insights from attentional modulation of responses in the visual cortex

... ligand in all zinc-containing MtaA proteins [i.e 2.0 (N/O) plus (S)] We interpret these results as indicating the binding of the thiol sulfur of HS-CoM to the zinc atom of MtaA in a way that it ... Ala, the pronounced changes in the EXAFS spectra resulting from HS-CoM addition are indicative of an increase in the number of sulfur ligands (visual inspection of Fig 1C) Thus, in both mutants the ... Ala the HS-CoM binding results in sulfur ligation to the active-site zinc XANES spectra of wild-type and mutants As shown in the following, the interpretation of the EXAFS of the mutant enzymes...

Ngày tải lên: 17/03/2014, 23:20

... identify the site of action of the fatty acids in the plasmin molecule, the amidolytic activity of two truncated plasmin variants was examined (Fig 8) Miniplasmin (des-kringle 1-4 plasmin) contains the ... resulted in a decrease, of up to two-fold, in the kp of plasmin Considering the recently described reversible nature of the plasmin inhibition by oleic acid [3] and the changes of the kinetic parameters ... are the rate constants for inactivation of the respective forms of the enzyme In independent measurements with fatty acids we showed that the inactivation of free plasmin for the duration of the...

Ngày tải lên: 18/02/2014, 17:20

... determined the F structure containing the truncated region of the C-terminal domain; however, we failed to determine the structure of the intact glutaminase because the crystals exhibited heavy twinning ... 428 aa; nine aa in total) were located near the interface of the physiological dimer The Cterminal domain may contain structural features involved in protein–protein interactions to form the physiological ... (disordered in the ligand-free state in YbgJ) In the absence of the ligand, the lid part is separated from the active site, which leads to a more open active site Upon the binding of ligand in the acyl-enzyme...

Ngày tải lên: 06/03/2014, 09:22

... passed the days in loafing, in setting traps for wolves, or in boring holes through the ice for fishing Many of them spent a great portion of their time in the little house at the bend of the river, ... through the store?" Mrs Burton asked, as she rapidly spread the dinner on the table in the centre of the room, while Katherine joined in the frolic that was going on with the twins and the dog ... with the current to be a menace to the shipping anchored in the river below All day long, heedless of the pouring rain, the men had worked at getting the boats free from their winter coating of...

Ngày tải lên: 06/03/2014, 23:21

... diversity The advantage of this index is that it takes into account the number of species and the evenness of the species The index is increased either by having additional unique species, or by having ... dependencies in the indices through space and time in an attempt to reveal the extent of fish migrations and the location of spawning areas in the basin, as well as to improve understanding of the life-cycles ... identify spawning locations in the basin, and to improve understanding of the life-cycles and dynamics of fish stocks in the basin Significant long-term (1997–2010) trends in the indices were...

Ngày tải lên: 14/03/2014, 08:47

... form Initially, determination of the amino-terminal amino acid sequence of purified protein was attempted, but no information was obtained, probably due to the protein modification Therefore, the ... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement ... terminus that is required for binding to the plasma membrane, thereby being involved in the formation of the corneum [47] Additional amino-terminal residues of TGase include the sequences that are post-translationally...

Ngày tải lên: 17/03/2014, 23:20

... mutants of the MetAP-I from E coli S Mitra et al affect the DG value for the binding of the rst metal ion; however, the entropic factor (TDS) for the binding of the rst metal ion decreases in the ... Co(II)-binding site, and indeed bidentate binding of Glu97 may prevent binding of the solvent ligand that appears to be present in other mono-cobalt(II) species of EcMetAP-I Combination of these ... metal-binding site, but also probably assists in binding and positioning the substrate through interactions with the N-terminal amine The 6256 data reported herein highlight the complexity of the...

Ngày tải lên: 30/03/2014, 02:20

... Kroo|zrrg lv d qhw0surwv frqwudfw/ lq zklfk qhw surwv lv d frqwudfwxdoo| ghqhg whup/ qrw surw dv fdofxodwhg dffruglqj wr Jhqhu0 doo| Dffhswhg Dffrxqwlqj Sulqflsohv +JDDS,1 Vhyhudo glvsxwhv kdyh dulvhq ... ryhukhdg fkdujhv/ dqg lwv vkduh ri qhw surwv1 Hdfk frvw frpsrqhqw kdv vrph pdujlq ri surw fdofxodwhg lqwr lw1 Wkh vwxglr kdv d srwhqwldo frq lfw ri lqwhuhvw ehfdxvh lw pxvw eh wuxvwhg wr shuirup ... wkh qhjdwlyh frvw1 Wkh euhdn0hyhq srlqw ri wzlfh wkh qhjdwlyh frvw zdv fkrvhq ehfdxvh lw zdv fdofxodwhg wr eh wkh srlqw dw zklfk wkh vwxglr zrxog uhfryhu lwv glvwulexwlrq dqg dgyhuwlvlqj h{shqvhv...

Ngày tải lên: 30/03/2014, 12:21

... routine protocol Peripheral blood samples were obtained from the antecubital fossa of the upper limb at the initiation of surgery and at hour of ischaemia to coincide with the muscle sampling ... Accordingly, we sought to investigate the effect of IPC in patients undergoing total knee arthroplasty The primary objective of this study was to investigate the genomic response induced by IPC in ... the release of signalling molecules such as adenosine [3], bradykinin [9] and reactive oxygen species (ROS) [10] The release of these molecules then activates protective signalling pathways involving...

