neural stem cells new perspectives

... Section Neural Stem Cells as Progenitor Cells Chapter Systems for ex-vivo Isolation and Culturing of Neural Stem Cells Simona Casarosa, Jacopo Zasso and Luciano Conti Chapter Neural Stem Cell ... drive the generation of new cells (Wilson et al., 2008; Essers et al., 2009; Fuchs, 2009; Li and Clevers, 2010) These active 31 32 Neural Stem Cells - New Perspectives stem cells are the force behind ... original work is properly cited 4 Neural Stem Cells - New Perspectives Figure Process of NSC self-renewal and differentiation NSCs are tri-potent cells These cells during the differen‐ tiation...

Ngày tải lên: 08/03/2014, 19:20

... orders@intechweb.org Neural Stem Cells and Therapy, Edited by Tao Sun p cm ISBN 978-953-307-958-5 Contents Preface IX Part Chapter Characterization of Neural Stem Cells Neural Stem Cells from Mammalian ... Noncoding RNAs in Neural Stem Cell Development 239 Shan Bian and Tao Sun Part Neural Stem Cells and Therapy 257 Chapter 13 Neural Stem/ Progenitor Cell Clones as Models for Neural Development ... (slowly dividing astroglial cells and the bona fide adult neural stem cells) , type C cells (transit-amplifying cells derived from asymmetric division of Type B cells) , type A cells (immature neuroblasts...

Ngày tải lên: 30/03/2014, 23:20

... change a neural stem cell’s fate Under certain conditions, neural stem cells have been induced to differentiate into cells outside the expected neural lineage and conversely, stem cells from nonneural ... “Utilization/Characterization of Neural Stem Cells in vivo,” is a collection of techniques to identify and characterize endogenous stem cells as well as exogenous stem cells after transplantation ... zone astrocytes are neural stem cells in the adult mammalian brain Cell 97, 703–716 Stem Cells, Neuroblasts, and Glioblasts from Fetal Tissue 29 Isolation of Stem and Precursor Cells from Fetal...

Ngày tải lên: 11/04/2014, 09:58

... cultured Schwann cells Plast Reconstr Surg 2001, 107:485-494 Fong SP, Tsang KS, Chan AB, Lu G, Poon WS, Li K, Baum LW, Ng HK: Trophism of neural progenitor cells to embryonic stem cells: neural induction ... Schwann cells Microsurgery 2002, 22:311-315 Heath CA: Cells for tissue engineering Trends Biotechnol 2000, 18:17-19 Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ: Neural progenitor cells ... (HA)-collagen neural corRepresentative image of scanning electron microscopy of neural stem cell (NSC) at passage three derived from the neural cortex of E16 Sprague-Dawley rat embryos implanted on neurotrophon-3-supplemented...

Ngày tải lên: 18/06/2014, 15:20

... of endogenous neural progenitor or stem cells and the transplantation of adult-derived neural progenitor and stem cells [39] Self-renewing multipotent neural progenitor and stem cells have been ... neuronal cells in the adult brain originate from residual stem cells The existence of stem cells in the adult brain suggests that it has the potential for self-repair and that newborn neuronal cells ... the nervous system Adult-derived neural progenitor and stem cells grafted in the brain promote neuroprotection, by an immunomodulatory mechanism Grafted neural progenitor and stem cells interact...

Ngày tải lên: 08/08/2014, 17:20

... breast cancer 22 1.4 Stem cells 1.4.1 Adult stem cells 1.4.1.1 Neural stem cells 1.4.2 Induced pluripotent stem cells 1.5 Stem cell as a vehicle for cancer gene therapy 1.5.1 Stem cell based cancer ... pluripotent stem cell derived -neural stem cell human induced pluripotent stem cell derived -neural stem cell expressing CodA human induced pluripotent stem cell derived -neural stem cell expressing Fcy ... al., 2001) Stem cells as delivery vehicles have been shown to enhance gene delivery efficiency (elaborated in section 3.1) 1.4 Stem cells 1.4.1 Adult stem cells (ASCs) Adult stem cells (ASCs),...

Ngày tải lên: 09/09/2015, 18:56

... growth factor Ventricular zone xii Chapter 1: Introduction 1.1 Neural stem cells 1.1.1 A brief history of NSCs The field of neural stem cell (NSC) biology has its humble beginnings in the second ... of NSCs from other neural or non -neural cells, none of the markers can exclusively identify NSCs as many are also found in more committed neural progenitors, differentiated cells or even in other ... 1.1.5.2 Pluripotent stem cell-derived NSCs Human embryonic stem cells (hESCs), which are pluripotent cells derived from the inner cell mass of blastocyst-stage embryos, offer a renewable and unlimited...

Ngày tải lên: 10/09/2015, 09:08

... 1.4.3 Stem cells and cancer 14 1.5 Neural development 16 1.6 Neural stem cells 19 1.6.1 Embryonic neural stem cells 20 1.6.2 Adult neural stem cells ... The stem cell concept 1.3 Symmetrical and asymmetrical division 1.4 Types of stem cells 1.4.1 Embryonic stem cells 1.4.2 Somatic stem cells 1.4.3 Stem ... neural stem cells .24 1.6.3 Neural stem cell applications .26 1.7 Methods to study neural stem cells 28 1.7.1 Identifying neural stem cells in vivo 28 1.7.2 In vitro...

