6 cytokine signaling regulation of epidermal homeostasis and repair
Báo cáo khoa học: E2A participates in a fine control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes pot
Ngày tải lên :
16/03/2014, 04:20
... and BCR signaling collaborate to induce apoptotic cell death of the DT40 cell line, through depletion of ICAD [inhibitor of caspase-activated DNase (CAD)] and inhibitor of apoptosis (IAP2), and ... factors and CAD/ICAD) mediated by PMA/ionomycin results in suppression of activities of caspase-3, caspase-8 and caspase-9, and alterations in the protein levels of survivin, IAP2 and ICAD (and probably ... control of pre-mature B-cell apoptosis by E2A B C Fig Analyses of apoptosis in E2A)/) (A) Effects of PMA/ionomycin and etoposide treatments on cell-cycle distributions of DT40 and E2A)/) DT40 and...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
Ngày tải lên :
08/03/2014, 08:20
... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their effects and that of insulin on p70S6K, PKB, ... and myotubes with antibodies against GSK3a and b Fig 1B shows that whilst preadipocytes express both GSK3 isoforms, the abundance of the b isoform declines by 85%, whereas that of the a isoform...
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Characteristics and Regulation of Exempt Institutions and the Implications of Removing the Exemptions pptx
Ngày tải lên :
15/03/2014, 09:20
... corporation Office of the Comptroller of the Currency Office of Thrift Supervision savings and loans Securities and Exchange Commission Summary of Deposits Department of the Treasury This is a work of ... availability and allocation of credit, the stability of the financial system and the economy, and the safe and sound operations of such institutions To determine the number of certain types of financial ... other hand, accounted for about percent of credit card loans, but they accounted for less than percent of construction and land development loans and almost none of any other type of loan Grandfathered...
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Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx
Ngày tải lên :
29/03/2014, 21:20
... alternate transcript of the GALP gene Further elucidation of the function of GALP and alarin will provide the necessary basis for the treatment and prevention of obesity and related disorders ... rat brain Injection of GALP into the third ventricle induces c-Fos expression, a marker of cell activation, in the horizontal limb of the diagonal band of Broca, POA, ARC and median eminence ... occurs via the activation of orexin- and ⁄ or NPY-expressing neurons, and that long-term body weight loss is a result of the promotion of energy expenditure GALP in feeding and energy metabolism...
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Báo cáo khoa học: Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts doc
Ngày tải lên :
30/03/2014, 15:20
... phosphorylation of IjB and activation of NF-jB Thus, the effect of longterm exposure to TNFa, and most probably to H2O2, on taurine uptake could involve modulation of the NF-jB mediated regulation of the ... stimulation of PKC and PKA Stimulation of PKC and PKA has no detectable effect on the expression of TauT in NIH3T3 fibroblasts (data not shown) and most probably does not involve modulation of the ... has a high specificity and affinity towards taurine and 2.5 Na+ and Cl– are involved in the uptake of one taurine Acute regulation of TauT transport activity by PKC, PKA and H2O2 TauT possesses...
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báo cáo hóa học:" Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients" pdf
Ngày tải lên :
20/06/2014, 07:20
... expression levels of 17 of the highest upregulated and 18 of the highest downregulated miRNAs in undifferenThe comparative expression levels of 17 of the highest upregulated and 18 of the highest ... expression of pluripotency markers Oct4 and Nanog and increased expression of differentiation markers Ncam1, Eno3 and Afp (Figure 4) While eIF6 expression was unaltered, that of Drosha and Dicer ... gene expression in differentiated NTera2 and 2102Ep cells The expression of markers of pluripotency (Oct4 and Nanog) and of endoderm (Afp), ectoderm (Ncam1) and mesoderm (Eno3) differentiation is...
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Báo cáo khoa học: " Water flux in boreal forest during two hydrologically contrasting years; species specific regulation of canopy conductance and transpiration" pps
Ngày tải lên :
09/08/2014, 04:20
... the goodness of fit were standard error of the estimate and coefficient of deter- ) mination (r 2.5 Effect of soil drought on water and carbon fluxes - quantification The effect of drought on ... sap flow and the product of VPD and radiation was tight and reached r 0.92 and r 0.91 for pine and spruce, respectively Sap flow was thereby accordingly shifted in time to mimic the rate of transpiration ... functions of Marklund [26] The species foliage mass represented 14 and 86 % of the total actual stand foliage mass for pine and spruce, respectively Using the current basal area for stand and species,...
