no il 1β and tnf α production in bv 2 cells

... Glia 20 03, 43 :28 1 -29 1 22 Rasley A, Bost KL, Marriott I: Murine gammaherpesvirus-68 elicits robust levels of interleukin- 12 p40, but not interleukin- 12 p70 production, by murine microglia and astrocytes ... Once production is initiated, cytokines such as TNF- a and IL- 6 would be anticipated to promote inflammation and to increase blood-brain barrier permeability, facilitating leukocyte recruitment into ... receptors including Toll-like receptor (TLR) 2, and TLR9 [13,14], the means by which resident CNS cells perceive DNA virus infection and initiate inflammatory cytokine production have not been defined...

Ngày tải lên: 19/06/2014, 22:20

... 4-aminoquinoline and cyclic b-ketoester Tetrahedron 66: 520 4– 521 1 24 Chandra A, Singh B, Upadhyay S, Singh RM (20 08) Copper-free Sonogashira coupling of 2- chloroquinolines with phenyl acetylene and ... 4-(arylamino)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylates (5a–k) in yields 52 82% [26 , 29 ] Similarly, aminopicolines were used to obtain ethyl 4[(methylpyridin -2- yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylates (6a–c) in yields 50–60% ... Bernardino AMR (20 08) Synthesis of new 4-(phenylamino)thieno [2, 3-b]pyridines and derivatives of the novel benzo[b]thieno[3 ,2- h]-1,6-naphthyridine tetracyclic system Arkivoc 14:77–87 30 Bernardino...

Ngày tải lên: 20/06/2014, 20:20

... = 20 11 giá trị cần tìm 0,50 II Giải phương trình: 3 (2 cos x + cos x − 2) + (3 − cos x)sin x =  sin x = ⇔ (2sin x − 3)( sin x + cos x) = ⇔    tan x = −  π   x = + k 2  2 ⇔ x = + k 2 ... 0,50 0 ,25 0 ,25 0 ,25 0 ,25 π Tính I = ∫ III π π I =∫ π cot x sin x + cot x cot x sin x + sin x dx dx 0 ,25 π π → t = 3; x = → t = 3 t t dt = ∫ dt = + t = − + t2 + t2 Đặt t = cot x ; x = I = −∫ 0 ,25 ... x − y − = A có toạ độ thoả mãn hệ x − y =  x = 2 ⇒ ⇒ A( 2; 2)   x − y − =  y = 2 C đối xứng với A( 2; 2) qua M (1;1) nên C (4; 4) 0 ,25 B VI.a M (1;1) C Dễ thấy đường thẳng (d ) : x −...

Ngày tải lên: 19/04/2015, 05:00

... to the fibrinogen domain; unexpectedly, no further domain, e.g a collagen domain as in the ficolins [21 ], or lectin as in the horseshoe crab [20 ], or a coiled-coil domain in angiopoietin [67], could ... AAA91336; amino acids 443–487), rat cubilin (CUBIL_RAT, NP_445784; amino acids 28 19 28 64), frog (Xenopus laevis) neurogenic locus notch protein homolog precursor (NOTC_XENLA, P21783; amino acids ... fibrinogendomain containing proteins, fibrinogens, fibroleukins/ techylectins, angiopoietins, ficolins and tenascins, the following consensus was deduced: FSTxDNDND It is located in the human fibrinogen...

Ngày tải lên: 16/03/2014, 16:20

... COS-1 cells were labeled 48–60 h post-transfection for h with 80 lCi of [35S]methionine in methionine-free DMEM containing 2% fetal calf serum, 50 UÆmL penicillin and 50 mgÆmL)1 streptomycin (denoted ... REFERENCES International Human Genome Sequencing Consortium (20 01) Initial sequencing and analysis of the human genome Nature 409, 860– 921 Kawai, J., Shinagawa, A., Shibata, K., Yoshino, M., Itoh, ... conserved open reading frame in all three species In all three species, the encoded NICN1 protein consists of 21 3 amino acids and has a calculated molecular weight of 24 kDa (Fig 1) The amino acid sequences...

