t 11 14 q13 q32 mantle cell lymphoma

... http://www.wjso.com/content/8/1/69 Page of Figure Cut section of the second tumor also infiltrating the intestinal wall (arrow pointing to the tumor) Figure Cytological appearance (HEX10):Intestinal ... of the disease Most of the patients have advanced stages of the disease at the time of diagnosis, being also delayed by the difficulty in direct visualization of small intestine Patients with ... journal’s Editor-in-Chief Abbreviations MCL: mantle cell lymphoma; CT: computed tomography; WBC: white blood cells; CRP: c-reactive protein; MLP: multiple lymphomatous polyposis; Author details 1st Surgical...

Ngày tải lên: 09/08/2014, 03:22

... aryotype + - Weak CD23+ FMC7+ + + + FMC7+ + ++ Deltion Trisomy t (14; 18) t (11; 14) +/- - - - No consistant anomaly t (11; 18) AP12/MALT1 Antiapoptosis t (1 ;14) t( 3 ;14) ; t( 3;v) BCL10 Antiapoptosis ... investigation BCL2 Antiapoptosis Cyclin D1 Cell cycle regulator To our knowledge, this is the first reported case of MCL presenting with multiple intussusceptions of gastrointestinal tract, separately ... declare that they have no competing interests Authors' contributions VK, wrote the manuscript and involved in the patient care, RC performed the surgery, NP reviewed the histology and contributed to...

Ngày tải lên: 09/08/2014, 04:21

... copy of the written consent is available for review by the Editor-in-Chief of this journal 10 11 12 13 14 Competing interests The authors declare that they have no competing interests 15 Authors' ... were incidentally identified Poor results of pulmonary function tests and the coexistence of mantle cell lymphoma precluded the patient from further surgical treatment (lobectomy) for his early ... resected en bloc with the bullectomy specimen by a wide wedge resection of lung parenchyma Mantle cell lymphoma (MCL) is a distinct type of B -cell non-Hodgkin lymphoma characterized by t( 11; 14) (q13; q32) ...

Ngày tải lên: 09/08/2014, 07:22

... 5’-tttttctcgaGTGTCTAAATGGACCTCATATC TTTGAG-3’, and 5’-gtttttgaattCCAAATCTGACACGCAACCC-3’ (antisense) and Phusion Taq Polymerase (New England Biolabs, Boston, MA) The PCR product was then cloned into the TMP2 ... relevant to the radiation sensitivity or not in the clinical cases in the future PTEN is a lipid phosphatase that removes the activating signal and ultimately prevents Akt phosphorylation and activation, ... (OpenBioSystem, Huntsville, AL) was modified by deleting the miR-30 sequence using PCR with the following primers: 5’-PO4-GCCTCGAGCCTGAGGCTGGATCGGTCC CGGTGTCTTCTATGG-3’, and 5’-PO4-TGAGGGAAT TCGGACCGGGTAGGGGAGGCGCTTTTCCCAAG-3’...

Ngày tải lên: 09/08/2014, 09:20

... mechanisms of action, but the main event is thought to be a direct radiation-induced apoptotic cell death that leads to the elimination of malignant cells located in the spleen (since lymphocytes undergo ... patients Among NHLs, MCL subtype has the highest rate of ATM (Ataxia Teleangiectasia Mutated) inactivation, due to the presence of deletions or mutations in up to 40– 50% of patients [23-25] The ... sensitivity to ionizing radiations MCL patients bearing ATM inactivation seem not to have a worse prognosis, while recent in vitro data suggest that ATM loss may actually contribute to radiosensitivity...

Ngày tải lên: 09/08/2014, 10:21

... could thus reduce tumor burden through a direct cytostatic effect on the tumor cells, but also through an associated effect on tumor angiogenesis This dual effect of temsirolimus on tumor tissue ... contribute to its recently reported efficiency in refractory MCL resistant to conventional cytotoxic drugs On the long term, this supports the evaluation of antiangiogenic drugs in refractory ... Bergamin S, Rizzo S, Tirelli U, et al: Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma Blood 2008, 111 : 5142 -5151 Witzig TE, Geyer SM, Ghobrial...

Ngày tải lên: 10/08/2014, 22:21

... accurate diagnosis by correlating anatomo-pathologist and cytogenetic exams so as not to underestimate the incidence of atypical MCL in cancer/MALT localisation This case illustrates the necessity ... did the cytogenetic exam and IQR performed the anatomopathologic exam All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... from mantle cell lymphoma Radiolology Case Report 2008, 3:194, Online doi:10 .118 6/1756-8722-3-34 Cite this article as: Ianotto et al.: Acute dyspnoea and single tracheal localisation of mantle cell...

Ngày tải lên: 10/08/2014, 22:21

... Giacchetti A, Morichetti D, Tassetti A, Pulini S, Mulattieri S, Stronati A, Leoni P: Coexistence of two discordant B -cell lymphomas in the skin and lymph node: report of a case with primary cutaneous ... providing that other small B -cell lymphomas are excluded The pattern of spleen infiltration provides the best diagnostic piece of information and splenectomy represents a very useful diagnostic tool The ... Camaiore, Italy 6Laboratory of Cytogenetics, AOUP, Santa Chiara Hospital, 56126 Pisa, Italy Authors’ contributions GC evaluated the patient and wrote the manuscript AM, EC and VO carried out flow cytometry...

