nature and role of research and development in strategy implementation
Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... UniversityRegional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern ... Economic Development Programs and InitiativesBusiness accelerators and/ or entrepreneurial initiativesLinking teaching and research to business opportunitiesCollaboration with local business and industrySmall ... business and industry/entrepreneurial activity; providing business development assistanceThe Role of Public Regional Universities in Community and Economic Development December 6, 2005Indirect...
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The Role of Small and Large Businesses in Economic Development doc
... growth from the second quarter of 2000 into jobclasses using beginning size of firm, mean size of firm over the period, and end size of firm. If the beginning size of the firm is used to classifyfirms, ... enterprises with tax breaks, financial incentives, and other induce-ments. Instead, they are relying on building businesses from the groundup and supporting the growth of existing enterprises. This ... larger businesses in innovation. More research is needed to properly evaluate the case for asmall business strategy, and, indeed, to determine whether or not publicengagement in economic development...
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Tài liệu ISSUES IN THE INTEGRATION OF RESEARCH AND OPERATIONAL SATELLITE SYSTEMS FOR CLIMATE RESEARCH pdf
... Academy of EngineeringInstitute of MedicineNational Research CouncilINTEGRATING RESEARCH AND OPERATIONAL MISSIONS IN SUPPORT OF CLIMATE RESEARCH 11Current NASA plans include continuation of a ... Policy, February 1, 1999.INTEGRATING RESEARCH AND OPERATIONAL MISSIONS IN SUPPORT OF CLIMATE RESEARCH 771Integrating Research and Operational Missions in Support of Climate Research That Earth’s ... as the time scale of the phenomena of interest increases.Both operational and research satellite systems have played an important role in the development of ourunderstanding of Earth processes...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... targeting of CYP2E1The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. Thefirst approach involved measuring the level of mito-chondrial targeting of wild-type ... University of Pennsylvania. Journal compilation ª 2007 FEBSMitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomycescerevisiae) role of protein kinase ... were initiated by theaddition of 3 mm NADPH, and incubation was continuedfor 30 min at 37 °C in a shaking water bath. The reactionswere terminated by adding 2 mL of ice-cold methanol, and insoluble...
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Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
... double-chaininsulin is synthesized in vivo as a single-chain precursor(preproinsulin) and folded as proinsulin, in which aconnecting peptide of 35 residues links the C terminus of the B chain and ... C-peptide in the folding/unfolding of HPI (Eur. J. Biochem. 271) 1739Unfolding of human proinsulinIntermediates and possible role of its C-peptide in folding/unfoldingCheng-Yin Min, Zhi-Song Qiao and ... character-ization of the unfolding of insulin and proinsulin using thereductive unfolding method has not been thoroughlyinvestigated. We have characterized the unfolding process of an artificial porcine insulin...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... of fosfomycin binding to the K22V and K22E mutant proteins.However, two other positively charged amino acid sidechains, R397 and R120, are also involved in fosfomycinbinding, and in view of ... fosfomycin binding due to charge–chargerepulsions. Most interestingly, the uncharged valine sidechain completely abolishes fosfomycin binding in theabsence of UDPNAG. Clearly, UDPNAG binding createsadditional ... UDP-N-acetylmuramic acid) (A) and inactivation mechanism of MurA byfosfomycin as a result of the covalent linkage between Cys115 of MurA and fosfomycin (B).Ó FEBS 2004 Lysine 22 and arginine 120 in MurA (Eur....
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... [15–18]. In thebovine complex a large subdomain is made up of 20integral membrane proteins contributing > 60 transmem-brane segments. Some of these must be intimately involved in proton pumping. ... composition of complex I frombovine heart has revealed the existence of two additionalsubunits (bringing the total to 46), and one of these, theESSS protein, is also encoded by an X-linked g ene in humans...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... B. (1994) The pteridine b inding site of brain nitric oxidesynthase. Tetrahydrobiopterin binding k inetics, specificity, and allosteric interaction w ith the substrate d omain. J. Biol. Chem.269, ... reflect ring opening of an epoxide inter-mediate at either of its two C-O bonds [219,220].The sum of these findings strongly invokes the notion of oxygen activation during redox cycling of the ... nsertion of oxygen into the benzene ring of aniline to yieldp-aminophenol [151]. Formation o f the oxygenatingspecies has been recognized to be fac ilitated by the b indingto HbO2 of aniline and...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... periods of times (0–60 min)at 37 °C. The concentration of the biotinylated Ig remainingon the cell surface was then quantified by measuring thebinding of [125I]Streptavidin. In the absence of ... image.Ó FEBS 2003 Role of cleavage and shedding in TSHR function (Eur. J. Biochem. 270) 3491 Role of cleavage and shedding in human thyrotropin receptor function and traffickingMyle`ne Quellari1, ... five amino acids of theextracellular domain and devoid of any tag was notfunctional [27], while a mutant containing four amino acids of the ectodomain and including a rhodopsine tag wasfound...
