báo cáo khoa học y dược

Ngày tải lên: 26/07/2014, 15:20

... nâng cao hiệu quả công tác quản lý nghiên cứu khoa học lĩnh vực y - dược học tại HVQY. Keywords: Nghiên cứu khoa học; Y học; Dược học; Quản lý khoa học Content 1. Lý do chọn đề tài nghiên cứu ... Quân y trong lĩnh vực Y - Dược học? 7. Giả thuyết nghiên cứu Để nâng cao hiệu quả công tác quản lý NCKH trong lĩnh vực Y - Dược học tại Học viện Quân y, nghiên cứu kiểm chứng các giả thuyết ... ngành y tế nói chung và ngành Quân y nói riêng thì các đề tài nghiên cứu được tiến hành ở các lĩnh vực như y học cơ sở, y học quân sự, y học lâm sàng, dược bào chế, nghiên cứu y sinh học Việc...

Ngày tải lên: 15/01/2014, 12:06

... rapidly passed back from the R1E subunit to the tyrosyl of the R2F sub- unit. Subsequently, the dicysteine unit is re-reduced by an exogenous reductant and catalytic activity is restored. By not ... catalysis, as expected. The tyrosyl radical of the R2F subunit was also monitored during the course of the enzyme assay. Curiously, under conditions where the product was formed, the tyrosyl radical, ... 408 nm, characteris- tic of a tyrosyl radical (Y ặ), which is sensitive to the radical scavenger hydroxyurea. A novel enzyme assay revealed the direct involvement of Y ặ in ribonucleotide reduction...

Ngày tải lên: 15/02/2014, 01:20

... activity. NPY is able to act through five different receptors (Y1 , Y2 , Y4 , Y5 and y6 ) that vary in their binding profiles and in their distribution in the central nervous system and periphery. Y1 , Y2 and ... Cytokines, estrogen, and postmeno- pausal osteoporosis – the second decade. Endocrinology 139, 2659–2661. Leptin NPY Y2 Y1 Y2 NPY NPY Osteoblasts HypothalamusFat tissue Sympathic nervous system NPY Circulating ... response is mediated centrally, the Y1 response is mediated by osteoblastic Y1 . Thus, hypothalamic signals sustain a systemic regulatory influence via Y2 , whereas osteoblas- tic Y1 enables additional...

Ngày tải lên: 18/02/2014, 04:20

... carboxypeptidase Y; FM4-64, N-(3-triethylammoniumpropyl)-4-(p-diethylaminophenylhexatrienyl) pyridinium dibromide; GFP, green fluorescent protein; I C , carboxypeptidase Y inhibitor; PC, phosphatidylcholine; ... Hayashida M, Fujii T, Hata Y, Hayashi R & Ueda M (2004) Crystallization and preliminary X-ray analysis of carboxypeptidase Y inhibitor I C complexed with the cognate proteinase. Acta Crystallogr ... carboxy- peptidase Y in yeast. Biochem Biophys Res Commun 60, 1051–1057. 3 Lenney JF, Matile Ph, Wiemken A, Schellenberg M & Meyer J (1974) Activities and cellular localization of yeast proteases...

Ngày tải lên: 19/02/2014, 05:20

... ovary; cNPY, chicken neuropeptide Y; cPP, chicken pancreatic polypeptide; cPYY, chicken peptide YY; Hsa, Homo sapiens chromosome; pNPY, porcine neuropeptide Y; PP, pancreatic polypeptide; pPYY, ... > cPP (see Table 1). Interestingly, pNPY had a lower affinity than pPYY, thereby making it unlikely that cNPY would bind with higher affinity (they differ by only two conservative replacements as ... determine the affinity of cPYY also to the previously cloned Y- family receptors in chicken. Among the intact peptide ligands, the rank order of potency was pPYY > pNPY > cPYY > cPP (see Table...

Ngày tải lên: 19/02/2014, 07:20

... [24–27]. There are two types of nongerm cell CSD proteins and these are called dbpB (also known as YB-1, MSY-1, chkYB-1b, EF1A, p50 and FRGY1) and dbpA (MSY4, chkYB-2 and YB2/RYBa). DbpB and dbpA ... [47], dbpB/YB-1 binding to the IL-2 5Â-UTR [31] and the VEGF 5Â-UTR CSD site 1. MSY1, ChkYB-1b and FRGY1 are dbpB/YB-1 proteins. MSY-4 and chkYB-2 are dbpA proteins, and MSY2 and FRGY2 are germ ... of stably transfected cell lines was as described previously [15]. Hypoxic conditions (1% O 2 )were generated in a hypoxic chamber (Edwards Instrument Company, Sydney, Australia). Analysis of...

Ngày tải lên: 19/02/2014, 12:20

... th y sản”,“Công nghệ chế biến tôm chua.”, “Công nghệ chế biến mắm ruc, mắm nêm”,   3. Ths. ,“CÔNG NGHỆ CHẾ BIẾN NƯỚC MẮM”, “Công nghệ chế biến th y sản”, ... CHẾ BIẾN NƯỚC MẮM”, “Công nghệ chế biến th y sản”,  4. “X y dựng quy trình sản xut chế phẩm vi khuẩn lactic ứng dng trong lên men tôm chua”,  ...   4.4.2 Mm ruc Bng 4.6 ng và s c khi ch bin mm ruc   Nguyên nhân   +  +  không...

