clinical relevance of cancer stem cells

Báo cáo y học: "Population genetics of cancer cell clones: possible implications of cancer stem cells" pptx

Ngày tải lên : 13/08/2014, 16:20

... by comparison of the relative strength of selection with non -stem cells could furthermore provide a method of testing the relative strength of selection of stem cells and non -stem cells and thereby ... this process The inclusion of cancer stem cells into models of clonal evolution leads to the prediction that in cancers which contain stem cells, clonal evolution of stem cells may be considerably ... size of tumour, because of the much smaller number of stem cells, clonal evolution is predicted to be faster in stem cells compared to non -stem cells What are the mechanisms by which one cancer...

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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations

Ngày tải lên : 03/10/2015, 20:57

... Currently, there are limited data to support the clinical relevance of cancer stem cells Taking into consideration that the working mechanisms of the cancer stem- cell concept may incorporate many molecular ... minority of cancer stem cells These cancer stem cells possess tumour-related features such as uncontrolled growth and the ability to form metastases They also maintain their inherent stem cell ... the cancer stem- cell concept, tumours are not merely simple monoclonal expansions of transformed cells, but complex tissues where 12 abnormal growth is driven by a minority of cancer stem cells...

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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc

Ngày tải lên : 09/08/2014, 02:21

... development of resistance to tamoxifen itself due to clonal selection of breast cancer cells that grow in the presence of tamoxifen [4,6] An in vitro study of cells derived from tumors of postmenopausal ... Segaloff A, Rubens RD: Assessment of response to therapy in advanced breast cancer: a project of the Programme on Clinical Oncology of the International Union Against Cancer, Geneva, Switzerland Cancer ... doi:10.1186/1477-7819-9-101 Cite this article as: Agrawal et al.: Clinical relevance of “withdrawal therapy” as a form of hormonal manipulation for breast cancer World Journal of Surgical Oncology 2011 9:101 Submit your...

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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps

Ngày tải lên : 10/08/2014, 05:21

... P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... basal/ stem cells Patch1 and Smo were found highly expressed in the P63+ basal /stem cells of the pCX-shh-IG-injected prostates, being located in the cell membrane of P63+ basal cells in regions of ... biology of the prostate: stem cell biology Urology 2003, 62:11-20 Bonkhoff H: Role of the basal cells in premalignant changes of the human prostate: a stem cell concept for the development of prostate...

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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx

Ngày tải lên : 10/08/2014, 09:22

... Page 13 of 13 18 Seo DC, Sung JM, Cho HJ, Yi H, Seo KH, Choi IS, Kim DK, Kim JS, ElAty AMA, Shin HC: Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer ... et al.: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung An FFPE proteomic study Journal of Clinical Bioinformatics 2011 1:23 ... markers of cancer stem cells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor prognosis, which are common characteristics of LCNEC...

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báo cáo khoa học: " MicroRNAs involved in neoplastic transformation of liver cancer stem cells" pot

Ngày tải lên : 10/08/2014, 10:20

... According to the hierarchical model of cancer, the origin of the cancer stem cells may be long-lived somatic stem cells Therefore, markers of “normal” stem cells are being sought with the expectation ... neoplastic mechanism of liver cancer stem cells Conclusions This work provides an in vivo model for the study of mechanisms of neoplastic transformation of liver cancer stem cells by separately ... carcinogenesis and differentiation of normal stem cells strongly suggest that miRNA may be involved in the transformation of normal stem cells into cancer stem cells Therefore, screening for differences...

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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc

Ngày tải lên : 10/08/2014, 10:20

... al Journal of Experimental & Clinical Cancer Research 2010, 29:174 http://www.jeccr.com/content/29/1/174 cancer stem cells http://www.mirbase.org/ Thus, the identification of cancer stem cell-related ... regulatory factor in cancer cells, even cancer stem cells Another example is miR21, which has been reported to have extensive roles and is expressed in embryonic stem cells [29], neuronal cells [30] and ... understanding of the complex picture of BCSCs and assisting cancer biologists and clinical oncologists in designing and testing novel therapeutic strategies Sun et al Journal of Experimental & Clinical Cancer...

