mechanisms of prostate cancer initiation and progression

... initiation and progression of a cancer cell as: (a) a distinct anatomical cell entity; or (b) an anatomical entity that retains a number of the characteristics of a natural cell Natural and cancer ... starting set A and the final set B are distinct (Figure 3a) If we consider the area of intersection as proportional to the number of shared Analysis of the initiation and progression of cancer cells ... completion of the various genome projects [19,20], which have stimulated a search for new ways of understanding the complex processes underlying cancer initiation, progression and metastasis [1923] Initiation...

Ngày tải lên: 13/08/2014, 16:21

... in PSA and differences in progression or survival, PSA is used as a primary end point meausre of virtually all standard treatments of prostate cancer Also, it is unusual for prostate cancer to ... strength of evidence While the evidence linking the effects of diet and lifestyle on the development and progression of prostate cancer is not conclusive, it is hardly meager A wide body of evidence ... care and promote an attitude of optimism and hope Paul H Lange Department of Urology University of Washington Seattle, Washington REPLY BY AUTHORS Changes in diet and lifestyle are of profound...

Ngày tải lên: 29/03/2014, 01:20

... protein signature of prostate cancer biopsies revealed the overexpression of TPD52 in cancer patient material [22] To date, the main physiological role of TPD52 in prostate cancer progression remains ... normal prostate development and in human prostate cancer progression Clin Cancer Res 13, 6040–6048 Hullinger TG, McCauley LK, DeJoode ML & Somerman MJ (1998) Effect of bone proteins on human prostate ... rate of prostate cancer has been decreased significantly In spite of all new treatment strategies to increase survival, PCA is the most common type of cancer found in men in Western countries and...

Ngày tải lên: 30/03/2014, 02:20

Ngày tải lên: 01/04/2014, 13:20

... Despite the usefulness of the information provided by these studies, the early gene expression events at the site of inflammation (joint and synovium) and the mechanisms of disease initiation remain ... of oil and bacterial proteins present in Freund's adjuvants [35,36] Booster injections of the same doses of PG with DDA were given on days 21 and 42 BALB/c mice develop swelling and redness of ... National Cancer Institute and maintained under germ-free conditions Stimulation of lymphocytes in vitro, and adoptive transfer of arthritis To ensure uniformity and reproducibility of disease...

Ngày tải lên: 09/08/2014, 06:22

... http://www.ro-journal.com/content/5/1/108 Page of 12 Figure Anti-neoplastic effects of ErPC3 and ionizing radiation on prostate cancer cells The prostate cancer cell lines PC3, DU145, and LNCaP, were irradiated ... down-regulation of p-Akt may be required for the anti-neoplastic action of small molecule inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate ... to the design of the study VJ performed conception and design of the study and substantially contributed to interpretation of data, drafting and critical revision of the manuscript and final approval...

Ngày tải lên: 09/08/2014, 09:20

... http://www.jmedicalcasereports.com/content/5/1/413 (CpG) islands and cancer initiation, promotion, and progression is well established [18,19] Its relevance to the genesis of prostate cancer is illustrated by methylation of the glutathione ... tumor invasion and metastasis, is decreased or absent in many cancers and is predictive of tumor progression and poor patient outcome In prostate cancer, decreased expression of E-cadherin correlates ... Kutik S, Rainville C: Coexistence of pernicious anemia and prostate cancer: ‘an experiment of nature’ involving vitamin B12 modulation of prostate cancer growth and metabolism: a case report J...

Ngày tải lên: 10/08/2014, 23:20

... over-expression of hChK on invasion potential of PC-3 and LNCaP prostate cancer cells 87 Figure 31 Effect of hypoxia and over-expression of hChK on expression of promigratory factor, uPA in LNCaP prostate ... over-expression of choline kinase and hypoxia on invasion potential of prostate cancer cells 86 4.6 Effect of over-expression of choline kinase and hypoxia on expression of pro-invasion ... [14C]acetate and [18F]FDG in prostate cancer cells 31 Figure 12 Uptake of radiolabeled choline in PC-3 prostate cancer cells 41 Figure 13 Uptake of radiolabeled choline in LNCaP prostate cancer...

Ngày tải lên: 24/08/2014, 10:38

... composition of 2H and 18O The compositions of the isotopes 2H (D) and 18O were analyzed to obtain δD (‰) and δ18O (‰), respectively, which are defined as the relative deviation of the parts per thousand ... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... the discharge of new water and the migration of hazardous elements, which has not been sufficiently analyzed or reported previously As a result of the calculation, and by setting C1 and C2 as mentioned...

Ngày tải lên: 05/09/2013, 09:08

... Quinary age band Figure 1.2 Rate of diagnosis of prostate cancer by 5-year age band Data source: cancer registries of England and Wales Fraction of cases Since 1996 the proportion of new diagnoses ... Directly Age Standardised Rate (ASR) of prostate cancer incidence in England and Wales (to European standard population) Data source: Office of National Statistics MB1 series and Welsh Cancer Intelligence ... cancer registries of England and Wales Data Source: Office of National Statistics and Ordnance Survey Prostate cancer: diagnosis and treatment 1.4 Survival In most cases prostate cancer has a long...

Ngày tải lên: 15/03/2014, 00:20

... Introduction Prostate cancer is one of the most common cancers in men Every year there are 34,986 new cases in England and Wales and 10,000 deaths Prostate cancer is predominantly a disease of older ... with prostate cancer and those who might die from prostate cancer Why this is important The greatest uncertainties in managing prostate cancer are around the identification of which cancers are of ... any stage of the illness and its treatment 1.2 Diagnosis and staging of prostate cancer Men who are diagnosed with prostate cancer usually present in primary care with no clear symptoms of the disease...

