Ngày tải lên: 23/03/2014, 13:20
Ngày tải lên: 08/04/2014, 18:33
Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
... of in vitro and in vivo experiments have proved that GJ may be involved in the injury or dis- ease induced activation of vessel wall cells. It is indi- cated that the expression of Cx43 in the ... Hyperfilm (Amersham-Pharmacia, Buck- inghamshire, UK) were identical for all experimental conditions. The intensity of the bands was determined by laser scanning the films followed by quantitative ... incubated with secondary antibody conjugated to horseradish pe- roxidase (Histofine simple-stain kit, Nichivei, Japan) for 30 min. The sections were visualized with 3, 3’-diaminobenzidine and...
Ngày tải lên: 26/10/2012, 09:39
LECTURE SLIDES ON NONLINEAR PROGRAMMING BASED ON LECTURES GIVEN AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS DIMITRI P. BERTSEKAS
... Characterization of minima Necessary conditions Sufcient conditions Lagrange multiplier theory Sensitivity Duality ã Computation by iterative algorithms Iterative descent − Approximation methods − ... OUTLINE ã Nonlinear Programming ã Application Contexts ã Characterization Issue ã Computation Issue ã Duality ã Organization COMPUTATION PROBLEM ã Iterative descent ã Approximation ã Role of ... c 1 . . . Quadratic Approximation of f at x 0 Quadratic Approximation of f at x 1 Fast convergence of New- ton’s method w/ α k =1. Given x k , the method ob- tains x k+1 as the minimum of a quadratic approxima- tion...
Ngày tải lên: 26/10/2013, 17:15
Tài liệu Looking At the ADO Object Models ppt
... manner. This is another way that ADO allows developers to read outside data, such as from other applications or over the Internet. You could not do this easily with DAO. Figure A.1. The object model ... read in special tree-structured hierarchies, such as e-mail messages or file systems. You can even point the object to an URL, provided the system has set it up in a consistent manner. This is ... Recordset object. Similar to the DAO Recordset object, you can open the Recordset objects as read-only or dynamic. Each Recordset object also has a Fields collection. ã Stream object. This object allows...
Ngày tải lên: 21/01/2014, 12:20
Tài liệu Looking at the SQL Server DMF APIs pdf
... Looking at the SQL Server DMF APIs The SQL Distributed Management Framework is a framework of objects, services, and components used to manage Microsoft SQL Server 2000. It is made up of ... perform the requested tasks. Following is a brief description of each of the APIs. We will be using the last two directly in the rest of this chapter. ã SQL-NS. SQL Namespace provides a ... of a few APIs that you can use to accomplish tasks in your applications. You can see how these APIs are used in Figure 7.3. Figure 7.3. Under the covers, the SQL-DMO objects are being used to...
Ngày tải lên: 26/01/2014, 11:20
Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... of mutations on catalytic activity The catalytic activity of E1 mutants was investigated using three different assays: the DCPIP assay, which measures E1 activity bymonitoring the reduction ofDCPIP ... at the C-terminal end (Fig. 2). Choice of mutations The importance of the loop region in the a-subunit of the B. stearothermophilus E1p component was highlighted by its susceptibility to limited ... side of a 30-residue motif previously recognized as involved in binding thiamin diphosphate (ThDP) in all ThDP-dependent enzymes. The role of individual residues in this set of conserved amino acids...
Ngày tải lên: 20/02/2014, 23:20
Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc
... es- tablishing mathematical facts. What is interesting is that a mathematical statement of fact is a free- standing entity with intrinsic merit and value. But a proof is a device of communication. The ... relations with siblings. This is an entirely different kind of proof from the kind treated in the present book. It is in the spirit of this book in the sense that it is a “device for convincing ... child that a mathematician is someone who does “scientific arithmetic”. Others think that a mathemati- cian is someone who spends all day hacking away at a computer. Neither of these contentions...
Ngày tải lên: 21/02/2014, 09:20
Báo cáo " Sequence stratigraphy of Quatemary depositions on the land and at the continental shelf of Vietnam " pot
...
Ngày tải lên: 05/03/2014, 16:20
Gender-based Violence and Sexual and Reproductive Health and Rights: Looking at the Health Sector Response in the Asia-Pacific Region doc
... experiences of GBV. Recognising diversity also means looking at experiences of young women living with disabilities. While there is dearth in data in the region on GBV and young women with disabilities, ... develop their capabilities for self-actualisation, strengthening of the participation of rural women in development eorts and for the advocacy of their rights, development of empowering strategies ... experience in invoking human rights to ensure international commitments, such as those stated in the Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW), International...
