Ngày tải lên: 23/03/2014, 13:20
Ngày tải lên: 08/04/2014, 18:33
Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
... by treatment. RT-PCR and Western blot assay showed that the mRNA and protein expression of Cx40 and Cx43 were elevated in the neointimal area at the early stage of atherosclerosis. The mRNA ... involved in the injury or dis- ease induced activation of vessel wall cells. It is indi- cated that the expression of Cx43 in the smooth mus- cle cells was markedly elevated at the early stage of coronary ... the normal group. Vessel wall is in the condition of rugosity and the yellow athero- matous plaques were found in the lumens of high fat diet group. However, the vessel wall was expanded to different...
Ngày tải lên: 26/10/2012, 09:39
LECTURE SLIDES ON NONLINEAR PROGRAMMING BASED ON LECTURES GIVEN AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS DIMITRI P. BERTSEKAS
... Application Contexts ã Characterization Issue ã Computation Issue ã Duality ã Organization COMPUTATION PROBLEM ã Iterative descent ã Approximation ã Role of convergence analysis ã Role of rate of ... convergence of steep- est descent x 0 x 1 x 2 f(x) = c 1 f(x) = c 3 < c 2 f(x) = c 2 < c 1 . . . Quadratic Approximation of f at x 0 Quadratic Approximation of f at x 1 Fast convergence of New- ton’s ... New- ton’s method w/ α k =1. Given x k , the method ob- tains x k+1 as the minimum of a quadratic approxima- tion of f based on a sec- ond order Taylor expansion around x k . CONVERGENCE RATE OF PURE...
Ngày tải lên: 26/10/2013, 17:15
Tài liệu Looking At the ADO Object Models ppt
... data, such as from other applications or over the Internet. You could not do this easily with DAO. Figure A.1. The object model for ActiveX Data Objects 2.7. Most of the work is done in the ... hierarchies, such as e-mail messages or file systems. You can even point the object to an URL, provided the system has set it up in a consistent manner. This is another way that ADO allows developers ... • Recordset object. Similar to the DAO Recordset object, you can open the Recordset objects as read-only or dynamic. Each Recordset object also has...
Ngày tải lên: 21/01/2014, 12:20
Tài liệu Looking at the SQL Server DMF APIs pdf
... Looking at the SQL Server DMF APIs The SQL Distributed Management Framework is a framework of objects, services, and components used to manage Microsoft SQL Server 2000. It is made up of ... is a brief description of each of the APIs. We will be using the last two directly in the rest of this chapter. ã SQL-NS. SQL Namespace provides a way to actually call the Enterprise Managers ... that you can use to accomplish tasks in your applications. You can see how these APIs are used in Figure 7.3. Figure 7.3. Under the covers, the SQL-DMO objects are being used to perform the...
Ngày tải lên: 26/01/2014, 11:20
Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... site of E1, at the bottom of which lies the ThDP cofactor some 20–25 A ˚ from the protein ÔsurfaceÕ [14]. Thus it may be that these mutations are affecting the efficacy of the recognition of the ... affecting the ability of E1 to catalyse the reductive acetylation of the tethered lipoyl domain in the assembled PDH complex. It should be noted that Tyr281 and Arg282 are located at the mouth of the funnel-shaped ... estimated to have a dissociation constant in the millimolar range or higher despite the fact that the K m is c. 20 l M [37,38]. Another difference in the assays is the concentration of the substrate,...
Ngày tải lên: 20/02/2014, 23:20
Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc
... bullet-proof fashion that will stand the test of time. The second, and for the working mathematician the most important, aspect of proof is that the proof of a new theorem explains why the result ... convincing another mathe- matician that a given statement (the theorem) is true. Thus a proof can take many different forms. The most traditional form of mathematical proof is that it is a tightly ... we are able to acquaint the reader with the culture of mathematics: who mathematicians are, what they care about, and what they do. We also give indications of why mathematics is important, and why...
Ngày tải lên: 21/02/2014, 09:20
Báo cáo " Sequence stratigraphy of Quatemary depositions on the land and at the continental shelf of Vietnam " pot
Ngày tải lên: 05/03/2014, 16:20
Gender-based Violence and Sexual and Reproductive Health and Rights: Looking at the Health Sector Response in the Asia-Pacific Region doc
... members and even the State itself. e Beijing Platform of Action (BPfA) 11 reiterates the above denition and expands it to include “violations of the rights of women in situations of armed ... self-actualisation, strengthening of the participation of rural women in development eorts and for the advocacy of their rights, development of empowering strategies and structures which promote the ... international commitments, such as those stated in the Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW), International Conference on Population and Development...