Ngày tải lên: 10/08/2014, 23:20

... pattern with low intensity on T1 -weighted and high intensity on T2 -weighted sequences Although this MRI pattern is highly suggestive of the lymphoma, there is no absolute correlation between the ... broad mantles of small lymphoid cells or the so-called mantle zone pattern [2] Later in the course of the disease the mantle zonal or nodular pattern progresses to a diffuse pattern [4] The immunohistological ... examined the specimens from our patient TK and PP participated in manuscript preparation All authors read and approved the final manuscript Competing interests The authors declare that they have...

Ngày tải lên: 11/08/2014, 12:20

... 5’-TCCTTCTCATCAGCAAGCTGTC-3’ and reverse 5’-GAGGCAGCCCAGGTCCTTGAA-3’ (529 bp fragment); PI3K, forward 5’-CATCACTTCC TCCTGCTCTAT-3’ and reverse 5’-CAGTTGTTGGCAATCTTCTTC-3’ (377 bp fragment); Akt, forward ... individually Statistical Analysis Data were analyzed with SPSS 11. 5 software Statistics processing about clinical data were evaluated with c2 test, Spearman’s rank correlation test Statistics processing ... by the value agreed to by a majority of observers In vitro Experimentation Materials Cell Culture The human cutaneous T cell lymphoma cell line Hut78 and the adult T lymphocytic leukemia/ lymphoma...

Ngày tải lên: 10/08/2014, 10:21

... patients with PTCL-NOS treated with anthracycline-containing chemotherapy Patients and methods Patients Patients diagnosed with PTCL between January 2000 and December 2009 from Korean institutions ... evaluated for inclusion into the study Patients with a diagnosis of PTCL other than PTCL-NOS, such as anaplastic large cell lymphoma, angioimmunoblastic T- cell lymphoma, enteropathy-associated T- cell ... performed at the time of diagnosis and prior to treatment No patients showed clinical signs of severe infection at the time of laboratory testing The study protocol was approved by the institutional...

Ngày tải lên: 10/08/2014, 21:23

... suggesting that the TCR transgene vector bIa yielded a better function of human antigen-specific TCR-redirected T cells than did vector aIb Cytotoxicity of TCR gene-transduced CD3 +T cells against Toledo ... plasmid-transferred T cells was superior to that of the TCR Va6-IRES-TCR Vb13-transferred T cells; specifically, the cytotoxicity of TCR-transferred T cells with cassette bIa directed to the DLBCL cell line ... effector cells with target cells, we found that the cocultivation of TCR gene-transduced CD3 +T cells with the Toledo cell line achieved the highest LDH level (Figure 5), indicating that TCR Figure...

Ngày tải lên: 10/08/2014, 22:21

... vincristine, prednisone) His gastric outlet obstruction was supported with total parenteral nutrition (TPN) for a few weeks, after which the patient was able to eat well A repeat PET scan after the ... unusual in that the lymphoma tested positive for EBV, even though it was of T- cell origin, which is only seen in a small minority of patients [12] The initial step in treating PTLD is reduction in ... Non-specific uptake in the stomach was also observed The patient was re-admitted to the hospital 10 days later, with increasing abdominal pain, symptoms of gastric outlet obstruction, weight loss, headaches...

Ngày tải lên: 11/08/2014, 02:22

... by the Editor-in-Chief of this journal Competing interests The authors declare that they have no competing interests Authors’ contributions OA attended the patient, collected data and wrote the ... wrote the manuscript GC attended the patient and revised the manuscript MW (head of department) attended the patient, and conceptualized the peculiarity of the case AS revised the pathological specimens ... for hepatitis, Rickettsiae and other zoonotic infections PPD (tuberculin) tests were negative (twice) as was an HIV test, and we ruled out parasitic infection The results of a complete panel...

Ngày tải lên: 11/08/2014, 14:21

... tuổi thơ *T m h t vi t với giọng rê thứ -Ghi n t nhạc, t p h t n t TĐN số -Nghe để so sánh -Vẽ, ghi chép Nhận x t ghi chép -Nghe, hiểu bi t thêm -Cả lớp -Ghi nhớ ! TI T 13 *n T N Số *m Nhạc Thường ... độ thang âm rê thứ hoà theo đàn -Gõ đệm theo phách -Giới thiệu h t toàn toàn h t Cánh n tuổi Thơ -Đệm đàn -Vi t công thức  Củng cố : h t hoàn chỉnh  Dặn dò Ho t Động HS *H t hoàn chỉnh h t Lý ... Rê thứ -Luyện đọc gam Fa trưởng, n t trụ -Đọc n t tập đọc nhạc số -Luyện đọc gam Rê thứ, T N số đọc n t -Phân bi t giọng song song học Giống khác TI T 15 - Kiểm Tra TI T 15 – Kiểm Tra 21 Trường...

