functional rescue of mutant p53 as a strategy to combat cancer

... transition is producing a change in the patterns of cardiovascular disease, in addition to increased rates of cardiovascular disease1 CVD related to atherosclerosis (coronary heart disease and ... tolerance test (after at least 10 hours' fasting) of 75 g of dextrose in 296 ml of carbonated orange (Trutol 75, Custom Laboratories Inc, USA) They then had measurements of plasma glucose at fasting ... interassay CV 1.8%) and glucose (intra-assay CV 0.9%, interassay CV 1.8%) were measured using enzymatic colorimetric assays HDL-C (intra-assay CV 2.9%, interassay CV 3.6%) was measured using a homogenous...

Ngày tải lên: 12/09/2015, 10:42

... decreased weight, often referred to as rheumatoid cachexia [45] It has been reported that almost two thirds of patients with RA have features of rheumatoid cachexia [46], and a recent study has ... details regarding RA and cardiovascular disease), and current disease activity and physical function, using the 28-joint disease activity score (DAS-28) [30] and health assessment questionnaire ... Stavropoulos-Kalinoglou A, Douglas KM, Koutedakis Y, Nevill AM, Panoulas VF, Kitas GD: Blockade of TNF-alpha in rhuematoid arthritis: the effects on components of rheumatoid cachexia Rheumatology...

Ngày tải lên: 09/08/2014, 01:22

... decreased weight, often referred to as rheumatoid cachexia [45] It has been reported that almost two thirds of patients with RA have features of rheumatoid cachexia [46], and a recent study has ... details regarding RA and cardiovascular disease), and current disease activity and physical function, using the 28-joint disease activity score (DAS-28) [30] and health assessment questionnaire ... Stavropoulos-Kalinoglou A, Douglas KM, Koutedakis Y, Nevill AM, Panoulas VF, Kitas GD: Blockade of TNF-alpha in rhuematoid arthritis: the effects on components of rheumatoid cachexia Rheumatology...

Ngày tải lên: 09/08/2014, 13:22

... NPAS2: an analog of clock operative in the mammalian forebrain Science 2001, 293:6-9 Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, Atsumi G, Ohkura N, Azama T, Mesaki M, Yukimasa S, Kobayashi ... were CGCACGAGGGCACCAT and TGGGCCCCGCTAAGC and the reporter sequences ACTTTGGGCTTGTCGAA and ACTTTGGGCTT- http://www.jcircadianrhythms.com/content/7/1/5 GTTGAA for ADA 22G >A (Asp8Asn), AAGCCGACTTTGC ... JE, Takahashi JS, Hastings MH: cAMP-dependent signaling as a core component of the mammalian circadian pacemaker Science 2008, 320:949-53 Green CB, Takahashi JS, Bass J: The meter of metabolism...

Ngày tải lên: 10/08/2014, 09:20

... development of inflammation and increased risk of atherosclerosis [21], focal ANGPTL2 secreted by vascular endothelial cells may be a mediator linking smoking to cardiovascular disease in an autocrine ... or paracrine manner Blocking ANGPTL2 signaling may also be beneficial also in preventing and treating cardiovascular disease (Fig 1) To date, integrins have been regarded as a functional ANGPTL2 ... Suda T (2003) Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein Cancer Res 63, 6651–6657 Oike Y, Ito Y, Maekawa H, Morisada T, Kubota Y, Akao M, Urano T, Yasunaga...

Ngày tải lên: 14/02/2014, 22:20

... committees of the Laboratory Animal Science Centers of Boston University and The University of Patras ment plasma samples were isolated from three mice from each group Then, lL of plasma was analyzed ... elevated steady-state plasma ApoE levels Since ApoE is a known inhibitor of LpL [47], and plasma triglyceride levels correlate with plasma ApoE levels [48], accumulation of ApoE in the blood of ... steady-state plasma ApoE levels between ApoE3knock-in and C57BL/6 mice, at week of the experiment plasma samples were isolated from 4798 three mice from each group and lL of plasma was analyzed...

