... dialysis membranes of to KDa and 12 to 14 KDa These results may be important for future drug delivery applications using nanoliposomes for the encapsulation and transport of this promising antitumoral ... polydispersity index, and good stability after weeks The Egg-PC/Ch/DPPG (6.25:3:0.75) and Egg-PC/DPPG/ DSPE-PEG (5:5:1) showed to be the best formulations for encapsulation of this compound, considering ... UK), at 25°C, using a He-Ne laser of 633 nm and a detector angle of 173° Five independent measurements were performed for each sample Malvern dispersion technology software (DTS) (Worcestershire,...
Ngày tải lên: 21/06/2014, 01:20
... standards of care, but studies of the quality of care for patients with diabetes suggest less than optimum care in a number of areas [2] Quality and outcomes framework (QOF) data for 2004 and ... about self-monitoring and education Second, we will collect QOF scores for diabetes and for additional items that reflect aspects of good organisation and that, on the basis of QOF scores, can be ... website), a comparison of the level of agreement between patients' and health professionals' perceptions and a comparison of patient perceptions and physiological measures of diabetes control Ethics...
Ngày tải lên: 11/08/2014, 05:21
báo cáo khoa học: " Improving the delivery of care for patients with diabetes through understanding optimised team work and organisation in primary care" ppt
... standards of care, but studies of the quality of care for patients with diabetes suggest less than optimum care in a number of areas [2] Quality and outcomes framework (QOF) data for 2004 and ... about self-monitoring and education Second, we will collect QOF scores for diabetes and for additional items that reflect aspects of good organisation and that, on the basis of QOF scores, can be ... website), a comparison of the level of agreement between patients' and health professionals' perceptions and a comparison of patient perceptions and physiological measures of diabetes control Ethics...
Ngày tải lên: 11/08/2014, 16:20
Formulation design and development of transdermal delivery system nanoemulsion of schizandrol a
... detailed preformulation and solubility profile of schizandrol A Physicochemical properties of schizandrol A will be examined, focusing on elemental, phase and thermal analysis Solubility of schizandrol ... (root of Aristolochia fangchi) was substituted for Fang Ji (root of Stephania tetrandar), and Guan Mu Tong (stem of Aristolochia manshuriensis) for Chuan Mu Tong (stem of Clematis armandii) and ... use the formulation as directed Performance, fulfillment of the claimed benefits, is 12 the other part The formulation of the delivery system is intended to maximize the performance of the active...
Ngày tải lên: 10/09/2015, 09:03
Use of upconversion fluorescent nanoparticles for simultaneous imaging, detection and delivery of sirna
... imaging contrast agents and targeting moieties The nanoparticle can be used for specific delivery of anticancer agents, tracking of therapeutic delivery, and detection of treatment effects in ... Figure 6.5 Images of SK-BR-3 cells incubated with UCN-Ab-siRNA for 1, 3, 6, 12 and 24 h The confocal fluorescent image of UCNs (left) and superimposed xv image of UCNs and DAPi (for nucleus) are ... demonstrated the use of multicolor QDs for quantitative and simultaneous profiling of multiple biomarkers using FFPE (formalin-fixed and paraffin embedded) breast cancer cells and FFPE clinical...
Ngày tải lên: 14/09/2015, 08:39
Design and fabrication of microneedles for drug delivery
... DESIGN AND FABRICATION OF MICRONEEDLES FOR DRUG DELIVERY JI JING ( B.Eng.,M.Eng., NWPU, CHINA) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MECHANICAL ENGINEERING ... implementation of time varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and ... diameter of the microneedle DG the diameter of glass member DPZT the diameter of PZT disc f frequency F force applied by the needle Fz the body force E Young’s modulus of the material G roughness of...
