drug discrimination and development of novel agents and pharmacological tools
development of novel micro-embossing methods and microfluidic designs for biomedical applications
Ngày tải lên :
14/11/2014, 13:26
... design and implementation of necessary microfluidic functions; integration of these functions with complete automation; and development of cost-effective manufacturing technology [Madou 2001] Microfluidics ... proteins and contaminating the microfluidic channels 1.3 Outline Chapter contains a comprehensive literature review of microfabrication and and microfluidics Chapter contains experimental and simulation ... substrate), and (c) photo of a single assay………………… …… 52 Photograph of channel produced with IR embossing of high density polyethylene (a) cross section the mold replicate (b) and (c) top and...
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Investigation of new properties and applications of quadruplex DNA and development of novel oligonucleotide based topoisomerase i inhibitors
Ngày tải lên :
11/09/2015, 16:04
... INVESTIGATION OF NEW PROPERTIES AND APPLICATIONS OF QUADRUPLEX DNA AND DEVELOPMENT OF NOVEL OLIGONUCLEOTIDEBASED TOPOISOMERASE I INHIBITORS WANG YIFAN ... Protection and Elongation 1.2.2.3.3 Interaction of Small-Molecule with G-Quadruplex 1.3 i-Motif Structure of DNA 10 10 1.3.1 Discovery of i-Motif Form of DNA 11 1.3.2 Stoichiometries and Topologies of ... analysis of self-cleavage of Oligonucleotide in the presence of mM transition metal ions (Zn2+, Pb2+, Ni2+, Co2+ and Mn2+) 45 PAGE analysis of self-cleavage of Oligonucleotide in the presence of 20...
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Development of novel chitosan based hollow fiber membranes for applications in water treatment and bioengineering
Ngày tải lên :
14/09/2015, 08:49
... of free and immobilized lipase for batch hydrolysis reaction 4.2.5 Effect of pH and temperature on the activity of lipase 4.2.6 Effect of pH and temperature on the stability of free and immobilized ... continuous love, support and encouragement I TABLE OF CONTENTS ACKNOWLEDGEMENT I TABLE OF CONTENTS II SUMMARY V LIST OF FIGURES VIII LIST OF TABLES XII LIST OF SYMBOLS LIST OF NOMENCLATURE XIII XV ... Objectives and scopes of this study CHAPTER LITERATURE REVIEW 12 2.1 Introduction of membrane and membrane process 2.2 Mass transfer and selectivity of membranes 2.3 Classification of membranes...
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Development of novel positively charged single isomer cyclodextrins and applications in enatiomeric separation and chiral synthesis 1
Ngày tải lên :
16/09/2015, 08:30
... 110 Effect of pH and CD concentration on EOF 111 Effect of pH on migration times 112 3 Effect of pH on enantioseparation of acid analytes …………….114 Effect of β-CDNH2 concentration ... ability of mono-amino CDs 124 Comparison of the resolution ability between β-CD-NH2 and β-CD-NH3Cl: Effect of BGE pH values 124 Comparison of the resolution ability between β-CD-NH2 and ... separation of mixture of Dns-amino acids with ALAMCDCl 86 Part II Chiral recognition ability of mono-alkylammonium cationic β-CDs 88 Influence of BGE pH on the enantioseparation of anionic...
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Development of novel positively charged single isomer cyclodextrins and applications in enatiomeric separation and chiral synthesis
Ngày tải lên :
16/09/2015, 08:30
... above, the key aim of this project focuses on the development of a novel family of positively charged single-isomer CDs and their application in the enantioseparation of acidic and neutral compounds ... required for market approval of a racemate of chiral drugs Single enantiomer drug sales have shown a continuous growth worldwide since 1996 and many of the top-selling drugs are marketed as single ... firm, 40% of all dosage-form drug sales in 2000 were of single enantiomers [21-23] Figure Worldwide Sales of single enantiomeic drugs until 2003 and expected for the year 2005 Researchers and economic...
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Development of novel and efficient biocatalytic systems for oxidoreductions in pharmaceutical synthesis
Ngày tải lên :
30/09/2015, 06:27
... materials, elimination of waste and avoiding the use of toxic and/ or hazardous reagents and solvents in the manufacture and application of chemical products 45,90 Furthermore, the use of enzymes generally ... Advantages and applications of tandem catalysis 50 2.6.1.1 Chemo-chemo tandem catalysis 51 2.6.1.2 Chemo-bio tandem catalysis 52 2.6.2 Advantages and applications of tandem biocatalysis ... Prof Li Zhi and Prof Daniel I C Wang Prof Li’s patient guidance through my entire PhD candidature led me to a world full of excitement and challenges He not only taught me the basic skills and...
