a roadmap of cancer systems biology

... Data Sparsity, Cold Start Problem, Fraud, Scalability, Gray sheep, Shilling attack and synonymy [6-7, 9, 15] Data Sparsity: In practice, many commercial recommender systems are used to evaluate ... evaluate the performance of the developed systems The evaluation of the systems enables to determine the accuracy of the systems HYBRID RECOMMENDER SYSTEMS A hybrid is combination of at least ... have knowledge about how a particular item satisfies a particular user need, and can therefore reason about the relationship between a need and possible recommendation [12] The user profile can...

Ngày tải lên: 25/04/2014, 18:27

... Data Sparsity, Cold Start Problem, Fraud, Scalability, Gray sheep, Shilling attack and synonymy [6-7, 9, 15] Data Sparsity: In practice, many commercial recommender systems are used to evaluate ... evaluate the performance of the developed systems The evaluation of the systems enables to determine the accuracy of the systems HYBRID RECOMMENDER SYSTEMS A hybrid is combination of at least ... have knowledge about how a particular item satisfies a particular user need, and can therefore reason about the relationship between a need and possible recommendation [12] The user profile can...

Ngày tải lên: 25/04/2014, 18:27

... may have intended his absurdly totalitarian cancer hospital to parallel the absurdly totalitarian state outside it, yet when I once asked a woman with invasive cervical cancer about the parallel, ... 1902, a new theory of cancer had slowly coalesced out of all these observations Cancer was a disease of pathological hyperplasia in which cells acquired an autonomous will to divide This aberrant, ... was assembled from universities and hospitals A state -of- the-art laboratory space, with gleaming halls and conference rooms, was built among leafy arcades and gardens in suburban Bethesda, a...

Ngày tải lên: 03/05/2014, 19:11

... elliptic systems, ” Bulletin of the Australian Mathematical Society, vol 50, no 3, pp 501–519, 1994 D G de Figueiredo, “Nonlinear elliptic systems, ” Anais da Academia Brasileira de Ciˆ ncias, vol ... nonlinearities in the critical growth range,” Calculus of Variations and Partial Differential Equations, vol 3, no 2, pp 139–153, 1995 Y Shen, Y Yao, and Z Chen, “On a class of nonlinear elliptic ... a nontrivial solution As the potential V x and the nonlinearity f x, t are asymptotically periodic at infinity, Alves et al 11 proved the existence of at least one positive weak solution Our aim...

Ngày tải lên: 21/06/2014, 22:20

... x -Laplacian problems on a bounded domain,” Journal of Mathematical Analysis and Applications, vol 306, no 2, pp 604–618, 2005 17 X.-L Fan, Q Zhang, and D Zhao, “Eigenvalues of p x -Laplacian ... of the calculus of variations and elasticity theory,” Izvestiya Akademii Nauk SSSR Seriya Matematicheskaya, vol 50, no 4, pp 675–710, 1986 Russian 14 C O Alves and M A Souto, “Existence of solutions ... Journal of Mathematical Analysis and Applications, vol 302, no 2, pp 306–317, 2005 18 X.-L Fan, “Solutions for p x -Laplacian Dirichlet problems with singular coefficients,” Journal of Mathematical...

Ngày tải lên: 22/06/2014, 03:20

... of Mathematics and Econometrics, Hunan University, Changsha, Hunan 410082, China E-mail address: lhhuang@hnu.net.cn Guang Zhang: Department of Mathematics, Qingdao Institute of Architecture and ... Equations: An Introduction with Applications, Academic Press, Massachusetts, 1991 [9] Y M Meng, L Huang, and K Y Liu, Asymptotic behavior of solutions for a class of neural network models of two ... thresholds, Acta Mathematicae Applicatae Sinica 26 (2003), no 1, 158–175 [10] Z Yuan, L Huang, and Y Chen, Convergence and periodicity of solutions for a discrete-time network model of two neurons, Mathematical...

