functional neuroanatomy of pain

Ngày tải lên: 06/03/2014, 18:20

... function of vascular caliber and rate of blood flow. Cutaneous blood flow can range from ~ 0 to 30% of cardiac output, depending on requirements. Heat con- duction via the blood from interior sites of ... Fever Inflammatory pain Pain of colic Acetaminophen Acetylsalicylic acid Dipyrone Acute massive over- dose Chronic abuse Hepato- toxicity Nephro- toxicity Impaired hemostasis with risk of bleeding Agranulo- cytosis Broncho- constriction Irritation of gastro- intestinal mucosa Risk ... bleeding Agranulo- cytosis Broncho- constriction Irritation of gastro- intestinal mucosa Risk of anaphylactoid shock >10g ? Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved. Usage subject to terms and conditions of license. Drugs...

Ngày tải lên: 24/10/2013, 19:15

... benets of abstraction in a functional language. This article assumes no knowledge of JPEG or any of its algorithms, nor of specialized functional programming techniques. Basic knowledge of functional ... Human trees are used. Each of them is specied in the header of the le as a list of lists. These lists contain the values that have codes of equal length. The construction of the corresponding Human ... Picture that is the result of jpegDecode is a matrix of pixels, where each pixel consists of a list of integer components with values in the range ;128to127. Theinterpretation of the components is...

Ngày tải lên: 09/12/2013, 15:15

Ngày tải lên: 31/12/2013, 10:33

... gloves, and coveralls when spray painting. Two operations–paint mixing and cleanup–are often overlooked when shops are considering safety measures. Many work- ers perform paint mixing and cleanup in small, ... choice. Talk to your paint distributor or equipment supplier to determine the most appropriate types of gloves for your operations. • Close all containers of solvents, paints, and reducers ... and coveralls when spray painting. Two operations–paint mixing and cleanup–are often overlooked when shops are considering safety measures. Many work- ers perform paint mixing and cleanup...

Ngày tải lên: 16/01/2014, 22:20

... Years of life expectancy free of problems with PADL 12.32 13.43 Years of LE free of problems with all ADL 7.81 8.33 % of total LE free of problems with PADL 93.3 91.2 % of ... females, years of life expectancy free of problems with ADL activities was relatively low for both genders (Table 8). Discussion Identification of health problems and functional ability of an elderly ... member of the household present at the time of the interview was identified as an "informant". At each interview where an informant was present, assessment of the informant of the...

Ngày tải lên: 14/02/2014, 06:20

... containing subunits of both PRTFDC1 and HPRT, thereby providing an addi- tional means of regulating the activity of HPRT. Recently, Suzuki et al. [9] showed that PRTFDC1 expression often was silenced ... elucidation of the structure of PRTFDC1 and the definition of its ligand binding specificity from a large metabolome library provides an initial start point for defining the molecular function of PRTFDC1. ... metabolic consequences of having HPRT deficiency are an overproduction of uric acid and elevated levels of PRPP [3]. Patients hav- ing mutations resulting in partial HPRT deficiency often suffer from...

Ngày tải lên: 15/02/2014, 01:20

... in the course of the reaction. The principle of the assay is that the presence of a SOD inhibits the reduction of cytochrome c. This was vali- dated by adding a total of 2.5 U of commercial SOD ... kinetics and mechanisms of the reactions of iron(III) with b-dik- etones. The formation of monoacetylacetoatoiron(III) and the effect of copper (II) on the formation of monothenoyltrifluoroacetonatoiron ... according to prior studies of nonheme Fe 2+ centers [29–31], is assigned to the mixing of the 4p orbital with the 3d orbital of the metal cofactor. Two important pieces of information can be gleaned from...

Ngày tải lên: 18/02/2014, 06:20

... the dynamics and features of this protein. Role of MCPIP in regulation of the endogenous IL-1b transcript level After identification of a PIN domain in the MCPIP by use of bioinformatics, we decided ... transcript independently of the presence of AREs (Fig. 6B, lanes 2 and 5). It is possible that in the region located before the AREs, consisting of 343 bp of the 3¢ UTR of the IL-1b transcript, ... present in the 3¢ UTR of IL-6 mRNA [4,17]. The presence of such a sequence may account for the degra- dation of both types of IL-1b transcripts, with and with- out AREs. The influence of MCPIP on the...

Ngày tải lên: 18/02/2014, 14:20

... ratio of UpUMPK ⁄ phos- phate of 25 ⁄ 1. The effect of orthophosphate on enzyme activity was examined. It was shown that phosphate inhibited UpUMPK activity with an IC 50 value of 1 mm (Fig. 7). Functional ... interaction between Thr131 and Phe133 (Fig. 3D). The central channel of the hexamer is made up of two layers of electrostatic forces on top of each other, with one layer rotated by 60°. The amino acids ... various concentrations of ATP (l M). (B) Activity versus [ATP] at various concentrations of UMP (l M). (C) Lineweaver–Burk plot of 1 ⁄ v against 1 ⁄ [UMP] at various concentrations of ATP (l M). UMP...

