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... percentile) BMI 97th percentile (z-score, 2.0 or more) Hypertriglyceridaemia Low HDL-cholesterol Hyperglycaemia Hypertension Hypercholesterolemia High LDL-cholesterol Features of metabolic syndrome{ or ... Hispanic female diagnosed with cirrhotic-stage non-alcoholic steatohepatitis (NASH) at 11 years of age, when she presented with a BMI of 26.9 kg/m2, hypercholesterolaemia and hypertriglyceridaemia ... (kg/m2) Abdominal pain at presentation Obesity (BMI.95th percentile) Dyslipidaemia Hypertriglyceridaemia Hypercholesterolaemia Hypertension ALT (IU/l) AST (IU/l) Glucose (mg/dl) Cholesterol (mg/dl)...

Ngày tải lên: 22/03/2014, 10:20

... room temperature for h After washing six times with Tween/PBS, 100 μL of streptavidin-horse-radish peroxidase was added into the wells, and the plates were allowed to incubate at room temperature ... generated after combining with chemiluminescence ELISA reagent (Boehringer Mannheim, Germany) according to the manufacturer’s instructions The intensities of the chemiluminescence reactions in the ... 58.9 ± 7.3 Male:Female 27:19 39:16 Alcoholic:non-alcoholic 30:16 30:25 Portal vein invasion NA 11 Single nodule Two nodules NA NA 14 10 ≥ nodules NA 18 NA: Not applicable Kemik et al World Journal...

Ngày tải lên: 09/08/2014, 03:22

... intestinal lumen into the systemic circulation and the absorbed endotoxin will rapidly be removed by monocytes, particularly resident kupffer cells within the liver However, emerging evidence indicates ... monoclonal antibodies, in a system absent of membrane bound CD14, blocked monocyte activation [25] Furthermore, that the introduction of sCD14, present in replacement serum, initiated the LPS/endotoxin ... reduced hepatic inflammation, as a direct result [19,20] However, the role of endotoxinaemia in human NAFLD remains unclear Prior studies have illustrated that bacterial overgrowth may impact on...

Ngày tải lên: 11/08/2014, 03:20

... intestinal lumen into the systemic circulation and the absorbed endotoxin will rapidly be removed by monocytes, particularly resident kupffer cells within the liver However, emerging evidence indicates ... monoclonal antibodies, in a system absent of membrane bound CD14, blocked monocyte activation [25] Furthermore, that the introduction of sCD14, present in replacement serum, initiated the LPS/endotoxin ... reduced hepatic inflammation, as a direct result [19,20] However, the role of endotoxinaemia in human NAFLD remains unclear Prior studies have illustrated that bacterial overgrowth may impact on...

Ngày tải lên: 11/08/2014, 06:22

... effects of Spirulina, such as its antihyperlipidemic and antihypertensive effects, were demonstrated at all doses [12] Although the exact biochemical mechanism by which Spirulina reduces lipid ... postprandial triacylglycerolemia Yakugaku Zasshi 2006, 126(1):43-49 15 Premkumar K, Abraham SK, Santhiya ST, Ramesh A: Protective effect of Spirulina fusiformis on chemical-induced genotoxicity ... showed normal results, with a hip-to-waist ratio of 0.90 His musculoskeletal system was also normal He noted an improvement in his general status during the treatment with Spirulina No adverse side-effects...

Ngày tải lên: 11/08/2014, 12:20

... Apolipoprotein E Mol Cell Biochem 42, 3–20 Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM & Breslow JL (1992) Severe hypercholesterolemia and atherosclerosis in apolipoprotein ... triglyceride-rich lipid emulsions in vitro and in vivo J Biol Chem 271, 14791–14799 Kypreos KE, Li X, Van Dijk KW, Havekes LM & Zannis VI (2003) Molecular mechanisms of type III hyperlipoproteinemia: the contribution ... Biochem 372, 222–226 Apolipoprotein E and diet-induced NAFLD 33 Kypreos KE & Zannis VI (2006) LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia...

