policy as the missing link between research and practice

... imbalance between elastinolytic proteases and their naturally occurring inhibitors In particular, neutrophil elastase (NE), and other elastolytic proteases, such as cathepsin G, and macrophage elastase ... leukocyte protease inhibitor (SLPI), as well as the synthetic inhibitor of leukocyte elastase ONO-5046, significantly attenuate the fibrotic response to BLM in rodents [10-12] In man, the inactivation ... TGF-β and TGF-α and for determination of the mean linear intercept (Lm) [17] as well as the percent volume densities of fibrosis Vv(f) and emphysematous changes Vv(e) Details of the morphometric assessment...

Ngày tải lên: 12/08/2014, 18:21

... whom had received their research funding from the ARC, to discuss and review their work in the reading area As noted by Pratt and Coltheart7, the issues covered and the emphases of the different ... 249 children and an experimental sample of 366 children The comparison between these two groups was then used as the basis for evaluating the effectiveness of the SWELL program The measures used ... socio-cultural approach has its supporters in other countries, it is less dominant and has not been as influential in terms of its impact on educational policy and research as has been the case in Australia...

Ngày tải lên: 17/02/2014, 06:20

... effects and the differences in the five early-legalizing states, and across time, since the theory implies there is a time lag between the abortion decision and the crime impact For this reason, ... specifications of the model and their impact on the results The coefficients listed as “Baseline” are the same as were discussed above in Table IV The next few rows exclude the various outliers in the relationship ... mistake, they argue that it shrinks the magnitude of the effects of abortion without altering the overall result As to the second argument, they answer that the method as used in Foote and Goetz...

Ngày tải lên: 01/10/2015, 16:59

... serve as further avenues for controlling land-based pollution relevant to the Arctic: the 1992 Paris Convention for the Protection of the Marine Environment of the North-East Atlantic and the 1992 ... practices relating to landbased pollution control in the Arctic, on the other Following an introductory summary of the sources of land-based marine pollution in and into the Arctic, further sections review ... ‘regional seas’ agreements tangential to Arctic land-based pollution control, specifically the two 1992 conventions for the protection of the marine environment of the northeast Atlantic8 and the Baltic...

Ngày tải lên: 01/11/2013, 09:20

... because the latter depends on (a) the structural integrity of the vascular bed of the penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium ... contribute to endothelial dysfunction and microvascular disease and reduced androgen levels; (b) the insult on the endothelium resulting in endothelial injury and reduced NO synthase activity and NO production, ... system, as well as the vascular bed of the penis, and depends on a functional venoocclusive mechanism [3] The latter is maintained by the hormonal milieu Thus, androgen deficiency and endothelial...

Ngày tải lên: 18/02/2014, 06:20

Ngày tải lên: 06/03/2014, 23:20

... double-strand breaks (DSBs) A single-strand overhang is formed by exonuclease activity and invades the homologous doublestranded region of the other allele These steps of homology search and recombination ... was fused in-frame with the GAL4 DNA-binding domain in the pBKDT7 vector as bait The cDNA library was subsequently cloned into the pGADT7 vector encoding the GAL4 activation domain, and used as ... (Fig 3A) The FEBS Journal 275 (2008) 2032–2041 ª 2008 The Authors Journal compilation ª 2008 FEBS 2035 Link between Lim15/Dmc1 and the CAF-1–PCNA complex S Ishii et al phase together with the meiosis-specific...

Ngày tải lên: 07/03/2014, 05:20

Ngày tải lên: 16/03/2014, 03:20

... worse baseline visual acuity than the other four groups (p < 0.01) The only other significant difference was between the group that improved by to letters and the no change group (p < 0.01) The association ... functional changes as well Future research with larger samples and assessments at multiple time points is needed to better understand the link between visual acuity and HRQL over time Despite these limitations, ... vision), and the total score was 84.1 At baseline, there was substantial heterogeneity in the sample, with scores ranging from to 100 in several subscales The multi-item subscales of the VFQ-25...

Ngày tải lên: 18/06/2014, 19:20

... mere association with the increased serum levels of neurokinin A in autism A more detailed understanding of the interactions between tachykinins and immune cells may provide the basis for the ... USA) The data were non-parametric, thus they were presented as median and interquartile range (IQR), which are between the 25th and 75th percentiles Mann-Whitney test was used for comparison between ... clinical examination and neuropsychiatric assessment In addition, the degree of the disease severity was assessed by using the Childhood Autism Rating Scale (CARS) [31] which rates the child on a scale...