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báo cáo khoa học: "The grapevine guard cell-related VvMYB60 transcription factor is involved in the regulation of stomatal activity and is differentially expressed in response to ABA and osmotic stress" ppt
Ngày tải lên :
11/08/2014, 11:21
... activity of both VvMYB30 and VvMYB60 promoters A region of approximately kb located upstream of the ATG codon of VvMYB30 and VvMYB60 was fused to the b-glucuronidase (GUS) reporter gene and the ... sensitivity of guard cells to ABA [10] We used the atmyb60-1 allele to investigate the role of VvMYB60 in the regulation of stomatal activity and to Page of 14 explore the conservation of the MYB60 ... sequence of the VvMYB60 and AtMYB60 proteins is highly conserved, ii) the VvMYB60 and AtMYB60 genes show very similar expression profiles, both in terms of tissue- and cell-specificity and response...
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ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
Ngày tải lên :
24/08/2014, 11:02
... THE ROLE OF REDOX EFFECTS AND THE KU80 CTERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU DNA double strand breaks (DSB) are among the most lethal forms of DNA damage and can ... binding activity To further understand these methods of regulation of Ku and DNA-PK, a pair of mutants has been constructed; one consisting of full length Ku70 and truncated Ku80 (Ku70/80C) lacking ... mM NHS, 900 nM Ku70/80C and varied concentrations of Ku80CTR Reactions were formed in the presence and absence of 22 pmol 30-bp double strand DNA 30A and 30C (Table 1) and g BSA as indicated...
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REGULATION OF ADHERENS JUNCTION AND MECHANICAL FORCE DURING APOPTOSIS IN EPITHELIAL TISSUE MORPHOGENESIS
Ngày tải lên :
09/09/2015, 08:18
... 1.1 Life cycle of Drosophila and the development of histoblast Schematic showing of the development process of histoblast through the life cycle of Drosophila Histoblasts consist of four nests: ... edge of neighboring cells during late stage of apoptosis……………………………………………………….108 Figure 4.4 Overview of the timing of apoptotic events…………………………… 111 ix List of Movies Movie Confocal movie of ... deformation upon apoptosis of non-boundary LECs 42 3.2 Apical constriction of apoptotic LECs and caspase activation 44 3.3 Regulation of cell adhesion and tissue tension during...
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Regulation of substance p and neurokinin 1 receptor expression in a mouse model of acute pancreatitis
Ngày tải lên :
09/09/2015, 17:54
... stimulates NF-B and AP-1 56 3.3.6 Effect of PD98059 and SP600125 on DNA binding activity of NF-B and AP-1 58 3.3.7 Effect of Bay 11-7082 on the expression of SP, PPTA and NK1R ... severity of SP, highlighting the importance of TRPV1 and NK1R (Hutter et al., 2005) High doses of Resiniferatoxin caused disruption of 20 the celiac ganglion and inhibited SP release, and showed ... product of the preprotachykinin-A (PPTA) gene, and it binds mainly to neurokinin-1 receptor (NK1R) SP and NK1R were previously detected in isolated pancreatic acinar cells, and up -regulation of pancreatic...
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Regulation of interleukin 12 and interleukin 23 production by tristetraprolin
Ngày tải lên :
09/09/2015, 17:56
... Roles of IL-12 and IL-23 in innate immunity 44 1.4 Transcriptional regulation of IL-12 and IL-23 production 48 1.4.1 Regulation of IL-12p40 promoter 48 1.4.2 Regulation of IL-12p35 ... 184 List of Figures and Tables Figure 1.1 Model of divergent differentiation of TH1 and TH17 lineages and role of Treg cells 38 Figure 1.2 Mechanism of Tristetraprolin ... Figure 1.1 Model of divergent differentiation of TH1 and TH17 lineages and role of Treg cells Differentiation of naïve CD4 T cells in the presence of dendritic cells, NK cells and T cells derived...
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Molecular mechanisms underlying the regulation of the positioning and formation of the cleavage furrow in cytokinesis in mammalian cells
Ngày tải lên :
14/09/2015, 14:09
... step of cell division crucial for cell growth and development A clear understanding of the spatial and temporal regulatory mechanisms of cytokinesis is important not only for basic knowledge of ... cytoskeleton………………………………63 4.2.3.1 Effects of inhibition of Cdc42 activity on actin dynamics and organization…………… 63 4.2.3.2 Effects of overstimulation of Cdc42 activity on actin dynamics and organization………………… ... cytokinesis……………………………………………………….59 4.2.2 Effects of modulation of Cdc42 activity on RhoA localization………………………………………………………61 4.2.3 Effects of modulation of Cdc42 activity on the dynamics and organization of actin cytoskeleton………………………………63...
