention, on the one hand, and actual practices ... practices relating to landbased pollution control in the Arctic, on the other Following an introductory summary of the sources of land-based marine pollution in and into the Arctic, further sections review ... serve as further avenues for controlling land-based pollution relevant to the Arctic: the 1992 Paris Convention for the Protection of the Marine Environment of the North-East Atlantic and the 1992...

Ngày tải lên: 01/11/2013, 09:20

... quarter of the century in the United States and in the Netherlands, Sweden and Germany This coincides with an increase in both access to and the generosity of publicly provided social insurance and ... health In Bound (1991) and Stern (1990) reporting errors are SG modelled as a relationship between H and the wage rate rather than the labour market status S In the Netherlands the unemployment benefits, ... fi• (S) and Xi• as extra regressors in (4) and (5) The random effects of the resulting equation (4) (and (5)) includes the term ηµi The first part of table 1a includes the results for the control...

Ngày tải lên: 05/03/2014, 21:20

Ngày tải lên: 06/03/2014, 23:20

Ngày tải lên: 16/03/2014, 03:20

... observed between the mutated and the wild-type strains relied solely on the disruption of the Rv2951c gene Together, these results established that Rv2951c is involved in the biosynthesis of DIM A and ... group in the a position of the fatty acyl residues The signals that correspond to the resonance of the methine proton of the a carbon (d) and that of the carbon bearing the methyl group near the keto ... i.e DIMs and PGL-tb; and (b) to address the question of the function of the two related molecules DIM A and DIM B According to the accepted model of DIM and PGL biosynthesis [17], DIM A and PGL-tb...

Ngày tải lên: 23/03/2014, 09:20

... flexible linker between the AC subdomain and the PCP domain, and the absence of a contact surface between these two folded units [19], argue for a certain degree of flexibility and mobility of the ... of the effect of compound with that of the natural substrates ATP and l-Phe on the apoand holo-forms of the A-PCP construct in the partial tryptic digest is shown in Fig The apo-form and the ... domain are tethered Furthermore, this SrfA–C construct lacks the attachment site of the Ppant group (S1003A mutant) and shows the PCP on the acceptor site of the C-domain The distance of the S1003A...

Ngày tải lên: 29/03/2014, 08:20

... Reznick, and Joan Valentine, among others The length of human life, according to the Greeks, was in the hands of the Fates, or Moerae These three sisters, daughters of the Goddess of the Night, ... for both the detection and the treatment of cancer, strategies that are already finding their way to the clinic T h e lesson from cancer that we can apply to aging is the need to understand physiological ... senescence and aging (gerontology) and a medical specialty dealing with the problems of the aged (geriatrics) were not formed until the 1940s As with any new field, the early years of the study of aging...

Ngày tải lên: 11/06/2014, 05:26

... is the adjacency matrix of G Then χ(G) = 32 and the electronic journal of combinatorics (1997), #R19 and α(G) < min{ rank(B) |B ∈ B(G)} by theorem Acknowledgement The author is grateful to the ... us further information about the graph G (i) If v ∈ S then exists u ∈ S such that u − v Indeed, Yvv = and Xwv ≥ for all w ∈ S − Hence, w∈S Xwv = and Xuv > for some u ∈ S (ii) If v , v ∈ S and Xuv ... Lov´sz, “On the Shannon capacity of a graph”, IEEE Transactions on Information Theory a IT–25 (1979), 1–7 Martin Gr¨tschel, L´szl´ Lov´sz, and Alexander Schrijver, Geometric Algorithms and Combinao...

Ngày tải lên: 07/08/2014, 06:20

... from the other in the oriented matroid of the arrangement by reversing the sign of the hyperplane supporting the common facet Proposition 3.1 [2] Let H be a supersolvable arrangement, and H H The ... image under α if and only if they have the same active partition, and one can be obtained from the other by reorienting parts of the active partition The number of regions in the inverse image ... Then the edges d and c are directed away from b, yielding the mapping for 123d and 123c Independently, the path g, f, e yields the mapping for 123f and 123g Then c, d, f, g are deleted, and we...

Ngày tải lên: 07/08/2014, 08:22

... catalyze the hydrolysis of medium- and long-chain acyl-CoAs to FFA and CoA, and therefore prevent the b-oxidation of medium- and long-chain fatty acids once they are formed, was upregulated in the ... across the mitochondrion The PPARδ agonist also decreased the concentration of glucose and other carbohydrates in adipose cells, as well as increased the concentration of citrate and glutamate (the ... from the chromatogram for the period of sample injection and the exact masses were exported; the data points were summed between M and M+1, normalized to total metabolite concentration and integrated...

Ngày tải lên: 09/08/2014, 23:20