role of immune cells
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
Ngày tải lên :
14/02/2014, 18:20
... play a critical role in the immune system by providing an early recognition of pathogen invasion and a facilitation of the body’s subsequent immune responses [27] The stimulation of these receptors ... (CLP), the hepatic mRNA level of CD163 was similar with that of the sham group, which markedly decreased to approximately 7.0% of that of the CLP group (Fig 1) Table Effect of GdCl3 on serum aminotransferase ... to the inhibition of CYP activity observed in the absence of changes in protein expression in rabbit hepatocytes [22] ROS indirectly reduced the activity of selected isoforms of CYP by inducing...
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Báo cáo hóa học: " Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11" ppt
Ngày tải lên :
20/06/2014, 01:20
... return of CD8+ cells and became undetectable from 28 to 35 days of infection onwards throughout the rest of the observation period (> months) These results indicate that CD8+ cells play a major role ... high dose of SIVmac1A11 (5 × 105 50% tissue culture infectious doses, grown in CEMx174 cells) Immediately before virus inoculation, animals were depleted of CD8+ cells via administration of the ... depletion of CD8+ cells (K Reimann, personal communication) In the current study, CD8+ cells (both CD8+CD3+ T lymphocytes and CD8+CD3- NK cells) in peripheral blood were undetectable or low (< 1% of...
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Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
Ngày tải lên :
11/08/2014, 08:21
... controls2(A) of histological sections of tongue stained with chloroacetate esterase for identification of mast cells in littermate An example and Wf/Wf (B) mice An example of histological sections of tongue ... susceptibility of skeletal muscles to IR injury irrespective of the other abnormalities in these mice The role of mast cells has not been considered when investigating the susceptibility of different ... profile counts A probability level of p < 0.05 was taken to indicate statistical significance Results Morphologic appearance of labelled mast cells After CAE or toluidine blue staining, mast cells...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
Ngày tải lên :
12/08/2014, 15:20
... influence the regenerative response of the epithelium to chlorine [12] To evaluate the role of γδ T cells in chlorine induced airway injury we studied the responses of TCR δ -/- (γδ T cell deficient) ... magnitude of the inflammatory response in the two study groups Differences in levels of constitutive expression of KGF not seem to play a substantial role in determining the rates of epithelial ... recruitment of phagocytic cells is an important mechanism for removal of damaged epithelial cells [25] Increases in neutrophils and macrophages were greater in wild type mice whereas shed epithelial cells...
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Báo cáo y học: "Role of γδ T cells in protecting normal airway function" docx
Ngày tải lên :
12/08/2014, 18:20
... involved [22,24] These cells are therefore potential candidates for the role of protectors of epithelial cells, but Vγ4+ cells might also be involved In particular, Vγ4+ cells have been found ... portion of the Vγ6+ cells and perhaps all of the Vγ4+ populations originate in the thymus Unlike Vγ6+ cells, the later developing Vγ4+ cells initially express diverse TCRs However, these cells ... cells As outlined briefly at the beginningof this review, in adult mice the vast majority of γδ T cells express either Vγ4 or Vγ6 Vγ6+ cells are more likely to be associated with epithelial cells...
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The role of b cells in the pathogenesis of atherosclerosis 1
Ngày tải lên :
10/09/2015, 09:23
... The role of B cells in Atherosclerosis: Pathogenic or protective? Recent studies have revisited the role of B cells to clarify its role in atherosclerosis As described earlier, the transfer of ... cells 40 1.5.4.1 Migratory competency 44 1.5.4.2 Survival factors for plasma cells 47 1.5.4.3 Role of CD28 on longevity of plasma cells 50 1.5.4.4 Cellular sources of ... adoptive transfer strategies of PEC B1 cells of IgMa allotype to investigate contribution of B1a cells to differentiate into IgM+ ASCs in apoE-/- mice 186 xx List of Abbreviations ABTS...
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The role of b cells in the pathogenesis of atherosclerosis 2
Ngày tải lên :
10/09/2015, 09:24
... population of B1a cells differentiating into IgM+ plasmablasts in the spleen of apoE-/- mice (A-B) Comparative flow cytometry analysis of relative (A) percentage and (B) number of CD19+CD5+ B1a cells ... Accumulation of IgM+ long-lived plasma cells in the bone marrow of apoE-/- mice Because B cells also express CD138 in almost all stages of B cell development in the bone marrow of adult mice ... 3.6 Evaluation of the impact of splenic CD138+ ASCs on atherosclerosis Elegant studies by Caliguri et al, demonstrated that the adoptive transfer of splenic B cells, but not T cells, from old...