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Regulation of subcellular localization and functions of RGK proteins by 14 3 3 and calmodulin
Ngày tải lên :
14/09/2015, 18:28
... relocalization of RGK proteins by 14-3-3 3-3A Regulation of localization of Kir/Gem by 14-3-3 3-3B Regulation of localization of Rad by 14-3-3 3-3C Regulation of localization of Rem1 by 14-3-3 3-3D Regulation ... localization of Kir/Gem W269G and mutants by 14-3-3 3-5B Binding of 14-3-3 to Kir/Gem mutants lacking CaM binding 3-5C Regulation of localization of Rad L281G and mutants by 14-3-3 3-5D Regulation of localization ... of work Kir/Gem, Rad, Rem and Rem2 (RGK) are members of a distinct family of Ras GTPases Two important functions of RGK proteins are the regulation of voltage gated calcium channels (VDCCs) and...
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color atlas of cutaneous excisions and repairs - k. lee, et al., (cambridge, 2008)
Ngày tải lên :
12/05/2014, 17:35
... bevel of the blade out will allow for closer reapproximation of the skin-wound edges 19 SIMPLE EXCISION AND REPAIR B A C D Figure 2.4 Rule of Halves A The rule of halves in the repair of a simple ... along RSTL 22 SIMPLE EXCISION AND REPAIR 23 SIMPLE EXCISION AND REPAIR Figure 2.7 Dog-Ear Removal Management of redundant triangles of tissue also known as standing cones and dog-ears is important ... University Portland, Oregon Neil A Swanson, MD Professor and Chair, Department of Dermatology Professor of Surgery, Otolaryngology/Head & Neck Surgery Oregon Health & Science University Portland, Oregon...
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Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx
Ngày tải lên :
09/08/2014, 06:23
... and induces the expression of IFN-responsive genes in SOCS3- Regulation of lipopolysaccharide (LPS) signaling by STAT3 (signal transduction and activators of transcription 3) and suppressor of ... negative regulation of LPS responses Immunity 2002, 17:677-687 Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ: Re-examination of the role of suppressor of cytokine signaling (SOCS1) in the regulation ... activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils Immunity 1999, 10:39-49 Egan PJ, Lawlor KE, Alexander WS, Wicks IP: Suppressor of cytokine signaling- 1...
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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
Ngày tải lên :
14/02/2014, 19:20
... role of miRNAs with respect to the complicated regulation of the transcriptome and signal transduction Although miRNAs and well-established cell signaling pathways have been the subject of recent ... have focused upon the role of miRNAs in regulatory network of various cell signaling pathways We summarize the current knowledge of the interdependence of miRNA and cell signaling pathways, which ... regulator of the MAPK-ERK signaling pathway because miR-21 is both induced by the activation of ERK1 ⁄ and enhances the activity of ERK1 ⁄ by repressing negative regulators of the ERK ⁄ MAPK signaling...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
Ngày tải lên :
18/02/2014, 16:20
... activation of the p38-type MAPK and thereby inhibition of 5800 autophagic proteolysis [14] Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling ... cholesterol-enriched microdomains of the plasma membrane (caveolae), intracellular organelles, ligandindependent activation of growth factor- and cytokine receptors and autocrine stimulation of signal transduction ... sites (‘osmosignaling’) Anisoosmotically exposed cells and tissues were frequently used as a model in order to study osmosensing and osmosignaling By this approach, the activation of signaling...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
Ngày tải lên :
08/03/2014, 08:20
... SRF of an, as yet, unidentified accessory factor [54] The regulation of c-jun is complex and may involve an increase in the levels of c-jun protein and/ or phosphorylation of specific serines (63 and/ or ... the phosphorylation of CREB and MSK1 was not depleted by Pd-98059 and SP-600125 that inhibit ERK1/2 and JNK, respectively, consistent with the absence of effects of these signaling molecules ... RNA was purified and analyzed by Northern blot and phosphorimaging densitometry The relative amounts of normalized messenger RNA were plotted as a function of time and the slope of this curve was...
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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
Ngày tải lên :
28/03/2014, 22:21
... implicating Tec kinase signaling in multiple levels of regulation of cytokine production Itk and the regulation of cytokineproducing innate T-cell populations The contributions of TFKs to peripheral ... Cytokine regulation by Itk and Rlk ⁄ Txk J Gomez-Rodriguez et al common effects may involve activation of NFAT transcription factors, as seen for Th2 and Th17 cytokine regulation, or the regulation of ... activator of the Ras–Raf–ERK pathway in T cells Mutation of Itk prevents full activation of Ca2+ mobilization and ERK activation – these defects are worsened by mutation of both Rlk ⁄ Txk and Itk...
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