Nguy~n Hoang Linh, Huynh Kim Khang, Nguy~n Du-cVii, DU'ongVan Hai, Nguy~n Cong Minh Nghien cuu d~c diem lam sang va c~n lam sang cua b~nh nhan viem gan B m9n tfnh du'Q'cdi'eutr.. bang th[r]
(1)AI ..:.
LEKETNAP .
THANG 11 SO 2 2020
A A A
TONG HQI Y HOC VI~T NAM VIETNAM MEDICAL ASSOCIATION
68A Ba Tri~u - Hoan Kie'm - Ha NQi;Tel: 024-39431866
Email: tapchiyhocvietnam@gmail.com; Webslte: tonghoiyhoc.vn
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
._ - - -
-1
MUCLUC
• •
T~p CHi Y HQC VII;T NAM T~P 496 - THANG 11 -so 2 - 2020 VIETNAM MEDICAL JOURNAL N02- NOVEMBER - 2020 anh gia vai tro nQisoi6bunq chan doan va dieu tr] vet thu'dng tanq rang Evaluation the role of laparoscopic in diagnostic and treatment of holow viscus perforation wounds
Nguy~n Hoang Linh, Huynh Kim Khang, Ng_uy~nDuc Vd, Duong Van Hai, Nguyen Cong Minh Phl:lc hoi cong rang ora sua sau va Ion bang chup Zirconia co san
Treatment anterior crown with pre-fabricated Zirconia
Nguy~n Anh DU'O'ng,Vo Truong NhU'Ngoc, Ngo Van Toan Thl/c tranq hoat dQng tiem phong benh dai t9i tinh Gia Lai, giai dean 2015 - 2019 Situation of rabies vaccination in Gia Lai province, 2015-2019
Nguy~n Van Chuyen, Nguy~n Van Khai, Nguy~n Th] Minh Ngoc B~c diem lam sang va ket qua dieu tr! nQisoi cam rnau mOi bang dong di~n
l:linical characteristicsand endoscopicelectrocauterytreatment outcomesof epistaxis Ha Phuong Thao, Trin Thi Mai Nghien cuu bao che vien nen Fexofenadin hydroclorid phan tan nhanh de tang hi~u
qua dieu tr] vlem mOid! ung
Preparation and evaluation of Fexofenadinehydrochloride rapid dispersible tablets to increasethe effectiveness for treatment of allergic rhinitis
ViiVan Tu~n, Nguy~n Van B~ch Nghien cuu cai thien dQon d!nh thudc tlern Rotundin sulfat de tang tac dl,mgan than Study on improving stability of Rotundine sulfate injection to increase sedative effect
Nguy~n Thi Ha, Nguy~n Van B~ch Ket qua bu'ocdau nQisoi0bl:lng dieu tr! vet thu'dngcd hoanh
The initial result of laparoscopictreatment diaphragm wounds
Nguy~n Hoang Linh, Huynh Kim Khang, Nguy~n Du-cVii, DU'ongVan Hai, Nguy~n Cong Minh Nghien cuu d~c diem lam sang va c~n lam sang cua b~nh nhan viem gan B m9n tfnh du'Q'cdi'eutr! bang thuac Tenofovir
l:linical characteristics of chronic hepatitis B cured by Tenofovir
Da Thi Quynh, Vii Van Nga, Bid Thi Thu Hoai Banh gia rai lo~n chuyen hoa cald - phospho - PTHa b~nh nhan 19Cmau chu ky t9i Khoath~n Tiet ni~u - L9Cmau, B~nh vi~n Huu Nghi
Evaluating the metabolism trouble in dialysis patients at neuphrourology - dialysis department, Huu Nghi Hopital
Trinh Thi Thanh H~ng, Nguy~n Van Tin, Nguy~n Th~ Anh 10 Khao sat sl/ tuan thu dieu tri Tenofovir tren b~nh nhan viem gan B m~n tfnh
Investigation of Tenofovir treatment adherence in chronJchepatitis B patients
Vii Van Nga, Do Thj Quynh, Vii Thj ThO'm, Le Thj Di~m HAng, Bui Thj Thu Hoai 11 O'ng dl:lngky thu~t multiplex PCRphat hi~n cac gen mcr-1, mcr-2 va mcr-5 khang
colistinacac chung Escherichiacoli phan I~p tu cac trang tr9i gaa Ha Nam
Application of the multiplex PCRtechnology for detection of colistin resistant mcr-1, mcr-2 and mcr-5 genes in the Escherichiacoli strains isolated from the chicken farms in Ha Nam
Hoang Thi }\1aiHU'O'ng,Hoang Thj An Ha, Vii Nhi Ha, Hoang Thj L~an, Phung The Khang, Ph~m Duy Thai, Trin Huy Hoang 12 Banh qia tlnh tranq nhiem virus viem qan B, Cab~nh nhan 19Cmau chu ky t9i khoa
Th~n tiet ni~u-19Cmau, B~nh vi~n Huu Nghi
Infection with hepatitis Band C virus in dinalysis patients at the nephrology-dialysis
department, Huu Nqhi Hospital ,
Nguy~n Van Tin, Trinh Thi Thanh Han!! Hoan!! Manh Tron!!.• • x X I
Nguyen Le Hoa, Nguyen The Anh
2.
