dna methylation and histone modifications in breast cancer
báo cáo khoa học: " Dynamics of DNA methylation and Histone H4 acetylation during floral bud differentiation in azalea" doc
Ngày tải lên :
12/08/2014, 03:21
... profiles in every phase, indicating that H4 deacetylation and DNA methylation cooperate in restructuring chromatin during floral development in azalea Discussion The floral transition in azalea involves ... tubulin and AcH4 of bud in phase B; Lane 3: tubulin and AcH4 of bud in phase C; Lane 4: tubulin and AcH4 of bud in phase D Marker bands are indicated to the left of the blot Different letters indicate ... proteins are involved in controlling the functional state of chromatin and gene expression [14,22,23] Histone acetylation and DNA methylation can activate or repress transcription by generating...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
Ngày tải lên :
23/03/2014, 17:20
... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of ... efficient in apoptosis induction DNA- damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006) ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible...
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TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER pot
Ngày tải lên :
27/06/2014, 11:20
... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of ... efficient in apoptosis induction DNA- damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006) ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible...
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báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx
Ngày tải lên :
10/08/2014, 10:21
... up-regulation in invasive cancers, including breast cancer After silencing of MTA1 gene, we investigated the alteration of tumor cells invasiveness using Boyden chamber assay mentioned in Albini’s[20] ... ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF7 in vitro Journal of ... cells in vitro The effects of inhibiting MTA1 gene on invasion of breast cancer cells were evaluated by Boyden chamber migration assay The invasion index before silencing MTA1 in MDA-MB-231 and...
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Investigating functions of ERp29 in mesenchymal to epithelial transition (MET) and epithelial plasticity in breast cancer cells
Ngày tải lên :
13/10/2015, 15:55
... upon in vivo tumor induction by oncogene myc These cells lacked epithelial-cytokeratins and E-cadherin while expressing mesenchymal-vimentin and fibronectin Considering its involvement in cancer ... Serving these vital roles are reticuloplasmins such as PDIs, Binding Protein (BiP), calreticulin, and endoplasmin These proteins have overlapping tasks such as protein-folding assistants and ... domain mediates lateral cell-cell contacts by forming homotypic binding with E-cadherin of neighboring cells Its cytoplasmic domain interacts with actin cytoskeleton via α-catenin and β-catenin...
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Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
Ngày tải lên :
09/08/2014, 09:20
... late toxicity in our series This finding opens the possibility to develop new predictor assays taking into account the initial DNA damage and radiation-induced apoptosis levels, and introduces new ... apoptosis in breast cancer patients Initial DNA damage was determined as radiationinduced double-strand breaks (DSB) in irradiated lymphocyte from all 26 LABC patients There was a wide variation in ... the study and has made the DNA- DSB experiments and analyses PCL has been involved in conception and design of the study and in drafting the manuscript and has given final approval of the version...
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European guidelines for quality assurance in breast cancer screening and diagnosis pot
Ngày tải lên :
15/03/2014, 00:20
... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring and ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
Ngày tải lên :
30/03/2014, 03:20
... truncated BRCA1 or induce apoptosis in a cell line expressing mutated BRCA1 The data in Figs and suggest that TRAIL can alter BRCA1 localization and induce apoptosis in breast cancer cells Therefore, ... to increase We observed an increase in HIF-1a protein, and thus were confident that the cells were being maintained in a low-oxygen environment and were responsive to low oxygen There is also increasing ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
Ngày tải lên :
18/06/2014, 16:20
... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... profiles in lung cancer The advantages of MS-MLPA technique as an alternative for MS-PCR include: allowing screening of multiple predefined promoter methylation candidates in one experiment using...
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Báo cáo y học: "Physical Exercise and Quality of Life in Breast Cancer Survivors" potx
Ngày tải lên :
08/08/2014, 16:23
... exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer ... other diseases, and extending survival in cancer survivors Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer survivors and that this effect ... few in number, however, and of limited quality Further research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL in cancer...
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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
Ngày tải lên :
09/08/2014, 01:24
... cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal objective of this study was to determine the relationship between serum IL-6 and CRP levels and staging and prognosis ... prognosis in breast cancer patients Page of immunoassay The sandwich principle was used and the total duration of assay took 18 minutes The measuring range of IL-6 is 1.5-5000 pg/ml(defined by ... TNM staging system of breast cancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer, ...
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báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
Ngày tải lên :
09/08/2014, 01:24
... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ... design and coordination and helped to draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received:...
