role of ebers in the pathogenesis of ebv infection

Ngày tải lên: 13/08/2014, 01:20

... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... not enhance the osteoclastogenesis of OPCs Therefore, the role of VEGF in osteoclastogenesis in GCTs in vivo should be further investigated To assess the pathological significance of the VEGFFlt-1-FAK...

Ngày tải lên: 20/06/2014, 04:20

... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... not enhance the osteoclastogenesis of OPCs Therefore, the role of VEGF in osteoclastogenesis in GCTs in vivo should be further investigated To assess the pathological significance of the VEGFFlt-1-FAK...

Ngày tải lên: 20/06/2014, 07:20

... protein; matrilin-1) Matrilin-3 CILP (cartilage intermediate layer protein) Fibronectin PRELP (proline/arginine-rich and leucine-rich repeat protein) Chondroadherin Fibrillin Tenascin-C Elastin MGP (matrix ... cartilage of all joints, this joint selectivity is quite puzzling We suggest that the answer may be found in a more careful examination of the interactions between intrinsic and extrinsic factors ... epiphyseal dysplasia of several joints during childhood, and OA of the knees in adulthood A complex splicing defect of exon and/or exon 10 in the COL9A1 gene has been identified in other families [59]...

Ngày tải lên: 09/08/2014, 06:22

... result in an increase in the gene expression of the aggrecanase ADAMTS4 in cells derived from degenerate NP In vivo, the NP contains the highest concentration of aggrecan in the IVD The response of ... observed on the other cell types (Fig 6d) Discussion In this study, we investigated whether in IVD degeneration there is local production of the cytokine IL-1 and whether IL-1 could induce the cellular ... immunopositivity was observed in the matrix of the IVDs or in blood vessels, with the exception of immunopositivity for ICE, which showed some staining in the matrix and blood vessels of the most degenerate...

Ngày tải lên: 09/08/2014, 06:22

... in this model A mechanism of activating the alternative pathway via mannose-binding protein in the MB lectin pathway was excluded [30] The crucial role of C5 in arthritis progression was further ... through the regulation of FcRs much like the instructive role of the innate immune system for the adaptive response [56] The production of autoantibodies as a result of the failure of the immune ... suggesting a more general mechanism of these receptors in inflammatory diseases Maintaining autoantibody titers through FcRn-mediated recycling One of the most striking characteristics of the K/B...

Ngày tải lên: 09/08/2014, 06:23

... neither the β3 integrin nor the CTR are expressed by osteoclast precursors The expression of these genes increases during the late stages of osteoclast differentiation [42], after induction of the ... bone resorption in mice in which either of these genes has been deleted [36,37] In humans, inactivating mutations in the cathepsin K gene are associated with an osteoclast resorbing defect manifest ... loosening of prosthetic joint implants has emerged as the major long-term complication after TJR The radiographic hallmark of prosthetic loosening is the presence of radiolucent zones at the interface...

Ngày tải lên: 09/08/2014, 07:20

... block of tissue (incorporating AF and NP in continuity) was fixed in 10% neutral buffered formalin and processed to paraffin wax Sections were taken for haematoxylin and eosin staining to score the ... decrease in MTL of 0.85 kbp per decade of life in non-degenerate discs (Figure 1a) Interestingly, the MTL differed according to the degree of degeneration in two discs from the same individual ... cells into the degenerate disc to achieve success Competing interests 10 11 The authors declare that they have no competing interests 12 Authors' contributions CLM participated in the design of the...

Ngày tải lên: 09/08/2014, 10:20

... anti-α-actinin antibodies in lupus patients was associated with a 2.5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin antibodies correlated with those of anti-DNA ... to several of the studies cited in this editorial Studies in the laboratory of CP are funded by the National Institute of Arthritis and Musculoskeletal Disease, the National Institute of Diabetes ... considering that only of the 16 patients had pure proliferative disease (in which the association with pathogenic antibodies is the strongest) The low frequency of αactinin antibodies in this...

Ngày tải lên: 12/08/2014, 11:22

... ζ chain in SLE T cells [64], which may explain the enhanced T-cell-activation-induced Ca2+ fluxing The potential role of NO in the regulation of FcR gamma expression clearly needs further investigation ... synthesis, suggesting that overproduction of NO may be important in the pathogenesis of RA The in amed joint in RA is the predominant source of NO [45,46] Several investigators found correlations between ... therapeutic approach in the treatment of chronic autoimmune diseases Abbreviations eNOS = endothelial NOS; GSH = glutathione; IFN = interferon; IL = interleukin; iNOS = inducible NOS; IP3 = inositol-1,4,5-triphosphate;...

Ngày tải lên: 12/08/2014, 14:22

... involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation ... eliminated Several cytokines, including IL-2, IL-4, IL-7, and IL-15, are effective in preventing the death of activated T cells Of these, IL-4 and IL-15 are the most effective [11] Inhibition of ... surface The expression of IL-4 in the asthmatic lung and the secondary lack of Fas expression might explain the persistence of inflammatory cellular infiltrates in allergic asthma Apoptosis of TH2...

