efficient document similarity search
Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf
Ngày tải lên :
18/02/2014, 08:20
... assays. However, the
same cells were efficiently killed by interferon-c. This effect was counter-
acted by the STAT3 oligodeoxynucleotide, which was found to efficiently
inhibit STAT1. Thus, although ... oligodeoxy-
nucleotide was added to a colon carcinoma cell line in which it induced cell
death as efficiently as the STAT3 inhibitor stattic. The hairpin STAT3
oligodeoxynucleotide co-localized with ... Efficient killing of SW480 colon carcinoma cells by a
signal transducer and activator of transcription...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
Ngày tải lên :
18/02/2014, 12:20
... and
K
0.5
= K
m
.
Acknowledgements
This work was supported by grants from the Danish
Research council and the Novo Nordic Research
Council. The skilful technical assistance of Marianne
Lauridsen is gratefully ... as indicated by con-
cave Hofstee plots of v versus v ⁄ s (insets to the kinetic
plots), Hill coefficients < 1 and high K
0.5
values
(Table 1). All of the tetrameric forms showed approxi-
mately ... the molecular mass, as the standard varia-
tion in V
e
⁄ V
0
for the markers was less than 2% (coefficient
of variation) from 20 separate marker elution profiles.
Fractions (200 lL) were collected...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
Ngày tải lên :
19/02/2014, 17:20
... extracellular
Na
+
concentrations. The solid lines represent fits of the Hill equa-
tion with Hill coefficients of n ¼ 1.3 for the wild type GAT1 and
n ¼ 1 for the mutants (as used previously by Liu ... synthesized
proteins in the ER. If N-glycosylation is inhibited,
some glycoproteins fail to fold or assemble efficiently,
resulting in a prolonged retention in the ER and an
increased proteolytic breakdown ... 7.2).
Acknowledgements
This work was supported in part by the Special Funds
for Major State Basic Research of China (Grant
G1999053907), a grant from the Chinese Academy of
Sciences, a grant from...
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Tài liệu Efficient Pattern Matching over Event Streams doc
Ngày tải lên :
19/02/2014, 18:20
... that expands dur-
ing event processing, the backtrack algorithm processes runs
in a depth first search manner. That is, we process the sin-
gleton run until it either fails or produces a result ... singleton run. Our basic algorithm, on
the other hand, expands the “run tree” in a breadth first
search manner; it creates and evaluates all runs at once.
5.3 Memory Management
There are a number ... window, called
the pruning timestamp. We use the pruning timestamp
as a key to perform a binary search in each stack of the
5
Regular expression matching in network intrusion detection sys-
tems...
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Tài liệu Báo cáo khoa học: Efficient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units ppt
Ngày tải lên :
20/02/2014, 01:20
... ribozymes
that are structurally optimized and which, in addition to cleavage, catalyse
efficient RNA ligation. The most efficient variant ligated its appropriate
RNA substrate with a single turnover rate ... substrate
and the ribozyme seems to be most favourable for
an efficient reaction among the studied species.
HP–RJWTA7 is also an efficient endonuclease; it
cleaves the substrate S40F3F5 with k
obs
¼ ... stability of the pro-
perly folded substrate–ribozyme complex. Strikingly,
the hairpin ribozyme is an efficient ligase if the ribo-
zyme substrate complex is folded into a stable secon-
dary and tertiary...
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Tài liệu Báo cáo khoa học: "Efficient Online Locality Sensitive Hashing via Reservoir Counting" ppt
Ngày tải lên :
20/02/2014, 04:20
... a
prediction of a running sum being positive or negative.
States are numerically labeled to reflect the similarity to
a small bit integer data type, one that never overflows.
transitions. Assuming a fixed ... June.
Shane Bergsma and Benjamin Van Durme. 2011. Learn-
ing Bilingual Lexicons using the Visual Similarity of
Labeled Web Images. In Proc. of the International
Joint Conference on Artificial Intelligence ... Linguistics (ACL).
Thorsten Brants and Alex Franz. 2006. Web 1T 5-gram
version 1.
Moses Charikar. 2002. Similarity estimation techniques
from rounding algorithms. In Proceedings of STOC.
Michel X. Goemans...
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Tài liệu Báo cáo khoa học: "Computationally Efficient M-Estimation of Log-Linear Structure Models∗" doc
Ngày tải lên :
20/02/2014, 12:20
... 2003. Shallow parsing with conditional
random fields. In Proc. of HLT-NAACL.
A. Stolcke. 1995. An efficient probabilistic context-free pars-
ing algorithm that computes prefix probabilities. Computa-
tional ... 752–759,
Prague, Czech Republic, June 2007.
c
2007 Association for Computational Linguistics
Computationally Efficient M-Estimation of Log-Linear Structure Models
∗
Noah A. Smith and Douglas L. Vail and John ... (and decoding under
them) is tractable only when the model’s indepen-
dence assumptions permit efficient inference proce-
dures. For example, in the original conditional ran-
dom fields (Lafferty...
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Báo cáo khoa học: A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis doc
Ngày tải lên :
05/03/2014, 23:20
... concentrations were determined spectropho-
tometrically by absorbance at 280 nm, using an extinction
coefficient of 0.98 for a 1 mgÆmL
)1
solution [35]. Coenzyme
concentrations were also determined spectrophotometrically
using ... spectrophotome-
ter) due to the production of NAD(P)H at 340 nm, using a
millimolar extinction coefficient of 6.22 m
M
)1
Æcm
)1
. All rate
measurements were performed in triplicate and the results
shown ... inhibition of glutamate
dehydrogenase results from disruption of subunit
interactions necessary for efficient catalysis
Jaclyn Bailey
1
, Lakeila Powell
2
, Leander Sinanan
3
, Jacob Neal
3
, Ming...