Ngày tải lên: 22/06/2014, 22:20

... conventional electric motor (Boldea & Nasar, 1997) Linear actuators are classified types such as mechanical linear actuators, hydraulic and pneumatic linear actuators, piezoelectric linear actuators, ... Briefly a powerful user interface has features as summarized below:   Individual Functional 14    A Roadmap of Biomedical Engineers and Milestones Adaptation capability Easy-to-use and understandable ... classified as gear motor, gerotor motor, and radial piston motor Hydraulic actuators have great advantages like; have large lifting capacity, can used with servo control, have quick reaction capability,...

Ngày tải lên: 26/06/2014, 23:20

... conventional electric motor (Boldea & Nasar, 1997) Linear actuators are classified types such as mechanical linear actuators, hydraulic and pneumatic linear actuators, piezoelectric linear actuators, ... Briefly a powerful user interface has features as summarized below:   Individual Functional 14    A Roadmap of Biomedical Engineers and Milestones Adaptation capability Easy-to-use and understandable ... classified as gear motor, gerotor motor, and radial piston motor Hydraulic actuators have great advantages like; have large lifting capacity, can used with servo control, have quick reaction capability,...

Ngày tải lên: 27/06/2014, 00:20

... These systems as a whole are called cyclical systems in the sense that the pattern of male exchange between groups changes cyclically (Rochambeau and Chevalet, 1982) Assuming a simple model of each ... but also much easier to practise than random mating of the whole population (Rochambeau and Chevalet, 1990) Maintenance in different locations has the additional merit of reducing the risk of accidental ... value c G as ) C (AF is c obtained, with A showing the largest eigen value of t’ Introducing OF and AF as the average rate of inbreeding per generation and inbreeding at generation t’ within a...

Ngày tải lên: 09/08/2014, 18:22

... University, May 2011 Acquired STAT4 deficiency as a consequence of cancer chemotherapy Major Professor: Hua-Chen Chang Signal Transducer and Activator of Transcription (STAT4) is an important transcription ... cause tumor death in a variety of murine models such as melanomas, sarcomas and mammary, colon and renal carcinomas (124) Its antitumor effects are the main consequence of activating the primary ... experimental autoimmune encephalomyelitis (EAE) (133) Lovastatin, a 16 member of a class of drugs called statins, was initially reported to have anti-inflammatory effects that ameliorate the symptoms of...

Ngày tải lên: 24/08/2014, 10:35

... Heyer AG (2010) Mathematical modelling of the central carbohydrate metabolism in Arabidopsis thaliana reveals a substantial regulatory influence of vacuolar invertase on whole plant carbon metabolism ... exchange measurement Exchange rates of CO2 were measured with an infrared gas analysis system (Uras G; Hartmann & Braun AG, Frankfurt am Main, Germany) A whole-rosette cuvette design was used as ... SDs of experimental results (Fig 5A D), thus proving reproducibility of the obtained parameters and of simulation results Systems biology of cold acclimation in A thaliana Mean values of accession-specific...

Ngày tải lên: 14/02/2014, 22:20

... [30] MAPMAN is a tool to display large datasets onto diagrams of metabolic pathways Not only global distributions of changes in partial correlations but also structural properties of partial correlation ... combination was measured at least once per measuring day The raw data preparation was performed as in [25]; afterwards, the data were log-transformed Overall, 210 metabolites have been measured ... conceptual modeling approach Analyses of metabolite profiles of early development in Arabidopsis thaliana and further observations of heterosis in plants will serve as to validate and further adjust...

Ngày tải lên: 22/06/2014, 00:20

... following additional data are available with this paper online Additional data file contains additional figures Additional data file contains additional tables Additional data file contains the ... ChromaTOF v2.12 software to construct a data matrix (metabolite peak versus sample number) using response ratios (peak area metabolite/peak area [2H2]malonic acid) to calculate the relative amount ... ion ratios were calculated from the uncentroided peak lists using i-Tracker [35,128] Normalized reporter ion areas were calculated as follows: normalized area A = area A/ (area A + area B + area...

