the electronic structure of complex systems

... present for the last four residues at the C-terminus. The stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regions ... metal- bound hydroxyl group onto the substrate, as observed in other members of the amidohydrolase superfamily [24,25]. However, as no structure of complexes with either the substrate, product or inhibitors ... building using the program o [42]. Approximately 7% of the randomly chosen reflections were excluded from refinement of the structure and used for the free R-factor calculation [43]. The pro- gram...

Ngày tải lên: 18/02/2014, 06:20

... X-ray irradiation [59]. Therefore, we believe that the structure reported in this paper is also that of the glycerol dehydrataseÆcob(II)alamin complex. The dihedral angle of the northern and southern least-squares ... twofold axis around the center of Fig. 3A. The structure of an abc heterotrimer unit is shown in Fig. 3B. The central region of the a subunit constitutes the (b/a) 8 barrel, the so-called TIM (triosephosphate isomerase) ... A ˚ resolution by the molecular replacement method. The schematic view of the overall structure is shown in Fig. 3A. Theenzymeexistsasadimeroftheabc heterotrimer. There is a noncrystallographic twofold axis...

Ngày tải lên: 21/02/2014, 03:20

... three-dimensional crystal structure of Anx(Gh1) from cotton emphasizes the high conservation of the unique annexin fold even among the members of the plant subfamily of annexin proteins. The fold is comprised of the ... either distorted or the access of a cation to the site is blocked by the p resence of a side chain of a b asic residue. I n case of the IIAB s ite (Fig. 2), the acidic re sidue a cting a s the ... residue in the present structure is s omehow halfway between the loop-in and the loop-out position of the bell pepper annexin. Fig. 1. The three-dimensional structure of Anx(Gh1). (A) The fold of Anx(Gh1)...

Ngày tải lên: 17/03/2014, 03:20

... express ε AB R A43B in the form curl/π (2) + E (2) . 5. Strategy of the proof of the Asymptotics Theorem In this section we describe the main ideas in the proof of the Asymptotics Theorem. (1) Section ... given a detailed proof of the theorem by relying heav- ily on a result, which we have called the Asymptotics Theorem, concerning the geometric properties of the causal structure of appropriately ... I + 0 is the future domain of the origin on Σ 0 . Remark 9.3. The proof of Corollary 9.2 requires an extension argument. The estimates of the Asymptotics Theorem, which are uniform with respect to the...

Ngày tải lên: 16/02/2014, 05:20

... best IM:Type full time IM:Title the godfather Other the, in, that Other the, in, that Other the, in, that Table 3: Label sets and their respective query segment examples for the intent class Movie, Job ... goal of this work is to identify the semantic labels of IMs, i.e., the attribute names they implicitly refer to. We use A c to denote the set of IM semantic labels for the intent class c. Other Additionally, ... se- mantic understanding of noun phrase queries. As- suming that the intent class c ∈ C of a query is known, we cast the problem of extracting the se- mantic structure of the query into a joint...

Ngày tải lên: 20/02/2014, 04:20

... The difference between rmsd of monomeric and dimeric species is due to the indetermination of the reciprocal orientation of the two subunits. The average total penalty for the REM family of the ... was used to back calculate the NOESY cross-peaks from the calculated structure to assess the quality of the structure. The final family was made up of 30 structures with the lowest target function. ... NMR solution structure [26,27] as well as the crystal structure [28] of the reduced form were re ported. Also the b ackbone mobility of the monomeric state was investigated and compared with that of the...

Ngày tải lên: 21/02/2014, 03:20

... tertiary structure. For the two dimeric models of LPL (the closed and open forms, Fig. 1), the active dimeric form of LPL in particular was based on the cocrystallized structures of the complexes of ... on the crystal structures of the human, porcine, and horse PLs (Fig. 1). A frontal view illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the ... modeling of the dimeric structure of LPL. Two dimeric model structures of LPL were constructed using INSIGHT II version 2000 on a Silicon Graphics workstation. The model structure of the closed...

