molecular biology of cancer stem cells

... by comparison of the relative strength of selection with non -stem cells could furthermore provide a method of testing the relative strength of selection of stem cells and non -stem cells and thereby ... number of stem cells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stem cells would result in a less dramatic difference Naugler Theoretical Biology ... size of tumour, because of the much smaller number of stem cells, clonal evolution is predicted to be faster in stem cells compared to non -stem cells What are the mechanisms by which one cancer...

Ngày tải lên: 13/08/2014, 16:20

... Impact of Molecular Biology on Cancer Treatment: I Therapeutic Targets on endothelial cells which are involved in angiogenesis[3] ERBB receptors belong to the epidermal growth factor (EGF) family of ... in the treatment of ER-positive breast cancer The finding that tamoxifen could inhibit the growth of breast cancer, but at the same time stimulate the growth of endometrial cancer in the nude ... function between normal cells and cancer cells provide molecular sites against which novel and selective chemotherapeutic agents might be targeted[44] A new class of anti -cancer agents {lipophilic...

Ngày tải lên: 29/03/2014, 01:20

... P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... G: Cellular and molecular biology of the prostate: stem cell biology Urology 2003, 62:11-20 Bonkhoff H: Role of the basal cells in premalignant changes of the human prostate: a stem cell concept ... development of prostate cancer Eur Urol 1996, 30:201-205 Collins AT, Maitland NJ: Prostate cancer stem cells Eur J Cancer 2006, 42:1213-1218 Lawson DA, Witte ON: Stem cells in prostate cancer initiation...

Ngày tải lên: 10/08/2014, 05:21

... Page 13 of 13 18 Seo DC, Sung JM, Cho HJ, Yi H, Seo KH, Choi IS, Kim DK, Kim JS, ElAty AMA, Shin HC: Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer ... Japan 4Dept of Structural Biology, Graduate School of Pharmaceutical Science Hokkaido, University, Hokkaido, Japan Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, ... markers of cancer stem cells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor prognosis, which are common characteristics of LCNEC...

Ngày tải lên: 10/08/2014, 09:22

... According to the hierarchical model of cancer, the origin of the cancer stem cells may be long-lived somatic stem cells Therefore, markers of “normal” stem cells are being sought with the expectation ... neoplastic mechanism of liver cancer stem cells Conclusions This work provides an in vivo model for the study of mechanisms of neoplastic transformation of liver cancer stem cells by separately ... carcinogenesis and differentiation of normal stem cells strongly suggest that miRNA may be involved in the transformation of normal stem cells into cancer stem cells Therefore, screening for differences...

Ngày tải lên: 10/08/2014, 10:20

... al Journal of Experimental & Clinical Cancer Research 2010, 29:174 http://www.jeccr.com/content/29/1/174 cancer stem cells http://www.mirbase.org/ Thus, the identification of cancer stem cell-related ... regulatory factor in cancer cells, even cancer stem cells Another example is miR21, which has been reported to have extensive roles and is expressed in embryonic stem cells [29], neuronal cells [30] and ... information for a better understanding of cancer stem cell properties and even the molecular mechanisms of carcinogenesis Here, we investigated the miRNA expression profiles of ESA + CD44 + CD24 -/low BCSCs...

Ngày tải lên: 10/08/2014, 10:20

... primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing concentrations of PTL Cells ... cultures of cancer stem cells is likely to be important for maintaining gene expression patterns similar to cancer stem cells in vivo Genome Biology 2008, 9:R83 Genome Biology 2008, Cancer BPH ... comprising less than 0.1% of the tumor mass, has many of the properties of cancer stem cells [4] In particular, self renewal, extended lifespan (compared to normal stem cells) , a high invasive...

Ngày tải lên: 14/08/2014, 08:21

... shows the contribution of this strategy to the development of plants with biofarming potential in the frame of a high demand of natural and ecologically accepted sources of renewable compounds ... cultured cells as compared with intact plants of licorice Upregulation of bAS and SQS mRNAs by MeJA in cultured licorice cells suggests that transcripts of other enzymes involved in the later steps of ... export of the excess of reducing power via the malate valve, and productive consumption of the surplus of NADPH by the Calvin cycle Finally, as is the case with iron deficiency, the extent of protection...

Ngày tải lên: 25/10/2013, 05:20

... sections of tumor biopsies is not simple due to the high autofluorescence and the loss of antigen presentation associated with the Figure Molecular imaging of cells and tissues (A) 3D imaging of intracellular ... used to study the migration of cancer cells in vitro [57], monitor the metastasis of QD-labeled cells in vivo [73], and microscopically examine the microenvironment of cancer tissue in vivo [66] ... Prostate-specific antigen: a review of the validation of the most commonly used cancer biomarker Cancer 101(5), 894–904 (2004) 30 Goessl C Noninvasive molecular detection of cancer – the bench and the...

Ngày tải lên: 15/02/2014, 05:20

... study of embryonic stem cells TE N Hattori and K Shiota ICM PGC TS cells Placental cells 77 ES cells 49 EG cells Embryonic cells Fig Epigenetic distances between ES cells and other stem cells ... methylation profiles Epigenetic study of embryonic stem cells Differences in DNA methylation profiles between ES and other stem cells Comparing ES cells with other stem cells established from developing ... biology and cell biology is the establishment of embryonic stem (ES) cells, which maintain the ability to form all types of cells in the body, and can differentiate into a variety of cell types...

