core shell nanoparticles for drug delivery and molecular imaging

... designed for systemic delivery of drug and/ or gene 181 5.1.3 Encapsulation of drug molecules Two model drug compounds, indomethacin and pyrene, were encapsulated into P(MDS-co-CES) and P(MDA-co-CEA) ... importantly, after drug loading, size distribution became much more uniform and narrow possibility because of the interaction between the drug and the core- forming segment cholesterol The drug- loaded ... amine and quaternary ammonium It can be hydrolyzed and is used as the shell- forming segment Cholesterol is the pendant group and used as the core- forming segment The positive...

Ngày tải lên: 16/09/2015, 15:54

... be used for drug and gene delivery As introduced in Chapter 2, nanoscale size of polymer micelles makes them an ideal carrier for drug or gene delivery [Jones M-C, 1999; Merdan T., 2002] Nanoparticles ... buffer) 4.3 Encapsulation of model drugs To evaluate the possibility of using the polymers for codelivery of drug and gene, two model drug compounds, indomethacin and pyrene, were encapsulated into ... as the core- forming block and to produce positive charges on the main chain The successful synthesis of P(MDS-co-CES) and P(MDA-coCEA) was evidenced by 1H-NMR and FTIR spectra Figure 4.7 and Figure...

Ngày tải lên: 16/09/2015, 15:54

... solution was allowed to stand for 30 minutes before use 3.11.3.2 Animal surgery and delivery of the complexes Albino guinea pigs weighing between 250 and 300 g were used for this study The animals ... A loaded nanoparticles solution was firstly freeze-dried and then dissolved in 1ml ethanol and then filtered by using 0.2μm of filter paper and analyzed for CyA levels using high-performance ... indomethacin, 273 nm for pyrene, 266 nm for paclitaxel, and 277nm for verapamil The standard curves were obtained by preparing standard indomethacin pyrene, paclitaxel and verapamil solutions with different...

Ngày tải lên: 16/09/2015, 15:54

... researchers have applied polymeric micelles’ characteristics for drug delivery 2.1.4 Polymeric micelles as drug delivery carrier Delivery systems for drugs used in the treatment of human diseases have ... over other forms of drug carriers because of their core- shell structure, low CMC and targeting ability 2.1.4.1 Core of polymeric micelles as a reservoir for hydrophobic therapeutics The core of ... nanoparticles [Lee J H., 2003] and drug- polymer conjugates [Lu Z-R et al., 2000] are the commonly used formulations for drug delivery The polymeric micelles were first proposed as a drug carrier by Bader...

Ngày tải lên: 16/09/2015, 15:54

... blank and drug- loaded core- shell nanoparticles, and structural integrity of core- shell nanoparticles during the DNA binding process, • Testing cytotoxicity of the core- shell nanoparticles and examining ... polymers and utilizing these polymers to fabricate cationic core- shell nanoparticles (i.e micelles) for codelivery of drugs and genes, • Pegylating the amphiphilic polymers using PEG of various molecular ... complexes In these formulations, the drug and gene were administered by separate injections However, in order to achieve synergistic effect of drug and gene therapies, both the drug and gene have...

Ngày tải lên: 16/09/2015, 15:54

... gratitude and appreciation for their support and encouragement over the years of my study And my special thanks and appreciation to my wife and my daughter for their encouragement and patience ... been developed as a drug delivery system (DDS) for many peptide and protein drugs (Chan and Heng, 1998) An ideal DDS is able to control the drug concentration at the target site for a desired period ... reduced drug loss and possible controlled drug release It is widely known that poly (lactic-co-glycolic) acid (PLGA) is able to sustain drug release for a prolonged period of time and is therefore...

Ngày tải lên: 13/09/2015, 20:39

... al., 2010) Therefore, lipid shell and polymer core nanoparticles with antitumor targeting would be an ideal nanoscale drug delivery system for hydrophobic drugs such as docetaxel and paclitaxel ... insufficient drug loading, faster drug release and storage instability Meanwhile, nanoparticles can provide high drug encapsulation efficiency for hydrophobic drugs and controlled drug release ... SYNTHESIS AND CHARACTERIZATION OF LIPID SHELL 44 AND POLYMER CORE NANOPARTICLES 3.1 Introduction 44 3.2 Materials 45 3.3 Methods 45 3.3.1 Preparation of Lipid Shell and Polymer Core Nanoparticles...