Ngày tải lên: 04/06/2013, 01:25

... Cho bi t ® t tªn cho m t ®êng th¼ng § t tªn cho ®êng th¼ng: Cã c¸ch ® t cã mÊy c¸ch ® t tªn, chØ rã vµ vÏ h×nh minh t n cho ®êng th¼ng: häa C1: Dïng m t ch÷ c¸i in thêng a Hs: Lần lư t trả lời ... sinh thỉûc hiãûn t ìng bỉåïc - V âoản thàóng AB A Hs: Lãn thỉûc hiãûn t ìng bỉåïc mä t B - V âoản thàóng CD = AB trãn tia Cy C y D Ho t âäüng 2: V hai âoản thàóng trãn tia (8 ph t) V hai âoản thàóng ... l¹i c¸c néi dung ®· ®ỵc «n t p - Chn bÞ ti t sau kiĨm tra ti t Ngày soạn: Ti t 14: KIỂM TRA CHƯƠNG I A Mơc tiªu - KiÕn thøc: HƯ thèng, kiĨm tra l¹i néi dung cđa c¸c kiÕn thøc cđa ch¬ng - Kü n¨ng:...

Ngày tải lên: 09/07/2013, 01:26

... Toán Thể dục T p đọc Toán Mỹ thu t Thể dục Chính t Toán Luyện t T p vi t Tập làm văn Toán Kể chuyện Thủ công T n dạy Quan t m giúp đỡ bạn (tt) Sự t ch vú sữa Sự t ch vú sữa T m số bò trừ Ôn t p: ... x t bạn bảng - Thực hành t nh nhẩm - HS nối tiếp đọc k t phép t nh (theo bàn theo t ) - Đ t tính t nh - Vi t số cho đơn vò thẳng với c t đơn vò, chục thẳng với c t chục - T nh t phải sang trái ... nhắc lại toán - Thực phép trừ: 12 – - Thao t c que t nh Trả lời: 12 que t nh, b t que t nh, lại que t nh - Đầu tiên b t que t nh Sau tháo bỏ que t nh b t que (vì + = 8) Vậy lại que t nh - Còn...

Ngày tải lên: 17/07/2013, 01:25

... nc truy tng gii thng H Chớ Minh v hc ngh thut * T c phm tiờu biu: Ting gi niờn; Khi hon ca; ca ngi H Ch Tch; Tin v Si Gũn -GV ph t vn: ? Nhc s Lu Hu Phc sinh v mt vo ngy thỏng nm no ? * Bi h t ... LU HU PHC V BI HT LấN NG -GV yờu cu HS c phn ANTT trang 26 SGK -GV giỳp HS t m hiu ni dung bi ANTT * T c gi: Nhc s Lu Hu Phc (1921 - 1989) l mt nhc s vit nhc cũn nh (15 16 tui) - Cuc i v s ... nhỏỷn xe t -GV yờu cu c lp c ton bi TN -GV gi 1-3 HS c trn bi TN v cha li -GV hng dn HS gừ phỏch theo nhp 2/4,.chia nhúm HS õoỹc -HS Lừng nghe , baỡi TN thổỷc haỡnh HOT NG M NHC THNG THC 15P...

Ngày tải lên: 02/08/2013, 01:27

... HS học nhà:  Xem lại t p giải làm tiếp t p lại SGK t p t ơng t SBT  Xem trước học kế tiếp: “Bài 5: Ứng dụng thực t t số lượng giác góc nhọn Thực hành trời.” Luyện t p Trang ... Phương – THCS Thò trấn – NH : 06 - 07 * GV gọi HS lên bảng * Bài t p 30 / SGK * HS lên bảng làm làm * GV gọi HS lên bảng * Bài t p 31 / SGK * HS lên bảng làm làm * Câu b, GV gợi ý HS vẽ thêm AK ... thêm AK ⊥ CD b) X t ∆ vuông ANC : AN = AC.sin300 => AC = AN : sin300 ≈ 5,52 : 0,5 ≈ (m) a) X t ∆ vuông ABC có: AB = AC.cosC = 8.cos540 ≈ 8.0,5878 ≈ 4,7 (cm) b) Kẻ AK ⊥ CD, X t ∆ vuông CAK: AK...

Ngày tải lên: 06/08/2013, 01:26

... chủ, t o nên ph t triển thần kì kinh t II- Nh t Bản khôi phục ph t triển kinh t sau chiến tranh : Thành t u: - Kinh t t ng trởng thần kì đứng thứ hai giới (sau Mĩ) + T ng sản phẩm quốc dân t ng ... đúng, sai: Nh t Bản đợc gọi đế quốc kinh t dùng sức mạnh kinh t để xâm nhập thị trờng toàn giới Đ S T năm 70 kỉ XX, NB trở thành trung t m kinh t t i giới Đ S T c độ ph t triển kinh t nhanh chóng ... GV nhận x t, bổ sung ? T 1950 đến năm 70 kỉ XX kinh t Nh t Bản ph t triển nh nào? - HS trả lời - GV nhấn mạnh đến số số liệu thể ph t triển Nh t Bản - Kinh t t ng trởng thần kì: + T ng sản...

Ngày tải lên: 21/08/2013, 11:10