obesity is characterized by inflammation
Báo cáo y học: "Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin" pptx
Ngày tải lên :
09/08/2014, 06:22
... remission is unusual if inflammatory arthritis has persisted for longer than months [27] suggests that pathological mechanisms driving the switch to persistence are already established by this ... arthritis [n = 10]) and 22 developed persistent inflammatory arthritis (RA [n = 8], unclassified arthritis [n = 9], PsA [n = 2] and arthritis related to ulcerative colitis [n = 1], polymyositis [n ... contribution to this discrimination This analysis does not emphasize cytokines that are of general importance to inflammation The models developed using Random Forest can be visualized graphically by using...
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báo cáo hóa học: " The acute inflammatory response to intranigral a-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation" pptx
Ngày tải lên :
19/06/2014, 22:20
... grafted tissue [2] The mechanism for the physiological release is debated, but in vitro studies have demonstrated that SNCA is secreted by living neurons and enters the surrounding medium [3] It is ... of disease [10,11] What is important about these studies is that they produced a model of dopaminergic cell death caused by a local inflammatory response However, the inflammation in PD is unlikely ... data is discussed below NFĸB exists as a heterodimer of p65 and p50, which, in the resting state, has a cytoplasmic distribution The activation of macrophages by proinflammatory cytokines and by...
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Báo cáo y học: "Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized" ppsx
Ngày tải lên :
09/08/2014, 01:22
... The reduced tissue mineral density and mineral:collagen ratio in OA tissue [15,36] is consistent with this hypothesis Although the cellular basis for the reduced mineralization is not clear at ... TR/TE of ~4,000 milliseconds/15 milliseconds, 60 milliseconds, 2.5 to mm slices, no skip/gap, 256 × 256 matrix, 12 cm field of view (for distal femur and proximal tibia), and acquisition time 4.50 ... hydroxyapatite/cm) provided by the system manufacturer The tissue mineral density was calculated only for voxels exceeding the threshold (that is, only for voxels occupied by mineralized tissue) – and to...
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Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps
Ngày tải lên :
09/08/2014, 07:20
... We examined the pharmacologic mechanism by which methotrexate diminishes inflammation in the thioglycollate-induced peritoneal inflammation model of acute inflammation in the mouse We report ... instructions Statistical analysis All statistical analyses were performed by SigmaStat software (SPSS, Inc., Chicago, IL, USA) Differences between groups were analyzed by one-way analysis of variance ... agonist reduces IL-10 release by lipopolysaccharidestimulated RAW macrophages [27] IL-10 is therefore, as previously reported, a critical regulator of peritoneal inflammation that is regulated by...
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KRONE - What is Patch by Exception
Ngày tải lên :
26/10/2013, 19:15
... even easier HOW TO GET THE MOST OUT OF PATCH BY EXCEPTION Many organisations have successfully implemented the Patch by Exception solution by establishing a maintenance contract with an installer ... competitor module by providing the maximum available headroom above category minimum standards This means that data integrity is preserved to the highest possible level Immunity to noise is also of ... easily administered by the IT Manager in a matter of seconds by using the patching facility If these changes are to become permanent the installer can hardwire them at the next monthly visit and...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
Ngày tải lên :
15/02/2014, 01:20
... of other TTSPs To test this possibility, we have searched for TTSPs targeted by HAI-1, and found that the activity of TMPRSS13 is potentially inhibited by HAI-1 TMPRSS13 is a splice variant of ... the tissues producing it In response to tissue injury, such as hepatic and renal injury, the inactive single-chain HGF is converted to a two-chain form exclusively in the injured tissue This conversion ... exclusively in the injured tissue This conversion is mediated by serine protease activity, which is induced in the injured tissue [28] The two-chain form is required for the biological activity of HGF...
