functional implications and pharmacological modulators
Báo cáo khoa học: BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications pptx
... proteins are warranted, and will provide a better understanding of mutation-associated breast and ovarian cancer and improve the strength of prognosis and efficacy of prophylaxis and treatment for mutation ... enhanced breast cancer and ovarian cancer risk 52 50 46 39 41 38 22 26 24 21 59 Reference R J Linger and P A Kruk Risk-associated BRCA1 mutations and their functional implications 3089 Risk-associated ... R J Linger and P A Kruk Risk-associated BRCA1 mutations and their functional implications controllers, including p21, and by physically interacting with cell cycle...
- 11
- 458
- 0
Báo cáo khoa học: Characterization of the 16S rRNA- and membrane-binding domains of Streptococcus pneumoniae Era GTPase Structural and functional implications docx
... that contained the GTPase domain, and the RNA- and membrane-binding domain, respectively We purified and analyzed these proteins for their GTP hydrolysis, and RNA- and GTP, GDP, ampicillin, tetracycline, ... activities require the GTPase activity of Era, and whether the RNA- and membrane-binding domain is a self-sufficient functional entity, we constructed N- and C-terminally truncated Era proteins of ... required the GTP-binding and GTPase activities of the protein for function and whether, biochemically, the RNAand membrane-binding domains overlap To investigate whether the RNA- and membrane-binding...
- 9
- 544
- 0
Báo cáo y học: "Evolutionary history and functional implications of protein domains and their combinations in eukaryotes" pptx
... to τi and graft the child c in Cn to τn In step 4, consider two cases - τi and τn inherit the gene (Figure 6c) and τi and τn not inherit the gene (Figure 6d) and count the events for τi and τn ... 47 eukaryotes and 223 prokaryotes obtained from the genome and draft genome sequences stored in the Kyoto Encyclopedia of Genes and Genomes (KEGG) GENES and DGENES databases [52] and the Ensembl ... terms 'Euk', 'Ani', and 'Deu' refer to eukaryote, animal, and deuterostome, respectively 'Com' indicates that the domain is shared by prokaryotes and eukaryotes On the other hand, domains involved...
- 15
- 315
- 0
Báo cáo y học: "Primary lower limb lymphedema: a focus on its functional, social and emotional impac"
... that may suffer from the same problem”, and when information on his professional status was asked he added: “I could not spend too much time standing up and I lost my job” Case presentation The ... vitality, mental health, social functioning, and general health SF-36 metric patterns of the two patients were registered and are shown in Table and a description of these two cases follows below ... age of years from the left ankle progressing slowly up to the calf, thigh and inguinal area leading to disfigurement and functional impairment The patient had a negative family history of edema...
- 5
- 443
- 0
Tài liệu Chronic Disease, Functional Status and Quality Of Life Among The Elderly In Singapore pdf
... mortality and prolong survival Improved healthcare Little impact on functional wellbeing or quality of life Increased chronic diseases and functional disability Escalate use and costs of medical and ... deficiencies and barriers that can be identified and corrected? Essential for optimal policy and programme planning and provisions Data are available from official routine health statistics and reports ... disease prevention and health promotion for healthy and long life expectancy Wide range of research topics and issues relevant to public health, primary care, and hospital and nursing home care...
- 29
- 551
- 0
Tài liệu Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes docx
... Carroll, and John H Stewart, IV 11 Visualization of Carbon Nanoparticles Within Cells and Implications for Toxicity 267 Alexandra Porter and Mhairi Gass 12 Pharmacological ... al., 1996; Da Ros and Prato, 1999; Tagmatarchis and Shinohara, 2001; Bosi et al., 2003; Nakamura and Isobe, 2003; Sarova et al., 2006; Bianco and Da Ros, 2007) 1.2 Cell Protection and Antioxidant ... fullerene and light, so the polymer was tested on mice affected by bone tumor After injection and irradiation, tumor size and weight were reduced and the mouse survival time was extended (Jiang and...
- 411
- 354
- 0
Tài liệu Báo cáo khoa học: Functional expression and mutational analysis of flavonol synthase from Citrus unshiu pptx
... although this enzyme has not been functionally proved and the lability of substrate and product rule out any cocrystallization The setting of a helices and b-strands causes very similar CD spectra ... deoxycholate [40] and using bovine serum albumin as a standard Flavonol synthase (Eur J Biochem 269) 4137 and Matthiola incana), but functionality was only verified in case of Petunia and Arabidopsis ... was negligible and the band could be hardly recognized in the soluble Gly68fiPro and Gly261fiPro mutant extracts (lanes and 11) sequence alignments per se support only a preliminary functional assignment...