Ngày tải lên: 14/09/2015, 11:17
Tài liệu ‘Unheard voices’: listening to Refugees and Asylum seekers in the planning and delivery of mental health service provision in London. pptx
... is a necessary basis for a more thorough understanding of the complex needs of individuals and will inevitably affect the type, and way in which the service is offered Being forced to flee represents ... and the social contexts of distress 52 The main focus of trans-cultural psychiatry is the study and analysis of beliefs, practices and cultural values and their influence in shaping beliefs and ... services and service delivery refugees and asylum seekers The central concerns were for reforming the way that institutions and systems of the health care service worked, acknowledging significance of...
Ngày tải lên: 24/02/2014, 18:20
An Analyst''''s View Of The Uses And Abuses Of Modeling For Decisionmaking potx
Ngày tải lên: 07/03/2014, 15:20
Báo cáo toán học: " Existence and multiplicity of solutions for nonlocal p(x)-Laplacian equations with nonlinear Neumann boundary conditions" ppt
... ), (H2 ) and the following conditions hold true: (b+ ) b(t) ≥ for t ≥ (f+ ) f (x, t) ≥ for x ∈ Ω and t ≥ (g+ ) g(x, t) ≥ for x ∈ ∂Ω and t ≥ (f2 )+ There exist an open subset Ω0 of Ω and r1 > ... (x) for x ∈ Ω and lim inf t→0 |F (x,t)| |t|r1 (x) < +∞ uniformly for x ∈ Ω ¯ (g5 ) There exists r2 ∈ C (Ω) such that < r2 (x) < p∗ (x) for x ∈ ∂Ω and lim inf t→0 |G(x,t)| |t|r2 (x) < +∞ uniformly ... exist an open subset Ω0 of Ω and r1 > such that lim inf t→0 F (x,t) |t|r1 >0 uniformly for x ∈ Ω0 (g2 ) There exists r2 > such that lim inf t→0 G(x,t) |t|r2 > uniformly for x ∈ ∂Ω (H2 ) β2 r1...
Ngày tải lên: 20/06/2014, 21:20
báo cáo hóa học:" Existence and multiplicity of solutions for a fourth-order elliptic equation" potx
... R and a.e x in Ω, where a(x) ∈ Lq (Ω), b ∈ R and < p < N +4 N −4 if N > and < p < ∞ if N ≤ and q + p = 1; (H4) f (x, t) = o(|t|) as t → uniformly for x ∈ Ω ; (H5) There exists a constant Θ > and ... Existence and multiplicity of solutions for a fourth-order elliptic equation Fanglei Wang∗1 and Yukun An2 College Department of Science, Hohai University, Nanjing, 210098, P R China of Mathematics, ... (4) and (H5) Hence, I(tϕ1 ) ≤ l2 t2 ϕ1 2 − tΘ ϕ1 Θ Θ + C4 → −∞ as t → +∞ and part is proved Proof of Theorem 2.1 From Lemmas 2.2 and 2.3, it is clear to see that I(u) satisfies the hypotheses of...
Ngày tải lên: 21/06/2014, 17:20
Báo cáo hóa học: "Research Article On the Nonexistence and Existence of Solutions for a Fourth-Order Discrete Boundary Value Problem" doc
... Therefore, we have reduced the problem of finding a solution of 1.5 to that of seeking a critical point of the functional J defined on Rk In order to obtain the existence of critical points of J ... nonexistence of nontrivial solutions of BVP 1.5 Finally, in Section 4, we provide various sets of sufficient conditions on the existence of solutions of BVP 1.5 when f is superlinear, sublinear, and Lipschitz ... Moreover, in a special case of f we obtain a necessary and sufficient condition for the existence of unique solutions of BVP 1.5 To conclude the introduction, we refer to 21, 22 for the general background...