Ngày tải lên: 23/03/2014, 21:20

... of urine were collected and the laboratory results were as follows: Adrenaline μg /24 h (1.7 -22 .4), Noradrenaline 29 μg /24 h ( 12- 85), Metanefrine 337 μg /24 h (100800), Normetanefrine 29 8 μg /24 h (88-444), ... parathyroid glands and the well-differentiated non functioning pancreatic endocrine carcinoma, functioning bilateral adrenocortical carcinomas were diagnosed A not previously described, novel germline ... Protein family JunD regulates transcription from certain promoters by binding to TRE consensus Menin-JunD interaction involves the N-terminus (amino acids 1-40) and midregion (amino acids 323 - 428 )...

Ngày tải lên: 09/08/2014, 01:24

... ester]-threonine-proline-leucine-lysine~serine-proline-proline-proline-serineproline-arginine-[5-( (2- aminoethyl)amino)naphthalene1-sulfonic acid], and carboxybenzyl-phenylalaninearginine-7-amido-4-methylcoumarin were ... prostaglandin E2 production increased 3-fold in KD MAEC, but not in the Control cells (figure 2) LPS/IFN induced COX -2 mRNA in KD and Control shRNA cells as indicated by RT-PCR The message increased ... after induction of COX -2 with LPS/IFN [6] COX -2- dependent prostaglandin E2 production was measured after incubating cells with LPS/IFN for 24 h Cells were then incubated in fresh medium containing...

Ngày tải lên: 11/08/2014, 08:22

... reported finding that the HTLV-1 Gag protein could bind to a amino acid domain of CD 82 (another tetraspanin member) and use this interaction to enter the host cell suggests the VP26CTMP-7 interaction ... http://www.virologyj.com/content/7/1/156 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 infectious virus in the nervous system of infected mice Virology 1998, 24 7:115- 124 Krautwald M, Maresch C, Klupp BG, Fuchs ... Sci 20 08, 121 :22 87 -22 92 Mazurov D, Heidecker G, Derse D: The inner loop of tetraspanins CD 82 and CD81 mediates interactions with human T cell lymphotrophic virus type Gag protein J Biol Chem 20 07,...

Ngày tải lên: 12/08/2014, 04:20

... marker) immunostaining 24 h after HSV-1 GFP-VP 22 infection Briefly, cells were fixed by incubating slides in methanol for 10 followed by acetone for at 20 °C Afterwards, slides were rinsed three ... than Wild-Type Virus in Two Different Strains of Mice J Virol 20 07, 81: 129 62- 129 72 Osorio Y, La Point SF, Nusinowitz S, Hofman FM, Ghiasi H: CD8+dependent CNS demyelination following ocular infection ... qualitative increase in GFP labeling at each dose of HSV-1 GFP-VP 22 Furthermore, infected cells appeared morphologically distinct (often displaying a more round, activated phenotype) from non-infected cells...

Ngày tải lên: 12/08/2014, 04:21

... marker) immunostaining 24 h after HSV-1 GFP-VP 22 infection Briefly, cells were fixed by incubating slides in methanol for 10 followed by acetone for at 20 °C Afterwards, slides were rinsed three ... than Wild-Type Virus in Two Different Strains of Mice J Virol 20 07, 81: 129 62- 129 72 Osorio Y, La Point SF, Nusinowitz S, Hofman FM, Ghiasi H: CD8+dependent CNS demyelination following ocular infection ... qualitative increase in GFP labeling at each dose of HSV-1 GFP-VP 22 Furthermore, infected cells appeared morphologically distinct (often displaying a more round, activated phenotype) from non-infected cells...

