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Ngày tải lên: 02/11/2012, 11:23

Ngày tải lên: 30/03/2014, 05:21

... Staff Physician at the Department of Gastroenterology and Hepatology, University Hospital Freiburg, Germany. Since 2004 he is the head of the Division of Gastroenterology and Hepatology, Centre ... polymerase. Mol Cell 2005; 19: 111-22. Author biography Hubert E. Blum, MD, is the chairman of the Department of Gastroenterology and Hepatology, University Hospital Freiburg, Germany. His ... NS5B The key enzyme of the replicase that promotes synthesis of new RNA genomes is the NS5B RNA- dependent RNA polymerase (RdRp). NS5B is a tail- anchored protein, characterized by a transmembrane...

Ngày tải lên: 02/11/2012, 10:00

... D(d 1 -d 5 ); Y( d 1 )Y( d 1 -d 3 )Y( d 1 -d 3 )X(d 1 -d 5 ); Y( d 1 -d 5 ) 120 P; Y( d 2 )P; D(d 2 ); P; D(d 2 ); P; D(d 2 ); P; D(d 1 -d 4 ); Y( d 1 )Y( d 1 -d 3 )Y( d 1 -d 3 )X(d 1 -d 5 ); Y( d 1 -d 5 ) Total ... D(d 2 ); Y( d 2 ,d 5 )P; D(d 1 );X(d 3 ,d 4 ); P; D(d 2 ); X(d 3 ,d 4 )P; D(d 1 -d 4 ); P; D(d 1 -d 5 ); Y( d 1 ,d 2 ,d 5 )Y( d 1 ,d 2 ,d 5 )X(d 1 -d 5 ); Y( d 1 -d 5 )X(d 1 -d 5 ); Y( d 1 -d 5 ) 110 P; Y( d 2 )P; ... given by only the first two primary rows of the table. One readily sees from the table that for each beam we use as few as six and as many as 48 scans to perform the commissioning, a process yielding...

Ngày tải lên: 03/11/2012, 10:05

Ngày tải lên: 31/12/2013, 09:24

... endothelial lipase [1,2]. The primary function of LPL is triglyceride hydrolysis in triglyceride-rich lipoproteins, such as chylomicron and very low density lipoprotein (VLDL) particles, which ... the MARKIT-F LPL kit, and chromatography fractions were analyzed by Western blotting with LPL polyclonal antibody 7640 (B). Fig. 2. Heparin affinity of wild-type and basic amino acid–substituted LPL. ... purified from a prokaryotic system were eluted from the heparin affinity column at extremely low efficiency, the proteins produced in the in vitro system were measured for heparin affinity (Table 1). The...

Ngày tải lên: 21/02/2014, 15:20

... [20] Palmitoyl-Thr-Val-Ser-Tyr-Glu-Leu-OH 0.5 Kinetic analysis [20] Palmitoyl-Tyr-Glu-Leu-OH 0.15 Kinetic analysis [21] Palmitoyl-Tyr-Glu-( L -threonine)-OH 0.05 Kinetic analysis [21] Palmitoyl-Tyr-Glu-(p-biphenyl-alanine)-OH ... the ribo- nuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthalde- hyde hydrazone. Biochemistry 36, 3179–3185. 57. Arion,D.,Sluis-Cremer,N.,Min,K ... immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[spiro[4¢-amino- 2¢,2¢-dioxo-1¢,2¢-oxathiole-5¢,3¢-[2¢,5¢-bis-O-(tert-butyldimethylsi- lyl)-beta- D -ribofuranosyl]]]-3-ethylthymine....

Ngày tải lên: 08/03/2014, 09:20

... coupled to keyhole limpet haemocyanin via their endogenous (Rab31) or added (Rab32, Rab11A) cysteine residues, using 4-(N-maleimidomethyl) cyclohexane-1-carboxylate. Rabbits were immunized by intradermal ... hydrolysis in t he absence or presence of cytosol containing GAP activity [43]. Moreover, Rab25 has considerable GTPase activity [43], although the corresponding glutamine residue is naturally ... columns or antibody af®nity- puri®ed on an UltraLink I odoacetyl column containing covalently bound peptide. Bound antibody was visualized using horse-radish peroxidase-conjugated donkey anti- (rabbit...

Ngày tải lên: 08/03/2014, 16:20

... by b-amyrin synthase than to that by cycloartenol synthase, an isomultiflorenol synthase is expected to share greater sequence similarity with b-amyrin synthase. In this study, we used the Glycyrrhiza ... of Luffa cylindrica Roem. by heterologous hybridization with cDNA of Glycyrrhiza glabra b-amyrin synthase. Expression of LcIMS1 in yeast lacking endogenous oxidosqualene cyclase activity resulted in ... N., Ikeshiro, Y. , Kushiro, T., Shibuya, M. & Ebizuka, Y. (2001) Cloning and characterization of a cDNA encoding b-amyrin synthase involved in glycyrrhizin and soyasaponin biosynthesis in licorice....