3.
4.
6.
7.
8.
9.
1
5
8
13
16
20
26
31
35
39
43
48
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
- - - -_
13 Thl/c tranq kern khoanq hoa men rang ham Ion - rang ctra nhorn h9Csinh 12-15 51
tuoi t~i tinh Binh Dlnh narn 2019-2020
The current situation of molar incisor hypomineralistaton in group of 12-15 years old students in Binh Dinh province in 2019-2020
_ Nguy~n Phuc Minh, Vo Truong NhU'NgQc
14 Mqt so d~c diemdkh tehoc cacca tu vong dobenhdaitaitinhSdn La (2015 - 2019) 55
Some epidemiologicalcharacteristicsof human rabiesin Son La province (2015 - 2019) Nguy~n Van Chuyen, Nguy~n Van Ba, Hoang Th] Thuan
15 Thay dOi tham my m~t nha voi ph§u thuat phoi hop dich chuyen tien ham va tao 59
hlnh cam
Simulataneuos premaxilla osteotomy and genioplasty on the facial profile attractiveness of patients with convex face
DB Tuin Ngoc, But Huu Phurrc,
veHang Lie~, Hoang Tuin Anh
16 So sanh ke't qua dieu tr] dom nau anh sang cua Laser nano giay Q-Switched Nd: YAG 63
532 nm va Laser pico giay nd: YAG532 nm
Q-Switched double frequency Nd:YAG 532-nm nanosecond Laser vs double frequency Nd:YAG532-nm picosecond laser for the treatment of solar lentigines
Pham Thj Mai Trinh, Le Hfru Doanh, veThai Ha
17 B~c diem di can h~ch bachhuvet vung co ungthu bieu ma tuyen giap bi~thoa 68 Characteristics of cervical lymph node metastasisin differentiated thyroid cancer
Nguy~n Van Nam, TrAn Xuan BQ Vii Anh Hai, Le Thi Tuy~t Nhung
18 Mqt so d~c diem lam sang va c~n lam sang cua rang ham seraham tren co b~nh1'1 71
tuy ho~itU0 mqt nhom b~nh nhan den kham t~i B~nh vi~n Rang Ham M~t Trung L(dng Ha Nqi nam 2019
Clinical and radiographic evaluation of primary upper molars with necrotic pulp of young patients at Hanoi National Hospital of odonto-stomatology
Le NgQcDi~p, VOTruong Nhu NgQc, Ph~m Hoang Tuin, Nguy~n Thi Van Anh 19 Mqt so d~c diem dich t~ h9Cvi khuan Rickettsia0Mien sac Vi~t Nam 75
Epidemiological characteristics of Rickettsia in North Vietnam
LuO'ngThi HAng Nhung, Nguy~n Vii Trung, Le Thi HQi, Ma Thi Huyin 20 Thl/c tr~ng tai n~n thL(dng tfch cua tre nh~p khoa capcuu t~i B~nh vi~n Nhi Trung 79
L(dngtU'7/2019 - 6/2020
Situation of children's injury admitted the emergency department at viet nam National Children's Hospital from 7/2019 - 6/2020
Nguy~n Thi Huyin Sam, Truong Thi Mai HAng 21 Banh gia ket qua ph§u thu~t dieu tri h~p dqng m~ch canh ngoai S9 t~i B~nh vi~n Da 82
khoa Dong Nai
Results of extracranial carotid artery endarterectomy in Dong Nai Province Hospital Tr~n Quy~t Ti~n, Nguy~n Anh Diing 22 Hi~u qua rna hinh phl:1Choi chuc nang dl/a vao cQngdong cho ngL(Oikhuyet t~t v~n 86
dQngt~i huy~n Thong Nhat tinh Dong Nai
The effectiveness of community-based rehabilitation for people with mobility disabilities in thong nhat district Dong Nai Province
Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng
23 Ket qua ph§u thu~t nQisoi cat rUQtthLtaqua dL(ongam d~o 90
The results of laparoscopic appendectomy through vaginal route
DB Tit Thanh, Tr~n Binh Giang
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
24 Kha nang cung ung dich vu cham soc tre so sinh tal Trung tam Y te huyen Kim Boi, 93 tinh HoaBinh, narn 2019