Ngày tải lên: 06/08/2014, 18:21

... Maruyama-Nakashita A, Nakabayashi K, Li W, Ogawa M, Yamauchi Y, Preston J, Aoki K, Kiba T, Takatsuto S, Fujioka S, Asami T, Nakano T, Kato H, Mizuno T, Sakakibara H, Yamaguchi S, Nambara E, Kamiya ... to facilitate systems biology analyses especially in the area of bioinformatics Transcriptomics data can be collected in a matter of days or weeks, but the data analyses often take more than a ... [3] Another estimate of the adaxial side of the epidermal layer of the 7th leaf of Arabidopsis was close to 100,000 cells [4] per cm2 of leaf area An Arabidopsis plant can grow as large as 14...

Ngày tải lên: 11/08/2014, 11:21

... programs have generated adequate quantities of high-quality data to enable systems analysis [6] For example, Carerra et al [4] modeled the transcriptional network of Arabidopsis and identified plantspecific ... not trained on drought stress data Another module (characterized by motifs AS~TATAbox, AT~TATA-box, BN~TATA-box, PC~Box_4 and ZM~TATA-box) was affected by the removal of the budset data and is ... Tuskan GA, Casella G, Davis JM, Kirst M: Comparative analysis of the transcriptomes of Populus trichocarpa and Arabidopsis thaliana suggests extensive evolution of gene expression regulation in angiosperms...

Ngày tải lên: 11/08/2014, 11:21

... augment the detection process We are not alone in this vision, as others have also adopted this strategy as a way forward in molecular analysis Alagaratnam et al are utilising Bayesian approaches ... 17(5):323-329 Ito M, Nakamura F, Baba A, Tamada K, Ushijima H, Lau KHA, Manna A, Knoll W: Enhancement of surface plasmon resonance signals by gold nanoparticles on high-density DNA microarrays J Phys Chem ... 51(12):2333-2340 Okamoto M, Kawabe T, Iwasaki Y, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Shimokata K: Evaluation of interferon-gamma, interferon-gamma-inducing cytokines, and interferongamma-inducible...

Ngày tải lên: 12/08/2014, 14:20

... Figure A schematic diagram of computational, analytic and experimental strategies A schematic diagram of computational, analytic and experimental strategies COGRIM modeling was performed by integrating ... Yeh J, Van Waes C: Protein kinase casein kinase mediates inhibitor-kappaB kinase and aberrant nuclear factorkappaB activation by serum factor(s) in head and neck squamous carcinoma cells Cancer ... Siebenlist U, Van Waes C: Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine...

Ngày tải lên: 14/08/2014, 08:20

... state variables, boundaries, etc.) Examples of open systems are: groundwater systems, social systems, as well as most of the natural systems Four types of variables characterize a model of a ... means of the Morris analysis, as in this chapter Examples of the decision variables in RaMCo are the number of fish blasts, the total capacity of urban wastewater treatment plants, and the total ... 1.2.3 Integrated management and policy analysis Integrated management Rapid changes of objectives and methodological approaches towards the management of natural resources and environment can be observed...

Ngày tải lên: 06/11/2012, 10:35

... physical layer of WiMAX adopts a lot of advanced technologies such as scalable orthogonal frequency division multiplexing access (OFDMA), MIMO, adaptive antenna array and so on Current WiMAX that ... mean value of OFDM system capacity for Rayleigh fading channel and Ricean fading channel, by numerical method 165 Fig 6.9: The variance of OFDM system capacity for Rayleigh fading channel ... 802.11 WLAN protocols Table 1.1 Existing 802.11 WLAN Standards IEEE Protocol Name Standard Approved Available Bandwidth Frequency Band of Operation Non-Overlapping Channels (US) Data Rate per Channel...

Ngày tải lên: 20/11/2012, 11:28

... Transactions International Journal of Advanced Manufacturing International Journal of Human Factors in Manufacturing Internationa Journal of Operations and Production Management International ... Table Summary of journals on agile manufacturing Agile manufacturin g research Agile manufacturing as a new strategy is captivating the attention of researchers A growing amount of research has ... the fractal layout organization that has been introduced as an alternative to the more traditional function and product organizations Fractal layout with a nearly square arrangement of machines...

Ngày tải lên: 23/11/2013, 10:01