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Báo cáo y học: " Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions" pps

Ngày tải lên : 14/08/2014, 08:21

... primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing concentrations of PTL Cells ... comprising less than 0.1% of the tumor mass, has many of the properties of cancer stem cells [4] In particular, self renewal, extended lifespan (compared to normal stem cells) , a high invasive ... cultures of cancer stem cells is likely to be important for maintaining gene expression patterns similar to cancer stem cells in vivo Genome Biology 2008, 9:R83 Genome Biology 2008, Cancer BPH...

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Characterization of the secretion of mesenchymal stem cells and its relevance to cardioprotection

Ngày tải lên : 10/09/2015, 08:42

... interventions28 Mesenchymal Stem Cells In The Treatment Of Acute Myocardial Infarction With the emergence of stem cells as potential regenerative medicine, attempts to use stem cells to reduce infarct ... Mesenchymal stem cells and their potential as cardiac therapeutics Circ Res 95, 9–20 Quesenberry, P.J., Aliotta, J.M., 2008 The paradoxical dynamism of marrow stem cells: considerations of stem cells, ... CHARACTERIZATION OF THE SECRETION OF MESENCHYMAL STEM CELLS AND ITS RELEVANCE TO CARDIOPROTECTION LAI RUENN CHAI (B.Eng (Hons.)), NTU A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY NUS...

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Báo cáo khoa học: Epigenetics: the study of embryonic stem cells by restriction landmark genomic scanning pptx

Ngày tải lên : 23/03/2014, 07:20

... study of embryonic stem cells TE N Hattori and K Shiota ICM PGC TS cells Placental cells 77 ES cells 49 EG cells Embryonic cells Fig Epigenetic distances between ES cells and other stem cells ... methylation proﬁles Epigenetic study of embryonic stem cells Differences in DNA methylation proﬁles between ES and other stem cells Comparing ES cells with other stem cells established from developing ... establishment of embryonic stem (ES) cells, which maintain the ability to form all types of cells in the body, and can differentiate into a variety of cell types in vitro [8] The use of ES cells in...

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differentiation of embryonic stem cells

Ngày tải lên : 11/04/2014, 00:32

... TABLE OF CONTENTS Development of Hematopoietic Repopulating Cells from Embryonic Stem Cells The In Vitro Differentiation of Mouse Embryonic Stem Cells into Neutrophils 10 Development and Analysis of ... Murine Embryonic Stem Cells 11 Development of Lymphoid Lineages Embryonic Stem Cells In Vitro from 12 Probing Dendritic Cell Function by Guiding the Differentiation of Embryonic Stem Cells 13 Gene ... and Human Embryonic Stem Cells 29 Growth and Differentiation Monkey ES Cells of Cynomolgus 30 Isolation, Characterization, and Differentiation of Human Embryonic Stem Cells HIROFUMI SUEMORI NORIO...

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báo cáo hóa học:" Implantation of neural stem cells embedded in hyaluronic acid and collagen composite conduit promotes regeneration in a rabbit facial nerve injury model" doc

Ngày tải lên : 18/06/2014, 15:20

... immunohistochemical staining of BrdU and S-100 Representative images of immunohistochemical staining of BrdU and S-100 A: Localization of darkly brownish stained BrdU+ cells to transected tissues of rabbits having ... 7042014 of the National Science Foundation of Beijing, China, the 50573044 of the National Natural Science Foundation of China and the 2005CB623905 of the National Basic Research Program of China ... protruding processes Immunofluorescence staining of β-tubulin, GFAP and GalC demonstrated positive expressions in a substantial number of cells, suggesting that neurosphere-derived cells were able to...