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THE FUNDAMENTAL ROLE OF SCIENCE AND TECHNOLOGYIN INTERNATIONAL DEVELOPMENT pptx
... involved in combating HIV/AIDS in developing countries.Earmarks and initiatives will undoubtedly continue to play an important role in determining the priorities for USAID and, indeed, in sustaining ... transmission and distribution systems, requiring additional training and maintenance capabilities.Hydrogen technology and fuel cells are of increasing interest in some developingcountries.The integrated ... Technology Capacity Build-ing for Development. Against this background of new interest in the topic, senior officials of theNRC and USAID became engaged in a series of meetings and informal discus-sions...
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HUMAN PERFORMANCE: Role of General Mental Ability in Industrial, Work, and Organizational Psychology docx
... FactorProcessing information (perceiving, retrieving,manipulating, transmitting)Compiling information, importance of 0.90 Seeing (DOT) 0.66 Work with complex thingsCombining information, importance of ... use the very language of information processing, such as compiling and combining information. Some of the most highly correlated mental demands,such as reasoning and analyzing, are known as prototypical ... amount of 0.83 Catering and serving, importance of 0.61 Catering to peopleDecision making, level of 0.82 Entertaining, importance of 0.59 Catering to peopleNegotiating, importance of 0.79 Non-job-required...
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Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
... target(Fig. 1). Indeed, IL-1ra reduces brain injury in animalmodels of cerebral ischemia and, in a recent random-ized clinical trial, intravenous administration of recombinant human IL-1ra in patients ... K& Gearing A (2001) Immunohistochemistry of matrixmetalloproteinases in reperfusion injury in rat brain:activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res ... PJ, Hopkins SJ & Rowland M(2008) Pharmacokinetic modelling of interleukin-1receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br JClin Pharmacol...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... buffer A in 15 min, followed by a lineargradient down to 5% buffer A in 2 min. 5% buffer A washeld for an additional 2 min and followed by a lineargradient up to 95% buffer A in 6 min.Determination ... °C: loading 5% buffer B, after5 min linear gradient up to 95% buffer B in 37 min, and then holding 100% buffer B for 5 min. The product wasidentified by UV detection at 215 nm and by on-lineESI-MS ... domain is one of thefew ACPs in which valine replaces isoleucine (I) orleucine (L) in the conserved sequence. To determinewhether DptF is the putative partner of DptE, weexpressed dptF using...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... antigen-binding affinity and the VH⁄ VLinteraction strength determined, fiveclones in the H39Q group showed both high antigen-binding affinity and strong VH⁄ VLinteraction. In Table 1. Result of ... enhancement in VH⁄ VLinteraction signifi-cantly improved the antigen-binding affinity of Fv,similarly to the level of scFv (Table 2).Some single VHdomains of anti-protein IgG, inclu-ding HyHEL-10 ... of the H39 mutation,kinetic analysis for antigen–Fv interaction of thewild-type and H39KQ mutant of purified Fv and scFvproteins was performed using an SPR biosensor. Asshown in Table 2, in...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... & Lynch, K. (1999).Offeringahand to pragmatic understanding: The role of speech and gesture in comprehension and memory. Journal of Memory and Language, 40,577–592.Lansing, C. R., & McConkie, ... 314–331.Swain, M. (1995). Three functions of output in second language learning. In G. Cook & B. Seidlhofer (Eds.), Principle and practice in appliedlinguistics: Studies in honor of H. G. ... pottery and involved description and gesture use.Materials recording and editing. Two video-recording ses-sions using the same lecture outline were scheduled, each last-ing approximately 20 min....
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