nature and role of research and development in strategy implementation

Ngày tải lên: 01/11/2014, 22:05

... University Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern ... Economic Development Programs and Initiatives Business accelerators and/ or entrepreneurial initiatives Linking teaching and research to business opportunities Collaboration with local business and industry Small ... business and industry/entrepreneurial activity; providing business development assistance The Role of Public Regional Universities in Community and Economic Development December 6, 2005 Indirect...

Ngày tải lên: 21/02/2014, 01:20

... growth from the second quarter of 2000 into job classes using beginning size of firm, mean size of firm over the period, and end size of firm. If the beginning size of the firm is used to classify firms, ... enterprises with tax breaks, financial incentives, and other induce- ments. Instead, they are relying on building businesses from the ground up and supporting the growth of existing enterprises. This ... larger businesses in innovation. More research is needed to properly evaluate the case for a small business strategy, and, indeed, to determine whether or not public engagement in economic development...

Ngày tải lên: 06/03/2014, 19:20

Ngày tải lên: 24/03/2014, 04:20

Ngày tải lên: 29/06/2014, 09:20

Ngày tải lên: 12/08/2014, 11:22

Ngày tải lên: 11/09/2013, 11:44

... Academy of Engineering Institute of Medicine National Research Council INTEGRATING RESEARCH AND OPERATIONAL MISSIONS IN SUPPORT OF CLIMATE RESEARCH 11 Current NASA plans include continuation of a ... Policy, February 1, 1999. INTEGRATING RESEARCH AND OPERATIONAL MISSIONS IN SUPPORT OF CLIMATE RESEARCH 7 7 1 Integrating Research and Operational Missions in Support of Climate Research That Earth’s ... as the time scale of the phenomena of interest increases. Both operational and research satellite systems have played an important role in the development of our understanding of Earth processes...

Ngày tải lên: 17/02/2014, 07:20

... targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The first approach involved measuring the level of mito- chondrial targeting of wild-type ... University of Pennsylvania. Journal compilation ª 2007 FEBS Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase ... were initiated by the addition of 3 mm NADPH, and incubation was continued for 30 min at 37 °C in a shaking water bath. The reactions were terminated by adding 2 mL of ice-cold methanol, and insoluble...

Ngày tải lên: 18/02/2014, 16:20

... double-chain insulin is synthesized in vivo as a single-chain precursor (preproinsulin) and folded as proinsulin, in which a connecting peptide of 35 residues links the C terminus of the B chain and ... C-peptide in the folding/unfolding of HPI (Eur. J. Biochem. 271) 1739 Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding Cheng-Yin Min, Zhi-Song Qiao and ... character- ization of the unfolding of insulin and proinsulin using the reductive unfolding method has not been thoroughly investigated. We have characterized the unfolding process of an artificial porcine insulin...

Ngày tải lên: 19/02/2014, 12:20

... of fosfomycin binding to the K22V and K22E mutant proteins. However, two other positively charged amino acid side chains, R397 and R120, are also involved in fosfomycin binding, and in view of ... fosfomycin binding due to charge–charge repulsions. Most interestingly, the uncharged valine side chain completely abolishes fosfomycin binding in the absence of UDPNAG. Clearly, UDPNAG binding creates additional ... UDP-N-acetylmuramic acid) (A) and inactivation mechanism of MurA by fosfomycin as a result of the covalent linkage between Cys115 of MurA and fosfomycin (B). Ó FEBS 2004 Lysine 22 and arginine 120 in MurA (Eur....

Ngày tải lên: 19/02/2014, 13:20

... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible. From ... [15–18]. In the bovine complex a large subdomain is made up of  20 integral membrane proteins contributing > 60 transmem- brane segments. Some of these must be intimately involved in proton pumping. ... composition of complex I from bovine heart has revealed the existence of two additional subunits (bringing the total to 46), and one of these, the ESSS protein, is also encoded by an X-linked g ene in humans...

Ngày tải lên: 19/02/2014, 16:20

... B. (1994) The pteridine b inding site of brain nitric oxide synthase. Tetrahydrobiopterin binding k inetics, specificity, and allosteric interaction w ith the substrate d omain. J. Biol. Chem. 269, ... reflect ring opening of an epoxide inter- mediate at either of its two C-O bonds [219,220]. The sum of these findings strongly invokes the notion of oxygen activation during redox cycling of the ... nsertion of oxygen into the benzene ring of aniline to yield p-aminophenol [151]. Formation o f the oxygenating species has been recognized to be fac ilitated by the b inding to HbO 2 of aniline and...

