... S, et al Endothelial dysfunction and cardiovascular risk profile in nonalcoholicfattyliverdisease Hepatology 2005;42:473–80 Targher G, Arcaro G Non-alcoholic fattyliverdiseaseand increased ... pathogenesis and potential treatments of paediatric non-alcoholic fattyliverdisease Aliment Pharmacol Ther 2008;28:13–24 Schreuder TC, Verwer BJ, van Nieuwkerk CM, et al Nonalcoholicfattyliver disease: ... pathogenesis, diagnosis and treatment World J Gastroenterol 2008; 14:2474 –86 Adams LA, Lindor KD Nonalcoholicfattyliverdisease Ann Epidemiol 2007;17:863–9 Angulo P Nonalcoholicfattyliverdisease N Engl...
... pediatric nonalcoholicfattyliverdisease Hepatology 2005;42:641-649 32 Angulo P Nonalcoholicfattyliverdisease N Engl J Med 2002;346:1221-1231 33 Adams LA, Angulo P Role of liver biopsy and serum ... pattern in right hepatic vein Nonalcoholicfattyliverdisease in children 73 Adams LA, Sanderson S, Lindor KD, Angulo P The histological course of nonalcoholicfattyliver disease: a longitudinal ... of nonalcoholic steatohepatitis as a cause of advanced liverdiseaseLiver Transpl 2001;7:608-614 80 McCullough AJ The clinical features, diagnosis and natural history of nonalcoholicfatty liver...
... resistance and other metabolic abnormalities [12,13] Nonalcoholicfattyliverdisease (NAFLD) is a spectrum of metabolic abnormalities ranging from simple accumulation of triglycerides in theliver ... the hepatocytes andthe development of NAFLD in these mice In order to identify the molecular basis for this phenomenon, we determined a number of parameters which could affect the delivery and ... SEM Histological analysis of liver samples At the end of the 24-week period, mice were sacrificed, andliverand visceral fat specimens were collected and stored at either )80 °C or fixed in 10%...
... NonalcoholicFattyLiverDisease Hepat Mon 2009;9(4):265-70 34 Caldwell SH, Crespo DM The spectrum expanded: cryptogenic cirrhosis andthe natural history of non-alcoholic fattyliverdisease J ... A Non-alcoholic fattyliverdisease pathogenesis: the present andthe future Dig Liver Dis 2009;41(9):615-25 Abenavoli L, Capasso R, Milic N, Capasso F Milk thistle in liver diseases: past, present, ... resistance and other metabolic alterations, reduce the link between adipose tissue andliver function by acting as anti-inflammatory and immunomodulatory agents, and modulate the progression of liver...
... general population of the same age and sex The two deaths recorded were not liver related, but the inclusion of these two cases among the four cases reaching the outcome of death or liver transplantation ... to the liver/ kidney microsome type 1, and anti-mitochondrial antibody), and a standard metabolic/inborn error panel (lactate/pyruvate ratio, urine and serum organic acids and amino acids) The ... detailed.32 We used the relationship between the logrank test andthe Poisson distribution The p value calculated (from the one-sample log-rank test) depends on the assumption that the number of deaths...
... of liver injury that form the broad spectrum of injury encompassed by the terms nonalcoholicfattyliverdisease (NAFLD) andnonalcoholic steatohepatitis (NASH) Difficult concepts, such as the ... guiding us through the editorial process and we appreciate their professional input Finally, we wish to thank both the patients with NAFLD andthe clinicians who care for them These are the people for ... introduces the history, definitional and semantic issues, spectrum and general importance of non-alcoholic fattyliver diseases (NAFLD) Nonalcoholic steatohepatitis (NASH) is a form of metabolic liver disease...
... Anania C, et al Nonalcoholicfattyliverdiseaseand carotid atherosclerosis in children Pediatr Res 2008;63(4):423-7 78 Wieckowska A, Feldstein AE Nonalcoholicfattyliver dis- ease in the pediatric ... especially in augmenting the effects of oxidative stress on theliver (95) The other experimental study assessed the effects of oxidative stress elicited by DEP in the aorta, liver, and lungs of dyslipidemic ... the livers of diabetic obese mice This exposure increases the AST and ALT levels, liver weight, andthe degree of fatty change of the liver, as ascertained histologically This study suggested...
... liverdiseaseThe diagnosis of non-alcoholic fattyliverdisease cirrhosis was made in patients who had clinical features andliver biopsies compatible with non-alcoholic fattydisease Females and ... andnonalcoholicfattyliverdiseaseThe clinical characteristics of the patients in these groups are shown in Table Mean VAP-1 levels were significantly different between patients with HCC and ... bear their ligands [15] Moreover, because the levels of these adhesion molecules change in different states, the determination of their concentrations can be beneficial for the diagnosis and treatment...
... of liver injury that form the broad spectrum of injury encompassed by the terms nonalcoholicfattyliverdisease (NAFLD) andnonalcoholic steatohepatitis (NASH) Difficult concepts, such as the ... introduces the history, definitional and semantic issues, spectrum and general importance of non-alcoholic fattyliver diseases (NAFLD) Nonalcoholic steatohepatitis (NASH) is a form of metabolic liverdisease ... resistance and central obesity fails to normalize liver tests, and particularly if there are warning signs for cirrhosis or the patient expresses a strong desire to know the severity of their liver disease, ...