Ngày tải lên: 08/03/2014, 23:20

... monoterpene hydrocarbons from [1- 3 H]neryl pyrophosphate and [1- 3 H]geranyl pyrophosphate by soluble enzymes from Citrus limonum. Arch. Biochem. Biophys. 180, 318–327. 19. Maruyama, T., Ito, ... signals (only 16–18% identity) and the coding sequences (only 48–51% identity), suggesting that they have evolved separately. This is confirmed by the phylogenetic analysis (Fig. 2). The separate ... Cybernetics, Plant Research International, Wageningen, the Netherlands; 2 University of Wu ¨ rzburg, Chair of Food Chemistry, Germany; 3 Laboratory of Plant Physiology, Wageningen University,...

Ngày tải lên: 08/03/2014, 23:20

... activity in SKOV3 cells. In our EMSA analyses, aside from the shifted band that contained USF1 and USF2, we observed other shifted bands (X and Y) . As bands X and Y were only partially inhibited by ... Research Institute, University Health Network, Toronto, Ontario, Canada; 2 Laboratory of Gynecologic Oncology, Department of Obstetric Gynecology and Reproductive Biology, Brigham and Women’s Hospital, ... tyrosine kinases and phosphatases are the key players in the regulation of protein tyrosine phosphorylation. Among the known protein tyrosine phosphatases, SHP-1 and SHP-2 are distinguished by...

Ngày tải lên: 08/03/2014, 23:20

... metabolism is the hydro- lysis of trehalose to glucose. This is catalyzed by the enzyme neutral trehalase (NTH1), whose activity is regulated by phosphorylation of the enzyme protein at serine ... 2B, affinity-purified Ntp1p–Ha6H from growing cells displayed a typical pattern of neutral trehalase activity, with low level of enzyme activity in unstressed cells that increases strongly upon stress. ... disaccharide trehalose is carried out by several enzymes that are widely distributed and conserved among prokaryotes and eukary- otes. One probable reason for this conservation is the ability of trehalose to function...

Ngày tải lên: 08/03/2014, 23:20

... đai Lửa Thái Bình Dương, nơi thường xuyên chịu ảnh hưởng của núi lửa hoạt động. Trong số n y hoạt động mạnh nhất là ngọn Mayon cao 2.464 m. Núi lửa n y từng phun trào 49 lần kể từ khi được ... trong lịch sử năm 1616 và lần g y thiệt hại nặng nhất là năm 1814, khi nó làm chết hơn 1.200 người. Lần phun trào nham thạch quy mô lớn gần đ y nhất của Mayon là năm 1993. ... Philippines quyết định nâng mức báo động 3 đối với Mayon, mức cảnh báo núi lửa sẽ phun trào mạnh trong vòng vài tuần hoặc vài ng y sắp tới. 24 Núi lửa Ambrym tại Vanuatu thuộc Nam Thái Bình dương 33 Cận...

Ngày tải lên: 11/03/2014, 02:20

... CoOMT and the biosynthetic enzymes involved in benzylisoquinoline alkaloid biosynthe- sis, including berberine bridge enzyme [28–30] and (S)-N- methylcoclaurine 3¢-hydroxylase (CYP80B1) [31], also ... S-adenosyl- L -methionine: coclaurine N-methyltransferase; 4¢OMT, S-adenosyl- L -methionine:3¢- hydroxy-N-methylcoclaurine 4¢-O-methyltransferase; SMT, S-adenosyl- L -methionine:scoulerine 9-O-methyltransferase; ... M.H. (1990) S-adenosyl- L -methionine: 3¢-hydroxy-N-methyl-(S) -coclaurine-4¢-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway. Phytochemistry 29, 3505–3511. 12....

Ngày tải lên: 17/03/2014, 10:20

... angle almost typical for the 3 10 helix. In this region of the polypeptide chain, the secondary structure is characterized also by the O i H N i þ 3 hydrogen bonds, found in all 40 DYANA structures ... Cushing’s syndrome, inflammatory dis- eases, pre-eclampsia or preterm labour, anxiety and depres- sion and a potentially great number of other disorders. We have previously described the synthesis ... residue) in DYANA structural calculations [31]. Appropriate pseudo- atom corrections were applied to methylene and methyl hydrogens that were not stereospecifically assigned [32]. a-Aminoisobutyrilo...

Ngày tải lên: 17/03/2014, 10:20

...  y (bão hoà). Các nguyên t chuyn tip c chia thành 3 nhóm: 1. Nhóm c bn hay còn gi là nhóm d gm có 3 d y vi mi d y 10 nguyên t: - D y 3d: 21 Sc (Scandi) → 30 Zn (Km) - D y ... - Xenon) trên 5p. Gia các nguyên t s và p n y các nguyên t chuyn tip d y 4d: 39 Y (Ytri) → 48 Cd (Cadimi). 3.1.6. Chu kỳ 6. Chu k n y gm có 32 nguyên t. S phân b in t  các ... tích trong nguyên t ca 2 nguyên t n y  trng thái c bn bng không. 4 Chương 1 MỞ ĐẦU 1.1. HOÁ HỌC VÀ NHIỆM VỤ CỦA HOÁ HỌC: Hoá hc là mt trong nhng môn khoa hc c bn...

Ngày tải lên: 19/03/2014, 05:20

Ngày tải lên: 23/03/2014, 21:20

Ngày tải lên: 24/03/2014, 00:21

Ngày tải lên: 24/03/2014, 04:21

Ngày tải lên: 31/03/2014, 08:20