Infant care service delivery providing at Kim Boi District health center in Hoa Binh Province in 2019
Nguy~n QuAc Ti~n,Nguy~n Quang T,!, Nguy~n Dang Vtmg,
Pham Hai Thanh, Nguy~n Huu Thing
25 Cck yeu to dlj bao ket cue d benh nhan dQt quy thleu rnau nao cec bQ cap tfnh du'<;>'c97 dieu tr] tai tu'oi mau bang lay huyet khoi cd hoc ket hop d~t stent cap ciru thuoc tuan hoan nao truce
Outcome forecast factors in patient with acute ischemic stroke received reperfusin treatment using mechanical thromboembolism combined with anterior cerebral circulation emergency stent
Nguy~n Van Huy, Mai Duy Ton, LeHAng Trung
Dito Vi~t Phuong, Vii Dang LU'U, Tdn Anh Tu~n
26 Tinh hinh tang ap luc 0 bunq va mQt yeu to nguy co benh nhan n~ng nh~p vi~n 102 khoa Hoi sireTfch cue
Intra-abdominal hypertension and some risk factors in patients who admitted to the intensive care unit
D~ng Th] Huong, Dao Xuan CO'
27 Hoi tu'dng quan giG'aap luc nQi SQva diem glassgow d b~nh nhan xuat huyet nao 5 105 dau
Correlation between the intrcranial pressure and glassgow score in patients with brain hemorrhage for the first 5days
LeThi Bich Thiiy, ~guy~n Van ChU'O'llg
28 KhilO sat cac yeu to lien quan den mucdQ n~ng cua b~nh gan nhiem ma khong ru'<;>'u 109 Related factors of severe nonalcoholic fatty liver disease
Vo Duy Thong, D6 Duc Minh
29 Tinh tr~mg trCing qua huyet ap Iu'u dQngd b~nh nhan IQcth~n 113 Dipper pattern on ambulatory blood pressure monitoring in the hemolysis patients
Chau Huu HAu, Nguy~n Minh Tri
30 KhilO sat ta du'Q'cdong kho cho cong thl)'C bao che thuoc tiem dong kho liposome 117 amphotericin B
Investigation lyophilized excipients for the preparation formulation of liposomal amphotericin B for lyophilized injection
Nguy~n Tu~n Quang, Ph~m Thi Minh Hu~, Nguy~n Thai SO'll
31 HQt so yeu to lien quan toi thai gian dieu trl cua ngu'ai b~nh viem loet giac mi;lc 120 Factors related to treatment duration in patients with corneal ulcer
D~ng Thi Hai Hit, Ph~m HAng Van
32 Banh gia hi~u qua kiem soat ho hap cua phu'dng phap thong khf ap Iljc du'dng ngat 123 quang dau trung tam ket h<;>'pngoi;li vi ph§u thu~t ti;lo hinh khf quan
Evaluate the effectiveness of airway management using distal tracheal intubation and intermittent positive pressure ventilation for tracheal resection and reconstruction surgery
Dinh Thi Thu Trang, Nguy~n Minh Ly,
Cong Quy~t Thing, TAng Xuan Hung
33 Thljc tri;lng dam bao thuoc thong qua hinh thuc dau thau ti;li B~nh vi~n Quan Y 105 128
tltnam 2015 - 2018
Current situation of drug security through drug bidding at 105thmilitary hospital from
2015 to 2018
HA CanhH~u, Nguy~n Minh Chinh,
Hoang Hai, Nguy~n CAm Van, Vii NgQcMai
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
34 Nghien cuu d~c diem lal}l sang due the thuv tinh sau chan thu'dng va mQt so yeu to tien hrono thi nrc sau ohauthuat dieu tri
Clinical characteristics and prognostic factors for visual outcome of traumatic cataract
Pham Phuong Dung, Th§m Truong Khanh Van
35 8anh gia ket qua phuc hoichuc nang nh~n tmrc cho benh nhan chan thu'dngS9 nao tal B~nhvi~n Phuc hoiChuc nang Ha NQinarn2019 - 2020
Functional cognitive assessmentof the patient after traumatic brain injury
Phan Thi Ki~u Loan, Ph~m Van Minh
