neurophysiology and functional neuroanatomy of pain perception
Functional Neuroanatomy of Pain pdf
... Snider and McMahon 1998; Petruska et al. 2002).K.G. Usunoff · A. Popratiloff ·O. Schmitt · A. Wree Functional Neuroanatomy of P ainWith 19 Figures12334 Functional Neuroanatomy of the Pain ... 26 Functional Neuroanatomy of the Pain SystemThecriticalroleoftheSTTinpainisuniversallyacknowledged,buttherelativein volvement in pain sensation of lamina I neurons and the wide-d ... “neuropathic pain. ”Here, we presen t an updated review of the functional anatomy of normal and neuropathic pain. 2 Functional Neuroanatomy of the Pain System2.1Primary Afferent NeuronThe primary...
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Tài liệu Physical health and functional ability of an elderly, population in Sri, Lanka doc
... prepare own meals and handle money. A limited number of tests of physical performance for assessing the functioning of upper and lower extremities were carried out, using standard procedures. ... included: semi tandem stand, full tandem stand, rising from chair without using arms and shoulder external rotation (full). A younger member of the household present at the time of the interview ... Years of life expectancy free of problems with PADL 12.32 13.43 Years of LE free of problems with all ADL 7.81 8.33 % of total LE free of problems with PADL 93.3 91.2 % of ...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine.Table 2. Km and Vmaxvalues for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 filter paper assay and ... PRTFDC1towards hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remainsunclear and it is uncertain whether ... elucidation of the structure of PRTFDC1 and the definition of its ligand binding specificity froma large metabolome library provides an initial startpoint for defining the molecular function of PRTFDC1....
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Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc
... has structural and functional properties of RNase and participates indegradation of IL-1b mRNADanuta Mizgalska1, Paulina We˛ grzyn1, Krzysztof Murzyn2, Aneta Kasza1, Aleksander Koj1,Jacek ... 2,3 and 4, lower band). The levels of mutant and wild-type MCPIP mRNAs were higher when thesevectors were co-transfected with a vector overexpress-ing IL-1b (Fig. 5, lanes 3 and 4, upper bands). ... by many stimulants, and regulates the level of IL-1b mRNA and of its own transcript. Further stud-ies are necessary to clarify the biological role of MCPIP as a nuclease and to identify the...
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Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt
... D and E + F), (b) a few hydrogenbonds, and a hydrophobic interaction between A + C,B + E and D + F, and (c) electrostatic forces in thecentral channel of the hexamer between B, C and F, and ... Glu204(Fig. 3A,C), and a hydrophobic interaction betweenThr131 and Phe133 (Fig. 3D). The central channel of the hexamer is made up of two layers of electrostaticforces on top of each other, with ... three lysines from the B, C and F subunits, and there is no direct interaction between subunits A and F, B and D, or C and E.A phosphate ion was found in the donor site of allsubunits (Fig. 2B),...
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Tài liệu Báo cáo khoa học: Molecular modeling and functional characterization of the monomeric primase–polymerase domain from the Sulfolobus solfataricus plasmid pIT3 doc
... concentration of Rep245 pre-pared in 10 mm sodium phosphate (pH 7.4) was 5 lm. CDspectra were recorded at 60, 70 and 80 °C between 190 and 260 nm with a step increase of 0.2 nm, and a bandwidth of 1 ... plausibly involved in DNArecognition and binding and is positioned left of the active site [14].Rep245 is both capable of de novo synthesis of DNA primers and of elongating them. Long DNAextension ... 5.0, 5.4 and 5.8), Tris ⁄ HCl (pH 6.5, 7.0, 7.5 and 8.0) and glycine ⁄ NaOH (pH 8.6, 9.0 and 9.6). (B) Dependence of Rep245 polymerase activity on metal ions. The results are the means of three...
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Tài liệu Báo cáo khoa học: Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani pdf
... 29,24 and 12 h at temperatures of 4, 13 and 26.5 °C,respectively.Inhibition of AK by the specific inhibitor Ap5A and itseffect on growth of L. donovanipromastigotesin vitroThe effect of the ... inhibitor of AK, competitively inhibitedactivity of the recombinant enzymes with estimated Kivalues of 190 nM and 160 nMfor ATP and AMP, respectively.Ap5A also inhibited the growth ofL. donovani ... Kivalues of 190 nM and 160 nMfor ATP and AMP, respectively. Ap5A also inhibited growth of L. donovani promastigotes in vitro (Fig. 7) with IC50value of 27 ± 5 lM. The effect of Ap5A...