Ngày tải lên: 17/03/2014, 17:20

... Patient data was obtained via case note analysis and a faceto-face interview performed by a rheumatologist The dual approach facilitated the documentation of a detailed history to include: disease ... Clinical Diagnostics, Markham, Ontario, Canada), with multilayered slides used to measure TC, HDL, and TGs, whereas a dual chamber package was used to assess LDL, apolipoprotein (Apo) A and ApoB ... resistance Metabolism 1988, 37:125-130 Zonana-Nacach A, Santana-Sahagun E, Jimenez-Balderas FJ, Camargo-Coronel A: Prevalence and factors associated with metabolic syndrome in patients with rheumatoid...

Ngày tải lên: 09/08/2014, 14:22

... Criteria [29] The criteria for impaired fasting glucose is that used by the American Diabetes Association [30] as proposed by the updated American Heart Association/National Heart, Lung, and Blood ... glucose was defined as ≥ 100 mg/dl Smokers were defined as individuals who smoked at least cigarettes per day while past smokers had stopped smoking for at least 30 days prior to examination Measured ... participant are Chi-square Significance (N = 7,760) (N = 4,312) Statistical Methods All data was summarized and displayed as mean ± standard deviation (SD) for the continuous variables and as number...

Ngày tải lên: 11/08/2014, 03:20

... Criteria [29] The criteria for impaired fasting glucose is that used by the American Diabetes Association [30] as proposed by the updated American Heart Association/National Heart, Lung, and Blood ... glucose was defined as ≥ 100 mg/dl Smokers were defined as individuals who smoked at least cigarettes per day while past smokers had stopped smoking for at least 30 days prior to examination Measured ... participant are Chi-square Significance (N = 7,760) (N = 4,312) Statistical Methods All data was summarized and displayed as mean ± standard deviation (SD) for the continuous variables and as number...

Ngày tải lên: 11/08/2014, 06:22

... countries of Sub Saharan Africa[82] Indeed, it has been appreciated for many years that the global availability and marketing of cheap vegetable oils and fats is leading to increasing fat consumption ... individuals being treated with HAART as 70-80% and state that it can be associated with all available PIs[6] It has also been reported that severe hypertriglyceridaemia associated with PI therapy can ... increased rates of DM have been found amongst TB patients in an African setting A Tanzanian study found TB patients to have increased rates of IGT and a Nigerian study found an increased level of...

Ngày tải lên: 11/08/2014, 14:21

... Nurses are the most powerful and numerous allies of RRS Staff may be ashamed to call a medical emergency team The issue of professional pride or fear of blame has to be overcome Activation of an ... need for basic resuscitation measures Major causes of suboptimal care included failure of organisation, failure to appreciate clinical urgency, and failure to seek advice [6] In summary, there ... participating hospitals to standard care or the introduction of an MET The result was an increased overall MET calling rate in MET hospitals but no substantial effect on cardiac arrest, unplanned...

Ngày tải lên: 25/10/2012, 10:35

... tent caterpillars’ surface bacteria and/or oral commensal bacterial into the blood stream as an integral part of the pathogenesis of MRLS In this regard, the apparent efficacy of muzzling mares ... 2001, as we know it, may simply be a recently identified peracute manifestation of a long established Eastern tent caterpillar defensive mechanism It was on this basis that, as soon as Eastern ... that contains specific inhibitors of blood coagulation In fact, loss of such associated facilitating factors may be one limiting factor for Eastern tent caterpillar abortigenic activity Finally,...

Ngày tải lên: 13/02/2014, 15:20

... comprehensive approach aimed at making the healthy choices available, affordable and attractive involves taking account of mainstreaming nutrition and physical activity into all relevant policies at local, ... saturated fatty acids and salt Dietary factors are estimated to account for approximately 30% of all cancers in industrialized countries38, making diet second only to tobacco as a theoretically ... preventable cause of cancer Consumption of adequate amounts of fruits and vegetables, and physical activity, appear to be protective against certain cancers Body weight and physical inactivity together...

