iron distribution in the body
Tài liệu Color Atlas of Pharmacology (Part 3): Distribution in the Body docx
... Plasma ProteinsHaving entered the blood, drugs maybind to the protein molecules that arepresent in abundance, resulting in the formation of drug-protein complexes.Protein binding involves primarily ... from binding sites onplasma proteins. Binding to plasma pro-tein is equivalent to a depot in prolong-ing the duration of the effect by retard-ing elimination, whereas the intensityof the effect ... area in the sche-matic drawing, bottom left) and acts asa continuous barrier between the twospaces separated by the cell layer – in the case of the gut, the intestinal lumen(dark blue) and the...
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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
... 7–12of the iron box), explaining the regulation of desAexpression by binding of DmdR1 to the iron box. The same overlapping was found in S. pilosus.DmdR1 binds to the promoter region of desABCD in ... for the treatment of iron overload duringmetabolic alterations in humans. Initial work on the biosynthesis of desferrioxamine B in S. pilosus indica-ted that the first step in the desferrioxamine ... desferrioxamine cluster.Indeed, binding of the pure DmdR1 protein to the S. coelicolor desA promoter region was shown for the first time in this work. As described previously, bind-ing of DmdR1 to the iron...
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Báo cáo khóa học: Acharan sulfate, the new glycosaminoglycan fromAchatina fulica Bowdich 1822 Structural heterogeneity, metabolic labeling and localization in the body, mucus and the organic shell matrix docx
... belocated in the body of this species using alcian blue stainingand it was suggested to be the main constituent of the mucus. In the present work, we provide further information on the structure ... sulfate in the snail body by alcian blue staining and showed that it ismainly secreted into the outer surface of the body as amucous material from internal granules [11]. The mucussecreted on the ... assess the alteration in the degree of sulfation of GAGs synthesized under the in uence of the inhibitors.Finally, Achatina fulica is an intermediate host toAngiostrongylus cantonensis [13], the...
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Tài liệu Organic matter distribution of the root zone in a constructed subsuface flow wetland pptx
... wetland in tropical countries for domestic wastewater treatment. The linear decreasing OM distribution to the increasing vertical and horizontal flow direction is confirmed as the hypothesis in ... wetland in Can Tho University’s campus, Vietnam. The linear decreasing organic matter distribution to the increasing vertical and horizontal flow direction is confirmed as the hypothesis in highly ... The hypothesis is the OM distribution in sand bed descending linearly to the flow direction. 2. Materials and methods Sand sampling was done during January 2007 in the experimental constructed...
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Tài liệu HIGHLIGHTS OF THE AUTHORISATION REQUIREMENTS FOR FUND DISTRIBUTION IN HONG KONG doc
... Commission (the “SFC”) .3February 2012PwC3. Hong Kong Offering Document• The Hong Kong Offering Document of a scheme should contain, inter alia, the following information: Constitution of the ... existence); A letter nominating an individual to be an Approved Person of the scheme, containing the individual's details; The Hong Kong Representative related undertakings (where applicable); ... else acting, or refraining to act, in reliance on the information contained in this publication or for any decision based on it. © 2012 PricewaterhouseCoopers Limited. All rights reserved. In this...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... localizes in the cytoplasm ofhuman epithelial cells of the gastrointestinal tract andliver, two central organs in the regulation of iron metabolism [20,21]. After their synthesis in the endo-plasmic ... of iron accumulation in HepG2 cellscultured in iron- rich mediaTo examine changes in iron metabolism parameters weexamined expression of the transferrin receptor, ferritinand storage iron in ... phosphatidylserine in the plasma membranewith a third of these cells also expressing CD1d(Fig. 6A, left dot-plot). Interestingly, the increase in phosphatidylserine expression by HepG2 cells grown in iron- rich...
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Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt
... can be oxidized in brain homogenates and that catalase is involved in the accumulation of acetaldehyde in the brain [27], explainingits presence despite the absence of ADH1 and the factthat acetaldehyde ... drinking [30].Retinoic acid has been implicated in many importantfunctions during development, including development of the brain [31,32]. Accordingly, Adh4 expression has beendetected in the ... [34]. Furthermore, a remarkable number of proteinsinvolved in retinoid-related metabolism (retinoic acidreceptors, cellular binding proteins and oxidizing enzymes)have been mapped within the adult...
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Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio) pptx
... lipid-binding protein, intesti-nal 15 kDa protein, ileal bile acid-binding protein andgastrotropin, reflecting the speculations of authors onits intracellular function(s). In vitro binding assaysrevealed ... according to the tissue from which they were initially isolated, e.g. liver-type fatty acid-binding protein (L-FABP), brain-typefatty acid-binding protein (B-FABP), intestinal-typefatty acid-binding ... anintense hybridization signal in the distal region of the intestine (Fig. 6, 1A) and in the adrenal homolog of the kidney (Fig. 6, 1D). Less-intense hybridization sig-nals were observed in the...
