the balanced growth path
The ubiquitin-proteasome pathway in cell cycle control
... and then effects the processive attachment of ubiqui-tin monomers first to lysines on the targeted protein and then to lysines ofpreviously attached ubiquitins. The activation of ubiquitin by the ... down-regulated. The primarymechanism whereby this requirement is met is via the APC/C-dependent The ubiquitin-proteasome pathway in cell cycle control 157minal to the F-box. In addition, some members of the ... domainproperly with respect to the catalytic site of the SCF core. The essentialityof dimerization in the function of other Cdc4/Fbw7 homologs remains to bedetermined. The second class of SCF cofactor...
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Tài liệu Management by objectives and the Balanced Scorecard: will Rome fall again? doc
... remain as the focus (Bartol and Mar-tin, 1991; Odiorne, 1987; Reddin and Kehoe,1974). The Balanced ScorecardThis section details the development of the Balanced Scorecard, and defines the charac-teristics ... hasbeen detailed as the failure of management toshift their thinking to the human relationsmodel. It is worthwhile considering the impli-cations of this with respect to the Balanced Scorecard. ... is likely that the business envi-ronment of the 1990s is more conducive to the use of the human relations model than was the case with MBO implementation. This isassociated with the widespread...
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Effective Performance Management with the Balanced Scorecard
... strategy.Thus, the balanced scorecard designprocess is founded on the premise ofstrategy as a set of hypotheses aboutcause and effect. These hypothesesform the strategy for moving the organisation ... intake).Interestingly, users of the scorecardnoted that: the more you understand the scorecard and the more you get usedto reading it, the more you see theseconnections and the more youunderstand ... developed. The report should outline: The balanced scorecard objectivesand measures that the project hasan impact on; The actions required to implement the project;– Desired project outcomes;–The...
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A Practitioner’s Guide to the Balanced Scorecard
... teams developing the strategy and then grapplingwith the issues of communicating and aligning the rest of the organisation to the strategy. There were some notableexceptions, with the case studies ... the architectand the design team need to co-ordinate a series of meetingswith the sub–groups to refine the strategic objectives andensure they reflect the decisions made at the workshop. Theyneed ... essential that the architect and the team keep a clearoverview of the relationships between the various Scorecards, the measures in each quadrant and the relationship of the measures to each other. In...
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Tài liệu Báo cáo khoa học: Isoprenoid biosynthesis via the methylerythritol phosphate pathway Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase ppt
... wasincubatedwithH-DXRinthepresence of NADPH, consumption of the cofactor wasshown by the decrease in the absorption at 340 nm,suggesting that the enzyme reduced the aldehyde 4.Fortheidentification of MEP, the ... triterpenoids of the hopane series from Methylobacterium fujisawaense demon-strated for the first time the presence of a rearrangement in the MEP pathway [48]. By analogy with the biosynthesis of the amino ... NADPH-dependent reduction of the oxogroup to give the final product. In the reactions catalyzed by the two enzymes, the ketol-acid and the DXP isomero-reductase, the formation of the expected intermediates,3-hydroxy-3-methyl-2-oxo-butyrate...
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Your Guide to the Breast Cancer Pathology Report pptx
... is removed from the body to check for cancer. These are called pathology reports. Each report has the results of the studies done on the removed tissue. The information in these reports will ... Your Pathology Report• The pathology report answers questions about a breast abnormality 6• Is the breast abnormality a cancer? 6• Is the breast cancer invasive? 7• How different are the ... Your Guideto the Breast Cancer Pathology ReportTABLE OF CONTENTSWait for the Whole Picture• Waiting for test results 2• Get all the information you need 3• Parts of your pathology report...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... that the R645–R657 peptide competesto disrupt the interaction of the JM region withanother non-identified region in the receptor [67]. The non-identified region of the receptor to which the JMregion ... contributing to their pathogenesis [16–19]. The Ca2+signal generated by the EGFR The activation of the EGFR generates a Ca2+signal,broadly defined as the transient rise of the intracellularconcentration ... resultof the interaction of the distal segment of the JM, par-ticularly the E663–S671 residues, with the C-terminallobe of the kinase domain of the apposed monomer[48,69], as well as the stabilizing...
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Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc
... in metabolic pathways are found visuallyby looking at the connectivity between the enzyme genes on the pathway map reflecting current pathway knowledge.Suppose that there is a pathway hole between ... In this study the param-eter h is set to 105. This means that, the larger the distancebetween two genes along the chromosome, the smaller the value of the similarity score. The resulting ... by the number of nucleotides between the end of the i-th gene and the start of the j-th gene along the chro-mosomes. We then derived a distance kernel using the for-mula Kposition(xi,xj)...