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The role of b cells in the pathogenesis of atherosclerosis
Ngày tải lên :
10/09/2015, 09:24
... Chapter Discussion 4.1 Summary of findings Our investigations on the role of B cells in the pathogenesis of atherosclerosis have led us to a better understanding of the humoral responses taking ... of Ha et al demonstrated the migration of B1a cells from PEC into the spleen was due to the activation of B1a cells via TLR signaling (Ha et al., 2006) Therefore, if there is a contribution of ... route of administration, we could assess if B1a cells migrated to the spleen of apoE-/- mice in response to hypercholesterolemia This would enable us to differentiate contribution of PEC B1a cells...
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Báo cáo y học: " (R)-albuterol decreases immune responses: role of activated T cells" docx
Ngày tải lên :
12/08/2014, 15:21
... pictures are representative of two mice examined in each group Arrows show inflammatory cells Magnification 10× proliferation of these cells via activation of PKA and inhibition of PI-3 and NF-κB [18] ... μg) was added to EL4 cells (to × 106) resuspended in nucleofector solution (Amaxa Biosystems) and electroporated using the C-9 program of the nucleofector After 24 hours cells were treated Con ... by the insertion of a miniosmotic pump To analyze the effects of albuterol isomers in vivo in a murine model of allergic inflammation, we analyzed the potential immune effects of a delivery device...
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THE ROLE OF DMSO IN THE REGULATION OF IMMUNE RESPONSES BY DENDRITIC CELLS
Ngày tải lên :
16/10/2015, 11:59
... Myeloid Cells form a Major Arm of Innate Immunity The cellular component in innate immunity formed by myeloid cells is a major arm of the innate immune system The generation of immune cells through ... 293T Cells (HEK293T) 65 III 2.3.4.3 Cryopreservation of Cell Lines 66 2.3.4.4 Thawing of cryopreserved cells 66 2.3.5 Priming and Activation of Monocyte, Macrophage and DC 66 2.3.6 Generation of ... pathways in the regulation of T cells development with the Th2 phenotype 1.10 56 The role of cytokines in differentiation and effector functions of Th1, Th2 and Th17 cells 56 3.1 Phenotypic markers...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
Ngày tải lên :
31/10/2012, 15:28
... 1mM concentration of ethanol in HepG2 cells [19] Int J Med Sci 2007, 32 Figure Functional genomics of low concentrations of ethanol in HepG2 cells (A) Reported interactions of each ethanol-regulated ... concentrations of 1x105/ml Six sets of experiments were performed Each set consist of two groups as follow: group 1, HepG2 treated cells with mM ethanol for h; and group 2, HepG2 cells without ... matrix-receptor interaction and regulation of cytoskeleton These data suggest an important role of integrin in the molecular mechanisms of ethanol effects in HepG2 cells The other ethanol-regulated genes...
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
Ngày tải lên :
31/10/2012, 15:37
... numbers of cells with apoptosis-associated alterations of the nuclei and without membrane barrier dysfunction were determined within a field of view at a magnification of X400 A total of 10 randomly ... phosphorylation of GRK2 and PKCα; with values of 109% and 104%, respectively, combined with dephosphorylation of ROKα, PKCδ and PKCμ; with values of -56%, -44% and -28% of control cells, respectively ... Germany) at concentrations of 1x105/ml Six sets of experiments were performed (n=6) Each set consist of two groups as follow: HepG2 cells treated with mM ethanol and HepG2 cells without ethanol treatment...