Ngày tải lên: 05/03/2014, 23:20

... childbirth, and normal delivery, the hospital length of stay for females remained essentially unaltered (3.1 Æ 2.0 days, P value for males vs females ¼ 0.001) For chronic liver disease, the hospital length ... steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test Int J Obes Relat Metab Disord ... al Age- and sex-specific pediatric reference intervals for biochemistry analytes as measured with the Ektachem-700 analyzer Clin Chem 1988; 34:1622–5 41 Patton HM, Sirlin C, Behling C, et al Pediatric...

Ngày tải lên: 14/03/2014, 11:20

... index, improvement of insulin sensitivity, and improvement of biochemical and histological features were reported.[89] However the long-term effects of these medications on NAFLD remain to be ... histological follow-up, the efficacy of this approach remains uncertain Antihyperlipidemic agents may have a role in patients with significant dyslipidemia and increased risk for cardiovascular disorders ... conventional pulse sequence seems not to be a sensitive method for the detection of fat deposition in the liver.[60,61] The best results can be obtained with the use of gradient-echo chemical shift technique.[62]...

Ngày tải lên: 22/03/2014, 10:20

... Conference Panel Statement Management of hepatitis C Hepatology 1997; 26 (Suppl 1): 2S–10S 26 National Institutes of Health Consensus Development Conference Statement Management of Hepatitis C, ... hyperlipidaemia and hyperglycaemia Increased physical activity and low-fat diet improve insulin sensitivity and can, in some cases, reverse insulin resistance The value of exercise in improving glycaemic ... changes favouring weight gain (marriage, retirement, unemployment, antidepressants) Family history of type diabetes, NAFLD, vascular disorders or hyperlipidaemia Raised serum ferritin not attributable...

Ngày tải lên: 22/03/2014, 16:20

... systemic circulation Given that exposure to these particles may decrease the mitochondrial membrane potential, and may increase ROS, followed by cytochrome-c release and inner mitochondrial membrane ... steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test Int J Obes Relat Metab Disord ... (26) Diagnosis of Pediatric NAFLD 4.1 Biochemical Tests Liver biopsy is the gold standard for diagnosis, but giv- en that it is not feasible in large epidemiological studies, surrogate markers such...

Ngày tải lên: 29/03/2014, 18:20

... histology and measurement of triglyceride content Fresh liver sections were fixed in 4% paraformaldehyde, dehydrated, embedded in paraffin, and sectioned Formalin-fixed, paraffin-embedded sections ... (Figure 1), and mice in these groups remained healthy GH1 gene expression in AFLD mice We observed the development of the typical histological and biochemical features of liver steatosis in the ... malic enzyme; nSREBP-1: nuclear sterol regulatory element binding protein 1; SCD1: stearoyl coenzyme A desaturase 1; SREBP-1, sterol regulatory element binding protein n = mice per group Means without...

Ngày tải lên: 18/06/2014, 16:20

... at room temperature The membranes were washed three times in phosphate-buffered saline (PBS; 10 mM sodium phosphate (pH7.4) and 0.9% NaCl) between adding antibodies The Imaging System (Gel Doc ... (Invitrogen) was used to transfer proteins to a polyvinylidene difluoride (PVDF) membrane After using 0.5% milk to blot the PVDF membrane for 30 min, CRP and Hp were detected by a mouse anti-CRP immunoglobulin ... adding antibodies The Imaging System (Gel Doc XR System, Bio-Rad) was used to acquire images depending on a moderate exploration time and to semi-quantify protein expressions Clinical serum collection...

Ngày tải lên: 10/08/2014, 10:20

... Conference Panel Statement Management of hepatitis C Hepatology 1997; 26 (Suppl 1): 2S–10S 26 National Institutes of Health Consensus Development Conference Statement Management of Hepatitis C, ... hyperlipidaemia and hyperglycaemia Increased physical activity and low-fat diet improve insulin sensitivity and can, in some cases, reverse insulin resistance The value of exercise in improving glycaemic ... changes favouring weight gain (marriage, retirement, unemployment, antidepressants) Family history of type diabetes, NAFLD, vascular disorders or hyperlipidaemia Raised serum ferritin not attributable...