- 9
- 864
- 0
Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... based on their effects on stability and activity parameters of RNase-A Functional stability and activity by osmolytes Results and Discussion Protein stability and enzyme activity have a well-correlated ... advances in understanding the effect of osmolytes on protein stability, folding and the activity of proteins and enzymes, the relationship between protein stabilization by osmolytes and its consequent ... Fig (see also Table 1) that sugars and methylamines affect both the thermodynamic (DGD°) and the kinetic (Km and kcat) properties, whereas polyols, amino acids and amino acid derivatives not have...
- 9
- 547
- 0
Báo cáo khoa học: Functional implications of pigments bound to a cyanobacterial cytochrome b6f complex potx
... peaks at 422 nm and 430 nm correspond to the Soret bands of cyt f and cyt b6, respectively The b-bands of cyt f and cyt b6 are observed at 530 and 531 nm, respectively, while the X- and Y-transitions ... Y-transitions of the a-band of cyt f occur at 548 and 555 nm, respectively, and those of cyt b6 at 556 and 562 nm, respectively ([27] and references therein for definitions and orientations of the ... (which dominates the Chl absorption around 630 nm and between about 570 and 600 nm [28]), the X transition of the a-band of cyt f and of the b-band of cyt f Apart from the cyt b6 contribution,...
- 11
- 520
- 0
Small functional equations and how to solve them (PBM)
... not a functional equation itself, and the official solution did not involve functional equations However, iterations are closely connected to the theory of functional equations There is a functional ... z z x2 + x3 + (1.7) and showed by combinatorial arguments and rules for multiplying two such infinite sums that f (z + w) = f (z) f (w) (1.8) for all real z and w This functional equation is ... universities and colleges in the United States and Canada Problems involving functional equations made an early appearance in the history of this competition In early competition problems, the study of functional...
- 138
- 666
- 3
Functional Groups and Chemical Families pptx
... ethan amide NH2 C2 H5 NO acetamide O Using functional groups to predict reactivity Once having a list of common functional groups, the organization of those functional groups by oxidation state is ... carbon members of the oxahydrocarbon families (alkanes to carbon dioxide) Hydrogen and oxygen are redox standards at +1 and –2, respectively Thus, the carbon oxidation state in methane is –4, in methanol ... carbon is assigned for these functional groups it is possible to relate other functional groups to these redox archetypes in order to form a sort of periodic table of the functional groups (Table)...
- 6
- 339
- 0
CNS injuries : cellular responses and pharmacological strategies pdf
... e.g., platelet products, prostaglandins, cytokines, and chemokines produced and released by damaged cells and tissue elements such as blood vessels and the leucocytes and platelets released from the ... class I and II antigens, secrete cytokines (e.g., TGF-βs, IL-1, and IL-6), and may become phagocytic, actively stripping synapses from postsynaptic sites,91,92 and removing neuronal and glial ... growth-inhibitory ligands and also activate those for the production and secretion of proteases ©1999 CRC Press LLC REFERENCES Schall, T J and Bacon, K B., Chemokines, leucocyte trafficking, and inflammation,...
- 223
- 449
- 0
Báo cáo khoa học: Functional characterization and Me2+ ion specificity of a Ca2+–citrate transporter from Enterococcus faecalis1 pdf
... EDTA and bivalent metal ions, which corresponded to 139.3 ± 20.6 and 15.9 ± 1.8 pmolÆ(mg protein))1 for the control and EfCitH-expressing membranes, respectively Error bars represent the standard ... presence of mM EDTA and an excess of the indicated bivalent cations The cations Ca2+, Ba2+, Sr2+, Zn2+, Ni2+, Mg2+, Mn2+ and Co2+ were added at a final concentration of mM, and Cu2+, Cd2+ and Pb2+ were ... presence of mM EDTA and an excess of the indicated bivalent cation Ca2+, Ba2+, Sr2+, Zn2+, Ni2+, Mg2+, Mn2+, and Co2+ were added at a final concentration of mM Cu2+, Cd2+ and Pb2+ were added to...
- 10
- 386
- 0
Báo cáo khoa học: " Parsing the Wall Street Journal using a Lexical-Functional Grammar and Discriminative Estimation Techniques" doc
... randomly extracted from section 23 of the WSJ treebank and given gold-standard f-structure annotations according to our LFG scheme, and (ii) 500 sentences from the Brown corpus given gold standard ... total of 8,759 states and 19,695 arcs The grammar uses several lexicons and two guessers: one guesser for words recognized by the morphological analyzer but not in the lexicons and one for those ... adjectives, and adverbs have no explicit lexical entry The main verb lexicon contains 9,652 verb stems and 23,525 subcategorization frame-verb stem entries; there are also lexicons for adjectives and...