Ngày tải lên: 09/10/2015, 11:18

... are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis ... varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and the continuous delivery ... staying there for me and watching over me I also would like to thank my parents and the rest of my family, for their understanding and continual support I would like to thank my mum and dad for their...

Ngày tải lên: 14/09/2015, 11:17

... discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, and Chapter 12 for gene delivery Finally, the fourth section ... Monkhouse and Christopher T Rhodes 88 Development and Formulation of Veterinary Dosage Forms: Second Edition, Revised and Expanded, edited by Gregory E Hardee and J Desmond Baggot 89 Receptor-Based Drug ... T Rhodes 122 Surfactants and Polymers in Drug Delivery, Martin Malmsten 123 Transdermal Drug Delivery: Second Edition, Revised and Expanded, edited by Richard H Guy and Jonathan Hadgraft 124...

Ngày tải lên: 04/06/2014, 15:15

... cycles of 94°C for min., 58°C for and 72°C for MSV F &MSVR : PCR conditions consisted of 30 cycles of 94°C for min, 59°C for and 72°C for mins C1F &C2R: PCR conditions consisted of 94°C for 10 mins ... conditions consisted of 30 cycles of 94°C for min, 58°C for and 72°C for mins JSP001 &JSP002: PCR conditions consisted of 30 cycles of 94°C for min, 45°C for and 72°C for mins Uni F &Uni R: K = G + T, ... 94°C for 30 secs., 60°C for and 72°C for 1.5 mins followed and extension of mins at 72°C AC1F &AC1R : PCR conditions consisted 94°C of mins followed by 35 cycles of 94°C for 30 secs, 58°C for and...

Ngày tải lên: 19/06/2014, 08:20

... cycles of 94°C for min., 58°C for and 72°C for MSV F &MSVR : PCR conditions consisted of 30 cycles of 94°C for min, 59°C for and 72°C for mins C1F &C2R: PCR conditions consisted of 94°C for 10 mins ... conditions consisted of 30 cycles of 94°C for min, 58°C for and 72°C for mins JSP001 &JSP002: PCR conditions consisted of 30 cycles of 94°C for min, 45°C for and 72°C for mins Uni F &Uni R: K = G + T, ... 94°C for 30 secs., 60°C for and 72°C for 1.5 mins followed and extension of mins at 72°C AC1F &AC1R : PCR conditions consisted 94°C of mins followed by 35 cycles of 94°C for 30 secs, 58°C for and...

Ngày tải lên: 20/06/2014, 04:20

... of the alkoxides and covalent coupling through the SH group of Figure Absorption and PL spectra of CdSe QDs Page of MTMS, a mixed layer of SiO and TiO is formed above the CdSe nanoparticles The ... from dispersion and comparing the 665 nm absorption peak with the spectrum of pure MB in aqueous solution The results are shown in Figure for the CdSe/TiO2 nanoparticles and for commercial TiO ... min-1 As the TiO2 shell cannot absorb blue light, the observed photodegradation process at 405 nm must originate from Figure Absorption spectra of CdSe QDs and CdSe/TiO2 coreshell nanoparticles Fontes...

Ngày tải lên: 21/06/2014, 03:20

... oxidized quickly For PbSe/CdSe core/ shell structures, 123 CdSe shells effectively prevent PbSe cores from the quick oxidation The lifetime of PbSe QDs under ambient conditions therefore can be extended ... 10.81, 9.45, and 8.36 nm, respectively They are in good Fig LUMO and HOMO structures for 4.8 nm PbSe QDs and 0.35 nm CdSe shell agreement for the experimental data taking account of the effect of surface ... (a) and PbSe/CdSe (b) QDs The CdSe shells prevent PbSe core from the destructive oxidation Compared with the unstable PbSe core, the PbSe/CdSe QDs remained unchanged Different crystal lattices and...