Ngày tải lên: 12/09/2015, 21:26

... embryonic neural stem cells Diabetologia (2006) 49: 1027-1038 J Fu, S S W Tay, E A Ling, S T Dheen Aldose reductase is implicated in high glucose-induced oxidative stress in mouse neural stem cells ... proliferation and cell fate specification of embryonic neural stem cells Society for Neuroscience 35th Annual Meeting, Abstract Number 24.10 (24 Neural Stem Cells in Brain Injury and Disease, Theme A, A10), ... involved in neural tube development The developing neural tube is initially composed of neuroepithelium, a layer of rapidly dividing neural stem cells (NSCs) (Gilbert, 2003) NSCs are self-renewing,...

Ngày tải lên: 30/09/2015, 06:36

...   1.1   Stem cells   1.1.1   Human pluripotent stem cells   1.1.2   In vitro differentiation potential of human pluripotent and neural stem cells   1.2   ... Introduction 1.1 Stem cells Stem cells have the remarkable potential to differentiate into specialized cells and thereby are key factors for the development of the whole organism All types of stem cells ... and neural stem cells By translating knowledge from developmental neurobiology, protocols to generate distinct neural cell types from pluripotent cells have been established Pluripotent stem cells...

Ngày tải lên: 26/11/2015, 09:54

... the neural stem cells derived from the embryonic mesencephalon (E13.5) were used in the present study Generally, neural stem cells were grown to form as neurospheres in vitro The ability of stem ... astrocytes J Neurosci 12, 4565–4574 McKay R (1997) Stem cells in the central nervous system Science 276, 66–71 Gage FH (2000) Mammalian neural stem cells Science 287, 1433–1438 Svendsen CN, Clarke ... The ability of stem cells to form neurospheres is one of the indicators for proliferation of neural stem cells in vitro The passaged neurospheres were dissociated into single cells and planted...

Ngày tải lên: 30/03/2014, 04:20

... Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells 2008, 26(1):146-150 Zhang MJ, Liu B, Xia W, Sun ZY, Lu KH: Could cells from menstrual blood be a new source for ... experimental design with human dental pulp stem cells J Craniofac Surg 2008, 19(1):204-210 Evangelista M, Soncini M, Parolini O: Placenta-derived stem cells: new hope for cell therapy? Cytotechnology ... Discussion The possibility of using stem cells for regenerative medicine has opened a new field of investigation to find the best sources for obtaining multipotent stem cells, in particular through...

Ngày tải lên: 18/06/2014, 15:20

... TGF␤ signaling in NC stem cells and, as a result, in ocular NC derivatives in order to assess the actions of TGF␤ on these cells during eye development Results Neural- crest cells contribute to ... the dorsal neural tube, allowing Wnt1-Cremediated recombination in virtually all NC stem cells [11,15] In Wnt1-Cre/Rosa26R double transgenic mice, ␤-galactosidase-expressing NC-derived cells can ... Tgfbr2-mutant mice contains fibroblast-like cells, pigmented http://jbiol.com/content/4/3/11 cells, and vessels of the hyaloid vascular system, and proliferating cells are also seen Other mouse mutants...

Ngày tải lên: 06/08/2014, 18:21

... HE Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells Curr Drug Targets 2005, 6, 57-62 33 Satake K, Lou J, Lenke LG Migration of mesenchymal stem cells ... to ASCs because fibroblast cells also behave in this manner Some critics have suggested that even a low fraction of contaminating cells such as hematopoietic stem cells could be the source of ... factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells Stem Cells Dev 2008, 17, 681-693 Kang SK, Lee DH, Bae YC, Kim HK, Baik SY, Jung JS Improvement...

Ngày tải lên: 07/08/2014, 23:22

... 5-fluorocytosine XV CHAPTER INTRODUCTION 1.1 Neural stem cells Neural stem cells (NSCs) are a self-renewing and multipotent population that gives rise to the three major neural lineages (neurons, astrocytes ... pluripotent stem cells such as human embryonic stem cells (hESCs) to generate virtually any differentiated cell type provides the possibility of using these cells as new sources of human NSCs Self-renewing ... highly proliferating cells (hematopoietic progenitors, epithelial cells and endothelial cells) , all antigen-presenting cells (DCs, activated monocytes and activated B cells) , CD8+ T cells and eosinophil...

Ngày tải lên: 09/09/2015, 10:06

... variety of cells that make up the central nervous system including dopaminergic neurons, motor neurons, glial cells, astrocytes, oligodendrocytes, neural crest stem cell cells and retinal cells (Bjorklund ... underlying human nervous system development (Ben-Nun and Benvenisty, 2006; Dvash et al., 2006) 2.7 Embryonic stem cells and induced pluripotent stem cells Embryonic stem cells (ESC) have two characteristics ... 2.4 Formation of the neural tube (A) During neural induction, the neural plate is flanked by the non -neural ectoderm The notochord (N) lies below the neural plate (B) The neural plate folds up...

Ngày tải lên: 11/09/2015, 10:14

... Flk-1+CD31-CD34- mesenchymal stem cells: feasibility and safety from monkey to human Stem Cells Dev,2006,15(3):349-357 Devine SM, Bartholomew AM, Mahmud N, et al Mesenchymal stem cells are capable of ... transplantation of stem cells, it is very important to observe the survival and curative effects of transplanted stem cells Traditional immunohistochemical method can easily identify the transplanted cells ... expressed in injured tissues play important roles (2) Stem cells circulate among tissues, and stem cells migrate to the injured tissues once injury occurs Stem cell homing is a complicated process in...

Ngày tải lên: 25/10/2012, 11:18