36 Banh gia hi~u qua phuc hoi chirc nang thang bang tren ngu'oi benh nhoi rnau nao t1;li B~nhvi~n Lao khoa Trung u'dng
Assessment the effectiveness of balance rehabilitation for patients after cerebral infarction at National Geriatric Hospital
aaThi HUiYDgMinh, Cao Minh Chau
37 B~c diem lam sang va c~n lam sang cua benh nhan tnrot dot song don tang khuyet eo
Clinical and subclinical of patients with one-level lumbar spondylolisthesis
.Tdn HBng Vinh, Nguy~n Van Thach, Vii Van Hoe
38. Khao sat chi so FIB-4 dl,( doan giantinh machthirc quand b~nh nhanxd gan co chu'ang
Investigation apri indicator to predict esophageal varices in cirrhosis patients with ascites
ve Duy Thong, HAThi Van Anh
39. Thl/c tranq ngu'oi khuyet t~t v~n dQng va phuc hoi chirc nang cho ngu'oi khuyet t~t v~n dQngdl/a vao cQngdong tc;lihuy~n Thong Nhat tinh Dong Nai
The current situation and community-based rehabilitation for people with mobility disabilities in Thong Nhat district Dong Nai Province
Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng
40. Danh gia chat 1u'Q'ngkhOitieu (au qua trlnh bao quanva moi lien quan giO'acu'ong dQhuynh quang vai doi song cua tieu cau du'Q'csan xua'tbang phu'dngphap buffy coat Assessment the quality of platelets during storage period and the colleration between the fluorescence intesity and the lifetime of platelets produced by buffy coat method
Nguy~n Thj Lan, Luu Thj Thu Phuong,Tr§n Van Tinh,
Nguyin Dac Thao, Tr§n Thj Thanh Tam
41 Nhu cau cham soc dai hc;lncua ngu'oicao tuoi d mQt so xa thuQc huy~n Soc Sdn, Ha NQinam2018 - 2019
.tong-term care need of elders in some wards in SocSon district, Ha Noi in2018 - 2019
Nguyin Thi Thu Huy~n, Ph~m Le Tuin
42. Phau thu~t ung thu'tuyen giapd ngu'Oib~nh Basedowtc;IiB~nhvi~n NQitiet Trungu'dng Thyroid cancer surgery in patients with Basedowdisease at the National Hospital of endocrinology
" ' ,
Ph~m Quyet Thang, Tran NgQc Luong
Da Thanh Cong, Truong Quang Huy
43 Banh gia cau truc vi the va dQ ben cua ma van tim lQ'nsau bao quan Ic;lnhsau
Evaluation of the microstructure and tensile strength of the cryopreserved porcine heart valve
Cu Thj Bich Thuy, Ngo Duy Thin, Duong Cong Nguyen,
Le Thj HAng Nhung, M§u Van Cal!h
44 Kinh nghi~m bu'ac dau sU'dl,lng du'ong lIlo it xam Ian qua md ngl/c phai ph§u thu~t thay van hai 113tc;liB~nh vi~n ChQ'Ray
Early experience of minimal invasive surgery by the right thoracotomy in mitral valve replacement at the cardiac surgery deparment of Cho Ray Hospital
Lam Tri~u Phat, TrAn Quy~t Ti~n
132
136
139
142
145
149
153
157
160
164
168
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
45 U'ng dunq thuc nqhlern phau thuat n9i soi qua duang am dao tren lon giai doan 173 2011- 2014
Applying experimental laparoscopic appendectomy throu~h vaginal route on pig
D6 Tat Thanh, Trin Blnh Giang
46 Kha nang cung lIng dich vu cham soc SlICkhoe so sinh tal cac Tram Y te xa, huy~n Kim BOi,tinh Hoa Blnh, nam 2019
Ability to provide neonatal medical health care services at commune healthcare stations at Kim Boi Provine,Hoa Binh District, 2019
Nguy~n Qu6c Ti~n, Nguy~n Quang Tu, Nguy~n Dang Vu'ng, Pham Hai Thanh, Nguy~n Hfru Thi~g