Ngày tải lên: 12/08/2014, 04:21

... 7 824 ( : 123 45600, 124 5300,765400) d d ? qui tròn số sau : 12, 5 425 ; 0,5% Vậy d 5,7 824 .0,5% a 5, 7 824 9876 ,23 4; 123 4,541 đến hàng phần trục? ( số: 12, 5; 9876 ,2; 123 4,5) - sau nêu nguyên tắc 2, ... biết để MĐ Q(x) * VD2: CM trực tiếp định lí: Nếu n số tự nhiên lẻ n2+1 số chẵn CM: giả sử n số tự nhiên lẻ, ta có: n=2k+1, k N Khi đó: n2+1=( 2k+1 )2+ 1 =2( 2k2+2k+1) Do : n2+1 số chẵn * PP CM ... chức lớp: 2. Bài cũ : - cho tập hợp: A ={ -3, -2, -1,0,1 ,2, 3};B= { -2, 2,3},C= {-3,1,4,5} tìm A C, A C, A \ C, CAB 1 - tìm : ( ,2] (1,4) ; [-7, 4] (5,6) ; (-1 ,2] [1,3); (- ,2] \ (1,4) 2 - 21 - Bùi...

Ngày tải lên: 26/06/2013, 01:25

...  2x + + 2 − x  x2 +     2 x = x = ⇔ ⇔ 3  2x + + 2 − x = x + 4 2( 2 + x ) (2 − x ) + (2 − x )(x + 4) =     x = x = ⇔ ⇔ 3  x =2 − x (4 2( 2 + x ) + (x + 4) − x ) =     ( x2 ... 6) = −3(1; 2; − 2) = −3.n, n = (1; 2; − 2) Mặt phẳng (ABC ) qua A ( 0;1; ) có vecto pháp tuyến n = (1; 2; − 2) nên có phương trình x + 2y − 2z − = S ABC = + 2t + 2( 2 − t ) − 2( 3 + 2t ) − −4t ... 2; 2; ) ,C ( 2; 3;1) đường thẳng x = + 2t  d : y = 2 − t Tìm điểm M ∈ d để diện tích tam giác ABN nhỏ z = + 2t  ( ) ( ) M ∈ (d ) ⇒ M (1 + 2t; − − t ; + 2t ) AB = (2; 1; 2) , AC = ( 2; 2; 1)...

Ngày tải lên: 30/08/2013, 13:58

... +Ơ x 2- y= x 2- ỗ 3+ ữ = -Ơ + xđ ố x - 2 x - 2 ố thcúTC: x =2TCN: y =3. x đ 2+ Sbinthiờn: y ' = - < "xạ 2, suyrahmsnghchbintrờncỏckhong ( x -2) 0 .25 ( - 2) & (2 +Ơ ) BBT x y -Ơ +Ơ - - 0 .25 +Ơ ... 0 .25 y '( x ) = = -4 ( x0 - 2) 1,0im sin x + cos x + 5sin x - cos x- cos x - = (1) k: cos x p x + k 2p, k ẻ Â. 0 .25 (1) sin x + cos x + 5sin x - cos x - =0 0 .25 cos x (2 sin x - 1) - (2 sin ... (2 sin x - 5sin x + 2) =0 p ộ p x = + k2 (2sin x - 1)(cos x - sin x + 2) =0 sinx= ờ p x= + k p Kthpiukinsuyraphngtrỡnhcúnghim x = p + k 2p ( k ẻ Â ) 0 .25 0 .25 1,0im ỡ( x + y )2 + ( x + y)(...

