g protein signaling in chemotaxis
Báo cáo y học: "Could increased axial wall stress be responsible for the development of atheroma in the proximal segment of myocardial bridges?" pot
... tunneled segment pulls axially at that segment during systole, due to strong morphologic changes in the bridge region during the heart contraction (e .g. , deeper dipping of the tunneled segment into ... in Fig 3) Since the vessel is more or less tethered to the surrounding tissues, the local wall elongations induced by this force generate in turn retaining forces in these tissues The resulting ... Kearney P, G rge G, Haude M, Meyer J: Comparison of intravascular ultrasound and angiography in the assessment of myocardial bridging Circulation 1994, 89(4):1725-1732 Ge J, Erbel R, Gorge G, Haude...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... blot with GAPDH Ig mediated through various protein kinase and monomeric GTP-binding protein signaling pathways including MAP kinases and Rho GTPases [18,20,31] To determine the signal transduction ... cytoskeleton components in relaying signals between signaling molecules Another potential explanation suggests a model whereby, in the absence of Rho-induced actin polymerization, G- actin inhibits transcription ... extracellular-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), p38 mitogenactivated protein (MAP) kinase and nonreceptor tyrosine kinases [19,20] These signaling pathways are linked to...
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unsicker - cell signaling and growth factors in development
... and Definitive Anterior Endoderm 146 Ectodermal Signaling Centers 149 Summary 149 Signaling Pathways Involved in Anterior Specification 149 BMP Signaling 150 FGF Signaling 153 IGF Signaling 154 ... Regulation of Intracellular Signaling Networks 809 Regulation of TGF-b signaling by EGF Signaling 810 Calcium Signaling and the Mitochondrial Apoptosis Pathway 810 Developmental Modulation of Growth ... Notch1 signaling in the epidermis of mouse skin de-represses Wnt signaling and leads to increased levels of free, signaling competent b-catenin [99] In contrast, forced Notch1 signaling in the...
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Báo cáo y học: "The NFI-Regulome Database: A tool for annotation and analysis of control regions of genes regulated by Nuclear Factor I transcription factors" pdf
... be performed: 1) searching for specific TF Page of 10 binding sites and outputting all genes containing these sites and 2) searching for genes expressed in specific organs, tissues, cell types ... accomplish the same task GeneDB, GeneSynonymDB, SpeciesDB, BindingSiteDB, and TF_connect_TFBS_DB form the main grouping of tables used for holding gene and binding site information The TF_connect_TFBS_DB ... of the genes in the database contain known binding sites for p53 and therefore it is listed here only as a gene Clicking on the gene link in the search menu will display binding site information...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... CIRCUITS OXYGEN-SIGNALLING IN HYPEROXIA nγ-GCS GSSG BSO BCNU ↑ GSH γ-GCS 2GSH ? NF-κB Activation ROOH ROOH NAC PDTC ROS ↑ GSSG ROS NF-κB DNA Binding INDUCTION OF OXIDATIVE STRESS-RESPONSIVE GENES Schematic ... exacerbating in lung injury Regarding the mechanisms reported in hyperoxia-mediated lung injury, it was suggested that hyperoxia-associated production of ROS might lead to neutrophil infiltration into ... CCAAT/enhancer binding protein beta, Sp-1, AP-1 and CREB are present in the promoter regions of numerous cytokine genes, including those whose expression is increased after blood loss To investigate early...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... element binding protein; CBP, CREB-binding protein; DAG, diacyl glycerol; ECF, extracellular fluid; ICF, intracellular fluid; IP3, inositol triphosphate; MAPK, mitogen-activated protein kinase; ... NADP, nicotinamide dinucleotide oxidized; NADPH, nicotinamide dinucleotide reduced; PKC, protein kinase C; ROS, reactive oxygen species; SAPK, stress-activated protein kinase DNA binding In hypoxia, ... significant lung injury 48 Pugin and colleagues, for instance, have developed an in vitro model in which isolated lung cells can be submitted to a prolonged cyclic pressure-stretching strain...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... –ATTGCTTTAGCTTGGAAATTCCGGAGCTGAAGCGGCCAGCGAGGGAGGAT-ATTGCTTTAGCTTGGAAATTCCGGAGCTGAAGCGGCCAGCGAGGGAGGAT-ATTACTTCAGTTTGGAAATTCCTAGATCGCAGGGGCCAGCGAGGCAGGAC-ATTACTTCAGTTTGGAAATTCCTGGGTCGCAGGGGCCAGCGAGGCAGGAC- IL6 -76 ... –AGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAA-AGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAA-AGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAA-AGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAA- ... -CCCA-TGGAACATCTCTGGACATTACCTCAGGAGGAGGGGTTAAGAGAAG- 3’ Human 5’ -TCCATTGGAACATCTCTGGACATCAGCTTGGGAGGAGGGGCTAAGGAAAG- 3’ Mouse 5’ -TCCATTGGAACATCTCTGGACATCAGCTTGGGAGGAGGGGCTGAGGAGGG- 3’ Rat ARID1A 5’ 5’ 3’ 5’ +45 (EGR1) (p53)...