- 8
- 477
- 0
Báo cáo khoa học: Dimerization of mammalian adenylate cyclases Functional, biochemical and ¯uorescence resonance energy transfer (FRET) studies pot
... GFP/8C1 and 8NTm1 were as described in [20] CFP/AC8 and YFP/AC8 were obtained by switching the GFP of GFP/AC8 into CFP and YFP between the restriction enzyme sites Nhe1 and BglII, from pECFP and ... cluster (Tm2) and second cytoplasmic loop (C2) (see later) The C1 and C2 regions are further subdivided into the highly conserved catalytic C1a and C2a regions and the less conserved C1b and C2b domains ... measured for after adding, 20 lM forskolin and 10 lM prostaglandin E1 for transfections involving AC5 and AC6; 20 lM forskolin, 10 lM prostaglandin E1 and mM Ca2+ for transfections involving AC8...
- 9
- 233
- 0
PROGRESS I N BRAIN RESEARCH VOLUME 36 BIOCHEMICAL AND PHARMACOLOGICAL MECHANISMS UNDERLYING BEHAVIOUR doc
... ChAc AND ACh SYNTHESIS 27 WHITTAKER, P (1970) The vesicle hypothesis In Excitatory Synaptic Mechanisms, P ANDERSEN V AND J K S JANSEN (Eds.), pp 67-76 WHITTAKER, P., MICHAELSON, A AND KIRKLAND, ... and Widlund, 1970), the addition of acetylcholine (ACh) (Hokin and Hokin, 1955, 1958; Durell and Sodd, 1964, 1966; Heilbronn and Widlund, 1970) or ACh-releasing substances, such as atropine and ... endings This fits in with observations of Lenard and Singer (1968) on the red cell membrane and those of Condrea and Rosenberg (1968) and Rosenberg and Condrea (1968) on the squid giant axon From...
- 217
- 262
- 0
Báo cáo khoa học: Helicobacter pylori single-stranded DNA binding protein – functional characterization and modulation of H. pylori DnaB helicase activity pptx
... fluoride and 10% glycerol For helicase and ATPase assays, HpSSB (Wt) and DC20SSB were dialysed against MonoQ and MonoS buffers and subjected to ion exchange chromatography using MonoQ and MonoS ... Wt and DC20 SSB protein in varying concentrations (0, 0.45, 0.9, 1.8, 2.7 and 3.6 lg, respectively) with 300 ng of M13mp18 single-stranded circular DNA and ⁄ or 300 ng of pUC18 double-stranded ... interaction To understand the basic DNA replication machinery of H pylori in detail, we have cloned, over-expressed and characterized the functional properties of HpSSB both in vitro and in vivo We...
- 13
- 438
- 0
Chapter 10 Functional Dependencies and Normalization for Relational Databases
... preservation of the functional dependencies Note that property (a) is extremely important and cannot be sacrificed Property (b) is less stringent and may be sacrificed (See Chapter 11) 2.1 Functional ... the meaning and interrelationships of the data attributes A set of attributes X functionally determines a set of attributes Y if the value of X determines a unique value for Y Functional Dependencies ... (Augmentation) If X -> Y, then XZ -> YZ (Notation: XZ stands for X U Z) IR3 (Transitive) If X -> Y and Y -> Z, then X -> Z IR1, IR2, IR3 form a sound and complete set of inference rules Inference Rules...
- 48
- 467
- 0
Báo cáo sinh học: " Imperfect DNA mirror repeats in the gag gene of HIV-1 (HXB2) identify key functional domains and coincide with protein structural elements in each of the mature proteins" doc
... combined IMRs and functional and structural data The sequence motifs of experimentally determined functional and structural data, and the sequence positions of the translations of mIMRs and rdIMRs ... coding DNA and that different levels of symmetry are associated with different functional aspects of gene and protein The interaction between DNA and protein structure and function is precise and interwoven ... helices, βsheets and turns – in 17 monomeric proteins In TnsA (E coli), 88% of the known or potential functional motifs occur within rdIMRs and the longest mIMRs translate key functional and/ or structural...
- 13
- 538
- 0
báo cáo hóa học: " Quantification of functional weakness and abnormal synergy patterns in the lower limb of individuals with chronic stroke" pdf
... ankle) and the flexion synergy (external rotation, abduction, and flexion of the hip, flexion of the knee, and flexion and eversion of the ankle) [16,17] with varying levels of completeness [18] and ... known as synergies and, for the lower limb, have been grouped into the extension synergy (internal rotation, adduction, and extension of the hip, extension of the knee and extension and inversion ... {o} to {a}, a a Po ×o R is a × skew matrix from {o} to {a}, and Fi and Ti denote force and torque in each respective frame Ankle forces and moments can then be transformed back to the knee as: Table...
- 11
- 574
- 0
Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25