... Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 1) Harrison's Internal Medicine > Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss Definitions A finite life ... classification of anemias comprises three groups: decreased production of red cells, increased destruction of red cells, and acuteblood loss. Red cell destruction and acute loss, both associated ... of anemia in these two groups of patients are quite different, and they will be considered separately. Hemolytic Anemias Anemias due to increased destruction of red cells, or hemolytic anemias...
... hemoglobinuria, often associated with hemosiderinuria and an Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 2) Table 101-2 General Features of Hemolytic Disorders General ... gradual loss of cellular organelles and of biosynthetic abilities. In the end the erythroid cell undergoes a process that has features of apoptosis, including nuclear pyknosis and actual loss ... reticulocytes is associated with an increased mean corpuscular volume (MCV) in the blood count. On the blood smear this is reflected in the presence of macrocytes; there is also polychromasia...
... Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 3) Figure 101-1 cause considerable iron loss, needing replacement. With chronic extravascular ... except there is no anemia. This notion is important from the diagnostic point of view, because a patient with a hemolytic condition, even an inherited one, may present without anemia. It is also ... "decompensated"—i.e., anemia may suddenly appear—in certain circumstances—for instance, pregnancy, folate deficiency, renal failure interfering with adequate EPO production, or an acute infection...
... being homozygous). Figure 101-3 Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 5) Hemolytic Anemias Due to Abnormalities of the Membrane-Cytoskeleton Complex ... these proteins are heavily glycosylated, and they carry antigenic determinants that correspond to blood groups. Underneath the membrane, and tangential to it, is a network of other proteins that ... thus diseases of the membrane-cytoskeleton complex belong to the category of inherited hemolytic anemias. Before the red cells lyse, they often exhibit more or less specific morphologic changes...
... Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 6) Peripheral blood smear from patients with membrane-cytoskeleton abnormalities....
... Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 7) Clinical Presentation and Diagnosis The spectrum of clinical ... present in infancy with severe anemia, whereas mild cases may present in young adults or even later in life. In women, HS is sometimes first diagnosed when anemia is investigated during pregnancy. ... which, in its first approximation, has two important functions: (1) to provide decompensation. The anemia is usually normocytic, with the characteristic morphology that gives the disease its name....
... Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 8) Abnormalities of the Glycolytic Pathway (Fig. 101-1) Since ... usually associated with a very high reticulocytosis. The anemia is of variable severity; sometimes it is so severe as to require regular blood transfusions; sometimes it is mild, bordering on ... instance, in a woman during her first pregnancy, when the anemia may get worse. In part the delay in diagnosis is due to the fact that the anemia is remarkably well-tolerated because the metabolic...
... require exchange transfusion; if the anemia is less severe, it may present later in life or may even remain asymptomatic and be detected incidentally when a blood count is done for unrelated ... or both. The diagnosis of HA is usually not difficult, thanks to the triad of normo-macrocytic anemia, reticulocytosis, and hyperbilirubinemia. Enzymopathies should be considered in the differential ... 101-4). In red cells, its Among the mutations, those underlying chronic nonspherocytic hemolytic anemia (CNSHA; see below) are a discrete subset. This much more severe clinical phenotype can be...
... of comorbidity, full recovery from acute HA associated with G6PD deficiency is the rule. Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 10) Epidemiology G6PD ... hemolysis. The most serious threat from acute HA in adults is the development of acute renal failure (exceedingly rare in children). Once the threat of acuteanemia is over, and in the absence of ... of them have an increased risk of developing neonatal jaundice (NNJ) and a risk of developing acute HA when challenged by a number of oxidative agents. NNJ related to G6PD deficiency is very...
... Favism Acute Destruction of older fraction of G6PD-deficient red G6PD assay Triggered by ingestion of large dish of fava beans; but trigger can be Chapter 101. Hemolytic Anemias and Anemia ... of fava beans; but trigger can be Chapter 101. Hemolytic Anemias and Anemia Due to AcuteBloodLoss (Part 11) Table 101-5 Drugs that Carry Risk of Clinical Hemolysis in Persons with ... Clostridium perfringens be responsible Microangiopathic Acute or chronic Red cell fragmentation Red cell morphology on blood smear Different causes ranging from endothelial damage...
... haemorrhage [8-10]. The pro blem ofexcessive bloodloss i s further highl ighted in cases ofsimultaneous bilateral total knee replacement where blood loss i s usually twice that of a unilateral ... reducesperioperative bloodloss associated with total knee arthroplasty. Br JAnesth 1995, 74:534-7.22. Benoni G, G H: Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion ... requirement of blood transfusion after knee replacement.IntroductionTotal knee replacement is a frequently done procedurein modern day practice of any Orthopedics unit. Limit-ing bloodloss both...
... order to reduce post-operative bloodloss [16-19]. The use of tranexamic acidin orthopedic surgery has also shown promising results.It radically reduced both bloodloss and the amount ofallogenic ... reducesperioperative bloodloss associated with total knee arthroplasty. Br JAnesth 1995, 74:534-7.22. Benoni G, G H: Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion ... haemorrhage [8-10]. The pro blem ofexcessive bloodloss i s further highl ighted in cases ofsimultaneous bilateral total knee replacement where blood loss i s usually twice that of a unilateral...