steroidal cyp17 inhibitors for prostate cancer treatment from concept to clinic

... 3D conformal radiotherapy for clinically localized prostate cancer Int J Radiat Oncol Biol Phys 1996, 35:869-874 Crook J, Esche B, Futter N: Effect of pelvic radiotherapy for prostate cancer ... projected contours on saggital/coronal view reconstruction In order to evaluate the impact of contouring intervariability on dose-volume histogram (DVH) parameters, for each patient, a prostate treatment ... radiotherapy for prostate cancer: a review Int J Radiat Oncol Biol Phys 2002, 52:681-693 Incrocci L: Sexual function after external-beam radiotherapy for prostate cancer: what we know? Oncol Hematol 2006,...

Ngày tải lên: 09/08/2014, 09:21

... and for radiation therapy treatment planning Nineteen patients presented with a recurrent prostate cancer (biochemical relapse) after previous radical prostatectomy with or without lymphadenectomy ... conformal irradiation or 50,4 Gy in IMRT with a boost to the FEC-PET/CT positive lymph nodes In recurrent cancer, the dose to the prostatic bed was 60 Gy from 2006 to 2008 and thereafter 64 to ... Figure SUVmax for primary and recurrent prostate cancer The maximum standardized uptake value (SUVmax) is given for primary and recurrent prostate cancer receiving a Choline-PET/CT for diagnosis...

Ngày tải lên: 09/08/2014, 09:20

... followed after treatment for prostate cancer are more likely to have their death attributed to prostate cancer In this study, this bias could lead to overestimation of survival from non -cancer causes ... (NCNG) for prostate cancer state that "life expectancy estimation is critical to informed decision-making in prostate cancer, early detection and treatment" The NCNG guidelines for curative treatment ... incidence of non -prostate cancer mortality unadjusted and adjusted for prostate cancer mortality Deaths from prostate cancer are a competing cause of mortality with non -prostate cancer deaths Figure...

Ngày tải lên: 09/08/2014, 10:21

... RT technique for treating prostate cancer is external beam radiotherapy, often delivered conformally to spare as much normal tissue as possible A great deal of effort has been put into improving ... (HT) on acute toxicity in men with prostate cancer treated with radiotherapy Peeters et al [34] concluded that neo-adjuvant HT appeared to be an independent prognostic factor for acute toxicity, ... overall treatment time of weeks and fraction number of 25 is estimated to be very unlikely to result in significantly increased late effects Previous late toxicity reports of radiation in prostate cancer...

Ngày tải lên: 09/08/2014, 10:21

... various human cancers including non-smallcell lung cancer, ovarian cancer, breast cancer, colon cancer, pancreatic cancer, liver cancer, oral cancer, head and neck cancer and neuroblastoma[12-20] ... subsequently incubated for 24 h to allow attachment After incubation for 2,3,4,5,6 days, 20 μl MTT solution (5 mg/mL in PBS) were added to the wells for h incubation before termination by aspiration ... PCa compared to BPH (Additional file 3, Figure S2B) Furthermore, immunohistochemical staining was performed to evaluate Periostin expression in the stromal or epithelial cells of prostate (Additional...

Ngày tải lên: 18/06/2014, 19:20

... various human cancers including non-smallcell lung cancer, ovarian cancer, breast cancer, colon cancer, pancreatic cancer, liver cancer, oral cancer, head and neck cancer and neuroblastoma[12-20] ... subsequently incubated for 24 h to allow attachment After incubation for 2,3,4,5,6 days, 20 μl MTT solution (5 mg/mL in PBS) were added to the wells for h incubation before termination by aspiration ... PCa compared to BPH (Additional file 3, Figure S2B) Furthermore, immunohistochemical staining was performed to evaluate Periostin expression in the stromal or epithelial cells of prostate (Additional...

Ngày tải lên: 20/06/2014, 04:20

... documented in small cell lung cancers [3], prostate cancers [4, 5], breast cancers [6-8] and others [9] In prostate cancer, the GRPR expression has been tied to neoplastic transformation [10], cell migration ... receptors; PC3 tumor Background Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer- related deaths for males in the USA One promising approach in prostate ... measured were 74 to 93 TBq/mmol (2,000 to 2,500 Ci/mmol) for NOTA-monomer, and 93 to 130 TBq/mmol (2,500 to 3,500 Ci/mmol) for 64Cu/NOTA-dimers and Figure shows radio-HPLC chromatograms of 64Cu/NOTAmonomer...

Ngày tải lên: 21/06/2014, 17:20

... analog commonly used in the treatment of breast cancer, oval cancer, small and nonsmall cell lung cancer, prostate cancer, etc Its commercial formulation TaxotereÒ is formulated in high concentration ... docetaxel formulation It can be found from Table that the IC50 value for MCF-7 TAX30 cells was decreased from 10.380, 8.726, and 5.945 lg/mL for TaxotereÒ to 7.388, 3.643, and 1.244 lg/mL for PCL NP formulation ... cytotoxicity, p [ 0.05) for PCL NP formulation and 36.63% (i.e a 38.88% increase in cytotoxicity, p \ 0.05) for PCL/Pluronic F68 NP formulation Similarly, it can be evaluated from Fig that compared...

Ngày tải lên: 22/06/2014, 00:20

... being more sensitive to changes in acute bowel toxicity in comparison to RTOG acute morbidity scoring criteria or proctoscopic toxicity scores [23] Apparently, prostate cancer radiotherapy with ... multivariate analysis was performed to demonstrate independent factors - intradomain score changes relative to baseline at time C proved to be independent significant predictors for adverse score changes ... technique to a dose of 70.2-72 Gy) We have to be aware that the dose-volume histogram is related to a single treatment planning CT scan Taking into account changing organ volumes during the treatment...

