the temporal structure of the narrative

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... the ter- tiary structure of ApeSOD has not been elucidated. In the present study, for the first time, we describe the crystal structure of ApeSOD. In particular, we focus on the coordination of ... ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, from the apical positions. The manga- nese was only 0.06 A ˚ out of the equatorial plane (Table 3). The angles around the metal ... metal cofactor. Figure 3D shows the superimposition of the active site structures of apo, Mn-bound and Fe-bound Ape- SODs. The most significant difference among them was related to the OH of Tyr39,...

Ngày tải lên: 14/02/2014, 22:20

... especially฀ those฀who฀hold฀general฀bachelor’s฀degrees,฀their฀qualifications฀serve฀only฀as฀a฀signal฀ of their฀potential฀to฀employers.฀In฀many฀cases,฀they฀take฀longer฀to฀realise฀employment฀ and฀when฀they฀do฀their฀entry฀level฀jobs฀do฀not฀necessarily฀require the years of schooling฀ they฀possess.฀They฀start฀at the bottom of the job฀ladder฀and฀have฀to฀prove฀themselves฀ in the labour฀market฀to฀reach฀higher฀income฀levels.฀A฀combination of their฀potential฀ and฀training฀will฀determine฀their฀progression฀up the ladder.฀As฀will฀be฀seen฀in the next฀ section, the field of study,฀which฀signals the type of skills฀acquired฀through฀education,฀ plays฀a฀significant฀role฀in฀employability of university฀graduates฀in฀this฀case. Percy฀Moleke Free ... www.hsrcpress.ac.za 4 Percy฀Moleke 5 Inequalities฀in฀Higher฀Education฀and the Structure of the Labour฀Market Despite the observed฀significant฀increases฀in the number of senior฀certificate฀holders฀ in the past฀decade, the proportion of learners฀who฀actually฀sit฀for the exam฀remains฀ low. The quality of the senior฀certificate฀exam฀also฀continues฀to฀be of concern. The large฀majority of learners฀still฀opt฀to฀write the senior฀certificate฀exam฀on the standard฀ grade฀rather฀than฀on the higher฀grade.฀Consequently, the proportion of those฀passing฀ with฀ ... www.hsrcpress.ac.za 14 Percy฀Moleke 15 Inequalities฀in฀Higher฀Education฀and the Structure of the Labour฀Market in฀education฀or฀in the labour฀market,฀have฀done฀little฀to฀address the inequalities of the past. The lack of labour฀ market฀information฀...

Ngày tải lên: 15/02/2014, 17:20

... express ε AB R A43B in the form curl/π (2) + E (2) . 5. Strategy of the proof of the Asymptotics Theorem In this section we describe the main ideas in the proof of the Asymptotics Theorem. (1) Section ... given a detailed proof of the theorem by relying heav- ily on a result, which we have called the Asymptotics Theorem, concerning the geometric properties of the causal structure of appropriately ... I + 0 is the future domain of the origin on Σ 0 . Remark 9.3. The proof of Corollary 9.2 requires an extension argument. The estimates of the Asymptotics Theorem, which are uniform with respect to the...

Ngày tải lên: 16/02/2014, 05:20

... to the intensification of the sovereign debt crisis in the euro area. The pricing of risk in the repo market has become more dependent on the geographic origin of both the counterparty and the ... maintaining the integrity of the single market. Finally, Chapter 5 draws together the analysis of the previous chapters. It reiterates the importance of banks in the EU economy, summarises the key ... mandate, the Group also expects the on-going fundamental review of the trading book by the Basel Committee to improve the control of market risk within the banking system. The Group sees the Commission's...

Ngày tải lên: 16/02/2014, 10:20

... present for the last four residues at the C-terminus. The stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regions ... Asp291 (2.2 A ˚ ) and the water molecule w1 (2.1 A ˚ ) (Fig. 3A). The DHAP binding site protrudes from the metal N-ter C-ter Fig. 2. Ribbon representation of the overall structure of hACMSD. The (a ⁄ b) 8 barrel ... building using the program o [42]. Approximately 7% of the randomly chosen reflections were excluded from refinement of the structure and used for the free R-factor calculation [43]. The pro- gram...

