a promising therapeutic target for alzheimer disease and related disorders pdf

... cutaneous and intracavitary superficial mucosal lesions such as vulvar intraepithelial neoplasia, cervical dysplasia or carcinoma in situ, oral cancer and nasopharyngeal bladder cavity mucosal surfaces, ... carcinoma, lung adenocarcinoma, in vitro and tumor ovarian cystadenocarcinoma, formation in mice colorectal carcinoma, renal cell (J.K Cheong et al, carcinoma, osteosarcoma and unpublished data) hepatocellular ... breast transformation adenocarcinoma cell lines MCF7 in vitro and tumor and ZR-75, human osteosarcoma formation in mice cell line SaOS-2 and human non(Darwish et al., small cell lung cancer cell...

Ngày tải lên: 12/09/2015, 08:19

... Takashi Kudo, Toshihisa Tanaka, Katsuhiko Yanagisawa, Akihiko Takashima, Takeshi Ishihara, Takeshi Tabira, Akihiko Nunomura, Tetsuaki Arai (Third row) Yoshitaka Tatebayashi, Taiichi Katayama, ... George-Hyslop, Harald Hampel (Second row) Takashi Kudo, Tetsuaki Arai, Katsuya Urakami, Katsuhiko Yanagisawa, Nobuo Yanagusawa, Takeshi Tabira, Hiroshi Mori, Tomohiro Miyasaka, Yoshitaka Tatebayashi, Toshihisa ... Osaka University Suita, Osaka 565–0871 (Japan) Tel ϩ81 6879 3221, Fax ϩ81 6879 3229, E-Mail katayama@anat2.med.osaka-u.ac.jp Katayama/Manabe/Imaizumi/Sato/Hitomi/Kudo/Yanagita/Matsuzaki/ Mayeda/Tohyama...

Ngày tải lên: 14/02/2014, 17:20

... Spinal myoclonus: Contractions of periscapular muscles Area supplementary motor area Afferent pathways Intrinsic pathways Efferent pathways Areas and Thalamus I,CM VA All areas of cerebral cortex ... bibliographical references and index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases ... nigral neurons is phasically inhibited in turn by cortical activity expressed through the striatonigral pathway Striatal outputs use gamma-aminobutyric acid (GABA) as a transmitter and comprise a...

Ngày tải lên: 14/03/2014, 22:20

... in several cancer types, including breast, colorectal, gastric, pancreatic, prostate, lung, endometrial, and ovarian cancers, as well as squamous cell carcinoma of the head and neck and multiple ... for the animal facility, participated in in vivo assays and in the radiolabeling of mAb AF-C was responsible for high activity mAb radiolabeling JW produced the B-B4 antibody and critically revised ... this article as: Rousseau et al.: Syndecan-1 antigen, a promising new target for triple-negative breast cancer immuno-PET and radioimmunotherapy A preclinical study on MDA-MB-468 xenograft tumors...

Ngày tải lên: 21/06/2014, 01:20

... patient might ask what the place is and why he or she is being brought there A moment after hearing the explanation, the patient may ask again And again, and again Dr William Nolen, a writer and ... THE OUTWARD SIGNS OF ALZHEIMER S DISEASE Although Alzheimer s disease causes many changes in an affected person’s brain, these changes cannot be seen until after a patient has died and an autopsy ... been a great deal of attention paid to learning about the causes and treatments of these disorders, and exciting new research has taught us a great deal in the last few decades The fact that many...

Ngày tải lên: 05/03/2014, 23:20

... chapter outlines the basic elements of a clinical diagnostic evaluation for Alzheimer s disease (AD) and other dementias; and also addresses how to identify candidates for a dementia evaluation, ... Examination The mental status evaluation involves observing patients and asking questions to gather information about a patient’s behavior and appearance, ambulation and movement, mood and affect, speech, ... in the Evaluation of Alzheimer s Disease and Related Disorders Daniel H.S Silverman Editor PET in the Evaluation of Alzheimer s Disease and Related Disorders Editor Daniel H.S Silverman, M.D.,...

Ngày tải lên: 05/03/2014, 23:20

... standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association Definite and probable ... individuals; IA = neuropathologic diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related ... NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association CERAD = Consortium to Establish a Register for Alzheimer s...

Ngày tải lên: 28/03/2014, 22:21

... Koga-Ban Y, Matsui E, Fang F, Higo H, Nagasaki H, Hori M, Miya M, Murayama-Kayano E, Takiguchi T, Takasuga A, Niki T, Ishimaru K, Ikeda H, Yamamoto Y, Mukai T, Ohta I, Miyadera N, Havukkala I, Minobe ... Seijo GJ, Lavia GI, Fernandez A, Krapovickas A, Ducasse E, Moscone DEA: Physical mapping of the 5s and 18s–25s rRNA genes by fish as evidence that Arachis duranensis and A ipaënsis are the wild ... transport and metabolism F Nucleotide transport and metabolism G Carbohydrate transport and metabolism H Coenzyme transport and metabolism I Lipid transport and metabolism P Inorganic ion transport...