... andthe development of a fattyliver We therefore discuss the causes and consequences of IR and how these may lead to a fattyliverand oxidative stress The development of additional ‘hits’ and ... pathways depends on both the nature of thefatty acid (degree of saturation and chain length) and whether the changes in FFA delivery to theliver are acute or long-standing An important pathway ... (BMI) andthe probability of having a fattyliver as defined by hepatic sonography In an autopsy series, where liver histology was used to define the presence of a fattyliver [4], fatty liver...
... metabolism andthe mechanisms of steatosis and lipotoxicity The concept of fatty acid overload andthe molecular and biochemical adaptive responses in theliver to fatty acid overload The value and limitations ... genes of hepatic fatty acid metabolism and transport to the pathogenesis andthe evolution of liverdiseaseThe peripheral model emphasizes the role of genes expressed outside of the liver, particularly ... glycerol andfatty acids following the activation of the latter to their acylCoA esters (for reviews see 110 FATTY ACID METABOLISM AND LIPOTOXICITY IN THE PATHOGENESIS OF NAFLD/NASH delivered into the...
... of fatty acids accumulating in theliverand fibrogenesis The balance between the amount and nature of intrahepatic lipids, andthe capacity for their oxidative and non-oxidative intrahepatic ... influence the proliferative response in theliver These include alteration in the priming phase of liver regeneration and in the expression of proteins involved in the control of cell cycle and apoptosis, ... Subsequently, a liver biopsy is often necessary to determine the severity of thefattyliverdiseaseThe decision to perform liver biopsies in patients with NAFLD is still controversial, and therefore...
... guide the clinician to proceed more aggressively and perform a liver biopsy, or take a more conservative approach and defer theliver biopsy and treat with current standard therapy for the associated ... of NAFLD and there appears to be no age difference between them Thus, it is more likely that the individual who develops fatty infiltration of the liver, soon thereafter either controls the problem ... liver, longstanding obesity and type diabetes Advanced liverdisease may become the dominant clinical problem in these patients, overtaking diabetes-related vascular disease Not uncommonly, these...
... to recognize the clinical importance of hepatic steatosis andthe metabolic syndrome both before and after liver transplantion Abstract Non-alcoholic fattyliverdisease (NAFLD) andnonalcoholic ... death on theliver transplant waiting list and to improve overall outcomes [16] Given the small graft size, the need for rapid regeneration of liver volume in both the donor and recipient andthe ... reference, the odds ratio for fattyliver for the other groups was 1.89, 2.57 and 5.64, respectively Therefore, fattyliver can occur in ‘lean’ but centrally obese individuals (group 2) and its...
... described the condition in children The three reported children, two boys and one girl, were obese and without any other identifiable cause of chronic liverdiseaseThe biopsies from these children ... detection and monitoring of fatty metamorphosis of theliver Pediatr Radiol 2001; 31: 806–9 27 Matteoni CA, Younossi ZM, Gramlich T et al Nonalcoholicfattyliver disease: a spectrum of clinical and ... acute and chronic complications, and was replaced by other operative procedures in the early 1980s One of the most important complications was liver injuryasevere forms of fattyliverand steatohepatitis...
... Valproate therapy andnonalcoholicfattyliverdisease Ann Neurol 2004; 55: 72009–32 Bellentani S, Tiribelli C The spectrum of liverdisease in the general population: lesson from the Dionysos ... IR, Shiota K The pathogenesis of nonalcoholic steatohepatitis and other fattyliver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression ... influenced the outcome: e.g whether or not the dosage of UCDA was optimal, whether or not the study was of sufficient duration, whether or not the correct preparation was used, and whether or not...
... with the following: chronic alcoholic liver disease, acute viral liver disease, chronic viral liver disease, mixed liverdisease (all chronic), cirrhosis, and alcoholic cirrhosis We adopted the ... Specifically, the meta command was used to compute and graph the randomeffects model estimates,63 the “galbr” command to assess heterogeneity and produce Galbraith plots,62 andthe metabias command to ... using over -the- counter “alternative agents” for the therapy of their liverdiseaseThe most commonly used nontraditional therapy was milk thistle, and over 50 percent of those patients felt they had...
... get together with others like them because of the supportive and therapeutic aspects They requested that they have lunch together at the end of the sessions During the dance classes, they were ... new people and having the regular opportunity to socialize and ‘work together’ were appreciated They felt the exercises were not boring, and neither did they ‘feel’ like exercise The afternoon ... ongoing basis The touch of others, the rhythm of the music, andthe novelty of the experience all contributed to the beneficial effects The sense of community spirit was evident when the tango group...
... of the manuscript and manuscript development; SJC for the drafting and revising of the manuscript; KM, TB and EMY for their practical and intellectual input; GT for the statistical analysis and ... NAFLD and NASH, which has pathogenic implications These cohorts were then further subdivided into fibrosis and cirrhosis (n = 20) and T2DM (DB, n = 49) to investigate the influence of these disease ... HMS and AIA for their interpretation of data and intellectual input; ADB for the acquisition and interpretation of data; SK for the interpretation of data and intellectual input; CPD for the...
... of the manuscript and manuscript development; SJC for the drafting and revising of the manuscript; KM, TB and EMY for their practical and intellectual input; GT for the statistical analysis and ... NAFLD and NASH, which has pathogenic implications These cohorts were then further subdivided into fibrosis and cirrhosis (n = 20) and T2DM (DB, n = 49) to investigate the influence of these disease ... HMS and AIA for their interpretation of data and intellectual input; ADB for the acquisition and interpretation of data; SK for the interpretation of data and intellectual input; CPD for the...