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Development of novel drug delivery system lipid microemulsion of tributyrin
Ngày tải lên :
16/09/2015, 08:30
... means of administering aqueous insoluble drugs by dissolution of the drugs within the oil phase [Lundberg, 1997 and 1994; Strickley and Anderson, 1993; Tarr et al., 1987] or to prevent drug hydrolysis ... delivery of increased doses and more frequent dosing schedules 1.2 Colloidal Drug Carriers The fate of a drug in vivo administration is determined by a combination of several processes: for example drugs ... properties of the drug and therefore on its chemical structure During the last few decades, much work has been directed toward the development of delivery systems which will allow the fate of drugs...
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A Development of Novel Integral Method for Prediction of Distorted Inlet Flow Propagation_2 docx
Ngày tải lên :
21/06/2014, 21:20
... distortion level, the radius of curvature of outlet size of distorted region tends to be increased whatever the inlet size of distorted region is 92 Chapter A Development of Novel Integral Method ξ ... 0.9 1.0 Fig 4.12 The predicted outlet size of distorted region vs α ( ) with higher inlet size of distorted region of 0.5 94 Chapter A Development of Novel Integral Method 0.22 ξ (0) = 0.1 0.20 ... then will increase with the increasing of incident angle Therefore, the results are presented in two figures: Fig 4.6 and Fig 4.8 90 Chapter A Development of Novel Integral Method o β α (0) = 0.1...
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Báo cáo y học: "Safety concerns on the development of novel therapeutic drugs" docx
Ngày tải lên :
09/08/2014, 08:22
... the mechanisms of action and off-target effects of a drug can be gained An understanding of the molecular mechanisms that are triggered by a substance possibly may widen its field of indication ... enzymes, drug transporters, or drug targets are studied and linked to the patient’s response to a drug A number of studies have been conducted in rheumatoid arthritis patients with the aim of predicting ... about pathophysiological mechanisms can be gained and differences in the activation of human and animal cells detected This is of special interest for novel therapeutic strategies that are specifically...
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Development of novel amino acid derived multifunctional phosphines for enantioselective reactions
Ngày tải lên :
09/09/2015, 10:06
... FANGRUI Table of Contents Acknowledgements i Thesis Declaration iii Table of Contents iv Summary x xiii List of Tables List of Schemes xv List of Figures xx List of Abbreviations xxii List of Publications ... I have benefited from Prof Lu, a professional chemist and supervisor, will have an extraordinary impact to my future life Among all the past and present members in Prof Lu’s group, I would like ... me and being my soul mate It was extremely fortunate for me to meet her, her endless love, support, and encouragement have helped me make key developments in my life, both professionally and...
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Development of novel chiral stationary phases for HPLC based on covalently bonded polysaccharide derivatives
Ngày tải lên :
14/09/2015, 08:40
... used for identification of adulterated foods and beverages, evaluation of food storage, evaluation of flavor and fragrance, and analysis of chiral metabolites of chiral and prochiral food components.21 ... advice and constant encouragement during my studies i Table of Contents Acknowledgements Table of Contents Summary List of Tables List of Figures List of Schemes List of Structures Abbreviations and ... toxic.7,8 With the development of technology to produce and analyze single enantiomer on a commercial scale, the US Food and Drug Administration issued a formal guideline on chiral drug development...
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Development of novel microextraction methods with application to environmental analysis
Ngày tải lên :
15/09/2015, 17:09
... analysis of acidic drugs (ibuprofen, naproxen, and ketoprofen) in aqueous samples and in human urine [75], chiral drugs in biological matrices [76], drugs from human breast milk [77], and protein-bound ... VS CS and CW are the analyte concentration in the SBSE and aqueous phase mS and mW are the mass of analyte in SBSE and aqueous phase, respectively V S and VW are the volumes of the coating and ... images of ZSM-5 coated layer 41 2.3.3 44 Structure and sorptive properties of ZSM-5 2.3.4 Effect of extraction time 45 2.3.4 Repeatability and reproducibility 46 2.3.5 Linearity and limits of detection...
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Part development of novel methods for the synthesis of homoallylic alcohols part II multigrams synthesis of ( ) epibatidine
Ngày tải lên :
16/09/2015, 17:11
... Synthetic Route 183 iii SUMMARY PART I: Development of Novel Methods for the Synthesis of Homoallylic Alcohols In the development of novel methods for the synthesis of homoallylic alcohols, two conceptual ... amount of the branched homoallylic adduct 104 was isolated Given the success of the development of a standard substrate for the crotyl transfer, Table demonstrates a broad scope of the effect of ... : DEVELOPMENT OF NOVEL METHODS FOR THE SYNTHESIS OF HOMOALLYLIC ALCOHOLS PART II : MULTIGRAM SYNTHESIS OF (−)-EPIBATIDINE KEN LEE CHI LIK B.Sc (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF...
