at the other side of love

Ngày tải lên: 20/05/2014, 14:03

... connections. The present study aimed to detect the expression of Cx40 and Cx43 in the artery at early stage of high fat diet induced atherosclerosis and to investigate the effects of AT1 antagonist ... reduced by treatment. RT-PCR and Western blot assay showed that the mRNA and protein expression of Cx40 and Cx43 were elevated in the neointimal area at the early stage of atherosclerosis. The mRNA ... involved in the injury or dis- ease induced activation of vessel wall cells. It is indi- cated that the expression of Cx43 in the smooth mus- cle cells was markedly elevated at the early stage of coronary...

Ngày tải lên: 26/10/2012, 09:39

... a single theme, crisply expressed in a sentence or two, and then tell the entire story of that theme: the history of salt; the fragility of democracy; the use and misuse of punctuation. This ... criminologists to real-estate agents—use their infor- mational advantage to serve their own agenda. However, they can be beat at their own game. And in the face of the Internet, their informa- tional ... mean that one causes the other. A correlation simply means that a relationship exists between two factors—let’s call them X and Y—but it tells you nothing about the direction of that relationship....

Ngày tải lên: 17/10/2013, 18:20

... Google’s method — and fortunate timing. The typical rev- enue path of online media companies is lined on one side with advertising and on the other side with special services. Consider Yahoo!. While ... controlled their costs and tracked their returns). In time, the advantages of eBay’s system got the attention of midsize brick-and-mortar stores, which now operate eBay outlets as an essen- tial part of ... Will this situation per- sist? Is marketing in Google a long-term strategy? 14 Part I: Meeting the Other Side of Google Google’s business isn’t just advertising In the beginning of this chapter,...

Ngày tải lên: 24/10/2013, 08:20

... Application Contexts • Characterization Issue • Computation Issue • Duality • Organization COMPUTATION PROBLEM • Iterative descent • Approximation • Role of convergence analysis • Role of rate of ... convergence of steep- est descent x 0 x 1 x 2 f(x) = c 1 f(x) = c 3 < c 2 f(x) = c 2 < c 1 . . . Quadratic Approximation of f at x 0 Quadratic Approximation of f at x 1 Fast convergence of New- ton’s ... x k , the method ob- tains x k+1 as the minimum of a quadratic approxima- tion of f based on a sec- ond order Taylor expansion around x k . CONVERGENCE RATE OF PURE FORM • Consider solution of nonlinear...

Ngày tải lên: 26/10/2013, 17:15

Ngày tải lên: 18/12/2013, 21:45

... affecting the ability of E1 to catalyse the reductive acetylation of the tethered lipoyl domain in the assembled PDH complex. It should be noted that Tyr281 and Arg282 are located at the mouth of the funnel-shaped ... site of E1, at the bottom of which lies the ThDP cofactor some 20–25 A ˚ from the protein ÔsurfaceÕ [14]. Thus it may be that these mutations are affecting the efficacy of the recognition of the ... estimated to have a dissociation constant in the millimolar range or higher despite the fact that the K m is c. 20 l M [37,38]. Another difference in the assays is the concentration of the substrate,...

Ngày tải lên: 20/02/2014, 23:20

... we are able to acquaint the reader with the culture of mathematics: who mathematicians are, what they care about, and what they do. We also give indications of why mathematics is important, and why ... bullet-proof fashion that will stand the test of time. The second, and for the working mathematician the most important, aspect of proof is that the proof of a new theorem explains why the result ... convincing another mathe- matician that a given statement (the theorem) is true. Thus a proof can take many different forms. The most traditional form of mathematical proof is that it is a tightly...

Ngày tải lên: 21/02/2014, 09:20

Ngày tải lên: 28/02/2014, 20:18

Ngày tải lên: 05/03/2014, 16:20

... following the change in ellipticity at 222 nm at a constant heating rate of 40 °CÆh )1 . The midpoint of the transition (T m ) was deter- mined from the first derivative of the smoothed denatur- ation ... Mg 2+ ), sat- urating amounts of Glc were used. In the case of the severely inactivating mutation T228M [9,20], an ATP con- centration of 10 mm was used. For determination of Hill coefficients of WT ... hyper- insulinism of infancy [6–11]. Some of the mutations greatly reduce the binding affinity of MgATP 2) [11,12], which is compatible with a direct interaction of these residues with the nucleotide at the...

Ngày tải lên: 06/03/2014, 00:20

... are situated at similar distances from the hydroxyl of the docked substrate, they could cooperate in facilitating the hydride transfer from sub- strate to FAD. The decrease of activity of the AAO H502A ... modulating the catalytic rate of the enzyme. Finaly, L315 affects the enzyme k cat , although it is not located in the near vicinity of the cofactor. The present study provides the first evidence for the ... glycoprotein of 70 kDa with dissociable flavin-adenine dinucleotide (FAD) as cofactor that catalyzes the oxidation of a variety of aromatic and aliphatic polyunsaturated alcohols to their corres- ponding...

Ngày tải lên: 07/03/2014, 11:20

... from cells from the nondiabetic control subjects. Similarly, the maximal effects of insulin on the state of tyrosine- phosphorylation of the insulin receptor or of IRS1, or of phosphorylation of ERK1 ... incubation. When the insulin-responsiveness of the cells was examined at different concentrations of insulin, we found that insulin enhanced the phosphorylation of PKB at lower concentrations ... been the subject of intensive research for many years. Yet, we don’t know the details of the molecular dysregulation in the target cells of the hormone. Studies of cells from patients with the...

Ngày tải lên: 07/03/2014, 16:20

... structure of TI for acetanilide, the two TSs of the nucleophilic attack of the side chain of SerB1 and the collapse of TI were modeled. The stable structures and the TSs were fully optimized at the ... conformation of the enzyme. Substrate binding causes considerable shortening of the hydrogen bonds of the side chain hydroxyl of SerB1 with the backbone amino group of GlnB23 and with the side ... the one between the carboxylate group of the Asp residue and the protonated imidazole ring of the His residue in the serine protease catalytic triad. In the second TS (TS2) of the expulsion of...

Ngày tải lên: 16/03/2014, 01:20

... is seen that on preincubation with saturating concentrations (Fig. 3B) of the biopterin cofactors or dopamine the rate of phosphory- lation was decreased, and at 200 l M of the ligands the inhibition ... binding of the cofactor at the active site results in the formation of stabilizing hydrogen bonds between the dihydroxypropyl side- chain and the carbonyl oxygen of Ser23 in the autoregulatory sequence. ... effects of the biopterin cofactor on the rate of phosphorylation of Ser16, the limited proteolysis by trypsin and the substrate induced conformational transition (hys- teresis) related to catalytic...

Ngày tải lên: 17/03/2014, 09:20

Ngày tải lên: 23/03/2014, 01:20

Ngày tải lên: 23/03/2014, 21:20

Ngày tải lên: 25/03/2014, 10:26