47 Banh gia ket qua phau thuat cat amidan bang dao Ligasure The evaluation results of tonsillectomy method with Ligasure
Nguy~n Phuong Thao, Nguy~n Quang Trung
48 Nghil~n ClIUsir thay doi the tfch the chai tren hinh anh c9n9 hu'angtir a benh nhan nghi~nruou
Research on change in volumes of corpus callosum on magnetic resonance imaging of the alcoholic patient
Le Phi Dlili, Nguyen Thi Sinh, Tran Ngoc Anh, D~ng Ti~n Truong
49 B~c diem lam sang, chan doan hinh anh b~nhIy d!ch nao vo nen S9 sau chan thu'dng S9nao t~i B~nh vi~n Vi~t £)lIC
«;Iinical characteristics and imaging evaluation of cerebrospinal liquid leak (csf) caused by skull base fracture post traumatic injury in Viet Duc Hospital
_ Ngo Manh Hung, TrAn Blnh Ngoc, Nguyjn Duc Dong
50 Banh gia tinh tranq nhiem khuan b~nh vi~n a b~nh nhan du'qc dieu tr! ECMOt~i B~nhvi~n B~ch Mai
Evaluate hospital associated infections in patients who were on ECMOat Bach Mai Hospital
Trin Duc Trung, Dao Xuan CO' 5! C.c3cyeu to anh huang ket qua dieu tr! viem loet d~ day ta trang helicobacter pylori
du'dng tfnh bang phac thuoc Amoxicilin,Levofloxancin, PPI t~i B~nh vi~n Trung U:dnaThai Nauven
Clinical factors influencing the efficacy of H.pylori eradication of triple therpy (Amoxicilin, Levofloxancin, PPI)in Thai Nguyen General Hospital
Ngo Duc hQ'P, Duong HAng Thai, Nguy~n Thj Thu Huy~n
52 Tinh hinh nhi~m nam Malasseziatren benh nhan viem da cd dia tai Benh vien Da
Ii~u Trung u'dng
Malassezla infection in patient with atopic dermatitis at National Hospital dermatology and venerology
Nguy~n Van Hi~u, Trin CAm Van, Phlilm 'fhi Minh Phuong
53 Banh gia ket qua hoax~tridong thai tjen phauungthu' bieu rna thl/c quan 1/3 giO'adu'Oi Assessment of the rusults of preoperative chemoradiotherapy for esophageal cancer
Phlilm Quang Anh, VO Van Xuan
54 Banh gia d9C tfnh ban tru'ang di ~n tren h~ t~o huyet cua vien nang ClIng Fucolen sau bao che tren d9n9 v~t thl/c nghi~m
Examines the semi-chronic toxicities of Fucolenon experimental animals
Trin Thanh Huong, TrAn Van Thuin, Vii Mlilnh TuAn, Nguy@n Van Khiem, Dao Van Tu, Nguy~n Ti~n Quang
55 Nh~n xet ket qua sau tuan dieu tr! Esomeprazoletrong viem diil day khang kern theo loet a tre nhi~m Helicobacter Pylori tiili B~nhvi~n Nhi Trung u'dng
Assesment of treatment result with esomeprazole after weeks for non- ulcer gastritiS combined Helicobacter Pylori infection in vietnam national Hospital'S Childr~n
DilO Thj Ngoan, Phan Thj Hien
176
179
182
185
188
193
197
201
205
210
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
56 B~c diem lam sang c~n lam sang va thai gian song them khang benh ung thir bieu 214
ma tuyen che nhay de day giai doan II, III
Clinical characteristics and complementary examination, disease free survival and some factor affect disease survival of mucious gastric cancer stage II-III
Nguy~n Thi H~ng, Trinh Le Huy, LeVan Thimh
57 B~c diem lam sang va m9t so yeu to lien quan den b~nh vlem da dau tal B~nh vi~n 218
Da Ii~u Trung u'dng
Clinical manifestations and several factors relating to seborrheic dermatitis in National Hospital of Dermatology and Venereology
TruongTh] Thanh Huong, Nguy~n Huu Sau, Trin cim Van
58 B~c diem lam sang va nhu cau cham soc dieu du'ong dau cua ngu'ai benh 221