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Tài liệu Báo cáo khoa học: Characterization and functional expression of cDNAs encoding thyrotropin-releasing hormone receptor from Xenopus laevis Identification of a novel subtype of thyrotropin-releasing hormone receptor ppt
... described the isolation of full-lengthcDNAs encoding three subtypes of the Xenopus laevis brainTRHR (xTRHR1, xTRHR2 and xTRHR3) and their functional expression in Xenopus oocytes and mammaliancells. ... consists of a large, rapid and transient response that is typical of Ca2+-dependent Cl–channels activated after stimulation of PLC and thesubsequent InsP3-dependent mobilization of Ca2+fromintracellular ... (Cys335 and 337) and xTRHR2 (Cys339 and 341). By contrast, onlyone of these residues (Cys342) corresponding to thehomologous Cys337 is present in xTRHR3 (also in fishTRHR2). Since palmitoylation of...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... lipoproteinlipase and functional studies of the carboxyl-terminal domainYoko Kobayashi, Toshiaki Nakajima and Ituro InoueDivision of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, ... modeling, addition of hydrogen,modification of bonds, potentials of forcefield, and fixation of heavy atom, backbone, and Ca, were performed formolecular mechanics calculations. and then the energyminimization ... chimeras of hepatic lipase and lipoprotein lipase. Localization of heparin and cofactor binding.J. Biol. Chem. 273, 30979–30984.22. Sendak, R.A. & Bensadoun, A. (1998) Identification of a heparin-binding...
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Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
... longa-helices and a final b-strand, F, which protrudes fromthe core of the monomer and runs anti-parallel to thesame strand of a second monomer, allowing for theformation of the dimer. The surface of ... glutamate and aspar-tate residues confined to the portion of the moleculeinvolving a-helix A, the nearby loop, the first and lastturns of helices E and F, and the C-terminus helices I and J. In ... structure of onlythree of these unique components (CagZ, CagS and CagD) is now available, along with Caga ATPase.The lack of a clear picture of the biological func-tion and organization of some...
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Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... the C-termini of other members of the secre-tion family, such as PilQ of Myxococcus xanthus [28],ExeD of Aeromonas salmonicida [29], PilQ of P. aerugi-nosa [25,30], and PilQ of N. gonorrhoeae ... compilation ª 2006 FEBSN-terminal domain of PilQ, and the colocalization of PilQ with PilW in inner and outer membranes and theresults from the pilW and pilQ mutant studies, it istempting to ... assembly and stability of PilQmultimers at the inner membrane and transport of thesesubassemblies to the outer membrane.The presence of the pilin-like PilA4 protein in theinner and outer...
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Báo cáo khoa học: Molecular and functional characterization of novel CRFR1 isoforms from the skin pptx
... Pisarchik and A. Slominski (Eur. J. Biochem. 271) Ó FEBS 2004Molecular and functional characterization of novel CRFR1 isoformsfrom the skinAlexander Pisarchik and Andrzej SlominskiDepartment of ... isoform where exon 3 and exon 6 are spliced out (U16273); CRFR1d isoform whereexons 6 and 13 are missing (AF180301); CRH-R1e withdeletion of exons 3 and 4 (AF369651); CRFR1f withdeletion of ... with deletion of exon 11, 27 basepairs of exon 10 and 28 basepairs of exon12 (AF369653); and CRFR1h with addition of a crypticexon (AF374231) [15–18]. In rodents, three CRFR1isoforms have already...
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Báo cáo khoa học: Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p pptx
... Here we confirm and extend earlier studies of these AAA-peroxins and givea further detailed functional analysis of their cassettestructure and interaction.The interaction of Pex1p and Pex6p involvestheir ... parts of the N-terminal fragment and ⁄ or the second cassette;ABDCEFFig. 5. Effects of point mutation of theWalkerA and B motifs of the AAA-cassettes of Pex6p on the morphological appearance of ... localization and I. Birschmann et al. Domain function of Pex1p and Pex6pFEBS Journal 272 (2005) 47–58 ª 2004 FEBS 57Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... distribution of VBARP isindependent of the cycling stage of the cells.Identification of biological function(s) of VBARPusing a siRNA assayTo examine the role of endogenous VBARP in theregulation of ... prosite motif scan and netphos software, also predicted the presence of several potential serine, threonine, and tyrosinephosphorylation sites (cAMP, PKC, and CK2), and the presence of nine potential ... consisted of a 576-bp fragmentabsent from the shorter VBARP-S and contained a114-bp UTR (Fig. 2A). Intron and exon analysis of VBARP revealed that VBARP-L and VBARP-S con-tain 11 and 9 exons,...
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Báo cáo khoa học: Sulfation of hydroxychlorobiphenyls Molecular cloning, expression, and functional characterization of zebrafish SULT1 sulfotransferases docx
... dose-dependence of the regula-tion of the activity of the zebrafish ST by these divalentmetal cations and their modes of action.Fig. 6. Effects of divalent metal cations on the sulfating activity of thezebrafish ... zebrafish SULT1 ST1 and ST2 mRNAs in cultured zebrafishcells (lanes 1 and 3) and whole zebrafish (lanes 2 and 4) by RT-PCR.The primers used for amplification of zebrafish SULT1 ST1 and 2 werethe same ... 3-chloro-4-biphenylol and 4,4¢-dihydroxy-3,3¢,5,5¢-tetrachlorobiphenyl in zebra-Fig.7. (A)DetectionofzebrafishSULT1ST1andST2mRNAsand(B) Western blot analysis of zebrafish SULT1 ST1 protein. (A) Detec-tion of zebrafish...
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