Ngày tải lên: 10/08/2014, 15:20

... free radicals [32], and a role for hyperinsulinaemia is suggested Quinones-Galvan et al [33] demonstrated that acute physiological hyperinsulinaemia enhances the oxidative susceptibility of LDL-cholesterol ... define the contemporary presence of diabetes and/or impaired glucose tolerance, hypertriglyceridaemia, low HDL-cholesterol and hypertension He pointed out the role of hyperinsulinaemia and insulin ... and are suitable for epidemiological purposes The limits for individual components (central obesity, hypertension, hypertriglyceridaemia, low HDL-cholesterol and hyperglycaemia) are derived from...

Ngày tải lên: 10/08/2014, 15:20

... [57] Survivors develop spontaneous atrophy of WAT with concomitant hyperinsulinaemia, hyperglycaemia, hypertriglyceridaemia and steatosis Signal transducer and activator of transcription-5 (STAT5) ... by a semisynthetic diet rich in sucrose Proc Natl Acad Sci USA 1977; 74: 3550–4 24 Bogin E, Avidar Y, Merom M Biochemical changes in liver and blood during liver fattening in rats J Clin Chem Clin ... steatohepatitis Semin Liver Dis 2001; 21: 27–41 80 Selzner M, Clavien PA Fatty liver in liver transplantation and surgery Semin Liver Dis 2001; 21: 105–13 81 Teoh NC, Farrell GC Hepatic ischemia reperfusion...

Ngày tải lên: 10/08/2014, 15:20

... mitochondrial matrix into the mitochondrial intermembranous space Proton extrusion creates a large electrochemical potential across the inner membrane, thus creating a reservoir of latent potential ... mitochondrial membrane to permeabilize this membrane Bid also induces a conformational change in Bcl-2-associated x protein (Bax) and its analogue Bak, which translocate to the outer mitochondrial membrane ... channels in the outer mitochondrial membrane (Fig 11.5) Increased permeability of the outer mitochondrial membrane may release cytochrome c from the intermembranous space of some mitochondria,...

Ngày tải lên: 10/08/2014, 15:20

... diagnosis and management of fatty liver disorders However, as emphasized thematically throughout the book, NAFLD is the hepatic manifestation of the metabolic 182 syndrome, a systemic disorder with ... near epidemic proportions of the problems of diabetes, overnutrition and obesity in industrialized and developing nations, primary care physicians will also bear the brunt for case management While ... Hypertriglyceridaemia Hypertension Complete abstinence from alcohol Family history VARIABLES: Weight loss Exercise Nutrition Anti-diabetic R treatment Anti-lipidemic R treatment Herbal remedies Toxic...

Ngày tải lên: 10/08/2014, 15:20

... Baseline Baseline Up to 12 Placebo No improvement Histology Improved No improvement ND No improvement Improvement Improved* ND ND, not done * Improvement in the inflammation, ballooning, Mallory ... noted with gemfibrozil compared to baseline values, and this did not occur in the untreated patients Body weight remained unchanged during treatment, and improvement in liver tests seemed to be ... and hepatomegaly show improvement in symptoms of hepatomegaly when appropriate control of hyperglycaemia is achieved Hypertriglyceridaemia, rather than hypercholesterolaemia, is a risk factor for...

Ngày tải lên: 10/08/2014, 15:20

... abdominal obesity, hyperinsulinaemia, dyslipidaemia and essential hypertension Children with NASH also demonstrate insulin resistance, hyperinsulinaemia and hyperlipidaemia Thus, paediatric NASH should ... distribution varies by race In San Diego, we diagnose Demographics Publications describing paediatric NASH over the past 20 years demonstrate remarkable concordance for gender and age (Table 19.2) ... cirrhosis may demonstrate physical findings such as ascites, splenomegaly or palmar erythema Clinical evaluation In all series of biopsy-proven paediatric NAFLD, patients uniformly demonstrate elevated...

Ngày tải lên: 10/08/2014, 15:20

... for a histological grading scheme for NAFLD/NASH that is ‘valid, precise and standardizable across research sites’ Such a scheme could generate quantitative or semi-quantitative data that improves ... potential therapeutic agents Regrettably, in most of the new studies employing either medical or surgical management, where improvement was assessed by comparison of scores in pre- and post-treatment ... for a histological scoring and grading system for nonalcoholic liver disease Liver Int 2005; 25: (in press) Brunt EM Nonalcoholic steatohepatitis Semin Liver Dis 2004; 24: 3–20 Clouston AD, Powell...

Ngày tải lên: 10/08/2014, 15:20