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Báo cáo Y học: Role of three isoforms of phospholipase A2 in capacitative calcium influx in human T-cells pot
Ngày tải lên :
08/03/2014, 09:20
... control (\P < 0.01) and TG-stimulated cells (\\P < 0.001) Fig Effects of TG on the induction of mRNA of different phospholipase A2 isoforms in Jurkat T -cells Cells were treated for two hours with ... isotype of PLA2 is phosphorylated after anti-CD3 stimulation in human T-lymphocytes Addition of TG potentiates the induction of mRNA of these four PLA2 isotypes The mechanism of action of TG on ... independently of increases in [Ca2+]i, probably via receptor coupling of this enzyme [36] Though TG stimulated the induction of expression of mRNA of four PLA2 isotypes, only three of them seem...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
Ngày tải lên :
16/03/2014, 18:20
... elements play a major role in determining both the level of expression and the location of the start of transcription of PS1 In the Ets family of transcription Ó FEBS 2004 Regulation of the presenilin ... SH-SY5Y cells and similarly by about tenfold in SK-N-SH and cells Further deletion to +42 increased transcription in both cells lines: about fivefold in SH-SY5Y cells and twofold in SK-N-SH cells ... p27 instead of Results Differential effect of 5¢-and 3¢-deletions in SH-SY5Y cells as compared to SK-N-SH cells The )118/+178 promoter fragment (Fig 1) produced the maximum level of expression...
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Báo cáo khoa học: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells docx
Ngày tải lên :
23/03/2014, 10:21
... depletion of gangliosides and the specificity of the antiGM3 serum The distribution of ErbB2 appeared more 1822 Fig Scanning confocal microscopy analysis of GM3–ErbB2 association on HC11 cells Cells ... functional role of the association between ErbB2 and lipid rafts, we analyzed the distribution of phospho-ErbB2 in sucrose-gradient fractions obtained from HC11 cells in the absence or presence of treatment ... fractions in HC11 cells Because in cells coexpressing both ErbB2 and EGFR, as is the case of HC11 cells, the two proteins strictly interact and EGF preferentially stimulates the formation of ErbB2 ⁄...
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Báo cáo khoa học: Hypoxia-driven proliferation of embryonic neural stem ⁄ progenitor cells – role of hypoxia-inducible transcription factor-1a ppt
Ngày tải lên :
30/03/2014, 04:20
... growth of most kinds of cells, promote the proliferation of some types of cells There is increasing evidence that mild hypoxia acts as a potent regulator of various types of stem cells [12] Therefore, ... by Lipofectamine 2000, and then cells were exposed to either normoxia (20% O2) or hypoxia (10% O2) for days The percentage of GFP-positive cells was about 70% of that of total neural stem cells ... is one of the indicators for proliferation of neural stem cells in vitro The passaged neurospheres were dissociated into single cells and planted in four-well plates at a density of · 104 cells...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
Ngày tải lên :
30/03/2014, 15:20
... U937 cells in parallel to the increase of enzymic activity RT-PCR amplification of cDNA of U937 cells showed a single band of the expected molecular size for FAAH gene, which increased in cells ... only in U937 cells treated with 10 nM leptin (Fig 3A) In addition, nuclear levels of Ikaros isoforms Ik1, Ik2 and Ik3 were increased by treatment of U937 cells, but not of CHP100 cells, for 24 ... binding of 125I-labeled leptin to human U937 or CHP100 cells, alone or in the presence of 100 nM ÔcoldÕ leptin (data of the ÔcoldÕ leptin experiment with CHP100 cells were superimposable to those of...
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Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
Ngày tải lên :
18/06/2014, 16:20
... presence of H pylori at a bacterium /cells ratio of 150: or 300:1) (B) AGS cells were treated with SBTI (0.5 μM) and cultured in the absence or the presence of H pylori at a bacterium /cells ratio of ... number of bacterium infected to the cells (Figure 2A) Cell death of H pylori-infected cells was augmented by transfection Figure Transfection of AS ODN for PAR-2 inhibits the expressiongn of PAR-2 ... AGS cells AGS cells were transfected with PAR-2 AS ODN or S ODN for 24 hours and cultured in the absence or the presence of H pylori at a bacterium/ cells ratio of 300:1 for hours The levels of...
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Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
Ngày tải lên :
19/06/2014, 08:20
... Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body [32,33] CD8+ T cells play a major role in immune surveillance of ... the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells not labeled ... of NK cells (Fig 2C) [46,47] Page of 15 (page number not for citation purposes) Virology Journal 2005, 2:56 http://www.virologyj.com/content/2/1/56 Immune1 Figure status of BALB/c scid mice Immune...
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báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
Ngày tải lên :
20/06/2014, 04:20
... Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body [32,33] CD8+ T cells play a major role in immune surveillance of ... the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells not labeled ... of NK cells (Fig 2C) [46,47] Page of 15 (page number not for citation purposes) Virology Journal 2005, 2:56 http://www.virologyj.com/content/2/1/56 Immune1 Figure status of BALB/c scid mice Immune...
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