Ngày tải lên: 23/03/2014, 07:20

... passage of a wide variety of anticancer agents The high incidence of recur‐ rence and poor prognosis of malignant gliomas compel the development of more powerful anti -cancer treatments Action of alkylating ... Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications nectin is almost absent but it is effective in the microenvironment of glioma cells, which coexpress large amounts of ... role in glioma invasion Increased expression of integrin αvβ3 results in increased motility of glioma cells with a de‐ Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications...

Ngày tải lên: 23/03/2014, 10:20

... phenotypes of multidrug resistance among panels of human cancer- cell lines Int J Cancer 65, 230–237 (1996) O’Connor, P.M et al Characterization of the p53-tumor suppressor pathway in cells of the ... were to understand molecular pharmacology, to aid in the process of drug discovery and to provide a rationale for selection of therapy on the basis of molecular characteristics of a patient’s tumour ... contain information on the molecular cell biology and molecular pharmacology of cancer Second, we generated our activity database using only one assay end-point, an index of short-term growth inhibition...

Ngày tải lên: 30/03/2014, 13:20

... Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark JESPER ZEUTHEN Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer ... Institutes of Health, Bethesda, MD KIRSTEN GRỉNBặK Department of Tumour Cell Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark PER GULDBERG Department of Tumour Cell Biology, ... technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer The application of molecular technology to the study of cancer has not only...

Ngày tải lên: 08/04/2014, 12:51

... MOLECULES, MECHANISMS, AND CELLS This page intentionally left blank MOLECULAR BIOLOGY OF HUMAN CANCERS This page intentionally left blank Molecular Biology of Human Cancers An Advanced Student’s ... evolving scope of molecular diagnostics 427 21.2 Molecular diagnosis of hematological cancers 429 21.3 Molecular detection of carcinomas 433 21.4 Molecular classification of carcinomas ... differentiation: Many cancers consist of cells which resemble precursor cells of their tissue of origin and have not embarked on the normal course of differentiation, whereas others show properties of cells...

Ngày tải lên: 08/04/2014, 12:51

... MOLECULAR BIOLOGY INTELLIGENCE UNIT NAVEH-MANY MBIU Tally Naveh-Many Molecular Biology of the Parathyroid Molecular Biology of the Parathyroid MOLECULAR BIOLOGY INTELLIGENCE UNIT Molecular Biology ... Implications of the Monoclonality of Parathyroid Tumors 141 Molecular Genetics of Parathyroid Adenomas 142 Molecular Genetics of Parathyroid Carcinoma 151 Molecular Genetics of Secondary ... characteristics of PTH-null mice and the skeletal and reproductive abnormalities that they present Together the chapters of this book offer a state of the art description of the major aspects of the molecular...

Ngày tải lên: 08/04/2014, 12:52

... TABLE OF CONTENTS Development of Hematopoietic Repopulating Cells from Embryonic Stem Cells The In Vitro Differentiation of Mouse Embryonic Stem Cells into Neutrophils 10 Development and Analysis of ... Murine Embryonic Stem Cells 11 Development of Lymphoid Lineages Embryonic Stem Cells In Vitro from 12 Probing Dendritic Cell Function by Guiding the Differentiation of Embryonic Stem Cells 13 Gene ... and Human Embryonic Stem Cells 29 Growth and Differentiation Monkey ES Cells of Cynomolgus 30 Isolation, Characterization, and Differentiation of Human Embryonic Stem Cells HIROFUMI SUEMORI NORIO...

Ngày tải lên: 11/04/2014, 00:32

... immunohistochemical staining of BrdU and S-100 Representative images of immunohistochemical staining of BrdU and S-100 A: Localization of darkly brownish stained BrdU+ cells to transected tissues of rabbits having ... 7042014 of the National Science Foundation of Beijing, China, the 50573044 of the National Natural Science Foundation of China and the 2005CB623905 of the National Basic Research Program of China ... protruding processes Immunofluorescence staining of β-tubulin, GFAP and GalC demonstrated positive expressions in a substantial number of cells, suggesting that neurosphere-derived cells were able to...

Ngày tải lên: 18/06/2014, 15:20

... results of result of gene expression profiling Jin et al Journal of Translational Medicine 2010, 8:4 http://www.translational-medicine.com/content/8/1/4 Page of 15 Figure Change in the expression of ... These Treg cells can counter the effects of Th1 responses by cytotoxic T cells, Th1 cells, and NK cells In contrast, we found that LPS and IFN-g maturated DCs did not increase the levels of CCL22 ... analysis of maturing DCs revealed two distinct patterns: down-regulation of groups of miR at hours of maturation with sustained low expression throughout the rest of maturation and up-regulation of...

Ngày tải lên: 18/06/2014, 16:20

... Induced pluripotent stem cells Induced pluripotent stem cells (iPSCs) from somatic cells are revolutionizing the field of stem cells Obtained by reprogramming somatic stem cells of a patient through ... here lies in implantation of hepatic stem cells, or in implantation of hepatic cells obtained by differentiation of a different type of stem cell, such as mesenchymal stem cells Other applications, ... the event of autologous implantation, but induced pluripotent stem cells are at least, if not more capable than those from adult (stem) cells Mesenchymal stem cells Although adult stem cells are...

Ngày tải lên: 18/06/2014, 16:20