genetic studies in experimental cancer

... OPG (encoding osteoprotegerin) Two novel regions included an area on chromosome 1p36 close to the gene ZBTB40 (encoding zinc finger and ETB domain containing 40) and, somewhat surprisingly, the ... significant interest in noninvasive assessment of bone microarchitecture Data from murine studies in particular indicate that although a large proportion of genetic variants can be identified by studies ... refine prognostic tests in order to improve targeting of primary prevention measures to those most in need Genetic epidemiology The first step in any condition thought to have an underlying genetic...

Ngày tải lên: 09/08/2014, 10:23

... binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase the repair rate of certain DNA adducts, including ... in lung cancer cases and in concurrent controls using a molecular method for genotyping Using the MEDLINE database, we identified genetic epidemiological studies [9-13] that provided information ... activated carcinogens can bind to DNA and form DNA adducts that are capable of inducing mutations and initiating carcinogenesis The capacity to repair DNA damage induced by activated carcinogens 61...

Ngày tải lên: 31/10/2012, 14:59

... Noninvasive imaging of αvβ3 integrin expression using 18F-labeled RGD-containing glycopeptide and β positron emission tomography Cancer Res 2001; 61: 1781–1785 46 Haubner R: αvβ3-Integrin imaging: ... Figure Experimental setting Our experimental setting demonstrating two rats prior to positioning in the PET-CT scanner and homemade injector (two animals can be examined in parallel per scanning) ... imaging of many human cancers overexpressing the GRP receptor such as breast cancer and prostate carcinoma [6–13, 40–41] Integrins play a key role in angiogenesis and tumor metastasis by mediating...

Ngày tải lên: 18/06/2014, 18:20

... FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression ... Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways Int ... activity by genistein pretreatment could be shown Furthermore, a significant increase in cleaved PARP protein was measured following combined genistein and radiation treatment, indicating increased apoptosis...

Ngày tải lên: 09/08/2014, 09:22

... polymorphism interacts with heavy cigarette smoking in a multiplicative manner These findings contribute to the growing understanding of how genetic and environmental factors interact in RA pathogenesis, ... the indices of additive interactions between binary smoking variable and binary PTPN22 genotype fPmulti is the P value for multiplicative interaction term between binary smoking variable and binary ... not included in the final models As is evident comparing the results of a model taking only the matching factors into account, adjustment for potential confounders did not significantly influence...

Ngày tải lên: 09/08/2014, 10:23

... suggestive evidence for interaction The inclusion of the clinical trial interventions in this testing procedure leads to interest in subregions containing FGFR2 SNP rs3750817 and MRPS30 SNP rs7705343 ... higher ranking overall with the combined versus the main effect test Moreover, the ordering of SNPs within this region is considerably altered by the inclusion of the interaction information ... clinical trial interventions lead to a detectable increase in the ability to distinguish breast cancer cases from controls Note, however, that AUC values in this context may be optimistic in...

Ngày tải lên: 11/08/2014, 12:21

... viz., minimum length of repeat-core, the size of the genomic library screened, screening stringency, oligos used for screening and SSR mining tools, notwithstanding the innate differences in genomic ... CS, Singh L: Fingerprinting of Indian coffee selections and development of reference DNA polymorphism panels for creating molecular IDs for variety identification In Proceedings of 20th international ... affinities within/between cultivated and wild coffee germplasm The diploid microsatellite data were examined for their potential in genetic diversity studies by studying the variation and interrelationship...

Ngày tải lên: 12/08/2014, 05:20

... eIF4E binding protein beclin-1-regulated autophagy AMP activated protein kinase artesunate bafilomycin A1 Bax-interacting factor big mitogen-activated protein kinase bovine serum albumin cycloheximide ... regulatory-associated protein of mTOR rapamycin-insensitive companion of mTOR reactive oxygen species Beclin-1 interacting and cystein-rich containing S6 kinase Small interfering RNA soluble N-ethylmaleimide-sensitive ... assembly site phosphate buffer saline phosphoinositide-dependent kinase phosphatidylethanolamine paraformaldehyde phosphoinositide 3- kinase protein kinase B protein kinase C proximity ligation assay...

Ngày tải lên: 09/09/2015, 08:16

... virus IAPs inhibitor of apoptosis proteins IL Interleukin Iκ B NF-κB inhibitory protein IKK IκB kinase INF-γ interferon-γ iNOS inducible nitric oxide synthase JAB Janus kinase binding protein JAKs ... protein-tyrosine kinases JNK c-Jun N-terminal kinases MAPK mitogen activated protein kinase xiv MAPKK mitogen activated protein kinase kinase MAPKKK mitogen activated protein kinase kinase kinase ... resistance to doxorubicin-induced cytotoxicity in cancer cells 4.3.5 Andro enhances doxorubicin-induced apoptosis in human cancer cells 123 127 4.3.6 Andro sensitizes doxorubicin-induced apoptosis...

