guibased efficient medline search tool

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... assays. However, the same cells were efficiently killed by interferon-c. This effect was counter- acted by the STAT3 oligodeoxynucleotide, which was found to efficiently inhibit STAT1. Thus, although ... oligodeoxy- nucleotide was added to a colon carcinoma cell line in which it induced cell death as efficiently as the STAT3 inhibitor stattic. The hairpin STAT3 oligodeoxynucleotide co-localized with ... Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription...

Ngày tải lên: 18/02/2014, 08:20

... and K 0.5 = K m . Acknowledgements This work was supported by grants from the Danish Research council and the Novo Nordic Research Council. The skilful technical assistance of Marianne Lauridsen is gratefully ... as indicated by con- cave Hofstee plots of v versus v ⁄ s (insets to the kinetic plots), Hill coefficients < 1 and high K 0.5 values (Table 1). All of the tetrameric forms showed approxi- mately ... the molecular mass, as the standard varia- tion in V e ⁄ V 0 for the markers was less than 2% (coefficient of variation) from 20 separate marker elution profiles. Fractions (200 lL) were collected...

Ngày tải lên: 18/02/2014, 12:20

... extracellular Na + concentrations. The solid lines represent fits of the Hill equa- tion with Hill coefficients of n ¼ 1.3 for the wild type GAT1 and n ¼ 1 for the mutants (as used previously by Liu ... synthesized proteins in the ER. If N-glycosylation is inhibited, some glycoproteins fail to fold or assemble efficiently, resulting in a prolonged retention in the ER and an increased proteolytic breakdown ... 7.2). Acknowledgements This work was supported in part by the Special Funds for Major State Basic Research of China (Grant G1999053907), a grant from the Chinese Academy of Sciences, a grant from...

Ngày tải lên: 19/02/2014, 17:20

... that expands dur- ing event processing, the backtrack algorithm processes runs in a depth first search manner. That is, we process the sin- gleton run until it either fails or produces a result ... singleton run. Our basic algorithm, on the other hand, expands the “run tree” in a breadth first search manner; it creates and evaluates all runs at once. 5.3 Memory Management There are a number ... window, called the pruning timestamp. We use the pruning timestamp as a key to perform a binary search in each stack of the 5 Regular expression matching in network intrusion detection sys- tems...

Ngày tải lên: 19/02/2014, 18:20

... ribozymes that are structurally optimized and which, in addition to cleavage, catalyse efficient RNA ligation. The most efficient variant ligated its appropriate RNA substrate with a single turnover rate ... substrate and the ribozyme seems to be most favourable for an efficient reaction among the studied species. HP–RJWTA7 is also an efficient endonuclease; it cleaves the substrate S40F3F5 with k obs ¼ ... (2003) Ribozymes: recent advances in the development of RNA tools. FEMS Microbiol Rev 27, 75–97. 5 Rimmele M (2003) Nucleic acid aptamers as tools and drugs: recent developments. Chembiochem 4, 963–971. 6...

Ngày tải lên: 20/02/2014, 01:20

... Patil, Emily Pitler, Rachel Lathbury, Vikram Rao, Kapil Dalwani, and Sushant Narsale. 2010. New Tools for Web-Scale N-grams. In Proceedings of LREC. Patrick Pantel, Eric Crestan, Arkady Borkovsky,...

Ngày tải lên: 20/02/2014, 04:20

... design; our estimator avoids normalization altogether. 8 The M-estimator may also be useful as a tool in design- ing and selecting feature combinations, since more trials can be run in less time. ... 2003. Shallow parsing with conditional random fields. In Proc. of HLT-NAACL. A. Stolcke. 1995. An efficient probabilistic context-free pars- ing algorithm that computes prefix probabilities. Computa- tional ... 752–759, Prague, Czech Republic, June 2007. c 2007 Association for Computational Linguistics Computationally Efficient M-Estimation of Log-Linear Structure Models ∗ Noah A. Smith and Douglas L. Vail and John...