Ngày tải lên: 18/06/2014, 16:20

... pain intensity, subjects were asked to rate their average pain due to FM over the past 24 hours with an 11-point numeric rating scale ranging from (indicating no pain) to 10 (indicating pain ... timing, and degree of interference in ADLs [21] The scores from the dimensions are summed to calculate the Global Fatigue Index (GFI), which ranges from (indicating no fatigue) to 50 (indicating ... understand FM patients in the US by conducting a comprehensive evaluation of their clinical and comorbid profile, and the impact of FM severity on HRQoL, symptom domains (such as, pain, sleep, depression),...

Ngày tải lên: 20/06/2014, 15:20

... elimination of the infectious agent from the blood streams and peritoneum In contrast, mice immunized with either PBS or IFA die within 1–3 days Underlying mechanisms defining the differences in ... immunization Figure Efficacy of adjuvants in sustaining antibody response induced Efficacy of adjuvants in sustaining antibody response induced BALB/c mice in groups of or more were immunized at ... adjuvants on inflammatory cytokines (IL-6 and TNF-α) In order to determine whether adjuvants exert any effects on induction of inflammatory cytokines, such as IL-6 and/ or TNF-α, the levels of these...

Ngày tải lên: 11/08/2014, 10:23

... skeletal muscle the concentrations of adenine were decreased and those of adenosines and ribose sugars from the adenosines were increased Therefore, the decrease in amino acids may relate to increased ... concentration of the longer chain fatty acids and simultaneously increased the concentration of the shorter chain fatty acids, indicative of an increase in fatty acid βoxidation resulting from PPARδ ... analysis of some of the key metabolic changes induced by PPARd stimulation (a) PLS-DA scores plot showing the clustering of the GC-MS chromatograms from the organic fraction of liver tissue from...

Ngày tải lên: 11/08/2014, 12:20

... was involved in the interpretation of data AD participated in the coordination of the study PM commented on drafts of paper AP was involved in the conception of the study RH was involved in the ... conception of the study and assisted in writing the manuscript All authors have read and approved the final version of the manuscript Competing interests The authors declare that they have no competing ... EQ-5D item Excluding participants with missing data in the EQ-5D index or in the covariates reduced the final sample size from 4,565 to 4,412 The 153 (3.35%) individuals excluded from analyses were...

Ngày tải lên: 12/08/2014, 00:20

... in other words, the genetic variance due to the gene frequencies segregating in the population at the generation in question In most situations, these are the parameters of interest because they ... only data from these generations are available In the former case, the component of variance estimates the genetic variance in the base population, and in the latter the genetic variance in generation ... population (10) The slight discrepancy, in these studies, occurs because the formulae derived in this paper have not taken into account the effect of inbreeding in the reduction of genetic variance...

Ngày tải lên: 14/08/2014, 20:20

Ngày tải lên: 26/03/2015, 10:24

... muslim Indonesians only In Australian news after the series of bombings in Indonesia in 2002-2005, especially the Bali bombing in 2002 and the bombing of the Australian Embassy in Jakarta in 2004, ... traditions which the reporters see during their assignment in Indonesia In construing Indonesia in the news, the reporters put Indonesia as the object of representation which they share to the Australian ... recognition of Indonesia’s independence by the Dutch in 1948 However, Australia was also suspected of holding back when it did not support the inclusion of West Papua into the Republic of Indonesia In...

Ngày tải lên: 09/09/2015, 10:13

... represented in the news of another country In particular, this study observes the media representation of Indonesia in an Australian broadsheet, The Sydney Morning Herald, from 2004 to 2009 The news ... candidates The government officials were mostly represented negatively in terms of incapability and involvements in corrupt practices The common people of Indonesia were often represented in terms of ... 6.11a Aspects of Evaluations of the Common People of 402 Indonesia Figure 6.11b Top-four Aspects of Evaluation of the Common 402 People of Indonesia Figure 6.12a Aspects of Evaluation of the Islamists...

Ngày tải lên: 09/09/2015, 10:13

... macrophages therefore play an important role in protecting the host against invading pathogens as the pro-inflammatory cytokines produced would result in the killing and elimination of the invading pathogens ... response towards the invading pathogen Hence, the host is protected from the invading foreign microorganisms via the effective interplay of the both arms in the immune system 1.2 Innate Immunity ... Nevertheless, the cells and molecules are able to act in concert to maintain the integrity of the immune system Cells of the immune system originate from their hemapoietic progenitors in the bone...

Ngày tải lên: 16/10/2015, 11:59

... poets who under the influence of Confucian ethical teaching In their writings,woman with certain masculine traits, such as bravery and heroism At the end of the Han, the moral image of woman was ... Abstract In the study of classical Chinese literature, Image of Women in poetry writing traces back to the Shijing and Qu Yuan's Chu elegies Almost all main typical images of women appeared in the ... a beauty in man's dream, who would understand the inner feeling of the male writer as a zhiyin 知 音 And since Confucian moral teaching was lax with the downfall of central authority in this period,...

Ngày tải lên: 16/10/2015, 15:39