regulation of the ovarian and uterine cycles

... lM) plus theophylline (0.5 mM), and H2O2 (2 mM) were included in the experimental medium from the time of the initiation of the influx experiment The influx was estimated from the slope of the uptake ... M) and used for estimation of the protein content using the Lowry procedure [19] and BSA as protein standard The residual 1000 lL of the suspension was centrifuged (20 000 g, 10 min) and the ... within the initial 24 and from 25% to 50% within the subsequent five UV absorption (330 nm) of the samples and taurine standard (0.1 mM) were used for estimation of the taurine content in the samples...

Ngày tải lên: 30/03/2014, 15:20

... mechanisms for the determination of the position of the cleavage furrow How are microtubules associated with the equatorial region stabilized and how these microtubules determine the position of the cleavage ... released from the nucleus and accumulates at the cortex overlaying the nucleus, which recruits the other components to form the contractile structure In animal cells, the position of the cleavage ... She offered me the rigorous scientific training from the fundamental techniques to the creation of the great ideas Her encouragement and guidance helped me move through all the up and downs of...

Ngày tải lên: 14/09/2015, 14:09

... and the use of the designation "European Venture Capital Fund" should be sanctioned by the prohibition of the use of the designation and the removal of the venture capital fund manager of the ... 45/2001 of the European Parliament and of the Council of 18 December 2000 on the protection of individuals with regard to the processing of personal data by the EU institutions and bodies and on the ... following the end of the financial year The report shall describe the composition of the portfolio of the qualifying venture capital fund and the activities of the past year It shall contain the audited...

Ngày tải lên: 19/02/2014, 14:20

... human and rat CB1 receptor The CB2 antibody was raised against a sequence between the N-terminal and the first transmembrane domain of the protein of the human and rat CB2 receptor The specificity of ... for AEA, PalEtn and 2AG, respectively Analysis of cannabinoid receptors and fatty acid amide hydrolase To determine the presence of the cannabinoid receptors (CB1 and CB2) and of the fatty acid ... supported by the observation that preabsorbing of the CB1 antibody with its corresponding blocking peptide eliminated almost all of the staining of these bands (Fig 3A) The most abundant band in human...

Ngày tải lên: 22/02/2014, 07:20

... dysfunction SH3 and SH2 domain dysfunction Deletion of N-terminal, SH3 and SH2 domain of active n-Src Deletion of N-terminal, SH3 and SH2 domain of kinase-dead n-Src of PP3, the inactive form of PP2, ... upstream of the conserved PXXP motif of the SH3 ligand The D99N mutation prevents formation of this salt bridge and disrupts the SH3 binding specificity R175 (corresponding to R183 in n-Src) in the ... R175K mutations therefore inhibit interactions with ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21]...

Ngày tải lên: 06/03/2014, 01:20

... Additionally, because the demand of the chloroplast is ‘sensed’ inside the organelle, the IEM is closest to the origin of the signal, and thus regulation at the Tic complex could be one of the fastest ... which anchor the protein in the membrane The position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic ... description of recent advances in the understanding of the channel-, motor- and regulatory components of the Tic complex For reference, some of the available knowledge, including the proposed function of...

Ngày tải lên: 07/03/2014, 03:20

... PARLIAMENT AND THE COUNCIL OF THE EUROPEAN UNION, Having regard to the Treaty on the Functioning of the European Union, and in particular the second paragraph of Article 177 thereof, Having regard to the ... respect the principle of subsidiarity as the tasks of the ERDF are set out in the Treaty and the policy is implemented in accordance with the principle of shared management and respecting the institutional ... increasing the use of conditionalities and simplifying the delivery are among the major hallmarks of the proposal This Regulation sets out the provisions governing the Cohesion Fund, and repealing Regulation...

Ngày tải lên: 07/03/2014, 16:20

... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their effects and that of insulin on p70S6K, PKB, ... and myotubes with antibodies against GSK3a and b Fig 1B shows that whilst preadipocytes express both GSK3 isoforms, the abundance of the b isoform declines by  85%, whereas that of the a isoform...

Ngày tải lên: 08/03/2014, 08:20

... authority of the Member State in whose territory the investigation is to be carried out of the investigation and of the identity of the authorised persons Officials of the competent authority of the ... proportionate to the nature and seriousness of the breach, the duration of the breach and the economic capacity of the credit rating agency concerned Detailed criteria for establishing the amount of the fines ... the adoption of a regulation on fees and the amendment of the annexes (19) Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995 on the protection of individuals...

Ngày tải lên: 15/03/2014, 07:20

... corporation Office of the Comptroller of the Currency Office of Thrift Supervision savings and loans Securities and Exchange Commission Summary of Deposits Department of the Treasury This is a work of the ... FDIC, the Federal Reserve, the Office of the Comptroller of the Currency (OCC), the Office of Thrift Supervision (OTS) and SNL Financial relating to the number of exempt institutions, their geographic ... relating to the types of activities in which such institutions may engage, the availability and allocation of credit, the stability of the financial system and the economy, and the safe and sound...