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Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt
... Woodstock, Virginia, at Pugh’s Run (USGS streamflow-gaging station number 1633650) and the second was near the town of Mount Jackson, Virginia, near Red Banks (USGS streamflow-gaging station number ... Virginia, near Red Rocks site was located at USGS streamflow-gaging station 1633000 Sampling Processing and Chemical Analysis Each POCIS and SPMD was extracted individually before designating ... Stuer-Lauridsen, F., Getting, D.T., Goddard, J.P., Gravell, A., 2007, Tool for monitoring hydrophilic contaminants in water: polar organic chemical integrative sampler (POCIS) in Greenwood, R., Mills, G. , Vrana,...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... GCTGCCTTTGTTATTTGTAAGCTTCAG GGAAACTTCCTGTCTCATCCAGTG GGAACACACAGAGGGGATGATA CTTCAACACGCACAAAGCAC TGCCACCTTTTCCATCATACA CTGCTTTTCTGGGGACTTCA TGAAGTCCCCAGAAAAGCAG GTGCTTTGTGCGTGTTGAAG TGTATGATGGAAAAGGTGGCA GGAACACACAGAGGGGATGATA ... CCATGTCTGCAGATGGTCGAGG GGACTGACATTGCTCCAGAGC GCTTCAGTGACTCAGAAATTGG GTCCAGAATATTCAGCCTTTCACC CTCCCTCAAACAAACCAGAGTC CACTGGATGAGACAGGAAGTT CTTCTCCAGGACAGTCCAAAGAGTC CTGGATTGAAGCGCCCTCGGTTAATC GCTGCCTTTGTTATTTGTAAGCTTCAG ... Oligo dG Adapter dT Adapter primer AGTGAGATGGATACAGGTGCTAAAC TCTGGACCTCAGACATGAACTTACT TGTCAGTCCTCTTTAATGCT AATGGTATCCTGTTTGGCTCAG GGTTGTAATTGTACACGGTAGTC CGGTAGTCAGGAAATCAATGCC CCATGTCTGCAGATGGTCGAGG...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... DDLQGSVEAQ-CGLVLNGQGGVIRRG -*.: ::: : : : * **:: Alpha Beta Gamma Epsilon Delta IPINKDNLFGGV-VNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGG LMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGG ... Gamma Epsilon Delta HPGWPGQRQ -SQESGLLHTHRGLPHQLSG-LDP -RRDY -RRHEDLLHGP-HA HPWGQRQRQEVGSEAGSLLPQPRAALPQLSG-LDP -RRDYHSVRRPDVLLHSAHHG QQAWPGRQSQEGAGLPSHHGRPAGLLPHLSG-LEAGAVSARRDAY RRSDLLLPHAHAL ... Beta Gamma Epsilon Delta VLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETE VLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETE VLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAE...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... factors, including insulin growth factor-1, platelet-derived growth factor and epidermal growth factor [14,15] Various protein phosphatases have been implicated in the regulation of MAPK signaling, including ... shown) JSP1-wt-GFP JSP1 -G2 A-GFP In contrast to most phosphatases, which negatively regulate MAPK signaling, JSP1 was shown to be a positive regulator of the JNK signaling pathway [20,21] Since myristoylation ... ⁄ PAGE The gel was fixed in 40% methanol ⁄ 10% acetic acid, and stained with SYPRO Ruby Protein Gel Stain (Invitrogen) according to the manufacturer’s protocol Bands containing JSP1-wt or G2 A...