Ngày tải lên: 19/06/2014, 22:20

... worse baseline visual acuity than the other four groups (p < 0.01) The only other significant difference was between the group that improved by to letters and the no change group (p < 0.01) The association ... functional changes as well Future research with larger samples and assessments at multiple time points is needed to better understand the link between visual acuity and HRQL over time Despite these limitations, ... vision), and the total score was 84.1 At baseline, there was substantial heterogeneity in the sample, with scores ranging from to 100 in several subscales The multi-item subscales of the VFQ-25...

Ngày tải lên: 20/06/2014, 16:20

Ngày tải lên: 09/08/2014, 13:22

Ngày tải lên: 09/08/2014, 13:22

... responses with the SDS model and have focused on low-income SSA countries as they bear the bulk of the disease burden and are the target of the mitigation strategies The "successes" The "successful" ... [7] The model of the State that the mitigation strategies assume is the SDS which views the State's role as providing public goods (health, education, physical infrastructure, regulation) with the ... environment and actors involved in implementing policy [16,17] Parkhurst critiques the prevailing international policy guidance as based on a policy model that sees response to disease as determined...

Ngày tải lên: 11/08/2014, 18:20

... divide by the number of elements, and multiply this ratio by 20 Thus, each subindex has a value between and 20 We define the overall standardized score as the sum of all the five subindices As the ... market power and negatively correlated with debt ratio and R&D intensity The correlation between ROA and market power and the Correlation between ROA and R&D intensity are expected, as the activity ... the regulator’s recommendations and are likely to disclose more on their governance status There is not necessarily a strong link between governance level and performance On the other hand, as...

Ngày tải lên: 06/01/2015, 19:48

... growth and unemployment, and the relationship between the two in the current US recovery As we pointed out then, Figure 13 plots the quarterly unemployment rate in our baseline scenario and the ... exports seem to be on the increase As shown in Figure 10, the parts of the world that import the most goods and services from the United States nonetheless have all increased their US imports somewhat ... attached to the workforce or employed less than full time for economic reasons The linkage between output and job creation has become increasingly weak in the last three decades The recoveries...

Ngày tải lên: 23/09/2015, 08:52

... physician in the past 12 months, whether one was hospitalised in the past 12 months, whether one has experienced a chronic condition and the outcome of the Hopkins Symptom Checklist (HSCL) The HSCL ... quarter of the century in the United States and in the Netherlands, Sweden and Germany This coincides with an increase in both access to and the generosity of publicly provided social insurance and ... for other reasons then health We therefore briefly discuss in section the main elements of the Social Security and pension system in the Netherlands Section presents a model for health and work...

Ngày tải lên: 05/03/2014, 21:20

... dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that ... complete the proposed research and technical support projects and to implement the countermeasures needed to Financial Resources and Policy Issues Assessments and Lessons Learned New Science and Research ... identification The EPA should carefully consider the scope of the tasks identified here, so that the data gathering efforts (e.g., the contaminant database and the surrogate/simulant database) focus on the...

Ngày tải lên: 06/03/2014, 15:20

... observed between the mutated and the wild-type strains relied solely on the disruption of the Rv2951c gene Together, these results established that Rv2951c is involved in the biosynthesis of DIM A and ... Biochemicals, Meylan, France) The PCR fragment was inserted within the vector pGEM-T to give pWM39 The km resistance cassette was then inserted between the KpnI and BglII sites of the ppsE gene fragment ... i.e DIMs and PGL-tb; and (b) to address the question of the function of the two related molecules DIM A and DIM B According to the accepted model of DIM and PGL biosynthesis [17], DIM A and PGL-tb...

Ngày tải lên: 23/03/2014, 09:20

... flexible linker between the AC subdomain and the PCP domain, and the absence of a contact surface between these two folded units [19], argue for a certain degree of flexibility and mobility of the ... domain are tethered Furthermore, this SrfA–C construct lacks the attachment site of the Ppant group (S1003A mutant) and shows the PCP on the acceptor site of the C-domain The distance of the S1003A ... the formation of the amino acyl thioester on the Ppant of the PCP domain and prime the enzyme for the next step in the reaction sequence Therefore, we turned to the sulfamoyl-based inhibitor 1,...

Ngày tải lên: 29/03/2014, 08:20