genetics and molecular biology commentary

... al 1998) GLI1 and GLI2 can act as transcriptional activators, whereas GLI3 has both activator and repressor functions (Huangfu and Anderson 2006) GLI1 and GLI2 have overlapping and distinct transcriptional ... colleagues and friends at CSI: Mei Xian, Ti Ling, Tada-san, Chee Wee, Sandy, Weiyi, Victor, Dawn, Norlizan, Feroz and Suhaimi, especially TK and Dominic for their kind assistance and constructive ... (Kenney and Rowitch 2000), FOXM1 (Schuller et al 2007, Teh et al 2002), CCNB1 (Schuller et al 2007) and CDC25B (Teh et al 2002) Figure SHH signaling pathway (Athar et al 2006) SHH ligand binds and...

Ngày tải lên: 10/09/2015, 15:50

... identification of the oncogene, miR-373, and its target gene, PPP6C, may help us to understand the molecular mechanism of tumorigenesis in HCC and may have potential diagnostic and therapeutic value in the ... lines (HepG2 and QGY-7703) were maintained in MEMa or RPMI-1640 (Gibco, Grand Island, NY, USA), respectively, and supplemented with 10% fetal bovine serum, 100 IUÆmL)1 penicillin, and 100 lgÆmL)1 ... [20], and human esophageal cancer [21] We determined the effect of miR-373 on the HCC cell lines HepG2 and QGY-7703 cells by gain and loss of function approaches MTT, colony formation and growth...

Ngày tải lên: 14/03/2014, 23:20

... pro-inflammatory cytokines (IL-6, IL-1b, and TNF-a) and the expression of inflammation-related proteins (iNOS, COX-1, and COX-2) in LPS-activated microglia and astrocytes, and we explored the association ... TZ and GD directed the work, contributed to design the study, reviewed the data and wrote the manuscript; XL performed cell culture, western blot analysis, ELISA assay and NO measurements; RL and ... mediators such as COX-1 and COX-2 in microglia and astrocytes contributes to the progressive character of AD LPS treatment significantly increased protein expression of COX-1 and COX-2 in both microglia...

Ngày tải lên: 19/06/2014, 22:20

... electrical noise, and high recording electrode impedance which may diminish reliability and increase the duration of the procedure.[7] On the other hand, capnography is a routine and mandatory anaesthetic ... techniques to guide the localization and repair of the injured nerves Consequently, muscle relaxants were avoided Anaesthesia was induced with propofol and fentanyl and the airway was secured with ... under the microscope away from the carotid sheath and the subclavian vein and retracted posterolaterally The omohyoid bellies were then identified and their common tendinous insertion was divided...

Ngày tải lên: 10/08/2014, 10:20

... Journal of Brachial Plexus and Peripheral Nerve Injury 2008, 3:20 http://www.jbppni.com/content/3/1/20 depth and mentioning of drug dose are important Nothing was mentioned ... localization: effects of cutaneous electrode placement and duration of stimulus on motor response Anesthesiology 2004, 100:1526-1530 Raj PP, Andres JD, Grossi P, et al.: Aids to localization of ... available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright BioMedcentral...

Ngày tải lên: 10/08/2014, 10:20

... available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright BioMedcentral ... anesthesia for lumbar discectomies Turk Neurosurg 2008, 18:125-33 Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant ... Journal of Brachial Plexus and Peripheral Nerve Injury 2008, 3:21 http://www.jbppni.com/content/3/1/21 With increase in the...

Ngày tải lên: 10/08/2014, 10:20

... developed typical neuropathic pain over his forearm and palm [burning and shock like], thermal and mechanical allodynia, hyperalgesia with edema Allodynia and edema increased over the next two weeks ... Plexus and Peripheral Nerve Injury 2008, 3:22 http://www.jbppni.com/content/3/1/22 Ketamine in CRPS [2] Proliferation of NMDA receptors and role of glutamate in producing central sensitization and ... for evoked pain was 10 and for static pain Detailed psychiatric evaluation excluded disorders other than depression He was started on Gabapentin, Tramadol and Amitryptylline and gradually increased...

Ngày tải lên: 10/08/2014, 10:20

... situation, and for the veterinary authorities in how to handle a potential outbreak Analysis of clustering of diseases To analyse whether a disease is clustered in space, time or in time and space ... nearby locations of different fish farms and slaughterhouses for fish Acta vet scand Suppl 94 - 2001 82 still have to be used because this is not yet a standard tool in the available GIS-packages ... spatial factors like distance to the source of outbreak, population density and climate conditions, vegetation and landscape, all of which have been defined as risk factors for the spread of the...

Ngày tải lên: 12/08/2014, 15:20

... ROD/B, and SBL6669) and two SIV strains (mac251 and mndGB1) (Fig 6B) NP-2/CD4/CXCR4 and NP-2/CD4/GPR1 cells were susceptible to these four HIV-2 strains and the mndGB-1 strain (Figs 6C and 6D), ... and then inoculated with two HIV-1 strains, GUN-7WT (m and l) and HCM342 (h and n), HIV-2 CBL23 strain (n and s), and SIV mndGB-1 strain ( and r) Six days after infection, cells positive for HIV-1 ... functions of CCR5 and CXCR4 for HIV-1 infection can be inhibited by their ligands, RANTES and SDF-1β, respectively [37,38] Some ligands have been used as starting materials to find and develop anti-HIV...