Ngày tải lên: 21/06/2014, 20:20
Báo cáo hóa học: "Research Article Existence and Uniqueness of Solutions for Higher-Order Three-Point Boundary Value Problems" ppt
... Ge, and X Lin, “Existence of solutions for a class of third-order nonlinear boundary value problems,” Journal of Mathematical Analysis and Applications, vol 294, no 1, pp 104–112, 2004 Y Feng and ... now formulate and prove our main results on the existence and uniqueness of solutions for nth-order three point boundary value problem 1.1 , 1.2 Theorem 3.1 Assume that i there exist lower and ... Hence x1 t is a solution of BVP 1.1 , 1.2 and satisfies 3.3 Now we give a uniqueness theorem by assuming additionally the differentiability for functions f, g and h, and a kind of estimating condition...
Ngày tải lên: 21/06/2014, 20:20
Báo cáo hóa học: " Research Article Existence and Uniqueness of Solutions for Singular Higher Order Continuous and Discrete Boundary Value Problems" pptx
... solution of 4.5 , then y i is a solutionn of 1.2 Proof Since we remark that x i is a solution of 4.5 , if and only if T K i, j λF j n − 1, T x j , Tx i x i n−1 , for ≤ i ≤ T 4.6 j Let y i for ≤ ... of 3.5 , then y t is a solution of 1.1 Further, if y t is a solution of 1.1 , imply that x t is a solution of 3.5 Let P {x ∈ C 0, | x t ≥ 0, for all t ∈ 0, } Obviously, P is a normal cone of ... 0, ∞ is continuous and nondecreasing; h : 0, ∞ → 0, ∞ is continuous and nonincreasing, and h may be singular at y Next, we consider the existence and uniqueness of solutions for the following...
Ngày tải lên: 22/06/2014, 00:20
Báo cáo hóa học: " Research Article Existence and Uniqueness of Solutions for Singular Higher Order Continuous and Discrete Boundary " doc
... solution of 4.5 , then y i is a solutionn of 1.2 Proof Since we remark that x i is a solution of 4.5 , if and only if T K i, j λF j n − 1, T x j , Tx i x i n−1 , for ≤ i ≤ T 4.6 j Let y i for ≤ ... of 3.5 , then y t is a solution of 1.1 Further, if y t is a solution of 1.1 , imply that x t is a solution of 3.5 Let P {x ∈ C 0, | x t ≥ 0, for all t ∈ 0, } Obviously, P is a normal cone of ... 0, ∞ is continuous and nondecreasing; h : 0, ∞ → 0, ∞ is continuous and nonincreasing, and h may be singular at y Next, we consider the existence and uniqueness of solutions for the following...
Ngày tải lên: 22/06/2014, 06:20
Báo cáo hóa học: " Stretching and immobilization of DNA for studies of protein–DNA interactions at the single-molecule level" ppt
... of force, namely gradient and scattering forces, are produced since the laser light can be both transmitted and reflected from the particle The gradient force is proportional to the gradient of ... 2:185–201 base sequence information from a single-stranded template and synthesizes the complimentary strand The differences between DNAP and RNAP include (1) catalyzing of addition of a new deoxyribonucleotide ... growing chain of DNA for DNAP while RNAP catalyzes the addition of NTP to the growing chain of RNA; and (2) DNAP requires a primer (a short piece of ssDNA annealed to the template strand) to initiate...
Ngày tải lên: 22/06/2014, 18:20
Báo cáo hóa học: "EXISTENCE AND MULTIPLICITY OF SOLUTIONS FOR SOME THREE-POINT NONLINEAR BOUNDARY VALUE PROBLEMS" pptx
... BVP (1.1λ ) X Xian and D O’Regan Proof Let z0 (t) = for t ∈ [0,1], and zλ (t) = λg(Rλ + 1)(Lτ z0 )(t) for t ∈ [0,1] Since L0 is increasing and g is nonincreasing, then we have for any n ∈ N, xn ... contradiction Therefore, β(t) ≥ un,λ (t) for t ∈ [0,1] Similarly, we can show that α(t) ≤ un,λ (t) for t ∈ [0,1] Thus, un,λ (t) is a positive solution of (2.1λ ) The proof is complete n Proof of the main ... (1.1λ ) has at least one positive solution The proof is complete Lemma 2.13 Let α(t) and β(t) be lower and upper solutions of (2.1λ ) for some n ∈ N and n λ > 0, ≤ α(t) ≤ β(t) Then (2.1λ ) has at...