Ngày tải lên: 05/09/2013, 10:46

...  2x + + 2 − x  x2 +     2 x = x = ⇔ ⇔ 3  2x + + 2 − x = x + 4 2( 2 + x ) (2 − x ) + (2 − x )(x + 4) =     x = x = ⇔ ⇔ 3  x =2 − x (4 2( 2 + x ) + (x + 4) − x ) =     ( x2 ... 6) = −3(1; 2; − 2) = −3.n, n = (1; 2; − 2) Mặt phẳng (ABC ) qua A ( 0;1; ) có vecto pháp tuyến n = (1; 2; − 2) nên có phương trình x + 2y − 2z − = S ABC = + 2t + 2( 2 − t ) − 2( 3 + 2t ) − −4t ... 2; 2; ) ,C ( 2; 3;1) đường thẳng x = + 2t  d : y = 2 − t Tìm điểm M ∈ d để diện tích tam giác ABN nhỏ z = + 2t  ( ) ( ) M ∈ (d ) ⇒ M (1 + 2t; − − t ; + 2t ) AB = (2; 1; 2) , AC = ( 2; 2; 1)...

Ngày tải lên: 12/12/2013, 16:15

... ộx = y 2) Ta cú: (1) ( x - y )2 ( x - y ) = (2) x = 4y ù x-y + x+y =2 ợ ã Vi x = y: (2) ị x = y = ã Vi x = 4y: (2) ị x = 32 - 15; y = - 15 Cõu III: I = + ln - ln 1 5a2 14 2a 10 = a 27 14 Cõu ... Cõu I: 2) y = x - 4(m - m + 1) x ; y = ởx = m - m +1 ổ 1ử Khong cỏch gia cỏc im cc tiu: d = m - m + = ỗ m - ữ + ị Mind = m = ố 2 p Cõu II: 1) PT sin3 x - 2sin 2 x + 3sin x + = sin x = ... r ỡa ^ n r r r ộ 2) E ẻ (d2) ị E(3; 7; 6) rV rP ị aV = nP , ad ự = -4(1;1; -1) ị (D): ỷ aV ^ ad1 ợ ỡx = + t ù ớy = + t ùz = - t ợ ộa = - i 2 Cõu VII.a: z1 + z2 = -4i a2 = -2i a = -1 + i Theo...

Ngày tải lên: 24/12/2013, 16:15

... C) D) E) their meanings eliminating anxiety building up tension creating silence meaningful talks In terms of meaning "How you do?" is A) B) C) D) E) not replied "How you do" not a question replied ... you' a question used for introducing two people What is important "How you do? " is its A) B) C) D) E) breaking silence meaning not being conversational answering remaining silent ... the words defined above Everything depends on how the country itself to using information technology The government, after a period of decline in manufacturing and a sharp rise in unemployment,...

Ngày tải lên: 25/01/2014, 22:20

... 84 61 52 2a 3a 5 525 26 10 640 29 1 kDa 14.3 24 .2 41 .2 69.0 1b 2. 0 4 .2 17 .2 36.0 2b 3b kDa 22 0 130 100 100 60 55 45 30 35 25 20 15 Fig Homogeneity of purified R2F eluted from a Mono Qâ HR ⁄ column ... protein utilizing the principle of protein-dye binding Anal Biochem 72, 24 8 25 4 Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 22 7, ... centrifugation (20 000 g for min), cells were washed in phosphatebuffered saline and subsequently incubated in 100 lL of lysis buffer (10 mm Tris-HCl, pH 6.8, 25 mm MgCl2, 20 0 mm NaCl), containing mgÆmL)1...

Ngày tải lên: 15/02/2014, 01:20

Ngày tải lên: 19/02/2014, 06:20

... endothelial Ó FEBS 20 04 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Anti-mitogenic action of EPA and DHA (Eur J Biochem 27 1) 4473 cell adhesion molecules Biochem Biophys Res Commun 22 0, 969–974 Kambe, ... in IL- 1b-stimulated cells was not significantly reduced by U0 126 or by LY2940 02 (data not shown), and it was strongly stimulated (up to threefold) by incubation in medium containing fetal bovine ... cells incubated with the MAPK kinase (MEK) inhibitor, U0 126 U0 126 completely inhibited the cyclin D1 promoter activity in AA-pretreated SMC incubated with IL- 1b and reduced it in cells incubated...

Ngày tải lên: 19/02/2014, 16:20