Ngày tải lên: 15/03/2014, 09:20

... effects of ligand-activated RARa and RXRa on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-cisRA, on the promoter ... Fig therefore imply that ligand-bound RAR and RXR are responsible for the repression of GnRH II gene in TE671 cells On the other hand, over-expression of RARs together with the application of ... to the results observed in placental cells and the current paradigm of the role of RA-induced activation, the application of RAs and introduction of ligand-activated RAR ⁄ RXR heterodimer further...

Ngày tải lên: 16/03/2014, 10:20

... known that the length of the CAG repeat affects the onset of HD in humans and in mice, we first confirmed that the rate of decrease in steady-state CB1 mRNA was dependent on the length of the CAG ... repeat and relative expression of the HD gene We then determined the structure of the mouse CB1 gene and determined that transcription of the CB1 gene was affected in striatal neurons of transgenic ... levels in the medial striatum of any of the wild-type and HD mice examined The optical density of the hybridization signal in the lateral striatum, corrected by subtracting the signal in the medial...

Ngày tải lên: 16/03/2014, 18:20

... investors and the use of the designation "European Social Entrepreneurship Fund" should be sanctioned by the prohibition of the use of the designation and the removal of the EuSEF manager of the register ... end of the financial year The report shall describe the composition of the portfolio of the EuSEF and the activities of the past year It shall contain the audited financial accounts for the EuSEF ... relevance) THE EUROPEAN PARLIAMENT AND THE COUNCIL OF THE EUROPEAN UNION, Having regard to the Treaty on the Functioning of the European Union, and in particular Article 114 thereof, Having regard to the...

Ngày tải lên: 23/03/2014, 08:21

... [86] Nevertheless, the observed homodimerization of the GCD and the metal ion dependence of the catalytic activity support the integrity of the expressed proteins As expected from the high sequence ... NPRA and the ligand ANP must be localized on the luminal side of the renal tubule (but not on the basolateral side, where the chloride concentration is stable at 90–110 mm) There is a plethora of ... view of the chloridebinding site in apo-ECD [18,34] Chloride is hydrogen bonded to the hydroxyl group of Ser53, and the backbone NH moieties of Gly85 and Cys86 The binding site also contains the...

Ngày tải lên: 28/03/2014, 23:20

... and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the potential cleavage sites, we identified the localization of the cleavage site ... a deregulation of the NF-jB pathway and an increase in muscle fiber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The ... activates the interaction of a protein complex with the kinase domain of titin, reducing the nuclear translocation of the transcription factor SRF and impeding gene transcription [16] In the elastic...

Ngày tải lên: 29/03/2014, 21:20

... neurons project from the ARC to the PVN, and the other in which they project to the MPA, bed nucleus of the stria terminalis and lateral septal nucleus Central administration of GALP activates neurons ... regions of the rat brain Injection of GALP into the third ventricle induces c-Fos expression, a marker of cell activation, in the horizontal limb of the diagonal band of Broca, POA, ARC and median ... and stimulates thermogenesis in rodents The short-term orexigenic actions of GALP are mediated via NPY and the orexinergic pathway in the rat The long-term anorectic and thermogenic actions of...

Ngày tải lên: 29/03/2014, 21:20

... equivalent to the R302Q substitution in c2, the dominant isoform of the c-subunit in the heart The R302Q mutation, together with several other substitutions identified in CBS domains of the c2 gene, ... to study the effect of the mutations within AMPK c3 on the activity of the enzyme, we introduced several missense mutations into the c3 gene (Fig 2), and investigated the effect of these substitutions ... heterotrimers with the a2 and b2 isoforms [23] The present study describes bacterial expression of AMPK a2b2c3 trimers, and provides the first characterization of the enzyme kinetic parameters and regulation...

Ngày tải lên: 30/03/2014, 08:20

... modulation of CTGF and Cyr61 gene expression in vitro and in vivo Mechanical regulation in bone and cartilage Cartilage and bone provide ideal tissues for the study of the mechanical regulation and ... represent another example of situation in which the mechanical regulation of Cyr61 and CTGF is of relevance TGF-b which is a major profibrotic and fibrogenic molecule, is one of the potent inducers of CTGF ... complexity and variability of the regulation of cellular communication Collectively, both the expression and function of the immediate early genes Cyr61 and CTGF cannot be separated from the mechanically...

Ngày tải lên: 30/03/2014, 10:20

... terms of the presentation of the problems and in relation to the options andi the policy choice The resubmitted version of 14 November contains the following improvements: In line with the IAB’s ... state aid rules and the EU Treaty) While the effectiveness of these other measures will have a strong impact on the take-up of the measures identified here, the justification for these latter measures ... certain risks of early intervention; • Clarifying further the phasing of options, their interactions, the costs and benefits of the approach to phasing of options, e.g under sections 6, and 8; • Outlining...

Ngày tải lên: 30/03/2014, 12:20

... cleavage of the p220 component of the cap-binding protein complex [32], resulting in the shut off of host protein synthesis On the other hand, the function of L of the cardioviruses is not well ... persistence L and picornaviruses The aphthoviruses and caridioviruses are the only members of the Picornaviridae family that contains an L coding region at the most 5' terminus of the ORF [13] In the case ... inhibit the iron/ferritinmediated activation of NFκB [34] The functions of L of Page of (page number not for citation purposes) Journal of Neuroinflammation 2006, 3:19 TMEV and the other cardioviruses...

Ngày tải lên: 19/06/2014, 22:20