Ngày tải lên: 18/02/2014, 16:20

... The ability of polymeras- es to use Mn 2+ instead of Mg 2+ as a required cofactor is well established [25]. However, the bio- chemical properties of polymerases are altered as a result of replacing ... showed that the C-terminal half of the RepA of the pIT3 plasmid is sequence-similar to the helicases of the phage-encoded superfamily III pro- teins. The N-terminal half of the pIT3 protein RepA shows ... presence of 0.2 mm dNTPs and 0.5 U of Taq DNA polymerase (Promega). To analyze the effect of temperature on primase activity, Rep245 and Rep516 proteins were incubated with 0.25 lg of M13 mp18...

Ngày tải lên: 18/02/2014, 18:20

... particular, phosphorylation of dGuo was reduced markedly. Structure of Dm-dNK-E52D in complex with dTTP The structure of one of the mutants, E52D, was solved using X-ray crystallography at a resolution of 2.5 A ˚ in complex ... levels of phosphorylation expressed in rela- tion to percentage dThd phosphorylation of the wild-type. Relative phosphorylation expressed as a relation of the percentage of dThd phosphorylation of ... quantitation of microgram quantities of protein util- izing the principle of protein–dye binding. Anal Biochem 72, 248–254. 22 Knecht W, Bergjohann U, Gonski S, Kirschbaum B & Loffler M (1996) Functional...

Ngày tải lên: 19/02/2014, 02:20

... results). In contrast, functionally dif- ferent proteins often give peaks of unequal intensity because of unequal rates of biosynthesis, utilization, or degradation. Variants of TTr that are associated ... vivo. Known variants of the ApoC1 gene are limited to un- translated regions of the gene, synonymous mutations of the coding sequence and a number of variants of the intron regions of the gene (NCBI ... Also shown are the relative ratios of the sum of peaks from ApoC3 to the sum of peak intensities from ApoC1 (r) and the ratios of several isoforms of ApoC3 (m ⁄ z ¼ 8765 : 9713, des- glycoApoC3-0...

Ngày tải lên: 19/02/2014, 05:20

... ng of FLAG-DEC1 expression vector and 50 ng of FLAG-BMAL1 expression vector resulted in adequate levels of expression. The transcriptional activity of FLAG-BMAL1, and the suppressive activity of ... Kato 1 1 Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan; 2 Department of Physiology, Hokkaido University Graduate School of Medicine, ... for the rhythmic expression of Dec1, and the feedback loop of DEC1 (as well as that of BMAL1) might be interlocked with the core feedback loop to constitute a network of the circadian clock system [11,12,14]....

Ngày tải lên: 19/02/2014, 16:20

... evaluation. Instead of measuring how well the color of a painting fits every model, we examine which type of model the color distribution of a painting fits best. Using these models instead of directly ... the golden section of the height of the painting. The trees and people are placed at golden sections of smaller sections of the painting [14].” Fig. 6. (a) Left: Example of Golden Section; ... to evaluate the aesthetic visual quality of a special type of visual media: digital images of paintings. Assessing the aesthetic visual quality of paintings can be considered a highly subjective...

Ngày tải lên: 19/02/2014, 17:20

... equation that allows calculation of the concentration of mAb that produces 50% of the inhibitory effect (IC 50 ) [61]. Effect of anti-LBS mAbs on the activation of plasminogen by fibrin- and cell-bound ... were starved of serum and then incubated with varying concentrations of Glu-Pg (0–2 lm) and a fixed concentration (0.75 mm final concentration) of CBS0065 in a total volume of 100 lL of Ham-F12 medium ... lysine-binding site (LBS) of human plasminogen. Role of LBS in the regulation of fibrinolysis. Eur J Biochem 157, 65–69. 48 Brockway WJ & Castellino FJ (1972) Measurement of the binding of antifibrinolytic...

Ngày tải lên: 20/02/2014, 01:20

... Specificity of monoclonal anti-(human transcobalamin) sera and their effect on the functional properties of transcobalamin. nd, not done. mAb Epitope cluster Precipitation of Apo-TC (%) Precipitation of Holo-TC ... significant part of TC, a composite organization of the receptor recognition site may be suggested, where its components come from different parts of the protein. Reconstruction of the functional receptor-binding ... maximal mAb ⁄ heparin effect on the functional activ- ity of TC. Arrows show the hypothetical movement of the domains after attachment of Cbl, see the main text. Mapping of transcobalamin using antibodies...

Ngày tải lên: 20/02/2014, 01:20

Ngày tải lên: 20/02/2014, 01:20

Ngày tải lên: 20/02/2014, 11:20