Ngày tải lên: 18/02/2014, 06:20

... of SAIL Fig. 3. Secondary structure of At3g16450.1. (A) Ribbon representa- tion of the NMR structure of At3g16450.1. These figures were pre- pared using MOLMOL [25]. Due to the lack of NOEs, the ... constraints. Solution structure of SAIL At3g16450.1 Assignment of the NOE peaks of At3g16450.1 and the structure determination were accomplished by use of the cyana program [17,18]. The structural statistics ... Three-dimensional NMR structure of At3g16450.1. (A) Superposition of the 20 energy-minimized conformers that repre- sent the 3D solution structure of the N-terminal domain. (B) Super- position of conformers...

Ngày tải lên: 18/02/2014, 14:20

... dispersion in the HN region as well as in the methyl region (data not shown) is an indicator of the lack of globular structure, and of little, if any, secondary structure [15]. The presence of strong ... e.g. the case of the association between the N-terminal region of the membrane-bound tyrosine kinase Lck with the cytoplasmic tail of the T-cell coreceptors CD4 or CD8 [37]. In solution, on the ... typical of disor- dered proteins. The content of secondary structure was estimated through deconvolution of the CD spectrum in the range 190–240 nm using several methods [13]. The best fit between the...

Ngày tải lên: 18/02/2014, 16:20

... reveals that the most similar regions of these proteinases medi- ate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain of the ... Asp189 at the bottom of the pocket determines the specificity of the S1 pocket for basic residues Arg and Lys at position P1 of the substrate. Consequently, in the DESC1 complex structure the bound ... below). The southern boundary of the active site cleft of DESC1 is formed by the 145 autolysis loop. The backbone of this loop differs mark- edly from the other serine proteinases, making the act- ive...

Ngày tải lên: 19/02/2014, 00:20

... determines the shape of the active site entry. (e) The structure of the active site is essentially identical with the active sites of the MshB and LpxC proteins. The conservation of catalytically important ... studying the corresponding proteins of B. anthracis because it lacks infectiousness of the latter. The objective of the present study is to shed light on the structure, function and the structure function ... diagram. B A Fig. 1. Structure of the BcZBP dimer. (A) Topology diagram of the dimer drawn with the program TOPDRAW [34]. The relative orienta- tion of the secondary structure elements is illustrated. The shaded areas...

Ngày tải lên: 19/02/2014, 00:20

... information on the heme pocket structure. As shown in Table 2, the hyperfine splitting constants of the 15 N nucleus of the distal NO and of the 14 N nucleus of the proximal His of the GmHO-1 complex ... against the concentration of azide of each solution. The intersection point corresponding to the mole fraction of 0.5 of the respective forms gives the amount of azide necessary to attain the equilibrium, ... characteristics of the heme pocket of GmHO-1 might be associated with the smaller values of K azide for GmHO-1 and SynHO-1, and with the ferric character of the heme. The K imidazole values of the three...

Ngày tải lên: 19/02/2014, 05:20

... the large P6 extension and the last three nucleotides (AU XG) of the intron. The sizes of the intron (InDG b ) and 5¢ exon (5E) are indicated. The arrow indicates cleavage of the pre-RNA at the ... Because of these and other properties of Cr.LSU, the tertiary structure of the intron from 23S.5DG b was examined using Fe 2+ -EDTA cleavage. The ground-state structure shows evidence of an unusually ... 23S.5DG b pre-RNA, and the binding of a minimum of n Mg 2+ ions leads to formation of the active complex, whereas binding of a minimum of m Mn 2+ ions forms the inactive complex. The sizes of the active and inactive...

Ngày tải lên: 19/02/2014, 07:20

... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework of the enzyme or the active site. The active sites of the enzymes are shown in stick format with the sigmaA ... productive binding of steroid substrates: in the first, a (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive conformation. ... bond in close proximity of the N5 atom. A putative flipping motion of the progesterone molecule along an axis parallel to the FMN plane aligns the C1-C2 with the plane of the isoalloxazine ring...

Ngày tải lên: 20/02/2014, 02:21