Ngày tải lên: 09/08/2014, 08:23

... into the pelvis to exclude small bowel from the pelvis to prevent injury from post-operative radiotherapy[8] Sugarbaker described covering the implant with a mesh which was sutured to the peritoneum ... or the abdomen to prevent radiation injury to small bowel (Table 1) All of these were inserted at open laparotomy Lasser first described its use prior to radiotherapy for rectal cancer [9] Many ... as an option for excluding small bowel from the pelvis prior to radiotherapy of the prostate Consent Written informed consent was obtained from the patient for publication of this case report and...

Ngày tải lên: 09/08/2014, 09:20

... urgency toxicity Furthermore, this patient suffered from Table 2: Pre -treatment complaints and acute toxicity according to the Common Toxicity Criteria (CTC) and late toxicity according to the ... before radiotherapy for both GU and GI Ninety-nine percent of the patients with pre -treatment grade ≥ GU symptoms demonstrated acute grade ≥ toxicity, compared to 36% of the patients with pre -treatment ... days after the start of treatment [21] Late toxicity was scored according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) morbidity...

Ngày tải lên: 09/08/2014, 09:22

... were addressed to respond before treatment agreed to take part in the evaluation (>98%) The response rate to the last questionnaire was 91%, so that 28 patients who responded before treatment were ... Takahashi M, Saito J, Kitamoto Y, Harashima K, Miyazawa Y, Yamada M, Ito K, Kurokawa K, et al.: Rectal bleeding after hypofractionated radiotherapy for prostate cancer: correlation between clinical ... Mitsuya M, Takai Y, Yamada S: Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer Anticancer Research 2009, 29:1831-1834...

Ngày tải lên: 09/08/2014, 10:20

... P, Todesco S, Doria A: Clinical implications of autoantibody screening in patients with autoimmune myositis Autoimmunity 2006, 39:217-221 11 Levine SM: Cancer and myositis: new insights into ... particularly of both adductors A biopsy of adductor muscle tissue was performed Histological and immunohistochemical tests (inflammation marker, membrane attack complex, and major histocompatibility complex ... Rheumatol 2006, 18:620-624 12 Crayton H, Bohlmann T, Sufit R, Graziano FM: Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma Clin Exp Rheumatol 1991,...

Ngày tải lên: 10/08/2014, 23:20

... rates, current treatment regimens for breast cancer remain unsatisfactory The relapse rate for breast cancer patients is 85% (Bernard-Marty, Cardoso et al 2004) This highlights the need for the continued ... research to develop and improve treatment regimens against breast cancer 1.3 Treatment regimens against breast cancer Surgery and radiation are often used to treat early stage localized breast cancer ... cornerstone therapy for advanced breast cancer, especially for breast cancers that not express estrogen, progesterone and HER2 receptors In addition, chemotherapy is not only given for the treatment of...

Ngày tải lên: 11/09/2015, 10:07

Ngày tải lên: 27/02/2014, 13:45

Ngày tải lên: 27/02/2014, 17:00

... sense for a leader I examined the usage of agape and agapao in the New Testament and while agape seemed to refer to God’s love for us or for Jesus’ love for the Father, agapao seemed to refer to ... well today and may be best understood in light of the Golden Rule: “Do unto others as you would have them unto to you,” and even more to the Platinum Rule of “Do unto others as they want you to ... the efforts to raise employees’ salaries to the minimum living wage and I have lost in other efforts I am committed, though, to continuing the efforts to raise salaries wherever I can This concept...

Ngày tải lên: 07/03/2014, 19:20

... receptors and maintaining the receptor in an auto-inhibited form Binding of its native ligand to the receptor brings domains I and III close together, switching the receptor’s conformation to the ... within a large clinical trial (121) sought to use serum markers to optimize treatment strategies in breast cancer The authors investigated serum 20 Oncogene and Cancer – From Bench to Clinic Her2 ... guidelines) is to monitor response to therapy in the metastatic breast cancer setting Candidate Protein Biomarkers with possible clinical application in breast cancer i Topo2-alpha (Topo2) DNA topoisomerase...

Ngày tải lên: 16/03/2014, 21:20

... receptors and maintaining the receptor in an auto-inhibited form Binding of its native ligand to the receptor brings domains I and III close together, switching the receptor’s conformation to the ... within a large clinical trial (121) sought to use serum markers to optimize treatment strategies in breast cancer The authors investigated serum 20 Oncogene and Cancer – From Bench to Clinic Her2 ... guidelines) is to monitor response to therapy in the metastatic breast cancer setting Candidate Protein Biomarkers with possible clinical application in breast cancer i Topo2-alpha (Topo2) DNA topoisomerase...

Ngày tải lên: 23/03/2014, 14:20

... importance to understand the molecular basis of the 16 Cancer Prevention – From Mechanisms to Translational Benefits treatment limitations and to formulate improved strategies to overcome them For example, ... targets for cancer treatment, inflammation inhibition, and chemoprevention Taken together, the acid-base transporters and proton-sensing receptors described above are important for cancer cells to ... MCTs may, therefore, represent potential targets for cancer treatment Vacuolar-type H+-ATPases (V-ATPases) are multi-subunit, complex enzymes that transport protons from the cytoplasm to vacuolar...

Ngày tải lên: 28/03/2014, 10:20