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Development of novel deNPAC catalysts for treatment of diesel engine exhaust
Ngày tải lên :
04/10/2015, 15:57
... SBA/SP-5 and SBA-15 102 Fig 6.9 NOx yield on free spinel, SBA/SP-5 and SBA-15 103 xi List of Tables and Scheme List of Tables and Scheme Table 1.1 The exhaust composition of diesel and Otto engines ... patterns of Cu/SBA-15 at different temperatures Fig 3.4 and Fig 3.5 demonstrate the isotherms of N2 adsorption and desorption, and the distribution of pore sizes of SBA-15, Cu/SBA-15 and CuO/SBA-15 ... 400 ℃ (Gland and Korchak, 1978; Bradley et al., 1995) A reaction mechanism of ammonia oxidation has been proposed by Mieher and Ho (1995) and Sobczyk et al (2004) and The dissociation of ammonia...
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Development of novel titanate nanotubesreduced graphene oxide composite for the removal of heavy metals from aqueous solution
Ngày tải lên :
12/10/2016, 10:22
... characteristic D and G bands at 1346 cm-1 and 1589 cm1 found in GO and the composite The D band is common feature for sp defects in carbon, and the G band provides information on plane vibrations of sp ... growing sector of industries, expansion of population, and urbanization have largely contributed to the severe contamination of water, air and soil Chemical and fertilizers use in domestic and agricultural ... region of analysis to the range between 800 and 1950 cm-1 (for nitrogenized films up to 2250 cm-1) The G band normally appears between 1480 and 1580cm-1, and the D band occurs between 1320 and 1440cm-1...
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Development and applications of novel solvent minimized techniques in the determination of chemical warfare agents and their degradation products
Ngày tải lên :
14/09/2015, 14:08
... Optimization of parameters for HF-LPME of chemical agents 91 4.3.2 Method validation for HF-LPME of chemical agents 96 4.3.3 Comparison of HF-LPME of chemical agents with SPME 97 4.3.4 Optimization of ... had the privilege of working under the expert guidance of Prof Lee Hian Kee and Dr Chanbasha Basheer of the Department of Chemistry at the National University of Singapore and would like to thank ... control agents Vomiting agents cause nausea and vomiting and can also induce cough, headache, and nose and throat irritation The vomiting agents are typically solids which when heated, vaporize and...
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Báo cáo hóa học: " Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus" pot
Ngày tải lên :
20/06/2014, 23:20
... thankful to Professor Les Copeland (Faculty of Agriculture, Food and Natural Resources - The University of Sydney, New South Wales, Australia) and Professor Kaeko Kamei (Department of Biomolecular ... alignment of fragments obtained from MS/MS analyses of FIII-1 and FIII-2 from P excavatus with lumbrokinase and its precursor from L rubellus (sp:P83298 and U25647) and E fetida (gpu:EU167737 and AY438624), ... 37 and 70°C for hours, and the remaining activity (expressed as % of the activity at 37°C) was determined after 30, 60, 120 and 180 minutes Determination of optimal pH and pH-tolerance Page of...
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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx
Ngày tải lên :
22/06/2014, 00:20
... entrapment and/ or delivery of a variety of biological agents [8] Alginate is a co-polymer extracted from some types of brown algae and it is made up of two uronic acids: D-mannuronic acid and L-guluronic ... Nikon) and with NIS Elements imaging software Number of cells and neurite length have been monitored with the image analysis software ‘‘ImageJ’’ (freely downloadable from the National Institutes of ... acquire most of the characteristic properties of sympathetic neurons Other salient responses to NGF include cessation of proliferation, generation of long neurites, acquisition of electrical...
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Báo cáo sinh học: "Drug-therapy networks and the prediction of novel drug targets" docx
Ngày tải lên :
06/08/2014, 18:21
... various drug- target and related networks, for predicting new drug targets, and to get around unwanted resistance and side effects of drugs These tools promise to increase the number of novel drug ... the analysis and visual representation of drug- therapy and drug- target networks, the weight of the links (such as the number of drugs binding to both of two linked targets in the drug- target network) ... the organization of the expanding drug- development data and give us a global view on major trends and limitations The advent of combinatorial therapies [2-4] and multi-target drugs [5] may greatly...
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