Ngày tải lên: 14/09/2015, 14:11

... carboxyl-terminal tail as illustrated in Figure 1.5C appears to be the docking site for at least two interacting sites including calmodulin (CAM) binding sites and region involved in microfilament-associated ... to a rise in intracellular Ca2+ concentration Our in- vitro studies indicated that silencing of TRPV4 significantly abolished the invasiveness and the ability of murine mammary breast cancer metastatic ... proteins such as E-cadherin and β-catenin, which may account for the decrease in cancer cell plasticity following TRPV4 knockdown Our preliminary data showed that Twist might be involved in AKT-mediated...

Ngày tải lên: 02/10/2015, 17:15

... protecting against DIC in experimental LPS-induced shock It has been argued that the experimental model of sepsis induced by infusion of LPS in high doses is unphysiological and differs from a clinical ... vitamin D3 against LPS-induced DIC but not against tissue-facter-induced DIC in rats Thromb Haemost 2001;85:287-90 Hemmingsen C, Staun M, Lewin E, Nielsen PK, Olgaard K Effects of vitamin D metabolites ... analogs on renal intestinal calbindin-D in the rat Calcified Tissue Int 1996;59:371-6 Hewison M, O`Riordan JLH Immunomodulatory and cell differentiation effects of vitamin D In: Vitamin D Feldman...

Ngày tải lên: 26/10/2012, 09:57

... design objectives may include minimizing intercellular movements, minimizing set-up time, minimizing machine load variation or maximizing machine utilization, and minimizing the system’s costs ... constructing a group technology database of parts and their process routings, finding the most suitable routings among parts’ alternative routings, grouping machines into machine groups, and forming ... Algorithm for Finding the Optimum Process Routings for Parts The aim of a cellular manufacturing system design is minimizing the cost of the system It can be gained by dividing the system into independent...

Ngày tải lên: 17/12/2013, 06:15

... cent respectively Wintgen’s results are in accord with those obtained in an extensive investigation by Wait, in which a utilization of 77 to 78 per cent was obtained for bean protein, and 70 to 83 ... produced brittle feces g ence ployed aa noted in the table t Forced feedIng necessary throughout l (4 days) FeedIng On 83.8 I the “indineatlble” in the remaining the was three period-no TABLE 94.5 I ... the during the bean periods negative balance during the phaseolin period, but the unfavorable nitrogen balance during the feeding of pea globulin is presumably attributable to its inherent inadequacy...

Ngày tải lên: 23/12/2013, 03:15

... cervical cancer (ACRIN-6651)(4) While positron emission tomography (PET) scans appear promising in single-institution studies, multiinstitutional prospective studies are needed to ascertain their ... utilizing erythropoietin in head and neck squamous cell carcinoma showed a decrease in local-regional 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in ... Italian Trials in Ovarian Cancer www.mito-group.it/ MRC—Medical Research Council www.mrc.ac.uk NCI—National Cancer Institute—ctep .cancer. gov NCIC-CTG—National Cancer Institute of Canada Clinical Trials...

Ngày tải lên: 13/02/2014, 07:20

... branches inclined to be longitudinal or spreading: leaves narrowly linear, rigid, sharp-pointed, to in long, about y8 in wide, midrib and marginal ribs prominent, cross-nerves spreading nearly ... cross-veinlets: flowering spikes creamy white (varying to pink and purple in Australia), 1% to in long, in wide, at first terminal, the axis growing out only after flowering: stamens nearly ^ in long ... overlapping, narrowly linear, acute, % to % in long, y^ in wide, apparently nerveless: flowering spikes of a rich scarlet color, cylindric, about 21/) in long and 11/2 to 1% in in diameter, forming...

Ngày tải lên: 13/02/2014, 12:20

... Clinical breast examination in primary care Each primary care team should include at least one practitioner who has had specific training in carrying out clinical breast examination (CBE) in ... overall increase in the incidence of both invasive and non-invasive breast cancer in England and Wales, the specific causes of which are unknown (Figure 1) Age-standardised incidence in the UK ... the highest in the world, but it has been increasing worldwide In England and Wales, the increase is Quinn MJ, Babb P, Brock A, et al Cancer Trends in England and Wales 1950-1999 Studies on Medical...

Ngày tải lên: 14/02/2014, 22:20

... responsible for arousing intellectual curiosity in their students, of developing minds and sharpening intellects, but they definitely not see themselves as mere “trainers,” aiming to reach objectives ... for participating in the design process: O = organizational P = personal Time-to-delivery: = course already begun or is about to begin = beginning in between and months = beginning in more than ... course planning tradition, in some cases stretching back centuries to the oldest universities of Europe However, as much as tradition once played the main role in deciding and defining what would...

Ngày tải lên: 17/02/2014, 06:20

... upward-sloping curve which, as described, arrays individual plants in an industry according to ascending average variable costs SLR is drawn as a horizontal line, representing the underlying assumption ... opposed regulations affecting local industry An obvious rationale for the relative unimportance of variations in compliance costs in explaining congressional voting is that intraindustry impacts were ... important both in determining the total cost of imposing regulations and in affecting the structure of the industry For example, if short-run effects fall predominantly on small, marginal producers,...

Ngày tải lên: 17/02/2014, 10:20