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Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate specificity docx
... E52D-rev: 5¢-GCGCCACTTCTCGACGGG GTCGGTCAGCAGGC-3¢ E52H-fwd: 5¢-GCCTGCTGAC CCACCCCGTCGAGAAGTGGCGC-3¢ E52H-rev: 5¢-GC GCCACTTCTCGACGGGGTGGGTCAGCAGGC-3¢ E52Qfwd: 5¢-GCCTGCTGACCCAGCCCGTCGAGAAGTGG CGC-3¢ ... 5¢-GCGCCACTTCTCGACGGGCTG GGTCAGCAGGC-3¢ Y70W-fwd: 5¢-CTGCTGGAGCT GATGTGGAAAGATCCCAAGAAG-3¢ Y70W-rev: 5¢-CTT CTTGGGATCTTTCCACATCAGCTCCAGCAG-3¢ Q81Nfwd: 5¢-TGGGCCATGCCCTTTAACAGTTATGTCACG CTG-3¢ ... Q81N-rev: 5¢-CAGCGTGACATAACTGTTAAA GGGCATGGCCCA-3¢ R105H-fwd: 5¢-GCTAAAAATAA R105HTGGAGCACTCCATTTTTAGCGCTCGC-3¢ rev: 5¢-GCGAGCGCTAAAAATGGAGTGCTCCATTAT TTTTAGC-3¢ R105K-fwd: 5¢-GCTAAAAATAATGGAG AAATCCATTTTTAGCGCTCGC-3¢...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... 5¢-ATGAGCTCGGGAACCCTTAAAGCCCG-3¢ 5¢-ATGAGCTCTGCTTTCCTTCCGGGGA-3¢ 5¢-ATTGAGCTCACCAGGAGGGCAGGAGG-3¢ 5¢-GACACCTGTCGGTAACCCTTAAAGCC-3¢ 5¢-CGGAGTCGCCTAAGGAGAGATGGAGA-3¢ 5¢-AGGGTTCCCGATCGGTGTCTGAGAGA-3¢ ... mGATA* mE-box* mEts-F* 5¢-GTGGTACCAGTAGCAGCCGCCGCAAG-3¢ 5¢-ATGGTACCGGGCTTTAAGGGTTCCCG-3¢ 5¢-ATGGTACCGGAAGGAAAGCAGAGCCC-3¢ 5¢-ATGGTACCTGGTGATCCAGGGCTTGC-3¢ 5¢-CCGTTCCGAGCTCCGAGCAC-3¢ 5¢-ATGAGCTCGGGAACCCTTAAAGCCCG-3¢ ... al [34] The DNA fragments containing the putative Etsbinding sequence of the 5¢-flanking region of the mouse a3 integrin gene were synthesized; 5¢-TTTTCTCTTTCCCCG GAAGGAAAGCAGAG-3¢ (wild-type) and...
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Báo cáo Y học: Identification and characterization of a new gene from Variovorax paradoxus Iso1 encoding N -acyl-D-amino acid amidohydrolase responsible for D-amino acid production pdf
... 5F (5¢-TGAAGAGTTT GATCATGGCT-3¢) and 1540R (5¢-AAGGAGGTGAT CCAACCGCA-3¢) numbered according to the E coli 16S rRNA sequence were used The PCR product was purified and ligated into the p-GEM-T Easy ... quantities of protein utilizing the principle of protein- dye binding Anal Biochem 72, 248–254 41 Laemmli, U.K (1970) Cleavage of structural proteins during the assembly of the head of bacterialphage T4 ... N-D-AAase gene (Eur J Biochem 269) 4877 37 Thompson, J.D., Higgins, D .G & Gibson, T.J (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
... CGCACGCGTGGCACAGTGATGTAAATC CGCGAGCTCTTGCTCCCTGGGGGCCTG CGCACGCGTGGCACAGTGATGTAAATC CGCGAGCTCCCAGGGCCCTTGAGAC CGCACGCGTCCTGGGGGCAGTACA CGCGAGCTCCAGGGACCCTGCCAG CGCACGCGTCCTGGGGGCAGTACA S AS S AS ... Oligonucleotide sequences (5¢ fi 3¢) Orientation CGCGAGCTCCACATAGACTTTTCCCTT CGCACGCGTGGCACAGTGATGTAAATC CGCGAGCTCCCAGGGCCCTTGAGAC CGCACGCGTGGCACAGTGATGTAAATC CGCGAGCTCCAGGGACCCTGCCAG CGCACGCGTGGCACAGTGATGTAAATC ... T242 GATA ()454 ⁄ )449) GATA CTGCCATGGCCCCTCCCCAAGAGCAAA CGGCAAACACAAGCCAAGGTTGTTGTC CGGCAAACAGTATCGTATGTTGTTGTC TCCAGGGCCCTTGAGACCCTTGGTCATTTC TCCAGGGCCAGTAAGACCAGTAGTCATTTC CCCCTGATCCTTGTAGTGTCTAGT...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... (5¢-CAGTGACCCCAGAC GGGGTCGACTTC-3¢) and DH974 (5¢-GGCTGGTCGTC GCCTCGGCAACAGCGGGTTCCTCCTTC-3¢) for pig CPT1B, and DH977 (5¢-CGGTGACCCCAGAAGGGGT CGACTTC-3¢) and DH978 (5¢-GAAGTCGACCCCTTCTG GGGTCAC CG-3¢) ... QuickChange Site-Directed Mutagenesis Kit (Stratagene) The primers used were DH801 (5¢-TTCTTCCGCCA AACCCTTAAGCTGCTGCTTTCCTAC-3¢) and DH802 (5¢-GTAGGAAAGCAGCAGCTTAAGGGTTTGGCGGA AGAA-3¢) Using this ... (5¢-AGCTGAATTC ATGGCGGAAGCTCACCAG-3¢) and DH803 (5¢-TCCA CCCATGGTAGCAGAGAAGCAGCTTAAGGGTTTGG CGGA-3¢) The PCR reaction yielded a 422-bp product, in which an EcoRI site (in bold in the forward primer...