Ngày tải lên: 05/03/2014, 17:20
Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc
... evidence in support of binding of ATP to the ligand-free hGK, resulting in a change of protein conformation. The MD simulations indicate that the binding triggers molecular motion of the flexi- ble ... steady-state kinetic analyses are also compatible with conformational con- trol of GK catalytic activity by the binding of (Mg)ATP, with possible implications for kinetic coo- perativity with respect ... conserved residue at the active site of the hexokinase family of enzymes, positioned in the phosphate-binding loop and part of a classical ATP- binding motif (phosphate 2 site) in hexokinases and homologous...
Ngày tải lên: 06/03/2014, 00:20
RESULTS BRIEFING SESSION: THE FIRST-HALF OF THE FISCAL YEAR ENDING MARCH 31,2009 pptx
... changes . The forward -looking statements regarding earnings contained in these materials were valid at the time these materials were drafted. SQUARE ENIX GROUP assumes no obligation to update or revise ... strategy 6180 7,000 Second -Half Operating Income First - Half Operating Income Soul Eater (Millions of yen) 5,157 5,426 5,210 6 , 180 5,000 6,000 First - Half Operating Income First -Half Net Sales âAtsushi Ohkubo 3,569 4,471 3 ... forward -looking statements, includin g forecasts or p ro j ections, whether as a result of new information, subse q uent events or gpj q otherwise. The financial information presented in this...
Ngày tải lên: 06/03/2014, 19:20
Báo cáo khoa học: Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme pot
... study, the first evidence for the involvement of some amino acid residues in the catalytic activity of this enzyme has been obtained by site-directed mutagenesis after in silico docking. Two histidine ... histidine residues (His502 and His546) in the vicinity of the flavin ring were found to be strictly required for AAO activity. One of these his- tidines is most likely involved in activation of the alco- hol ... together with their location near the isoalloxazine ring of FAD, suggested a contribution to catalysis by alcohol activation, enabling its oxidation by flavin-adenine dinucleotide (FAD). The presence of...
Ngày tải lên: 07/03/2014, 11:20
Trends in the European Investment Fund Industry in the Second Quarter of 2011 and Results for the First Half of 2011 potx
... UCITS attracted EUR 87 billion during the first half of the year, down from net inflows of EUR 142 billion for the same period in 2010. This reduction reflects the change in investor confidence ... 23 billion during the quarter. Overall, net inflows into UCITS amounted to EUR 48 billion during the first half of 2011, slightly behind the EUR 55 billion recorded in the first half of 2010. ... D D o o m m i i c c i i l l i i a a t t i i o o n n Eleven countries recorded net inflows into UCITS in the second quarter of 2011, with seven countries reporting net sales in excess of EUR 1 billion...
Ngày tải lên: 07/03/2014, 16:20
Trends in the European Investment Fund Industry in the Second Quarter of 2012 and Results for the First Half of 2012 pdf
... countries recorded net inflows into UCITS during the first half of 2012, with five countries attracting net inflows in excess of EUR 5 billion: Ireland (EUR 44 billion), Luxembourg (EUR 31 billion), ... D D o o m m i i c c i i l l i i a a t t i i o o n n Twelve countries recorded net inflows into UCITS in the second quarter of 2012, with four countries attracting net inflows in excess of EUR 1 billion: ... from equity funds. Of the other large domiciles, the UK attracted net inflows of EUR 800 million, whilst France and Germany registered net outflows of EUR 9 billion and EUR 1 billion respectively....
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot
... and thawed in boiling water to minimize postincubation signal- ling modifications in the cells and protein modifications during immunoprecipitation [22]. Equal amounts of cells (i. e. total cell volume), ... ⁄ threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamem- brane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphoryla- tion. ... genomic control via a mitogenic signalling pathway. This may also be medi- ated by IRS; insulin activation of the G-protein Ras leads to phosphorylation and activation of mitogen- activated protein...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
... feature of the PGA catalytic reaction. It is probably a cumulative result of intrinsic amino acid interactions in the active site of the E. coli enzyme that differentially (de)stabi- lize the ... and initial velocities were calculated, taking into account both the consumption of the substrate and the lib- eration of the arylamine with the time. The kinetic experi- ments with each substrate ... because of the substitution of the oxyanion hole with two water molecules. The effective stabilization of the oxy- anion is the main driving force of the first step of acyl- ation, and dominates all other...
Ngày tải lên: 16/03/2014, 01:20
Acne Symposium at the World Congress of Dermatology Pari doc
Ngày tải lên: 23/03/2014, 01:20
Báo cáo Y học: Biosynthesis of vitamin B2 An essential zinc ion at the catalytic site of GTP cyclohydrolase II ppt
Ngày tải lên: 23/03/2014, 21:20
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