Ngày tải lên: 21/06/2014, 17:20

... core shell architecture (Ni as core and Co as shell) and studies on their structural and magnetic properties 165 Experimental Alumina membranes (AAO template, Whatman) of high purity and uniform ... for h, and then Ni is electrodeposited using NiSO4Á6H2O also for h This has resulted into Ni-filled Co nanotubes (Ni @ Co nanorods) of length 15 lm and of diameter *150 nm The formation of a core shell ... electrode, and platinum was used as the counter electrode 0.2 M Cobalt acetate was used as the precursor for electrodeposition for making cobalt nanotubes, and the deposition was carried out for a...

Ngày tải lên: 22/06/2014, 00:20

... singlecomponent macromolecular capsules by using solid core and mesoporous shell (SC/MS) silica particles as templates The process involves the infiltration of polyelectrolyte or polymer -drug conjugates ... and causing tumor cell death The attachment of targeting ligands to the drug- conjugated capsules through established coupling protocols will further provide functional capsules for targeted drug ... properties, and the additional ability to post-functionalize the thick capsule shells, provides exciting new opportunities for designing advanced capsules for use in a range of therapeutic and diagnostic...

Ngày tải lên: 22/06/2014, 01:20

... NB and CAS helped to perform the experiments, design the study and draft the manuscript GP, P-AG, CG and ED helped to design the study, participated in the analysis and interpretation of data and ... helped to perform the experiments and design the study, participated in the analysis and interpretation of data and helped to draft and critically review the manuscript All authors read and approved ... of 2.2, reached for PBS-treated animals in the presence and absence of a magnet at days and after injection In groups treated with DXM suspension and microparticles embedding DXM and SPIONs, a...

Ngày tải lên: 09/08/2014, 14:20

... Reminders for prescribing of antibiotics and drugs for asthma, COPD, and dyslipidaemia 23*/53/3,496 Sum scores for appropriate prescribing of antibiotics, statins, cholesterollowering drugs or drugs for ... guidelines for use of aspirin, oestrogen or calcium, ACEIs, heparin prophylaxis, and b-blockers Alerts for drug allergies 6*/276/5,219 and drug- drug interactions, and options for cost-effective ... Additional file 1: Study methods scores for trials of drug prescribing Methods scores for the included studies Additional file 2: CCDSS characteristics for trials of drug prescribing CCDSS characteristics...

Ngày tải lên: 10/08/2014, 11:20

... Network of Drug Users (VANDU), a drug- user led organization, formed the Injection Support Team (IST) The IST responds to the unique needs of this population by providing peer-based education and support ... provided written informed consent At baseline and semi-annually, participants complete an interviewer-administered questionnaire, which elicits demographic data, and information regarding drug use, injection ... injectors and individuals who require assistance with injection for CIRI care [25,26] Importantly, drug user led organizations have been emerging globally and have demonstrated that drug users...

Ngày tải lên: 11/08/2014, 18:20

... plasma drug bound to albumin The flux of bound drug is similarly a function of θδS and B There are two versions for all transport parameters, one for free DOX (typically subscripted by F) and one for ... depends on both F and B, but only free drug is actually transported, and μ and υ only appear in the equation for F Transport across cell membranes at a given spatial point depends upon drug concentration ... vessel and tumor tissue The osmotic reflection coefficient for albumin, σ, is between and in most tissues, and approaches in skeletal muscle and the brain [21] Page of 20 (page number not for citation...

Ngày tải lên: 13/08/2014, 16:20

... CELLULAR AND MOLECULAR IMAGING 1.1 EMERGENCE OF CELLULAR AND MOLECULAR IMAGING 1.2 CELLULAR AND MOLECULAR IMAGING MODALITIES 1.2.1 Biomarkers 1.2.2 Molecular Imaging Probes ... M, Weissleder R Molecular imaging in drug discovery and development Nat Rev Drug Discov 2003;2(2):123-131 Gross S, Piwnica-Worms D Molecular imaging strategies for drug discovery and development ... roles in management and treatment of pathology 1.2.2 Molecular Imaging Probes Molecular imaging probes, on the other hand, are molecular compounds that can be sensed by an imaging modality They...

Ngày tải lên: 11/09/2015, 10:01