c6 h9i chung cai nrou
Clinical characteristics and needs for carein the first day of of patients with alcohol withdrawal syndrome
DBThi Hoa, Nguy~n Doan Phuong, Le Thi Thu Ha, Nguy~n Th] Hila,Pham Xuan Thing
59 Ket qua sam ph§u thuat teo ruot non bam sinh tal B~nh vi~n HO'unqhl Vi~tDuc giai 225
doan 2017 - 2019
Results of surgical treatment for jejunoileal atresia in infant at Viet Duc University Hospital from 2017 to 2019
Chu Minh Phuc, Nguy~n Vi~t Hoa, Vii Hang Tuan
60 Bi~u qua dieu tri cua colchcin may day man tfnh tilphat
Colchicine in the treatment vietnamese patient with chronic spontaneous urticaria Ngo Th] Minh Nguy~t, Pham Thj Lan
61 Banh gia ket qua dieu tr] Erlotinib bu'ac m9t tren benh nhan ung thu' phoi khang te bim nho giai dOe;!niv c6 d9t bien EGFR
Assessment treatment outcome of first-line Erlotinib in patients with advanced EGFR mutation-positive non-small-cell lung cancer
Nghiem TrAn VU'Q'Ilg,Nguy~n Ti~n Quang, Le Thi Y~n
62 Trai nghi~m cua giang vien ve chu'dngtrlnh giao dl,lc dieu du'ong dy'a vao nang h!c Perceived experiences of nurse educators in a competency - ba.sed nursing curriculum: a qualitative descriptive study
Nguy~n Thi HAng Anh, Ph~m Thi Thuy Dung 63. Thl/c tre;!ngtiem chung day du va dung lich cua tre em du'ai tuoi t9i huy~n Tr9m
Tau, tinh Yen Bai nam 2019
The fully and scheduled immunized situation among under 1-year-old children in Tram Tau district, Yen Bai province in 2019
Cao Bach, LQCThi Mai, Le Thi Thanh Xuan
64 Ket qua dieu tri soi ni~u quan 1/3 du'ai bangTamsulosinti;liB~nhvi~n De;!ihQcY Ha N9i Results of therapy of therapy of under 1/3 by Tamsulosin treatment in Hospital
University of Hanoi
Trinh Anh Tu§n, Vii Nguy~n Khai Ca 65 Gia tri cuatY I~ dau nang noan (FORT)vai ket qua kfch thfch buang trung
Use of follicular output rate (FORT)to predict ovarian stimulation outcome
Ph,m Thi Anh, Nguy~n Lien PhU'ong, LU'UQuynh HU'ong,HASy Hung
66 Khao sat cau truc vi the tinh machtinh cua nhO'nqbenh nhan qian tinh mi;lchtinh Evaluating the microstructure of veinous walls inpatients with varicocele
Nguy~n Hoai Bic, Dinh Van Toan, Ph,m ThuAn M,nh, Hoang Long
229
233
237
241
245
248
252
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
67 Hi~u qua khU'te bao mang nqoel tim bo bang Sodium Dodecy Sulfate 256 Decellularized effect and extracellular structure of bovine pericardium after treatment with Sodium Dodecy Sulfate
Nguy~n Van Hoang, Ngo Duy Thin,
i.eThi HAng Nhung, Miu Van Canh
68 "~c diem lam sang, nQisoiva mo benh hoc 0benh nhan dieu tr] cat tach nlem mac 259
dai truetrang
Clinical, endoscopic and histopathological features in patients undergoing endoscopic submucosaldissection
Le Phu Tai, Nguy~n Cdng Long
69 Khao sat tinh tri;!ngnhiemkhuantiet ni~u0benh nhantrong3thang aau saughepth~n 263 Investigationof the urinary tract infections in kidney transplant recipents in the first
3 months after transplantation in bach mai hospital
Hoang Thi Nhan, Mai Thi Hiin, Nguy~n Thi Hmrng 70 Hi~u qua cua phu'dngthircAVAPS0 benh nhan d<;1tcap b~nh phoi tac man 266
tlnh (COPD)du'<;1Cthong kh(nhan tao khongxam nh~p
