sex in schistosomes signaling mechanisms in the female gonads

... studies,treating each observationwith equal weight and giving no considerationto possible differences among the 20 study populations(including whetherthey were increasingor declining)or the fact ... longevity in the sense that the the patternof senescence roughly approximates pattern of survival Indeed, if theories about the evolution of senescence are correct,then the are inextricablylinked ... such a determination In this paper we model age-specific reproductive changes in the brown bear by combining data from multiple studies, then fitting those data to models describingthe processes...

Ngày tải lên: 05/03/2014, 17:20

... a correct diagnosis [3] The characteristic findings are interlacing spindle-shaped tumor cells in the dermis and subcutaneous fat layer that form definite bands that interweave or radiate like ... to obtain surgical margins According to a review of Mizutani et el., imatinib inhibited the growth of metastatic lung lesions in a patient with DFSP [13] In conclusion, although DFSP in the breast ... assistance in editing the manuscript Authors’ contributions TH was responsible for the conception and design for the manuscript, the clinical work, the search for the literature, and the editing work...

Ngày tải lên: 09/08/2014, 01:24

... female bonding in the Caribbean, “othermothers” share the mothering responsibilities to nurture children They can be a female bridge between the biological mother and the daughter like those in Beka ... to the stage of complicated puberty, demonstrating the pains of growing up in the Caribbean during the era of colonial domination Of the four writers, Cliff is a light-skinned mulatto, while the ... examines female bonding in women’s literature According to de Abruña, female bonding as a subject of study begins with the publication of Ronnie Scharfman’s article “Mirroring and Mothering” in...

Ngày tải lên: 06/10/2015, 20:56

... Subsequent studies using the yeast two-hybrid system revealed that decorin binds to a narrow region within ligand-binding domain L2 of the EGFR, overlapping with the EGF-binding domain [32] The structural ... whether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well The complexity of decorin signaling is further expanded by additional degradative pathways involved in decorin ... enhancing its binding to chordin [71] The latter, in turn, leads to BMP-4 inactivation by the chordin– twisted gastrulation complex [71] Lumican signaling in cell growth and in ammation The role...

Ngày tải lên: 15/03/2014, 23:20

... McClain DA, Litwin SE et al (2002) Insulin signaling coordinately FEBS Journal 274 (2007) 5278–5284 ª 2007 The Authors Journal compilation ª 2007 FEBS 5283 Metabolic gene switching in murine female ... in the murine female heart Moreover, our data suggest that these changes occur in an Akt-independent manner Further studies are therefore required to identify the precise signaling mechanisms ... additional insights into this interesting question Conclusions In summary, we have identified a novel metabolic gene switch (decrease in fatty acid utilization, increase in glucose utilization) in the...

Ngày tải lên: 18/02/2014, 16:20

... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... swelling [12–14] Integrin-inhibitory peptides exhibiting an arginine-glycine-aspartic acid (RGD) motif abolish hypoosmotic osmosignaling towards Src-type kinases, mitogen-activated protein kinases...

Ngày tải lên: 18/02/2014, 16:20

... During integrin outside in signaling, the binding of integrins to their extracellular ligands changes the integrin conformation and promotes integrin clustering The unidirectional signalings, in ... (juxtacrine signaling) as well as over short (auto- and paracrine signaling) and long (endocrine signaling) distances In juxtacrine signaling, plasma membranes of interacting cells come into contact ... often closely linked, as ligand binding associated with outside in signaling stimulates integrins and, conversely, integrin activation increases ligand binding for inside–out signaling 1.1.5.3 Modularity...

Ngày tải lên: 05/03/2014, 22:21

... dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic and degradative enzymes, the endocannabinoid ... significantly increased following the ischemia-like insult [42] The endocannabinoid system in cerebral ischemia The ‘dark side’ of CBs An independent line of research supports a contrasting, neurotoxic ... Concluding remarks The great deal of knowledge accumulated in the past three decades on the mechanisms underlying damage in icted to the brain tissue by cerebral ischemia has failed to translate into...

Ngày tải lên: 07/03/2014, 03:20

... is attenuated by the cAMP signaling pathway Our studies further indicate a novel regulatory mechanism of cAMP signaling for altering the sumoylation cycle, involving modulating the expression of ... associated with the targeting of LRH-1 into nuclear bodies that is inhibited by cAMP signaling Because the ovary expresses LRH-1, we further examined the effect of sumoylation site mutation on the nuclear ... localization in the nuclear speckles is associated with sumoylation, we therefore determine whether cAMP signaling affects the SUMO modification pathway We used RT-PCR to study the effects of forskolin...

Ngày tải lên: 23/03/2014, 06:20

... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus ... promoter reporter These two motifs (DR1 and IR1) contain identical half sites and the same intervening single base, the difference being the orientation of the second half site as in the same direction ... vector The green fluorescent protein (GFP)-dUSP fusion protein was prepared in pIE1-4 by subcloning the GFP coding sequence for into the EcoRI ⁄ SmaI sites of the pIE14 vector, upstream of and in the...