Ngày tải lên: 05/03/2014, 17:20
Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc
... following the change in ellipticity at 222 nm at a constant heating rate of 40 Cặh )1 . The midpoint of the transition (T m ) was deter- mined from the first derivative of the smoothed denatur- ation ... with the Hill and Michaelis– Menten equations. The reaction rates were measured from the linear part of the initial time-course. GST–hGK fluorescence measurements ITF measurements were performed ... hyper- insulinism of infancy [6–11]. Some of the mutations greatly reduce the binding affinity of MgATP 2) [11,12], which is compatible with a direct interaction of these residues with the nucleotide at the...
Ngày tải lên: 06/03/2014, 00:20
RESULTS BRIEFING SESSION: THE FIRST-HALF OF THE FISCAL YEAR ENDING MARCH 31,2009 pptx
... changes . The forward -looking statements regarding earnings contained in these materials were valid at the time these materials were drafted. SQUARE ENIX GROUP assumes no obligation to update or ... forward -looking statements about the future performance of SQUARE ENIX GROUP. These statements are based on management's assumptions and beliefs in light of information available to it at the ... successful media mix strategy 6180 7,000 Second -Half Operating Income First - Half Operating Income Soul Eater (Millions of yen) 5,157 5,426 5,210 6 , 180 5,000 6,000 First - Half Operating Income First-Half...
Ngày tải lên: 06/03/2014, 19:20
Báo cáo khoa học: Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme pot
... that this residue could affect the FAD environment, modulating the catalytic rate of the enzyme. Finaly, L315 affects the enzyme k cat , although it is not located in the near vicinity of the ... they are situated at similar distances from the hydroxyl of the docked substrate, they could cooperate in facilitating the hydride transfer from sub- strate to FAD. The decrease of activity of ... (re)-face of the isoalloxazine ring of the FAD cofactor. This substrate location is shown in Fig. 2A, which includes the 10 molecules of veratryl alcohol clustering together after docking. The putative substrate-binding...
Ngày tải lên: 07/03/2014, 11:20
Trends in the European Investment Fund Industry in the Second Quarter of 2011 and Results for the First Half of 2011 potx
... for EFAMA members for which data are available; (2) including funds of funds, except for France, Germany and Italy for which the funds of funds data are included in the other fund categories; ... half of 2010. Long-term UCITS attracted EUR 87 billion during the first half of the year, down from net inflows of EUR 142 billion for the same period in 2010. This reduction reflects the change ... inflows of EUR 23 billion during the quarter. Overall, net inflows into UCITS amounted to EUR 48 billion during the first half of 2011, slightly behind the EUR 55 billion recorded in the first half...
Ngày tải lên: 07/03/2014, 16:20
Trends in the European Investment Fund Industry in the Second Quarter of 2012 and Results for the First Half of 2012 pdf
... for EFAMA members for which data are available; (2) including funds of funds, except for France, Germany and Italy for which the funds of funds data are included in the other fund categories; ... remained relatively flat in the second quarter to stand at EUR 5,951 billion at end June 2012. Nine countries recorded an increase in net assets of UCITS during the quarter. Of the large domiciles, ... net outflows from equity funds. Of the other large domiciles, the UK attracted net inflows of EUR 800 million, whilst France and Germany registered net outflows of EUR 9 billion and EUR 1 billion...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot
... that the analyses of insulin effects on glucose transport and the different signal mediators of the hormone were performed on the same cell sam- ple from the same individual. Responses for the ... degree of phos- phorylation of the insulin receptor and IRS1 was required to increase the phosphorylation of ERK1 ⁄ 2 (Figs 1C and 5). Our findings indicate that the collagenase treatment to isolate ... from cells from the nondiabetic control subjects. Similarly, the maximal effects of insulin on the state of tyrosine- phosphorylation of the insulin receptor or of IRS1, or of phosphorylation of ERK1...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
... spectro- photometrically (k = 380 nm). The decrease of PGA activity as a function of the amount of the inhibitor was used to calculate the molar concentration of the enzyme [24]. Synthesis of substrates ... groups at the active site of PGA are discussed in relation to the catalytic efficiency of the enzyme. The energy barrier computed for the first step of acylation (the nucleophilic attack of SerB1) ... propose an interpretation of the complex character of the Ham- mett plot for the reaction catalyzed by PGA. We suggest a modified scheme of the catalytic mechanism in which some of the intramolecular interactions...
Ngày tải lên: 16/03/2014, 01:20
Acne Symposium at the World Congress of Dermatology Pari doc
Ngày tải lên: 23/03/2014, 01:20
Báo cáo Y học: Biosynthesis of vitamin B2 An essential zinc ion at the catalytic site of GTP cyclohydrolase II ppt
Ngày tải lên: 23/03/2014, 21:20
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