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Tài liệu Báo cáo khoa học: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT–MIM interaction pptx
Ngày tải lên :
18/02/2014, 04:20
... proteins (GST– IST1, GST–IST1MIM, GST–IST1MIML326D,L353A, GST– CHMP6NT, GST–pHis and GST–MIT–pHis) Expression of GST–IST1, GST–IST1MIM and GST–IST1L326D,L353A was induced with 0.5 mm isopropyl thio-b-d-galactoside ... followed by Strep-tag II was isolated by BamHI digestion and inserted into the BamHI site of pmGFP–calpain To construct pCMV3xFLAG–IST1 and pGEX–IST1, an IST1 cDNA fragment was amplified by PCR, ... Enhancement of calpain autolysis by IST1 detected This result strongly suggests that 30 K is generated by proteolytic activity of mGFP–calpain 7–Strep itself, not by potentially contaminating...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
Ngày tải lên :
18/02/2014, 12:20
... values is exclusively displayed by the tetramer forms, and lowefficiency kinetics with high Km values is displayed by the dimer forms These observations strengthen the previous hypothesis that ... this would result in nonlinear progress curves However, slow dissociation from tetramer to dimer will result in linear progress curves, as consistently observed with this enzyme Such a slow dissociation ... behaviour after dilution to lgÆmL)1 indicate that dissociation of the tetramer to the dimer is a slowly progressing process This is supported by the kinetic behaviour of the recombinant enzyme...
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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
Ngày tải lên :
18/02/2014, 13:20
... detected using MUPP1 antibodies Immunohistochemistry Mice were raised and maintained according to governmental and institutional care instructions Immunohistochemistry was carried out on 14 lm horizontal ... visual signal transduction cascade Flies lacking INAD exhibit a profound reduction of the light response [28] Interestingly, INAD is also required for normal deactivation of visual signaling by ... outlined to date is CamKII, which is known to play an important role in olfactory adaptation [20] By phosphorylation of adenylyl cyclase in OSNs, CamKII provides an important mechanism for the attenuation...
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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
Ngày tải lên :
18/02/2014, 18:20
... and that this phosphorylation is independent of p27KIP1 The finding that Y17 phosphorylation is mediated by Src family kinases is completely novel and it is interesting to note how this fits in ... found in HeLa lysates C-YES is a 62 kDa nonreceptor tyrosine kinase of the Src family that is expressed in a wide range of tissues [24] The N-terminus of C-YES is dually myristoylated and palmitoylated ... this context, Y17 phosphorylation is thought to be modulated by loss of the phosphatase CDC25A Our data suggest that Src kinases are candidates to provide the phosphorylation of CDK4 If this is...
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Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc
Ngày tải lên :
19/02/2014, 00:20
... were dissolved in distilled water Wort, HIMO, MK 886 and ETYA were dissolved in dimethylsulfoxide Apocynin was dissolved in ethanol Polymycin B was dissolved in normal saline Before use, all dissolved ... cytokine synthesis and febrile response induced by SEC1 is dependent on NADPH oxidase and not on PI3K ⁄ Akt or 5-LOX ⁄ 3640 FLAP because these phenomena are attenuated by apocynin and not by ETYA, MK ... IL-1b and IL-6 that is blocked by the NF-jB inhibitor (PDTC or SN-50) Moreover, the NF-jB binding ability is abrogated by binding site competition and antibody supershift analysis These findings...
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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf
Ngày tải lên :
19/02/2014, 06:20
... precipitated DNA was analyzed by 1% agarose gel electrophoresis DNA was visualized by staining with ethidium bromide Results are represented by negative images Asterisks indicate nucleic acids ... cell lines, HeLa S3 cells and placenta tissue (unpublished work), implying that the promotion of EJ by aggregation is common to many types of human cells It is very likely that the resultant organization ... conditions (unpublished work) This predisposition implies the possibility that in vivo, instead of centrifugal force, the pre-existing aggregates may develop into damage-mediated ones It is presumable...