Ngày tải lên: 21/02/2014, 15:20

... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the ... president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding ... 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences,...

Ngày tải lên: 06/03/2014, 15:20

... ª 2004 FEBS the full-length HOP, they act to facilitate the assembly of multichaperone regulatory complexes. The struc- tural independence of these TPR domains, and the presence of independent ... First, the only structures of natural TPRs in the PDB (13 TPR-containing coordi- nate sets) consist of nonglobular, extended arrays of helices [9,10,13–21]. Second, the majority of these (11 structures) ... region of NlpI. These constitute the most distant interactions between elements of primary structure, and include a hydrogen bond between the backbone carbonyl of Asn263 and the backbone amide of...

Ngày tải lên: 07/03/2014, 16:20

... another than to any other profile in the data set. The profiles of G can be summarized by a vector s whose dimensionality is that of the data, and each of whose elements contains the mean of ... significant finding of the proposed methodology. The scaling of the ‘Allah’ variable dominates all the other variables. To gain resolution for the others, ‘Allah’ was eliminated from the lexical ... supportive of the thematic structure of each group. Suras of group C are more abundant in the use of narratives and addressing Mohamed to provide evidence of his message to people. Suras of group...

Ngày tải lên: 08/03/2014, 04:22

... orientation. Accordingly, the present data on the molecular mass of the native Hb complex as well as the Hb subunits are inconsistent. In addition, there are only two hypo- thetical models concerning the structure of ... [2,4,8,11,12,42] offers the chance to relate the structure and function of this interesting molecule. The present study has contributed to this approach: (a) the determination of the molecular mass of the native ... identified on the basis of their mass spectra, their retention times and characteristic ratio of the a- and b-anomers. Analysis of phosphorylation For the detection of possible phosphorylation, Hb of red D....

Ngày tải lên: 16/03/2014, 13:20

... for the original. In the case of books and other printed matter, the copier may not be able to match the quality of paper or binding of the original or the crispness of the printing, and there ... restricting the use of the property, and if so this is as much a cost of the property right as the cost of the fence is. Suppose the owner of a shop- ping center does charge for the use of his parking ... ownership of the supplies of a particular good, and of all the easily substitutable alternatives for it, to enable the owners to control the prices of the property they own. Nei- ther the withholding,...

Ngày tải lên: 16/03/2014, 15:20

... both by the orientation of the energy transfer partners and by the distance between them [28]. The fact that the efficiency of transfer varies with the 6th-power of the distance between the fluorophores presents ... in 50% of the maximal efficacy (R 0 ). As indicated by the Fo ¨ rster equation, the efficiency of transfer varies inversely with the 6th-power of the distance. The extreme steepness of the relationship ... assessing the effect of ligand-binding on the quaternary structure of the receptors, the possibility that the antibodies could inhibit binding to the receptor also needs to be controlled. Finally, the...

Ngày tải lên: 16/03/2014, 22:20

... Proceedings of the Joint Conference of the 47th Annual Meeting of the ACL and the 4th Interna- tional Joint Conference on Natural Language Process- 1413 Proceedings of the 49th Annual Meeting of the ... with very complex structures. By (3)–(5), the generation of word structures is exactly the same as that of ordinary phrase struc- tures. Hence the probabilities of these words can be defined in the ... parse tree T , if we denote the set of lexicalized phrase structures in T by C, the set of lexicalized word structures by W, and the set of unknown flat words by F, then the joint probability Pr(T,...

Ngày tải lên: 17/03/2014, 00:20

... among E, R and S, but rather by successively taking account of the meanings of the nested pres, futr and perf operators in the LF of the sentence. As it happens, each of those operators implicitly ... tree nodes. The traver- sal of trees and the addition of new tokens is simply and fully determined by the logical forms of the sentences being interpreted. The major advantage of tense trees ... (indexical) LF of a new utter- ance always begins with the root node of the current tense tree (structure) in focus. The processing of the top-level operator immediately pushes a token for the surface...

Ngày tải lên: 17/03/2014, 08:20

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Ngày tải lên: 23/03/2014, 06:20