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Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... substrateand the inherent partioning of quinol into the Qosite. The Fig. 3. Steady-state level of the iron sulfur protein (ISP) in G167E.Immunoblots of denaturing gels, loaded with 40 lg of protein ... Beattie, D.S.(2001) Substituting leucine for alanine-86 in the tether region of the Iron- Sulfur protein of the cytochrome bc1complex affects the mobility of the [2Fe2S] domain. Biochemistry 40, 327–335.18. ... controlsamples, inhibited the activity in samples from the patient.This was in agreement with the data obtained in this study,using the mutant yeast enzyme. It has been reported that amutation in the hinge...
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Báo cáo Y học: Interaction of the anterior fat body protein with the hexamerin receptor in the blowfly Calliphora vicina pot
... proteins in two-hybrid experiments. On the other hand, the use ofantibodies against AFP in in vitro and in vivo experimentsinvestigating hexamerin uptake by the anterior fat body may g ive insights ... further experiments in twodistinct areas. On the one hand, the binding domains ofAFP and the hexamerin receptor could be m apped in detailby functional dissection using truncated prey proteins ... IgG. (A) In the border region of anterior (aF) and central fat body (cF), AFP-immunostaining appears only in the anterior fat body. (B) In a single fat body cell of the anterior fat body, AFP...
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Selective Distribution of Luxury Goods in the Age of e-commerce An Economic Report for CHANEL doc
... vertically integrate into internet retailing. Vertical integration into internet retailing would resolve the incentive issue because the manufacturer would fully take into account the incentive ... for restraints on internet distribution than they are in the case of any other distribution channel. Distribution over the internet should therefore not be treated differently as to the legality ... which includes a margin on the manufacturing cost. Because it includes this margin, the “marginal cost” which the independent retailer faces is higher than the marginal cost that an integrated...
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Báo cáo khoa học: Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR–/– pdf
... Itwould be interesting to determine whether it is suckling, like in the case of LRP [21], or weaning, as in the case of LDLR[24], which triggers the increase of LSR seen in liver, as suchan induction ... that were carried in apo B48-containing lipoproteins resembling remnants. Nevertheless, in LDLR-deficient mice the increase in TG levels was muchsmaller than that obtained in RAP overexpression ... measured in the postprandial stage [3]. The present work was u ndertaken to determine the distribution of LSR mRNA and protein in murine organs,and whether this distribution was c ompatible with the alleged...
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EFFICIENCY AND DISTRIBUTION IN CONTRACT FARMING: THE CASE OF INDIAN POULTRY GROWERS pdf
... buildings, labor, and other variable inputs such as electricity and disinfectants. Using the information on input sharing, Table 5 computes the total value of variable inputs and the value of inputs ... column in Table 12 is the IV counterpart to the OLS results in the second column in Table 9 assuming homogenous treatment effects while the third column in Table 13 is the IV counterpart to the ... heterogenous, then additional controls in the form of interactions of the contract dummy with the demeaned explanatory variables must be included (Wooldridge, 2002). These estimates are contained in the...
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Báo cáo " Quantitative distribution of groundwater chemical components in the Red River Delta based on frequency analysis " pot
... characterized by a fine grain size andcoarsegrainsize[4,5].Finesedimentscompos edmainlyofsand in the lowerpartandweatheredclay in the upper part of VinhPhuc Formation(Q13vp). ... are in accordancewithnormal distribution, while otherionsare in accordance with skew distribution. In the first case, the value ofmean equals the value ofmedian,but in the secondcase,thesetwovaluesshouldbe ... percentage. In general, the higher the intervalofconcentration, the lessquantity of samples is. So that, the freq uency distribution isskewedto the left(Fig.7). In thiscase, the averagevalueissignificantlydifferentfrom the median.Indeed, the averagevalueequals140.88mg/l,while the medianequals26.37mg/lwith...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... Nuclear body localization of LRH-1 was suppressed by forskolin and cholera toxin.Forskolin treatment obviously in uences the expression of membersinvolved in the SUMO pathway. The results obtained ... is attenuated by the cAMP signaling pathway. Our studies further indicatea novel regulatory mechanism of cAMP signaling foraltering the sumoylation cycle, involving modulating the expression ... 1 (Ftz-F1). LRH-1is mainly expressed in tissues derived from the gutendoderm, including the liver, pancreas and intestine,and high levels of LRH-1 are also found in the ovary [1,2]. LRH-1...
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