Ngày tải lên: 12/08/2014, 18:20

... data) These findings suggest, both in humans and in mouse models of SCD, that there is increased oxidative burden and that alterations in the redox state may play a role in the development of vaso-occlusion ... suggesting that the development of ACS in SCD may be accompanied by PMN infiltration into the lungs [31] SCD patients have increased levels of the PMN chemokine IL-8 during VOC, suggesting that during ... Within RBCs, one of the mechanisms of O2– formation is via the deoxygenation of hemoglobin During deoxygenation, there is a transfer of electrons between Fe and O2, leading to the production of...

Ngày tải lên: 12/08/2014, 18:20

... may result in changes of the folding process causing protein misfolding65 In a normal mammalian cell system, the amino acid sequence in the polypeptide chain contains all the necessary information ... suppressive role in AML-M5 pathogenesis through unmasking the growth promoting potential of Flt3 In this study, we identified and characterized the importance of the MCDL of N-CoR in the growth of AML-M5 ... importance of the transcription machinery in the regulation of hematopoiesis The transcription machinery plays a critical role in the control of normal hematopoiesis by having a major influence on the...

Ngày tải lên: 09/09/2015, 18:55

... intact B1 cells) suggesting BAFFR-targeting as a possible therapeutic intervention in CAD patients (Kyaw et al., 2012) Therefore, in line with these findings, it is thus not surprising that the ... The role of B cells in Atherosclerosis: Pathogenic or protective? Recent studies have revisited the role of B cells to clarify its role in atherosclerosis As described earlier, the transfer of ... encountering the antigen, the expression of CCR7 chemokine receptor for chemokines CCL19 and CCL21 in the T cell zone increases while remaining CXCR5+, to facilitate their rapid translocation to the...

Ngày tải lên: 10/09/2015, 09:23

... plasma cells in the bone marrow of apoE-/- mice Because we maintained the mice on BrdU in drinking water for one month, the result is also indicative that these plasma cells accumulated in the bone ... 2006), we included the non-proliferative state of plasma cells as an additional parameter when examining plasma cells in the bone marrow To begin our investigation into ASCs in the bone marrow of apoE-/- ... mice, we maintained apoE-/- mice with thymidine analog, BrdU in drinking water for one month The administration of BrdU on apoE-/- mice facilitates the detection of non-   124   proliferating plasma...

Ngày tải lên: 10/09/2015, 09:24

... fall into the state of anergy However, it remains to be determined if APOE protein is crucial in maintaining the anergy state of B cells 4.7 Role of B cell subpopulations However, it remains unclear ... autoantibodies in apoE-/- mice These studies will present a clearer picture in our experimental settings of the onset of initiating humoral responses against oxLDL in vivo in the context of atherosclerosis ... frequency of oxLDL-specific IgM ASCs in the bone marrow   157   Chapter Discussions   158   Chapter Discussion 4.1 Summary of findings Our investigations on the role of B cells in the pathogenesis of...

Ngày tải lên: 10/09/2015, 09:24

... contains the N-terminal heme-binding domain, the catalytic domain, and the C-terminal regulatory domain Two other gaseous transmitters, CO and NO, can bind to the heme-binding domain and result in ... be elevated in the SN from parkinsonian brains (138) In support of these findings, epidemiological studies reveal a role of neuroinflammation in the progression of PD given that in a prospective ... neurodegeneration and the underlying mechanisms were investigated in both in vitro and in vivo studies Neuroinflammation is one of the main pathological causes/features of PD In this thesis, the effect of H2S...

Ngày tải lên: 11/09/2015, 10:18

... resistance can also be a result of mutations in the DNA binding domain (109) or the ligand binding domain of the RARα gene (110), reducing DNA binding or ATRA binding and its ability to regulate ... PML-RAR fusion protein contains the N-terminus of PML fused to the DNA and hormone-binding domain of RARα (17, 18) The breakpoint on chromosome 17 is located at the second intron of RARα while those ... observed in the cytoplasm of the cortical and caudate cells, whereas in cells of healthy brains, they are found in both the cytoplasm and nucleus This suggests a role of N-CoR delocalisation in the pathogenesis...

Ngày tải lên: 14/09/2015, 14:11

... of RA FLSs, thus indicating that other factors must be involved in this proliferation In our previous studies, we have determined that GM-CSF in the synovial fluid plays an important role in the ... increment in the protein level of GM-CSF-induced MLN51 (Fig 2E) These data indicate that GM-CSF not only induces the expression of MLN51, but also blocks the proteasome-mediated degradation of ... GM-CSF is involved in the proliferation of primary RA FLSs [7] In the present study, we investigated cell proliferation and MLN51 expression using an RA FLS cell line, MH7A, in the presence of GM-CSF...

Ngày tải lên: 23/03/2014, 07:20

... as the development of offshore financial centers and off-balance-sheet methods of financing); • the diminishing effectiveness of traditional controls due to financial innovation (including the ... 1980s In the case of S&Ls the insurance premium was set by statute in 1950 at 1/12 of 1% of the assessable deposits and was the same for all insured institutions regardless of the riskiness of their ... to being changed and enforced in the interest of the regulated industry, rather than in the interest of the economy at large General laws, on the other hand, tend to be more immune and therefore...

Ngày tải lên: 29/03/2014, 08:20