na k atpase regulation role in physiology and pathophysiology

... events Based mainly on observations with rat myocytes, additional roles in signal-transducing function of ouabain’s interaction with Na+ /K+ -ATPase were attributed to tyrosine protein kinase, Src, ... elicited by the interaction of a minor fraction of ouabainaltered Na+ /K+ -ATPase with neighbouring proteins (Src, growth factor receptors and Ras), i.e by protein–protein interaction In myocytes, ... of Na, KATPase from western blots of tissue homogenates In Na, KATPase and Related ATPases (Taniguchi, K & Kaya, S eds), pp 131–138 Elsevier, Amsterdam 27 Juhaszova, M & Blaustein, M.P (1997) Na+ ...

Ngày tải lên: 23/03/2014, 17:21

... been effective in detecting general adaptability of the [3H]ouabain binding site content and NKA isoforms following training, inactivity induced by injury and ageing (Leivseth & Reikeras, 1994; ... Monensin Increases Na+ concentration Insulin/IGF-1 Increases Na+ affinity of NKA Possible translocation role Veratridine Increases Na+ influx per action potential Excitation Increases Na+ influx ... play role in maintenance of force production and muscle contractility In skeletal muscle knockout α2 mice and partial α2 knockout mice (α2 reduced by ~50%) marked decreases in treadmill running and...

Ngày tải lên: 04/12/2015, 13:59

... the supernatants were taken for scintillation counting Creatine kinase determination Creatine kinase activity was assayed following the method of Bernt and Bergmeyer [24], in the presence of fructose ... D.H., de Laat, S.W & van Wijk, R (1984) Analysis of K+ and Na+ transport and intracellular contents during and after heat shock and their role in protein synthesis in rat hepatoma cells Cancer ... retained In the present study we demonstrate the protection of the membrane enzyme Na/ K- ATPase from inactivation by the heat shock protein a-crystallin Na/ K- ATPase activity decreased upon incubation...

Ngày tải lên: 17/03/2014, 03:20

... p42/44 MAPK (also called ERK1/2) through the Ras/Raf/ MAPK kinase/MAPK cascade (where Raf is a MAPK kinase kinase and MEK is a MAPK kinase) [29,30] However, the activation of this cascade, unlike that ... additional mechanisms by which a rise in [Ca2+]i regulates the signaling events initiated by ouabain The Ca2+-calmodulin kinase also seems to be involved in ouabain-induced activation of MAPK and regulation ... predominant Na+ /K+ -ATPase isoforms of these cells; thus establishing firmly that ouabain effects on signaling pathways indeed begin at the Na+ /K+ ATPase, and are not due to unidentified ouabain interactions...

Ngày tải lên: 24/03/2014, 00:21

... nucleotide binding sites in Na, K- ATPase In Na/ KATPase and Related ATPases (Taniguchi, K & Kaya, S., eds), pp 115122 Elsevier Science, Amsterdam ể FEBS 2004 59 Linnertz, H., Miksik, I., Kvasnicka, P., ... N-domain (overview) (A) Docking of pNPP to the ATP binding site of the model containing N- and P-domains [20] The amino acids interacting with the adenine ring of ATP may also interact weekly with ... starting at L354 and ending at L773 contains the nucleotide (N)-domain interacting with TNP-ATP and the phosphorylation (P)-domain (D369 shown in blue) The amino acid sequence ALLK known to interact...

Ngày tải lên: 19/02/2014, 16:20

... affinity of Na+ ⁄ K+ -ATPase for Na+ [14] The resultant increase in Na+ binding was regarded as Na+ occlusion In the absence of oligomycin, NaCl gradually inhibited pNPPase activity and Rb+ binding (Fig ... pNPPase and ATPase by Na+ , K+ , pNPP and ATP E1 (Na) represents the Na+ -occluded E1 state E2(s)P and E2(i)P represent the K+ -sensitive E2P and K+ -insensitive E2P state, respectively lK and hK, (Na) and ... assayed in a mixture containing lg Na+ ⁄ K+ -ATPase, the standard ligands, 10 mM NaCl and 0–30 mM KCl Plots and bars represent the means ± SD from three determinations Fig Effects of ATP and KCl on...

Ngày tải lên: 07/03/2014, 16:20

... implementation and maintenance of effective internal controls by: - Developing and maintaining an internal control system that is adequate and effective in managing risk - Improving the efficiency and effectiveness ... the International Auditing Standard Based on "risk assessment and internal control" (ISA 400), it requires auditors to obtain an understanding of accounting and internal control systems Their knowledge ... auditing suggest the following activities for internal auditors in order to enhance their active role in the financial reporting process and thus, their role in prevention and detection financial...