Ngày tải lên: 20/02/2014, 12:20

... concentrations were determined spectropho- tometrically by absorbance at 280 nm, using an extinction coefficient of 0.98 for a 1 mgÆmL )1 solution [35]. Coenzyme concentrations were also determined spectrophotometrically using ... spectrophotome- ter) due to the production of NAD(P)H at 340 nm, using a millimolar extinction coefficient of 6.22 m M )1 Æcm )1 . All rate measurements were performed in triplicate and the results shown ... inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis Jaclyn Bailey 1 , Lakeila Powell 2 , Leander Sinanan 3 , Jacob Neal 3 , Ming...

Ngày tải lên: 05/03/2014, 23:20

... achieving efficient and targeted siRNA delivery in vivo. Acknowledgement This work was supported by NSF CAREER Award (DMR-0956091) and a Council on Research Comput- ing and Libraries Research Grant ... efficiency via efficient cytosolic release with high resistance to serum and low cytotoxicity [129]. It was demonstrated that ketalized linear polyethylenimine ⁄ siRNA poly- plexes were efficiently ... silencing because they were entrapped in the endosomes even after efficiently entering cells [117]. Photostimulating fluorescently labeled TAT efficiently released TAT– siRNA conjugates from the endosome,...

Ngày tải lên: 06/03/2014, 01:23

... heuristics such as forward maxi- mum match (Sproat et al., 1996). Exact search is possible with a Viterbi-style algorithm, but beam- search decoding is more popular as used in (Zhang and Clark, 2007) ... a beam (=5) search. on the development set, we set beam-width of our baseline model as 5. Our baseline model, which uses Ratnaparkhi (1996)’s feature set and conducts a beam (=5) search in the ... deterministic constraints first be- fore a probabilistic search, i.e. for some words, the number of possible tags is reduced to 1, the search space is reduced to T m , where m is the number of (unconstrained)...

Ngày tải lên: 07/03/2014, 18:20

... Linguistics, 24(4):613–632. Tadao Kasami. 1965. An Efficient Recognition and Syntax-analysis Algorithm for Context-free Lan- guages. Technical Report AFCRL-65-758, Air Force Cambridge Research Lab. Terry Koo, Amir Globerson, ... ex- pressive third-order factorizations while retaining an efficient O(n 4 ) runtime. In fact, our third- order parsing algorithms are “optimally” efficient in an asymptotic sense. Since each third-order ... has proven to be a very use- ful syntactic formalism, due in no small part to the development of efficient parsing algorithms (Eis- ner, 2000; McDonald et al., 2005b; McDonald and Pereira, 2006;...

Ngày tải lên: 07/03/2014, 22:20

... staggered decoding efficiently performs the search step. For this purpose, we can basically use the Viterbi algo- rithm. In earlier iterations, the Viterbi algorithm is indeed efficient because the ... this idea to other NLP tasks is still unclear. Approximate algorithms, such as beam search or island-driven search, have been proposed for speeding up decoding. Tsuruoka and Tsujii (2005) proposed ... calculated in the search step. This can be done by retaining the best path among those consisting of only active labels. The score of that path is obviously the lower bound. Since the search step is...

Ngày tải lên: 07/03/2014, 22:20

... 76203 rada@cs.unt.edu Abstract We introduce a new publicly available tool that implements efficient indexing and re- trieval of large N-gram datasets, such as the Web1T 5-gram corpus. Our tool indexes the entire Web1T dataset ... hence efficient ac- cessing of the N-gram frequencies becomes an is- sue. Trivial methods such as linear or binary search over the entire dataset in order to access a single N-gram prove inefficient, ... most pop- ular toolkits that are also freely available are the CMU Statistical Language Modeling (SLM) Toolkit (Clarkson and Rosenfeld, 1997), and the SRI Lan- guage Modeling Toolkit (Stolcke,...

Ngày tải lên: 07/03/2014, 22:20