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Báo cáo khoa học: "Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer" potx
Ngày tải lên :
09/08/2014, 03:21
... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant ... Rome Breast Cancer Study Group: Sentinel lymph node biopsy in women with pT1a or “microinvasive” breast cancer Breast 2008, 17:395-400 Zavagno G, Belardinelli V, Marconato R, Carcoforo P, Franchini ... stromal invasion Furthermore, having less than 0.5 cm of stromal invasion increases the incidence of sentinel lymph node metastases [15,16] As a result, many investigators insist that sentinel lymph...
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Báo cáo khoa học: "Postmastectomy locoregional recurrence and recurrence-free survival in breast cancer patients" pdf
Ngày tải lên :
09/08/2014, 03:21
... Stefanick ML: Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized ... contraceptives and prognosis in breast cancer: effects of duration, latency, recency, age at first use and relation to parity and body mass Page of 39 40 41 42 index in young women with breast cancer ... new era in breast cancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer...
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Báo cáo khoa học: "Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer" ppsx
Ngày tải lên :
09/08/2014, 04:21
... carcinoma of breast treated between July, 2008 and March, 2009 at The 181 Hospital and Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in ... results, including variability in tissue fixation and processing, variable sensitivity and specificity of commercially available antibodies, and differences in scoring criteria with considerable interobserver ... variability in interpretation of results [23] Our study is trying to answer a simpler question about the concordance between IHC and FISH in our local setting in Guilin city of China, using some...
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Báo cáo khoa học: "Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer" docx
Ngày tải lên :
09/08/2014, 07:21
... of lymph vessels leading to Sentinel nodes and the number of Sentinel nodes Single rout and Single node Multi routs and single node Single rout and multi nodes Multi routs and multi nodes 151(68%) ... detailed investigation Our results showed that there was a single route leading to a single SN in 68% of the patients, multiple routes leading to a single SN in 4%, a single route leading to multiple ... H, Inaji H: Sentinel node biopsy for breast cancer: technical aspects and controversies Breast Cancer 2007, 14:25-30 Giuliano AE, Jones RC, Brennan M, Statman R: Sentinel lymphadenectomy in breast...
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Báo cáo khoa học: "A biologically competitive 21 days hypofractionation scheme with weekly concomitant boost in breast cancer radiotherapy feasibility acute sub-acute and short term late effects" pot
Ngày tải lên :
09/08/2014, 09:20
... recurrence and cosmetic outcome [6-8] In order to intensify treatment, a simultaneous boost dose, concomitant or integrated, has been introduced in clinics by using 3-D conformal radiotherapy or intensity-modulated ... had stage I-II breast carcinoma as defined by the international Union Against Cancer (fifth edition) and had gone through macroscopic total resection of the primary tumor and sentinel node biopsy ... Freedman GM, Andersson PR, Goldstein LJ, Ma CM, Li J, Swaby RF, Litwin S, Watkins-Bruner D, Sigurdson ER, Morrow M: Four-week course of radiation for breast cancer using hypofractionated intensity...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
Ngày tải lên :
09/08/2014, 09:20
... clavicular fossa and above the seventh rib Any relapse involving the axillary lymph nodes, and/ or other nodes in the infra or supraclavicular fossa or in the internal mammary chain was considered ... supraclavicular and internal mammary lymph nodes alone) Local recurrence was defined as any relapse in the area of surgery between the sternum and the anterior axillary line, and below the inferior ... crude way of defining a potential indication for PMRT More information may come from other clinicopathologic parameters (e.g., capsule and lymphovascular invasion, malignancy grading, etc.) Moreover,...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
Ngày tải lên :
09/08/2014, 10:21
... both in monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding ... substrate binding domains, Leucine zipper, ATP-binding domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative ... Risk for developing breast cancer The association between any variant in the ATM gene and risk of breast cancer was computed by comparing the 95 cancer free women and the 272 breast cancer patients...
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báo cáo khoa học: " Gene expression and hypoxia in breast cancer" doc
Ngày tải lên :
11/08/2014, 12:21
... cervical and ovarian cancer EZN-2208 undergoing evaluation in phase trials for treatment of metastatic breast and colorectal cancer (www.clinicaltrials.gov) Doxorubicin and Anthracyclines Inhibits binding ... that can influence cell survival and growth through changes in several signaling pathways that are involved in protein synthesis, autophagy, apoptosis and metabolism [29] Intriguingly, mTOR and HIF1 ... Inhibits binding of HIF‑1α to the HRE sequence daunorubicin Anthracyclines licensed to treat breast, bladder and lung cancer, several hematological malignancies and sarcoma Echinomycin Quinoxaline antibiotic...
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