Ngày tải lên: 13/03/2014, 14:20

... and quasi-money Second, tl-e Government plays a dominantrole in the financialmarket and its interventiinstake many forms, not only in terms of deficit financing,but also equity participationand ... policy In a more liberalized investment environment and in a financialsystem dominatedby the banking sector, interestrates will be the key financial prices to guide investment decisions and to ... publicat largeremainvery dim In that case, of banks will continueto operateas the dominantfinancial intermediary the in Egyptian financial system Figure 1, Deposit Banking Institutions: Total...

Ngày tải lên: 15/03/2014, 14:20

... Shimada, Akihito Tsubota, Haruhiko Sakamoto, Masaki Ueno, Wu Bin, Yumiko Nagai, Kouichi Matsumoto, Takao Yamanaka, Sumiko Tanaka, Anna Gries Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia ... Ivana Pejin-Grubiša, Andriy L Zagayko, Anna B Kravchenko, Mykhaylo V Voloshchenko, Oxana A Krasilnikova, Amany M M Basuny, Isaac Karimi, Masashi Shiomi, Tomonari Koike, Tatsuro Ishida, Armando ... LDL nanoparticles for in vivo cancer imaging and treatment International Journal of Nanomedicine 2: 767-774 20 Lipoproteins – Role in Health and Diseases [70] Corbin IR, Li H, Chen J, Lund-Katz...

Ngày tải lên: 17/03/2014, 21:20

... The Inner or True Skin.~ The inner skin, like the inner bark of a tree, is much thicker than the outer skin It is much more important, and for this reason is sometimes called the true skin It ... (4) The Skin has Feeling. When anything touches the skin we know it by the feeling We can tell a great many things about objects by feeling of them If we happen to stick a pin into the skin we feel ... was, and he noticed that the inside of the stomach looked very red and inflamed ~16.~ If St Martin continued to drink whiskey for several days, the lining of the stomach looked very red and raw...

Ngày tải lên: 23/03/2014, 02:20

... for use in methodology in discriminating conformational changes Effects of pressure on intrinsic ¯uorescence The emission maximum (kmax) and intensity of intrinsic ¯uorescence of Na+ /K+ -ATPase ... irreversible tritium incorporation into Na+ /K+ -ATPase are shown in Fig Tritium incor- Fig E€ect of pressure on tritium incorporation into membrane-bound Na+ /K+ -ATPase Membrane-bound Na+ /K+ -ATPase was mixed ... accompanying formation of oligomycin-induced Na+ -bound forms and their conversion to ADPsensitive phosphoenzymes in Na+ , K+ -ATPase J Biochem 109, 299±306 15 Taniguchi, K. , Suzuki, K. , Sasaki, T.,...

Ngày tải lên: 24/03/2014, 00:21

... inflammatory molecules, such as chemokines and chemokine receptors, in leukocytes Chemokines induce cellular migration and are crucial players in initiating both innate and adaptive immune response (Figure ... Hyaluronic acid; IRAK-M: interleukin-1 receptor-associated kinase 3; IRF3: Interferon regulatory factor 3; JNK: Jun N-terminal kinase; LPS: Lipopolysaccharide; MKP1: MAP kinase phosphatase 1; MyD88: ... of transcription; TBK1: TANKbinding kinase 1; TRAF3: TNF receptor-associated factor 3; TRIF: TIR domain-containing adapter protein inducing IFN-beta Endotoxin Tolerance as a Key Mechanism for...

Ngày tải lên: 30/03/2014, 23:20

... and organosomatic indices of west ern king prawn (Penaeus latisulcatus Kishinouye, 1896) reared at di fferent salinities Aquaculture 234:601-614 Wilder M.N., K Ikuta, M Atmomarsono, T Hatta and ... regulation, In: Mantel L (Ed.) The biology of crustacean, Vol Internal anatomy and physiological regulation New York: Academic Press, pp:54-161 Menz A and B.F Blake 1980 Experiments on the growth of Penaeus ... C.R Emberson, D.A Davis, D McIntosh, A.L Lawrence and P.M Van Wyk 2002 Review of some recent developments in sustainable shrimp farming practices in Texas, Arizona and Florida J.Appl Aquac 12...

Ngày tải lên: 02/04/2014, 10:20

... but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult ... hampered in their ability to induce inflammation HMGB1 signaling, in part through RAGE, is associated with ERK1, ERK2, Jun-NH2-kinase (JNK), and p38 signaling This results in expression of NFκB, adhesion ... a role in the upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating...