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Báo cáo khoa học: Efficient and targeted delivery of siRNA in vivo pdf
Ngày tải lên :
06/03/2014, 01:23
... achieving efficient and targeted
siRNA delivery in vivo.
Acknowledgement
This work was supported by NSF CAREER Award
(DMR-0956091) and a Council on Research Comput-
ing and Libraries Research Grant ... efficiency
via efficient cytosolic release with high resistance to
serum and low cytotoxicity [129]. It was demonstrated
that ketalized linear polyethylenimine ⁄ siRNA poly-
plexes were efficiently ... silencing
because they were entrapped in the endosomes even
after efficiently entering cells [117]. Photostimulating
fluorescently labeled TAT efficiently released TAT–
siRNA conjugates from the endosome,...
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Báo cáo khoa học: "Exploring Deterministic Constraints: From a Constrained English POS Tagger to an Efficient ILP Solution to Chinese Word Segmentation" ppt
Ngày tải lên :
07/03/2014, 18:20
... heuristics such as forward maxi-
mum match (Sproat et al., 1996). Exact search is
possible with a Viterbi-style algorithm, but beam-
search decoding is more popular as used in (Zhang
and Clark, 2007) ... a beam (=5) search.
on the development set, we set beam-width of our
baseline model as 5. Our baseline model, which
uses Ratnaparkhi (1996)’s feature set and conducts
a beam (=5) search in the ... deterministic constraints first be-
fore a probabilistic search, i.e. for some words, the
number of possible tags is reduced to 1, the search
space is reduced to T
m
, where m is the number of
(unconstrained)...
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Báo cáo khoa học: "Efficient Third-order Dependency Parsers" pdf
Ngày tải lên :
07/03/2014, 22:20
... Linguistics,
24(4):613–632.
Tadao Kasami. 1965. An Efficient Recognition and
Syntax-analysis Algorithm for Context-free Lan-
guages. Technical Report AFCRL-65-758, Air
Force Cambridge Research Lab.
Terry Koo, Amir Globerson, ... ex-
pressive third-order factorizations while retaining
an efficient O(n
4
) runtime. In fact, our third-
order parsing algorithms are “optimally” efficient
in an asymptotic sense. Since each third-order ... has proven to be a very use-
ful syntactic formalism, due in no small part to the
development of efficient parsing algorithms (Eis-
ner, 2000; McDonald et al., 2005b; McDonald
and Pereira, 2006;...
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Báo cáo khoa học: "Efficient Staggered Decoding for Sequence Labeling" pptx
Ngày tải lên :
07/03/2014, 22:20
... staggered
decoding efficiently performs the search step. For
this purpose, we can basically use the Viterbi algo-
rithm. In earlier iterations, the Viterbi algorithm is
indeed efficient because the ... this idea to other NLP tasks is still
unclear.
Approximate algorithms, such as beam search
or island-driven search, have been proposed for
speeding up decoding. Tsuruoka and Tsujii (2005)
proposed ... calculated in the
search step. This can be done by retaining the
best path among those consisting of only active
labels. The score of that path is obviously the
lower bound. Since the search step is...
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Báo cáo khoa học: "An Efficient Indexer for Large N-Gram Corpora" docx
Ngày tải lên :
07/03/2014, 22:20
... hence efficient ac-
cessing of the N-gram frequencies becomes an is-
sue. Trivial methods such as linear or binary search
over the entire dataset in order to access a single
N-gram prove inefficient, ... given to be in order of a few
seconds. Other tools that implement a binary search
algorithm as a simpler, yet less efficient method are
also given in (Giuliano et al., 2007; Yuret, 2007).
3 The ... balanced search tree where each
node has several children. Indexing large files us-
ing B
+
trees is a popular technique implemented
by most database systems today as the underlying
structure for efficient...
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Báo cáo khoa học: "Efficient, Feature-based, Conditional Random Field Parsing" potx
Ngày tải lên :
08/03/2014, 01:20
... pieces of information. Firstly, each
word is annotated with a distributional similarity tag,
from a distributional similarity model (Clark, 2000)
trained on 100 million words from the British ... tenfold.
3 Stochastic Optimization Methods
Stochastic optimization methods have proven to be
extremely efficient for the training of models involv-
ing computationally expensive objective functions
like ... sev-
eral passes through the data in order to satisfy suffi-
cient descent conditions placed on line searches. In
our experiments SGD converged to a lower objective
function value than L-BFGS, however...
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Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc
Ngày tải lên :
08/03/2014, 08:20
... RNA after the 5¢-NHH-3¢
sequence, where N is A, U, C or G and H is A, U or C
[32], with the most efficient cleavage of the substrate
possessing the triplet GUC or CUC [23]. The messenger
RNA of ... interference
(RNAi) phenomena [36,37]. The power of RNAi is
remarkable, because it can serve as a very efficient
sequence-specific tool for gene silencing. RNAi is a valuable
therapeutic tool for drug ... designed for endogenous generation of siRNA [40–44].
As our tRNA-driven ribozyme transcripts are efficiently
exported from the nucleus to the cytoplasm, where they meet
their target mRNA, this expression...
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