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Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx
... subdivided into two main groups (i.e the quinoxalines and the quinolines), depending on the chromophore moiety bound to the N-termini of each oligopeptide chain Prominent members of the quinoxaline-group ... ring (Cy8 ⁄ 4) or to eight residue rings By contrast, GrsB T-TE is capable of trimerizing pentapeptidyl-SNAC substrates to form 15-residue rings It was suggested that the size of the resulting ... subsequently ligated into a BamHI and NcoI-digested pQE60 vector (Qiagen), appending an C-terminal hexahistidine tag to the expressed protein DNA sequencing of the derived plasmid was performed by GATC...
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Báo cáo Y học: Molecular interactions between nuclear factor kB (NF-kB) transcription factors and a PNA– DNA chimera mimicking NF-kB binding sites doc
... To preserve all protein DNA contacts the chimera was designed keeping the nonsymmetric HIV-1 NF-kB binding site (50 -GGGGACT TTCC-30 ) and linking to this DNA core a T base in the 50 position ... generate self- or inter-strand hybridization, possibly forming highly stable complexes [23–27] In this respect, palindromic DNA sequences (for example the symmetric GGGGATTCCCCT NF-kB binding ... carrying binding sites for GATA-1 and NF-IL2A were used, as indicated (B,C) Effects of increasing amounts of DNA–DNA and PDP–PDP hybrids carrying the target sites of HIV-1 NF-kB, on the interaction...
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Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... AAACGTTGCTGACGTGCACAC CGATATTCTCAAGCCCAAGCC TGATGGAGTCTGGGTTGGAAG AGCCAGATTGATTATGGCCGC ATTCGGACACCCTTGAAAGGG ATAGACAAGTCCGCAGTCCCC 4409 Role of NrpRII in M mazei K Weidenbach et al extracted using ... 5¢-GTTTGAAGCTTTTATAAAAGACCCATAC; Mm1028 His.for 5¢-GGTTGACATATGAGCGAATC ⁄ Mm1028 His rev 5¢-GAAGCTTCTTATAAAAGCCCC; and Mm 1772 His.for 5¢-GGTGATATCATATGGTAGAAGTCG ⁄ Mm 1772 His.rev 5¢-GAAGAAAGCTTTAGAGGATAATCTCG) ... each time using 300 lL of protein- binding buffer (see above) Potentially DNA-bound proteins were subsequently eluted step-by-step using 200 lL of binding buffer containing increasing amounts of...
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Báo cáo khoa học: Transcription factors Sp1 and C⁄EBP regulate NRAMP1 gene expression ppt
... gaa gaa gaa ggc ggA ggc aaa ggg Tgg gTA ggg ggg ggc CTA ggc ggc ggc tgt CTA tgt tgt cct GTC cct ctg ggt ggt CTC ggt ggt tgg GCA GCA tgg tgg tga GCT tga tga Predicted site caa GCa caa aag gtg gtg ... gtg Ctg gAC gtg gag gag TGC gag gag tgt tgt CAG tgt agg agg TCA cct gtc gtc gtc TCT gtc ggg ggg ggg CAT ggg aag aag TCA aag gaa gaa CTG tga atg atg atg Ctg aCA aac aac aac GTG GTG agg agg agg CTA ... gtg gtg gtg gtg gtg cac cac cac cac cac tga tga tga tga # ctc ctc ctc aaa gca gTC gca gca gca agg agg agg agg agg acc acc acc acc tgt tgt tgt ggg gag AGC gag gag gag gca gca gca gca gca gaa gaa...
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