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Tài liệu Báo cáo khoa học: Transcription of individual tRNA1Gly genes from within a multigene family is regulated by transcription factor TFIIIB pdf
Ngày tải lên :
20/02/2014, 02:21
... family is modulated by distal cis elements J Biol Chem 271, 28146–28153 24 Sharma S & Gopinathan KP (1996) Role of TATATAA Gly element in the regulation of tRNA1 gene expression in Bombyx mori is ... Lanes as marked The heparin-resistant complex on tRNA1Gly -1 (left) is marked by an arrow; ++ denotes lg of protein (B) The specificity of complex formation was examined by the competition with 10 ... rescue of transcription by externally supplemented TFIIIB (lane 5; compare with lane 4) was abolished by the anti-TBP serum (lanes 7, 8) Inhibition was again rescued by increasing concentrations...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
Ngày tải lên :
20/02/2014, 11:20
... presented in this study suggest that this PRD is necessary for the inducible expression of fgl2, we plan to undertake additional studies aimed at more precisely elucidating specific mechanisms regulating ... transcription initiation, the usage of this TATA box was not observed in our studies Determination of the 5¢-end of mRNAs isolated from liver tissue and cloned by 5¢-RACE showed similar results (data ... not formed by the binding of Sp1 or Sp3 However, we cannot rule out a Sp1 related transcription factor or an unknown factor at this time Future studies are required to address this issue We next...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
Ngày tải lên :
21/02/2014, 01:21
... SODs is not governed by one or even two residues, but is most likely accomplished by the concerted effects of a combination of key residues Further analysis of these and other mutant SODs is currently ... electrophoresis (PAGE) Native 8% polyacrylamide gels (acrylamide : N,N¢-methylenebisacrylamide, 29 : 1, w/w) containing NaCl/Tris, pH 8.8 utilized a Tris/glycine electrophoresis buffer system consisting ... originally identified to distinguish between FeSOD and MnSOD [7] The position of the glutamine residue, which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt
Ngày tải lên :
22/02/2014, 04:20
... semiquantitatively by this method The effects of enzymes, inhibitors and other reagents on the cell cycle– dependent interaction could also be examined very easily by means of this method This method is applicable ... chromatin is regulated by phosphorylation in the arginine-serine repeatcontaining region (RS-region) by multiple kinases The potential function of LBR and LAP2 in vesicle targeting to chromatin is discussed ... LBR and chromatin is important for elucidation of the nuclear envelope assembly/disassembly mechanism In this study, we first determined the chromatin binding region of LBR by using beads bearing...
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Tài liệu Báo cáo Y học: Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents pptx
Ngày tải lên :
22/02/2014, 07:20
... progression of trophoblast cell apoptosis in the tissue, and that apoptosis of primary cultured human chorion trophoblast cells induced by TNFa was also suppressed by this lower concentration of glucocorticoid ... antagonist, RU-486, during incubation inhibited the suppression of trophoblast apoptosis in the tissue by glucocorticoid (data not shown) This suggests that the suppression of trophoblast apoptosis ... function, and that apoptosis suppression by glucocorticoid in the tissue may also be affected by suppression of specific gene functions, such as c-Jun It is known that there is an increase in fetal...
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Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
Ngày tải lên :
22/02/2014, 07:20
... ACKNOWLEDGEMENTS This work is supported by grants from the National Health and Medical Research Council (NH & MRC) of Australia KB is supported by the Deutsche Forschungsgemeinschaft and the Bundesministerium ... matrix [37] In this study, we demonstrate that substrate-bound Ab is toxic to VSMC by the activation of apoptotic cell death pathways and that a known risk factor for cerebrovascular disease, homocysteine, ... the mechanism of this toxicity is unclear Ab peptides have been shown to be neurotoxic both in vivo [22] and in vitro [23,24] Several studies have shown that Ab disrupts calcium homeostasis and...
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Báo cáo khoa học: Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages pdf
Ngày tải lên :
06/03/2014, 22:21
... circulating levels of visfatin have been observed in many inflammatory diseases such as rheumatoid arthritis, obesity, insulin resistance and type diabetes [5–7] Visfatin is secreted by neutrophils in ... precursor Thus, the NAD pool is maintained, at least in part, by visfatin, which is important, for instance, in b-cell insulin secretion [2] Although still controversial, visfatin is thought to have insulin ... regulates visfatin gene expression at the transcriptional level To determine whether visfatin is a direct PPARc target gene, the human visfatin promoter was examined by bio-informatic analysis Three...
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Báo cáo khoa học: Autocatalytic processing of procathepsin B is triggered by proenzyme activity doc
Ngày tải lên :
07/03/2014, 03:20
... proteinaceous substrate at neutral pH Moreover, this conformational change, which is the only unimolecular step of the mechanism, is not accompanied by any larger structural changes, such as unfolding ... Baici A, Lang A, Horler D, Kissling R & Merlin C (1995) Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage Ann Rheum Dis 54, 289–297 Coulombe R, ... direction opposite to that of the substrate, thereby preventing substrate hydrolysis The data thus suggest that substrate hydrolysis can be explained by the FEBS Journal 276 (2009) 660–668 ª 2008...
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