Ngày tải lên: 15/03/2014, 00:20

... breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer Cancer Causes Control, 8, pp49-56 18 Collaborative Group on Hormonal Factors in Breast Cancer ... Risk of breast cancer in relation to lifetime alcohol consumption J Natl Cancer Inst., 87, pp923-929 35 Cancer Research UK (2007) About breast cancer: Breast cancer risks and causes http://www.cancerhelp.org.uk/help/default.asp?page=3285 ... history of breast cancer, age and benign breast disease Int J Cancer, 100(3), pp375-378 45 Davis S, Mirick DK, Stevens RG (2001) Night shift work, light at night, and risk of breast cancer J Natl Cancer...

Ngày tải lên: 15/03/2014, 01:20

... precise picture of water at the surface of the protein, we looked at the number of water molecules within a specific layer of 0.25 nm from the surface of the protein (Fig 3), and the ratio of Fig Average ... 2431 ˆ N M Micaelo and C M Soares Modeling hydration mechanisms of enzymes of time Final parameters and standard errors are shown in supplementary Table S2 The residence times of the water molecules ... significant role in solvating the enzyme, and also takes part in the modulation of the structural and dynamic properties of the enzyme It is also of note that ethanol and acetonitrile are significantly...

Ngày tải lên: 16/03/2014, 10:20

... high pressure NMR, and stopped flow and single–molecule analyses, have been established, and are applicable to the elucidation of the dynamic features of cytochromes c It is of interest to characterize ... that some of them are the residues responsible for stability, and in fact Ala7, Met13, and Tyr43 in HT c-552 have been shown, by mutagenesis and 3D structure analyses, to be determinants of the ... quintuple mutant, and the corresponding ones of the wild-type PA c-551 and HT c-552 are colored purple, green, and red, respectively (A) The region around A7/M13 in HT c-552 and the corresponding...

Ngày tải lên: 24/03/2014, 03:21

... smoking and risk of prostate cancer in the Physicians’ Health Study Int J Cancer 87, 141–144 67 Breslow, R A and Weed, D L (1998) Review of epidemiologic studies of alcohol and prostate cancer: ... the prostate of prostate cancer cell lines or by growing Human Prostate Cancer 23 Table Profile of Established Human Prostate Cancer and Immortalized Cell Lines Cell line PC-93 PC-3 AD primary prostate ... T., and McRae, C U (1998) Non-steroidal anti-inflammatory drugs and prostate cancer progression Int J Cancer 77, 511–515 43 Ghoshi, J and Myers, C (1998) Arachidonic acid metabolism and cancer of...

Ngày tải lên: 11/04/2014, 10:11

... of detecting prostate cancer, and it can signal the presence of cancer in individuals who display no symptoms of prostate abnormalities This test measures the level of a glycoprotein called prostate- speciÞc ... mixture of butter, ßour and milk ) and oftenÑegg yolks Fish, cheese, chocolate and fruit purŽe are also sometimes added and become important parts of the souÜŽ structure; vanilla, liqueurs and other ... Dilemmas of Prostate Cancer Do the risks of aggressive treatment for early prostate cancer outweigh the benefits? This question is one of several unresolved issues faced by those who treat, and those...

Ngày tải lên: 12/05/2014, 14:54

... Identification and validation of B cell epitopes from PCAA Similar to NY-ESO-1, XAGE-1b and SSX-2,4 are cancer/ testis antigens shared among cancers of the prostate, lung, breast and others [20,21] ... SSX-2, and XAGE-1b were less than 0.001 and the pvalues of NY-ESO-1 and AMACR autoAb were 0.029 and 0.134, respectively A combined A+PSA index was created as the predicted probability of prostate cancer ... in prostate cancer diagnosis Thus, patients with lung cancer and colon cancer, two common cancers for elder men will also be included in the crossvalidation in order to enhance the prostate cancer...

Ngày tải lên: 18/06/2014, 19:20

... Identification and validation of B cell epitopes from PCAA Similar to NY-ESO-1, XAGE-1b and SSX-2,4 are cancer/ testis antigens shared among cancers of the prostate, lung, breast and others [20,21] ... SSX-2, and XAGE-1b were less than 0.001 and the pvalues of NY-ESO-1 and AMACR autoAb were 0.029 and 0.134, respectively A combined A+PSA index was created as the predicted probability of prostate cancer ... in prostate cancer diagnosis Thus, patients with lung cancer and colon cancer, two common cancers for elder men will also be included in the crossvalidation in order to enhance the prostate cancer...

Ngày tải lên: 20/06/2014, 03:20

... modelling of neural mechanisms (functionality) and their interaction is motivated by principle findings of electrophysiology, anatomical studies, and theories of information processing of macaque ... flow of information via feedforward and feedback connections The mechanisms of this feedforward and feedback processing between model areas V1 and MT can be described by a unified architecture of ... two random dot kinematograms (the sequence shows 60 moving dots and consists of 60 frames with 40 × 40 px/frame) Random dots are initialized at random positions and a horizontal velocity of px/frame...

Ngày tải lên: 21/06/2014, 09:20

... for prostate cancer1 7, and was the most powerful indicator of disease activity in men under observation alone.18 When pretreatment variables in patients with androgen-independent prostate cancer ... pectin (MCP) increases the prostate- specific antigen doubling time in men with prostate cancer: a phase II pilot study Prostate Cancer and Prostatic Dis 2003; 6: 301 Sokal RR and Rohlf FJ Introduction ... watchful progression? Prostate specific antigen doubling times and clinical behavior in patients with early untreated prostate carcinoma Cancer 1998; 82: 342 Shulman MJ, Karam JA and Benaim EA Prostate- specific...

Ngày tải lên: 08/08/2014, 17:20