Ngày tải lên: 23/03/2014, 13:20

... leader in the field Clinicians will all benefit from these reviews The effort and dedication of the authors in the time expended in the writing of the different chapters is fully demonstrated by the ... is a group of genes involved in maintaining the integrity of the epithelial barrier at the mucosal surface and signalling to the immune system after environmental exposure The third group are ... keratinocytes dividing in the basal lamina and moving to the upper layer as they mature K10 is expressed in keratinocytes in the early stages following differentiation, whereas K14 is expressed in undifferentiated...

Ngày tải lên: 23/03/2014, 17:20

... While these findings are based on evidence in developed countries, the same is true in the developing world Investing in sexuality education, social programmes for youth, youth-friendly sexual ... in the Youth Coalition’s first ever regional training on the International Conference on Population and Development in the Southeast Asia region The Youth Coalition initially envisioned working ... produce lifelong inequalities and deep-seated feelings of injustice These inequities extend to things like access to information: while access to communication technologies, including the internet,...

Ngày tải lên: 28/03/2014, 20:20

... intolerance Fat cells Fig Model for the role of ApoE in the development of diet-induced obesity in mice Dietary lipids are packaged into chylomicrons in the intestine and then secreted into the ... avidly by adipose tissue than the lipoproteins containing mouse ApoE There has been much discussion in the medical community concerning the role of in ammation in obesity In particular, although some ... interpretation of the results obtained by Huang et al [41] is that intrinsic defense mechanisms in adipose tissue limit adipogenesis by reducing the expression of ApoE in the fed state Certainly,...

Ngày tải lên: 29/03/2014, 22:21

... are indicated in bold/underlined) from the template of a pUC19 plasmid DNA containing GH1 (Xinxiang Medical University, Xinxiang, Henan Province, China) The 677-bp GH1 DNA fragment (including the ... alcohol-fed mice These findings also indicate that GH administration coordinates the adiponectin-SIRT1-AMPK signaling system to modulate its downstream signaling molecules that regulate the transcription ... was gradually increased from 17% to 35% during the first week of feeding and then maintained at the same concentration for another weeks [25] Food intake was recorded daily in the control and...

Ngày tải lên: 18/06/2014, 16:20

... in the S phase [37] Furthermore, other members of aryl hydrocarbon receptor signaling, the inhibitors of cyclin-dependent kinases (p16 and p21), have been demonstrated to bind E7 increasing the ... subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the level of phosphorylated pRb In this way, ... during integration The aim of this study was to identify the molecular mechanisms commonly deregulated in SCLC induced by viral oncoproteins and in patients with SCLC Therefore, we examined the...

Ngày tải lên: 18/06/2014, 16:20

... during experimental stress Type D was also associated with a decreased activity in the amygdala in response to fearful expressions [10], suggesting inadequate emotion-processing in the brain Finally, ... endothelial progenitor cells [47] in cardiac patients These initial findings are promising, but more research is needed to examine the cardiovascular effects of stress in apparently healthy individuals ... myocardial infarction, and increased risk of mortality [4-7] Given the clinical relevance of findings on Type D research in the context of cardiovascular disorders, it is also important to assess the...

Ngày tải lên: 18/06/2014, 19:20

... expressing CCR1, CCR2 or CCR5 mRNA within and around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages, ... rats in the acute phase (day 13) revealed marked inflammatory lesions in the white and grey matter of the spinal cord (Fig 3D) Within the inflammatory infiltrates, numerous actively phagocytosing...

Ngày tải lên: 19/06/2014, 22:20

... coming year, and iii) training for ≥ hr/wk-1, considered frequent training [17] As previous research showed that participation in certain sports (e.g gymastics, running) increases the risk of the ... assessed using an adaptation of the screening questions routinely used in the 'Eating, Sports and Health in Females' project of the Better Eating Safer Training Research Study (B.E.S.T.) research ... training for the athletes was defined as the total number of hours training per week For the control population, amount of physical activity was defined as the total number of hours per week including...

Ngày tải lên: 20/06/2014, 00:20

... leader in the field Clinicians will all benefit from these reviews The effort and dedication of the authors in the time expended in the writing of the different chapters is fully demonstrated by the ... is a group of genes involved in maintaining the integrity of the epithelial barrier at the mucosal surface and signalling to the immune system after environmental exposure The third group are ... keratinocytes dividing in the basal lamina and moving to the upper layer as they mature K10 is expressed in keratinocytes in the early stages following differentiation, whereas K14 is expressed in undifferentiated...

Ngày tải lên: 27/06/2014, 10:20

... communication interventions, the health knowledge indicators was the fastest growing, then to the attitude indicator and the practising indicator were slowly increased The results of this study on the ... that to expand this intervention model for other centers over the nation The layout of the thesis The thesis is presented in 124 pages, excluding appendixes and is divided into: Introduction: pages ... Gonorrhea in FSW The Gonorrhea ratio in the neiboring contries are 5.7 % in Cambodia and 9.5 % in China Syphilis: caused by Treponema pallidum Research in border provinces of Vietnam showed the incidence...

Ngày tải lên: 25/07/2014, 13:32