Ngày tải lên: 14/02/2014, 13:20

... particular, is characterized by increased inflammatory factors, decreased plasma TT levels and endothelial dysfunction Obesity is associated with decreased TT, BAT and FT levels, as well as elevated E2 ... 116–119 Maggio M, Blackford A, Taub D, Carducci M, Ble A, Metter EJ, Braga-Basaria M, Dobs A & Basaria S (2006) Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen ... expression and release of cytokines and chemokines [122–124] Androgen deprivation therapy is associated with increased levels of proinflammatory factors and decreased antiinflammatory cytokines [125,126]...

Ngày tải lên: 18/02/2014, 06:20

... extramitochondrial AMP formation experimentally, as we used P1,P5-di(adenosine-5¢)-pentaphosphate (Ap 5A) as inhibitor of adenylate kinase to prevent depletion of available ATP and ADP and to maintain ... constant activation of AMPK may have some adverse effects, because stimulation of b-oxidation in response to activation of AMPK cannot lead to production of ATP because of lack of mitochondrial ADP ... was quantified using H2O2 as standard Calculation of extramitochondrial AMP concentrations AMP concentration was calculated as (for derivation see supplementary data, Appendix S1): FEBS Journal...

Ngày tải lên: 19/02/2014, 05:20

... media SOCE was induced by reintroduction of mM Ca2+ Increase in basal tone was used as a marker of Ca2+ entry Area under caffeine contracture curve (AUCCC) was used as a measure of sarcoplasmic ... Theocharis Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece E-mail: N.K.Karamanos@upatras.gr Matrix effectors involved in invasion and metastasis of breast cancer ... derivative reduced cell viability in lower dose than TAM Using specific peptide substrates, activation of caspases, specially caspase-3 and caspase-9 was observed A pan caspases inhibitor, Z-CH2-AspDCB...

Ngày tải lên: 19/02/2014, 07:20

... the same substrates as mammalian SDH, therefore suggesting that Lad1 may be a fungal orthologue of this enzyme To test this, we first made a BLAST search of GenBank and the genome databases of Neurospora ... genome databases of F graminearum and N crassa Fekete et al [30] have recently reported that galactitol is oxidized to L-sorbose in A nidulans by L-arabinitol dehydrogenase from cell-free extracts ... was We have previously shown [13] that a delta-lad1 strain is used with helium as the carrier gas at a head pressure of 44 strongly impaired in its ability to grow on galactitol, and p.s.i (at...

Ngày tải lên: 07/03/2014, 15:20

... off inflammation Barbara: Inflammation, Rheumatoid Arthritis, and Asthma At age forty-one, Barbara had suffered with rheumatoid arthritis and asthma for years and was taking half a dozen prescription ... years of her asthma diagnosis, Georgia was taking a variety of prescription drugs: oral and nasal, a bronchodilator, antibiotics, and other medications She began to feel addicted to her asthma drugs ... proposed what was then a bold and audacious idea—that many different types of inflammatory diseases were related to one another Today, this idea is widely accepted Indeed, a great deal has changed...

Ngày tải lên: 15/03/2014, 04:20

... regular physical activity and normal weight are both important indicators of a decreased risk of mortality from all causes, cardiovascular diseases and cancer, with physical activity conferring a ... increasing that the risk of cardiovascular and metabolic diseases associated with obesity is related to the amount and proportion of fat laid down in the abdomen, particularly at modest levels of ... Regional Office for Europe Vanessa Candeias Chronic Diseases and Health Promotion, WHO headquarters Margherita Caroli Prevention Department, Azienda Sanitaria Locale (ASL) Brindisi, Italy Rob Carter...

Ngày tải lên: 16/03/2014, 14:20