Ngày tải lên: 21/02/2014, 09:55

... commonly observed in adenylate- forming enzymes, such as aminoacyl-tRNA synthetases, Keywords acyl-CoA synthetase; enantiomer; fire y luciferase; kinetic resolution; nonsteroidal anti-inflamatory drugs Correspondence D ... kinds of hydrolytic conditions, chemical hydrolysis under high pH and enzymatic hydrolysis under neutral pH, were examined, because there was some fear of racemization by the chemical hydrolysis. The ... Identification of 2-arylpropanoyl-CoA produced by LUC-H with TOF-MS analysis. For the detection of 2-arylpropanoyl-CoAs by TOF-MS analysis, see the Experimental procedures section. Entry Thioester Predicted [M-H] – Observed [M-H] – Error (p.p.m.) 1...

Ngày tải lên: 07/03/2014, 10:20

... data). Tryptophan and tyro- sine residues (Y1 7, Y2 0, Y8 2, W84, and W369) in CPY would be perturbed by the carbohydrate moiety, thus increasing their fluorescence, since they are in close proximity to ... 2562–2567. Table 1. Summary of qualitative thermodynamic parameters for the temperature- and pressure-induced transitions of CPY, Dgly CPY, proCPY and Dgly proCPY calculated by fluorescence analysis. Errors ... pro- nounced hydration upon unfolding of the unglycosylated form. At high pressure, in the glycosylated forms the carbohy- drate moiety of CPY and proCPY would be hydrated to compensate the volume contraction...

Ngày tải lên: 07/03/2014, 21:20

... 6110. Abbreviations:ATEE,N-acetyl- L -tyrosine ethyl ester monohydrate; BTEE, benzoyl- L -tyrosine ethyl ester; CPY, carboxypeptidase Y; GdnHCl, guanidine hydrochloride. *Present address: Sanyo Chemical Co., Kyoto, Japan. Present ... of carbohydrate moiety in carboxypeptidase Y: structural study of mutant enzyme lacking carbohydrate moiety. Biochem. Biotechn Biosci. 63, 1045– 1050. 2. Jung, G., Ueno, H. & Hayashi, R. ... cleft of CPY is constructed with five a-helices, these locate as if they surround the catalytic triad. In addition, five disulfide bridges (Cys56–298, Cys198–207, Cys217–240, Cys224–233 and Cys262–268)...

Ngày tải lên: 08/03/2014, 10:20

... Gorrell 1 1 Centenary Institute, Sydney Medical School, University of Sydney, NSW, Australia 2 Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sydney, NSW, Australia Keywords antiplasmin-cleaving ... pmolặmin )1 ặlg )1 on benzyloxycar- bonyl (Z)-Gly-Pro-AMC and 1830 nmolặmin )1 ặlg )1 on H-Gly-Pro-p-nitroanilide, respectively. To assay the substrate specificity of each protease, enzyme activity assays were ... megakaryocytes, adipose tissue and gut [45,46]. Dipeptidyl peptidase truncation of NPY by FAP or DPP4 yields NPY 3–36 . NPY 3–36 is inactive on the Y1 receptor, and has greater affinity for the Y2 ...

Ngày tải lên: 14/03/2014, 23:20

... periosteum and bone marrow by RIA [13], particularly in megakaryo- cytes [14]. Recently, it was additionally reported that the NPY receptor Y1 , but not Y2 , Y4 , Y5 or Y6 , was expressed in cultured ... the adult, that NPY is synthesized by osteoblasts, osteocytes, and chondrocytes. Moreover, peptidylglycine a-am- idating monooxygenase, the enzyme responsible for NPY activation by amidation, was ... activity (nmolPNP·mg·h –1 ) 6 4 2 0 25 20 15 10 10 8 6 4 2 0 0 actin GAPDH HPRT GAPDH HPRT 2 4 6 8 10 12 14 b a a 5 0 Day 3 Day 3 Day 7 Day 7 c b b TTR KO TTR KO WT Day 14 Day 3 Day 7 Day 14 Day 14 WT WT TTR...

Ngày tải lên: 15/03/2014, 09:20

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Ngày tải lên: 15/03/2014, 23:20

... polymerization activity. Fidelity analysis of AtPOLK and AtPOLK n C We next analysed the catalytic efficiency and fidelity of AtPOLK and AtPOLKDC during DNA synthesis. To determine the fidelity of both full-length ... polymerase targeting and recruitment, our understanding of its role in Y- family DNA poly- merase catalytic activity is still limited. Efforts to relate the enzymatic properties of Y- family DNA ... (2001) The Y- family of DNA polymerases. Mol Cell 8, 7–8. 5 Yang W (2005) Portraits of a Y- family DNA poly- merase. FEBS Lett 579, 868–872. 6 Kunkel TA (2004) DNA replication fidelity. J Biol Chem...

Ngày tải lên: 16/03/2014, 10:20

... assay based on LUC biolumin- escence reaction is an important analytical tool, mainly Keywords Coenzyme A; dehydroluciferyl-adenylate; dehydroluciferyl-coenzyme A; dephospho- coenzyme A; fire y ... A; L, dehydroluciferin; L-AMP, dehydroluciferyl-adenylate; LUC, fire y luciferase; L-CoA, dehydroluciferyl-coenzyme A; L-dephospho-CoA, dehydroluciferyl-dephospho-coenzyme A; LH 2 , fire y luciferin; LH 2 -AMP, ... enzyme produced fire y luciferyl-adenylate and the enzyme synthesis of luciferyl-CoA. Chembio- chem 5, 110–115. 22 Hosaka K, Mishina M, Tanaka T, Kamiryo T & Numa S (1979) Acyl-coenzyme A synthetase...

Ngày tải lên: 16/03/2014, 23:20

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Ngày tải lên: 29/03/2014, 13:20

Ngày tải lên: 27/06/2014, 10:20