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Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx
... increase of synthesis of pyr-idine nucleotide cofactors, as the total pool of theseincreased. Whether the synthesis is regulated by the NADPH concentration remains speculation. The G6PDH overproducing ... 6-phosphate is a branching point to severalpathways. It leads to the pentose phosphate pathway,glycolysis and the pathways for biosynthesis of cellwall components. The Aspergillus niger gene encodingG6PDH ... Figure 4B shows the X-loading weights of the X-variables (measured variables other than NADPH)and the Y-loading of NADPH on the two PCs. AsNADPH is in the first quadrant of Fig. 4B (the fourquadrants...
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Báo cáo khoa học: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin⁄26S proteasome-mediated proteolysis potx
... interaction with the DSK2 homologfrom the respective species, we decided to test the hydrophobic patches within the UBLs of the DSK2homologs for their involvement in the interaction withRPN13. The potential ... abolished the association with RPN10 (Fig. 2B). These results indi-cate that the UBLs of the human RAD23 and DSK2homologs and yeast DSK2 play a role in the associa-tion with the RPN10 homolog. Furthermore, ... critical for the interaction. S5a in parentheses is the designated name for the human RPN10 homolog.dIF, the interface regions on the UBL–UBA factors that are involved in binding with the docking...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... focuses on whether the terms of bank lending ease or tightenover the course of the relationship as the relationship strengthens and the bank gains access to moreinformation. The extant theory offers ... in their life spans. During the early years of the fund, the senior managers search for andscreen new deals, and structure the contracts with the selected companies. During the middle years, the venture ... of the relationship (whether it extends to deposits and other services),3) the size of the borrowing firm and its outside finance options, 4) the structure of the banking industry, and5) the...
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Báo cáo khoa học: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway potx
... epidermal growth factor receptor; IP, immunoprecipitation by the antibody to the protein indicated at the right; WB, western immunoblot with the antibody to the compound indicated at the right. ... whether the SLexlevel of InR on insulin-responsive cells in diabeticpatients was changed. This may reveal the role of the sugar chains on InR in the pathogenesis of diabetes.In summary, the ... epidermal growth factor receptor (EGFR) on the cell surface and incells, as well as the sialyl Lewis X (SLex, the product of a1,3-FucT-VII)content of the EGFR were unchanged. However the level...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... serum-starvedandstimulatedwithEGForTGFa before the cells werewashed and Hrs was immunoprecipitated from the lysate.We chose to stimulate the cells with the growth factorsfor 8 min, as the growth factor-stimulated ... While EGF remains bound to the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa)rapidly dissociates and leaves the EGF receptor inactiveafter ... of the epidermal growth factor receptor signaling pathway. J. Biol. Chem. 277,1031–1039.37. Willingham, M.C., Jay, G. & Pastan, I. (1979) Localization of the ASV src gene product to the...
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Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc
... expected, the largest differences are found for the PPP split-ratio and the fluxes of the nonoxidative branch of the PPP. The minimized covariance-weighted sum ofsquared residuals (SSres) in these ... normalized for the glucose-uptake rate.Values outside parentheses denote the netfluxes, while values inside parenthesesrepresent the exchange fluxes. Solid arrow-heads denote the direction of the net ... of the traditionalmodel. The similarity of the flux estimates indicatesthat the presence of isoenzymes reduces the differencein13C-label distribution between the two models andimpedes their...
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The Next Growth Opportunity for Banks: How the Post-Crisis Financial Needs of Younger Consumers Will Transform Retail Banking Services pdf
... to address their needs using the tools they and their peers have adopted, including mobile devices, video, and social networking—and they are willing to switch to banks that embrace these technologies. ... Younger customers trust banks to help them. Despite challenges caused by the economic crisis, Gen Y and Gen X customers still trust their banks and want them to be their primary providers of advice. ... This finding does not predict the demise of the branch channel, but rather the advent of a much more prominent virtual one. In fact, when asked about where these customers would like to finalize...
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- factor viiactivating protease fsap circulates as an inactive zymogen in the plasma fsap also regulates fibrinolysis by activating prourokinase or cellular activation via cleavage of plateletderived growth factor bb pdgfbb as the marburg i polymorphism
- the pathophysiological link between obesity and erectile dysfunction remains poorly understood in this minireview
- we have attempted to evaluate the existing literature pertaining to obesity and erectile dysfunction to determine whether a common pathophysiological link exists
- have been studied as potential key molecules in the pathogenesis of the precancerous intestinal metaplasia of the human stomach however
- the pathfinders of africa
- the fastest path to vb 2005 mastery
- the probabilistic longest path
- growth stages of the rice plant
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