Ngày tải lên: 13/08/2014, 05:21

... Manufacturing Pte Ltd, and the National Science and Technology Board for providing me with the scholarship and financial assistance Special thanks and appreciation to the staff and students of Materials ... implantation and silicidation-induced generation of vacancies and interstitials, resulting in the deactivation and subsequent re-distribution of dopants around the transistor lightly doped drain (LDD) and ... measured between the incident beam and the crystal planes under consideration For incident rays and 2, scattered by atoms K and L, the path difference for rays 1K1’ and 2L2’ is: ML + LN = d sin θ...

Ngày tải lên: 11/09/2015, 14:27

... any soak time Figures 5-3(a) and 5-3(b) show the sheet resistances of the specimens A, F, G and H after etchback and RTA2, respectively Although the specimens F, G and H did not receive an isothermal ... RTA1 treatment Figures 5-8(a) and 5-8(b) show the sheet resistance taken after etchback and RTA2 respectively for specimens B, C, D, F, G and H The specimens B, C and D received a 20s 720 °C soak ... soak time at a lower temperature Figures 5-1(a) and 5-1(b) respectively show the sheet resistance of specimens A, B, C and D measured after etchback and RTA2 Results from specimen A are Page 71...

Ngày tải lên: 17/09/2015, 17:20

... thermosensitive and may be rapidly inactivated at high temperature, we analyzed the amount of Luc protein in the soluble and insoluble fractions of these cells treated at 39, 41 and 43 °C for h ... mammalian cells [17] Thus, the promoter activities of Hsp105 and Hsp70B can be measured easily using the pGL105/C3H and p173OR/C3H cells, and pGL105/C3H cells seemed to be more useful for screening ... with 15–60 mM SA at 37 °C for h and incubated further at 37 °C for h without SA, the Luc activity increased approximately 10- and 30-fold in cells treated with 45 and 60 mM SA, respectively, compared...

Ngày tải lên: 17/03/2014, 10:20

Ngày tải lên: 08/08/2012, 17:20

... brands • Brand preference: brands that are enjoy a high degree of brand preference Consumers would select those brands over the others • Brand loyalty: brands command high degree of brand loyalty ... a brand identity Table 2.1 The Brand Position Trap Brand Image Brand Identity Brand Position How the brand is now received How strategists want the brand to be perceived The part of the brand ... benefits • Brand identity consists of twelve dimensions organized around four perspectives - the brand-as-product, brand-as-organization, brand-as-person, and brand-as-symbol • Brand identity...

Ngày tải lên: 13/04/2013, 10:29

... waste in all stages (collection, transfer and transport, recovery and recycling, treatment and land filling), the public sanitary toilet system, sepulture and cemeteries (cp NGUYEN T., 2005) • The ... enough job opportunities, rural migrants and urban dwellers alike find employment in small-scale and microlevel production and distribution of goods and services These activities form the informal ... regulations governing contracts and work conditions, and/ or the lack of legal guarantees in relations with suppliers and clients.” It is essential to distinguish informal and illegal activities While...

Ngày tải lên: 24/08/2013, 18:48

... “[t]he dominance of English is asserted and maintained by the establishment and continuous reconstitution of structural and cultural inequalities between English and other languages” To illustrate ... 1997) requires teachers and students to build a community of learning and teaching where there is no fear of failure and where sharing is for common interests - Teachers and students Khoa Anh Viet ... levels of proficiency, needs, and interests Since CLT was introduced, the teacher’s roles have been taken into consideration Breen and Candlin (cited in Richards and Rodgers (1986) [13]) claim:...

Ngày tải lên: 05/03/2014, 12:20

... polymerisation and the serpinopathies: pathobiology and prospects for therapy J Clin Invest 110, 1585–1590 28 Stein, P.E & Carrell, R.W (1995) What dysfunctional serpins tell us about molecular mobility and ... an average of and mg for wild-type and Ser49Pro neuroserpin, respectively, when expressed under the same conditions Wild-type, Ser49Pro and Ser52Arg neuroserpin migrated as single bands on SDS, ... spectropolarimeter The path length and slit width were 1.0 cm and nm, respectively The fluorescence and CD measurements were performed at the incubation times of 3, 6, 12, and 24 h to confirm equilibrium...

Ngày tải lên: 07/03/2014, 16:20

... minorities,  such  as  Thai,  H’mong people. Agricultural land accounts for  76.13%,  non‐agricultural  land  is  20.38%  and non‐used land is 3.49% of total area. In general,  socio‐economic  ... measures, review and applications, National Institute  Public  Health  and the  Environment,  Netherlands, RIVM Report 408505 006, 2001 [5] G.  Hyman  et  al.,  Methods,  results  and policy  implications  of  poverty  and food  security  ... 750  households.  Each  household  can  get  1.0‐1.5  ha  of  agricultural  land  and 2.0‐2.5  ha  of  forestry land.   In  fact,  the  resettlement  activities  in  Yen  Chau  District  are ...

Ngày tải lên: 14/03/2014, 15:20

... between L-CoA and CoA, these compounds were added (to nal concentrations of 20 and 100 lm, respectively) into assay tubes that contained Hepes pH 8.2, MgCl2 and LUC (60 nm) and after 30 s, and 10 of ... (L-dephospho-CoA) and FEBS Journal 272 (2005) 52065216 ê 2005 FEBS H Fraga et al Fig Effect of the concentration of CoA and dephospho-CoA on the velocity of formation of L-CoA and L-dephospho-CoA (A) and on ... dephospho-CoA and acetylCoA In this work, we have investigated the inhibitory effects of chemically synthesized L-AMP [17] and dehydroluciferyl-CoA (L-CoA) [18] on light production and the role of CoA and...

Ngày tải lên: 16/03/2014, 23:20