Ngày tải lên: 18/06/2014, 15:20

... inflammatory molecules, such as chemokines and chemokine receptors, in leukocytes Chemokines induce cellular migration and are crucial players in initiating both innate and adaptive immune response (Figure ... Hyaluronic acid; IRAK-M: interleukin-1 receptor-associated kinase 3; IRF3: Interferon regulatory factor 3; JNK: Jun N-terminal kinase; LPS: Lipopolysaccharide; MKP1: MAP kinase phosphatase 1; MyD88: ... of transcription; TBK1: TANKbinding kinase 1; TRAF3: TNF receptor-associated factor 3; TRIF: TIR domain-containing adapter protein inducing IFN-beta Endotoxin Tolerance as a Key Mechanism for...

Ngày tải lên: 27/06/2014, 11:20

... the suffix ine and plant-derived alkaloids in clinical use include the analgesics morphine and codeine, the muscle relaxant (+)-tubocurarine, the antibiotics sanguinafine and berberine, the anticancer ... mechanism of Cinnamons insulin-like activity may be in part due to increase in the amounts of TTP, IR, and GLUT4 and that Cinnamon polyphenols may have additional roles as anti-inflammatory and/ or anti-angiogenesis ... extracts in liquid medium and at low pH levels enhances their potency even in the human stomach Their inhibitory effect on the intestinal and kidney Na+ /K+ ATPase activity and on alanine transport in...

Ngày tải lên: 28/06/2014, 11:20

... and organosomatic indices of west ern king prawn (Penaeus latisulcatus Kishinouye, 1896) reared at di fferent salinities Aquaculture 234:601-614 Wilder M.N., K Ikuta, M Atmomarsono, T Hatta and ... regulation, In: Mantel L (Ed.) The biology of crustacean, Vol Internal anatomy and physiological regulation New York: Academic Press, pp:54-161 Menz A and B.F Blake 1980 Experiments on the growth of Penaeus ... C.R Emberson, D.A Davis, D McIntosh, A.L Lawrence and P.M Van Wyk 2002 Review of some recent developments in sustainable shrimp farming practices in Texas, Arizona and Florida J.Appl Aquac 12...

Ngày tải lên: 22/07/2014, 11:21

... SM, Kim TH, Lee S, Kim D, Ghang H, Kim DS, Kim BC, Kim SY, Kim WY, Kim C, Park D, Lee YS, Kim S, Reja R, Jho S, Kim CG, Cha JY, Kim KH, Lee B, Bhak J, Kim SJ: The first Korean genome sequence and ... M, Kondoh T, Nagai T, Ohashi H, Naritomi K, Tsukahara M, Makita Y, Sugimoto T, Sonoda T, Hasegawa T, Chinen Y, Tomita Ha HA, Kinoshita A, Mizuguchi T, Yoshiura Ki K, Ohta T, Kishino T, Fukushima ... FoSTeS, fork stalling and template switching; kb, kilobase; LD, linkage disequilibrium; Mb, megabase; MMBIR, microhomology-mediated breakinduced replication; NAHR, non-allelic homologous recombination;...

Ngày tải lên: 11/08/2014, 12:20

... cytoplasm UL56 predominantly colocalized with marker proteins for TGN (TGN46, γ-adaptin and δ-adaptin), and partially with marker proteins for Golgi complex proteins (Golgi5 8K and GM130) and early endosomes ... suggests that the interaction of the two proteins is dynamic and transient Given that Nedd4 participates in many cellular trafficking activities including protein sorting and viral budding, UL56 can ... colocalized predominantly with marker proteins for TGN (TGN46, γ-adaptin and δ-adaptin), and partially with marker proteins for Golgi complex proteins (Golgi5 8K and GM130) and early endosomes (EEA1)...

Ngày tải lên: 12/08/2014, 04:20

... protein Wall-associated kinase (WAK1) Hin1 – role in hypersensitive response Mitochondrial protein of unknown function Zinc finger (C3HC4-type RING) family Calmodulin binding protein SigA-binding ... Protein kinase family protein Phosphohistidine phosphatase activity Disease resistance, leucine rich-repeats Similar to YGL010w-like protein NPR1/NIM1-interacting prot (NIMIN1) Protein kinase ... protein kinase (MAP kinase) genes MAPKK (At4g26070; r = 0.59), MPK 11 (At1g01560; r = 0.58) and MAPKK (At4g29810; r = 0.57) to AtPNP-A also ties in with the proposed cascades [see Additional file...

Ngày tải lên: 12/08/2014, 05:20