Ngày tải lên: 19/02/2014, 16:20

... periods of times (0–60 min) at 37 °C. The concentration of the biotinylated Ig remaining on the cell surface was then quantified by measuring the binding of [ 125 I]Streptavidin. In the absence of ... image. Ó FEBS 2003 Role of cleavage and shedding in TSHR function (Eur. J. Biochem. 270) 3491 Role of cleavage and shedding in human thyrotropin receptor function and trafficking Myle ` ne Quellari 1 , ... five amino acids of the extracellular domain and devoid of any tag was not functional [27], while a mutant containing four amino acids of the ectodomain and including a rhodopsine tag was found...

Ngày tải lên: 21/02/2014, 00:20

... involved in combating HIV/AIDS in developing countries. Earmarks and initiatives will undoubtedly continue to play an important role in determining the priorities for USAID and, indeed, in sustaining ... transmission and distribution systems, requiring additional training and maintenance capabilities. Hydrogen technology and fuel cells are of increasing interest in some developing countries. The integrated ... Technology Capacity Build- ing for Development. Against this background of new interest in the topic, senior officials of the NRC and USAID became engaged in a series of meetings and informal discus- sions...

Ngày tải lên: 05/03/2014, 12:20

... Factor Processing information (perceiving, retrieving, manipulating, transmitting) Compiling information, importance of 0.90 Seeing (DOT) 0.66 Work with complex things Combining information, importance of ... use the very language of information processing, such as compiling and combining information. Some of the most highly correlated mental demands, such as reasoning and analyzing, are known as prototypical ... amount of 0.83 Catering and serving, importance of 0.61 Catering to people Decision making, level of 0.82 Entertaining, importance of 0.59 Catering to people Negotiating, importance of 0.79 Non-job-required...

Ngày tải lên: 06/03/2014, 05:20

... target (Fig. 1). Indeed, IL-1ra reduces brain injury in animal models of cerebral ischemia and, in a recent random- ized clinical trial, intravenous administration of recombinant human IL-1ra in patients ... K & Gearing A (2001) Immunohistochemistry of matrix metalloproteinases in reperfusion injury in rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res ... PJ, Hopkins SJ & Rowland M (2008) Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol...

Ngày tải lên: 07/03/2014, 03:20

... buffer A in 15 min, followed by a linear gradient down to 5% buffer A in 2 min. 5% buffer A was held for an additional 2 min and followed by a linear gradient up to 95% buffer A in 6 min. Determination ... °C: loading 5% buffer B, after 5 min linear gradient up to 95% buffer B in 37 min, and then holding 100% buffer B for 5 min. The product was identified by UV detection at 215 nm and by on-line ESI-MS ... domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence. To determine whether DptF is the putative partner of DptE, we expressed dptF using...

Ngày tải lên: 07/03/2014, 04:20

... antigen-binding affinity and the V H ⁄ V L interaction strength determined, five clones in the H39Q group showed both high antigen- binding affinity and strong V H ⁄ V L interaction. In Table 1. Result of ... enhancement in V H ⁄ V L interaction signifi- cantly improved the antigen-binding affinity of Fv, similarly to the level of scFv (Table 2). Some single V H domains of anti-protein IgG, inclu- ding HyHEL-10 ... of the H39 mutation, kinetic analysis for antigen–Fv interaction of the wild-type and H39KQ mutant of purified Fv and scFv proteins was performed using an SPR biosensor. As shown in Table 2, in...

Ngày tải lên: 07/03/2014, 12:20

... & Lynch, K. (1999).Offeringa hand to pragmatic understanding: The role of speech and gesture in comprehension and memory. Journal of Memory and Language, 40, 577–592. Lansing, C. R., & McConkie, ... 314–331. Swain, M. (1995). Three functions of output in second language learning. In G. Cook & B. Seidlhofer (Eds.), Principle and practice in applied linguistics: Studies in honor of H. G. ... pottery and involved description and gesture use. Materials recording and editing. Two video-recording ses- sions using the same lecture outline were scheduled, each last- ing approximately 20 min....

Ngày tải lên: 10/03/2014, 05:20