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Báo cáo hóa học: "Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects" ppt

Ngày tải lên : 18/06/2014, 16:20

... Induced pluripotent stem cells Induced pluripotent stem cells (iPSCs) from somatic cells are revolutionizing the field of stem cells Obtained by reprogramming somatic stem cells of a patient through ... here lies in implantation of hepatic stem cells, or in implantation of hepatic cells obtained by differentiation of a different type of stem cell, such as mesenchymal stem cells Other applications, ... the event of autologous implantation, but induced pluripotent stem cells are at least, if not more capable than those from adult (stem) cells Mesenchymal stem cells Although adult stem cells are...

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báo cáo hóa học:" Ovarian cancer: emerging concept on cancer stem cells" docx

Ngày tải lên : 20/06/2014, 07:20

... Origin of cancer stem cells Self-renewal and differentiation potentials are the features of stem cells Origin of cancer stem cells Self-renewal and differentiation potentials are the features of stem ... stem cells, progenitor cells, mature cells, and cancer cells The genetic program controlling self-renewal and differentiation plays a key role in the genesis of cancer stem cells (Figure 1) Cancer ... hypothesis is that cancer stem cells are caused by transforming mutations occurring in multi-potential stem cells, tissue-specific stem cells, progenitor cells, mature cells, and cancer cells described...

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báo cáo hóa học:" Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor" docx

Ngày tải lên : 20/06/2014, 07:20

... phenomenon of MSCs was confirmed in different experimental systems [2,12] Other cell types, such as umbilical cord matrix stem cells (UCMS) [14], neural stem cells [15,16] and endothelial progenitor cells ... delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells Stem Cells 2007, 25(7):1618-26 12 Komarova S, Kawakami Y, Stoff-Khalili MA, Curiel DT, Pereboeva L: Mesenchymal progenitor cells ... localization advantage, compared to unmodified cells Given complexity of the processes of biodistribution and homing of injected cells, we reasoned that an effect of engineered cell targeting would be...

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Báo cáo khoa học: "In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood" ppt

Ngày tải lên : 07/08/2014, 18:21

... tnecseroulf gniwollof ehT SBP htiw semit eerht desnir erew selpmas ehT Co73 ta h rof sllec eht htiw detabucni erew seidobitna yramirp ehT ylevitcepser ,PAFG rof 002 : dna ESN rof 002 : ta ares ... 001-X notirT %4.0 neht dna ,nim rof enoteca %001 ,nim 01 rof lonahtem %001 dloc eci htiw detaert neht erew yehT erutarepmet moor ta nim 01 rof SBP ni edyhedlamrof %7.3 htiw dexif neht dna SBP ... llec gnimrofrep dna esu lacinilc rof SBF gnisu tuohtiw oviv xe sCSM dnapxe ot sdohtem dnif ot deen ew dna ,hcraeser ruo rof SBF desu ew ,yduts tneserp ni ,revewoH noitarefilorp sCSM rof noitidnoc...

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Báo cáo y học: "The clinical relevance of autoantibodies in scleroderma" pdf

Ngày tải lên : 09/08/2014, 01:21

... as few as 75% of patients with SSc with an overall diagnostic sensitivity of 85% and specificity of 54% when tested by IIF as published in a recent meta-analysis [10] The presence of anti-Scl-70 ... specificity and sensitivity of ANA vary depending on the antigen substrate used for the assay The use of HEp2 cells yields a better sensitivity for the detection of nuclear antigens present during ... can predict the future development of SSc [32–36] The presence of ACA has long been strongly associated with CREST, a variant of SSc, defined by the presence of calcinosis, Raynaud’s phenomenon,...

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Báo cáo y học: "An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue" pot

Ngày tải lên : 09/08/2014, 01:22

... accelerated degeneration of the treated IVD [18-24] An alternative cell source are adult stem cells, in particular, bone-marrow-derived mesenchymal stem cells (MSCs) The use of these cells would allow ... fluorescent protein (GFP)-infected cells Following identification of the position of injection site and the presence of GFP-labelled cells, serial sections in the area of the injection site were mounted ... by a number of groups worldwide is the use of autologous MSCs to aid in the regeneration of the IVD extracellular matrix To date, however, the optimum method of application of these cells for regeneration...

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