Ngày tải lên: 12/08/2014, 05:20

... Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders) , Saskia Biskup, Germany and Andrew B Singleton, USA (16th ICPD Junior Research Award), Jonathan Brodie, Canada and ... motor areas of the extrastriatal basal ganglia, and movementrelated areas in thalamus and precentral motor fields Thus, although pathologically a localized problem (at least initially), Parkinson’s ... Wilhelm Raab found a catecholamine (CA)-like substance in animal and human brain (Raab and Gigee, 1951) He knew that this CA was neither noradrenaline (NA) nor adrenaline; today, we know that it was,...

Ngày tải lên: 14/02/2014, 17:20

... Blades Court Deodar Road London SW15 2NU, UK Library of Congress Cataloging-in-Publication Data Data available on application British Library Cataloguing in Publication Data Data available on application ... involves one arm and the ipsilateral leg Segmental dystonia: either cranial (two or more parts of cranial and neck musculature), axial (neck and trunk), brachial (arm and axial or both arms ± neck, ... the globus pallidus and the substantia nigra pars reticula (SNr), and use gamma-aminobutyric acid (GABA) as a transmitter Major efferent pathways from the globus pallidus interna and the SNr...

Ngày tải lên: 14/03/2014, 22:20

... glabellar tap Persistent blinking is a feature of Parkinson’s disease, but is also seen in Alzheimer s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject (upper) compared ... normal) arcuate zone (white arrow), and rarefied pale-staining deep white matter, containing thick-walled arteriosclerotic blood vessels lying in dilated and fibrotic perivascular spaces (black arrow)(Luxol ... fast blue–H & E) ©2004 CRC Press LLC Figure 23 Histology showing a lacunar infarct (pale area) with an irregular cavity lined by reactive cells (astrocytes and macrophages) Debris and a few vascular...

Ngày tải lên: 09/08/2014, 16:21

... 11C-raclopride binding in a normal subject (left) compared with that in Parkinson's disease (middle) and in progressive supranuclear palsy (right) (11C-raclopride is a selective reversible antagonist ... degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 ... Coronal section of brain from a patient with striatonigral degeneration showing symmetrical atrophy and discoloration of the putamen ©2004 CRC Press LLC Figure 34 Histology of striatonigral degeneration...

Ngày tải lên: 09/08/2014, 16:21

... (arrowed) containing a basophilic inclusion (H & E) Figure 48 Dorsal (left) and palmar (right) views of dystonic posturing of the left hand of a patient with corticobasal degeneration In particular, note ... degeneration, sagittal T1-weighted MRI (upper) shows predominantly posterior frontal and parietal atrophy (arrowed) Coronal T2-weighted MRI (lower) shows that the parietal atrophy is asymmetrical ©2004 ... ulnar deviation at the wrist and the abducted posture of the little finger ©2004 CRC Press LLC A B C Figure 49 This patient with corticobasal degeneration shows ideomotor apraxia of the left hand...

Ngày tải lên: 09/08/2014, 16:21

... Huntington's disease shows symmetrical atrophy and brown discoloration (arrowed) of the caudate and putamen together with dilatation of the lateral ventricles Figure 69 Histological section of brain in ... Huntington's disease shows areas of increased signal in both the caudate nucleus (white arrow) and putamen (black arrow) Figure 72 Coronal protondensity MRI in a patient with Huntington's disease shows ... Wilson's disease shows atrophy and rarefaction of the putamen (black arrows) Loss of myelin bundles in the putamen contrasts with the more normal appearances in the globus pallidus (white arrow;...

Ngày tải lên: 09/08/2014, 16:21

... Scientific foundation Anatomy and physiology of the basal ganglia: relevance to Parkinson’s disease and related disorders Thomas Wichmann and Mahlon R DeLong (Atlanta, GA, USA) Functional neurochemistry ... basal ganglia Pershia Samadi, Claude Rouillard, Paul J Bdard and Thrse Di Paolo (Quebec, Canada) e ee 19 Neurophysiology of basal ganglia diseases Alfredo Berardelli (Rome, Italy) 67 Dopamine ... (Chicago, IL, USA) 109 Epidemiology of Parkinson’s disease Meike Kasten, Annabel Chade and Caroline M Tanner (Sunnyvale, CA, USA) 129 Neurochemistry of Parkinson’s disease Jayaraman Rao (New Orleans,...

Ngày tải lên: 10/08/2014, 00:21

... Neurophysiology of basal ganglia diseases ALFREDO BERARDELLI* ` Department of Neurosciences and Neuromed Institute, Universita La Sapienza, Rome, Italy The anatomical structures of the basal ganglia are connected ... have provided evidence that parkinsonian patients have an increased RT (Evarts et al., 1981; Jahanshahi et al., 1992), particularly for the more difficult tasks Preparation of movements can also ... (Hutchison et al., 1997) This abnormal neuronal activity brings about a functional change in the motor circuits that link the basal ganglia to the motor cortical area Striatal dopa- mine depletion...

Ngày tải lên: 10/08/2014, 00:21