Ngày tải lên: 22/06/2014, 22:20
Báo cáo hóa học: "BOUNDEDNESS AND VANISHING OF SOLUTIONS FOR A FORCED DELAY DYNAMIC EQUATION" pot
... behavior of solutions of (1.1) Theorem 3.1 If (H1), (H2), (H3) hold, then every solution of (1.1) goes to zero in the limit Proof If x is a nonoscillatory solution of (1.1), assume without loss of ... as n → ∞ By the choice of Xn , the solution x of (1.1) satisfies limt→∞ x(t) = Douglas R Anderson 15 Corollary 3.2 If (H1) and (H3) hold, then every solution of the unforced equation xΔ (t) + ... equations, Journal of Mathematical Analysis and Applications 234 (1999), no 1, 77–90 [13] C Qian and Y Sun, Global attractivity of solutions of nonlinear delay differential equations with a forcing term,...
Ngày tải lên: 22/06/2014, 22:20
Báo cáo hóa học: "CONVERGENCE AND PERIODICITY OF SOLUTIONS FOR A CLASS OF DIFFERENCE SYSTEMS" potx
... u ≤ σ, f (u) = −1 if u > σ, for some constant σ ∈ R The aim of this paper is to investigate the convergence and periodicity of solutions for system (1.1) as f is of the digital nature (1.2), ... input-output relation of a neuron For simplicity, let N denote the set of all nonnegative integers, and define N(m) = {m,m + 1,m + 2, }, N(m,n) = {m,m + 1, ,n} for any m,n ∈ N and m ≤ n Moreover, ... I33 (1.10) By a solution of the system (1.1), we mean a sequence {(xn , yn )} of points in R2 that is defined for all n ∈ N(1) and satisfies (1.1) for n ∈ N(1) Clearly, for any (x0 , y0 ) ∈ R2 ,...
Ngày tải lên: 22/06/2014, 22:20
Báo cáo hóa học: "EXISTENCE AND MULTIPLICITY OF SOLUTIONS FOR A CLASS OF SUPERLINEAR p-LAPLACIAN EQUATIONS" potx
... Foundation of China (No 10471113) and by the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, China References [1] A Ambrosetti and P H ... ) = +∞ uniformly in a.e x ∈ Ω, where a ∈ L∞ (Ω) satisfies a(x) ≤ λ1 for all x ∈ Ω and a(x) < λ1 on some Ω ⊂ Ω with |Ω | > 0, λ1 is the first eigenvalue of −Δ p and |Ω | is the measure of Ω Then ... [6] for p = 2, and recently by Liu and Li in [9] for general p > We can easily prove that Assumption 1.2 is equivalent to Assumption 1.1 when θ = and Assumption 1.2 gives some general sense of...
Ngày tải lên: 22/06/2014, 22:20
THERMODYNAMIC MODELING, ENERGY EQUIPARTITION, AND NONCONSERVATION OF ENTROPY FOR DISCRETE-TIME pptx
... (M) and ᏺ(M) for the range space and the null space of a matrix M, respectively, spec(M) for the spectrum of the square matrix M, rank(M) for the rank of the matrix M, ind(M) for the index of ... (E), E ∈ R+ (4.8) Proof The proof is identical to the proofs of Theorems 3.5 and 3.11 For the statement of the next result, recall the definition of p = [1/β1 , ,1/βq ]T and define P diag[β1 , ... Specifically, if qA and qB denote 302 Thermodynamic modeling for discrete-time systems the number of subsystems in ᏳA and ᏳB , respectively, and βA and βB denote the total energies of ᏳA and ᏳB , respectively,...
Ngày tải lên: 23/06/2014, 00:20