Effectiveness of AVAPS in acute exacerbation of chronic pulmonary obstructive diseasepatients on non invasive mechanicalventilation
Vii Trung Kien, B&NgQcSan 71 Cd cau benh tai mOi hQng0ngu'oi lao dQngcua t~p doan Viettel qua kharn srrc khoe 270
dlnh ki nam 2019 - 2020
Structure of ear, nose and throat disease among employees of Viettel group through periodic health examination in 2019 - 2020
Nguy~n L,p SO'n,Pham Huy Tin 72 Nghien cru d~c diem lam sang, c~n lam sang0benh nhan tang triglyceride mau cao
Study on clinical and subclinical characteristics in patients with high degree of hypertriglyceridemia
Nguy~n Vi~t Hung, Nguy~n Khoa Di~u Van 73 ~hi)Q sat d~c diem tinh dich cua nam gioi c6 chuc nang sinh san binh thu'ong
Evaluation of semen parameters in fertile men
Nguy~n Hoai B~c Nguy~n Cao Th~ng, Hoang Long 74 Gia trl cua thang diem hacor de dl,( doan ket qua cua tho may khong xam nh~p tren
b~nh nhan suy ho hap cap
The value of the hacor scale in predicting result of non-invasive mechanical ventilation in patients with acute respiratory failure
Ph an Thi Lan HUO'ng,BB NgQcSO'n,Phung Nam Lam 75 Banh gia ket qua dieu trl ph§u thu~t ung thu' phan Ii;!idi;!day
Efficacy of surgical management of gastric stump cancer
Phan Hfru Huynh, Ha Hili Nam Trin Blnh Tan, Ph~m Vii Minh Hoang 76 B~c diem lam sang va hinh anh hQC0b~nh nhan nhoi mau nao h~ song - nen
Clinical and imaging features of vertebrobasilar ischemic stroke patients
Nguy~n Thi Tuyit Trinh, Nguy~n Van HUOng,Le Tu§n Linh 77 Ket qua ph~u thu~t cattoan bQ di;! day ung thu' 0 b~nh nhan cao tuoi t<;liB~nh
vi~nKTrung u'dng
The results oftoltal gastrectomy in olderly patients with gastric cancer in National Cancer Hospital
Nguy~n Van Tung, Ph~m Van Binh, Vii Thi Hang Anh 274
279
283
288
291
294
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
78 Khaa sat dQ dai co tU' cung 1000 thai phu c6 tuoi thai tir 20-24 tuan bang sieu am 298
qua du'ang am dao
Evaluatian of the cervical length at 20-24 week' gestatian in 1000 pregnancies by transvaginal ultrasound
H~ Van Quy, Vii Ba Quy~t, Nguy~n Xuan Hq'i,
_Dao Thi Hoa, Phan Thi Thu Nga
79 Ket qua dieu tr] naa LIng thuy bam sinh bang phau thuat nQisot pha san naa that III 302
ket hop dot dam roi mach mac
Outcames of treatment cangenital hydracephalus by endoscopic third ventriculastamy withcharoid plexus cauterizatian
. Dao Th] Mo, Cao Vii Hung, 1)8 Thanh Huong
80 Banh gia ket qua dieu tr] ung thu' phoi khong te baa nh6 giai doan III tren ngu'ai caa 305
tuoi bang h6a X<;I tri dong thai
Assess the treatment results af concurrent chemaradiatian in elder patients with stage III nan - small cell lung cancer at K Hospital
Ph~m Van Phat, veVan Xuan
81 B~c diem rOi loan cu'dng du'dng va mQt s6 yeu to lien quan benh nhan benh th~n 310
man giai doan IV tal khoa Than - Tlet nieu B~nh vi~n Bach Mai
Characteristics af erectile dysfunctian and same related factars in patients with stage IV chranic kidney disease at the department af nephran - urolagy af Bach Mai Haspital
D8 Cong Huan, Nguy~n Quang
82 Nghien diu dQc tfnh va anh hu'ong cua la ng6n va hi;lt cay C9Craa len mQt so chi tieu 313
h6a sinh tren dQng v~t thl/c nghi~m
Studying an taxi city and efectiveness af the gelsemium elegans and jatropha curcas seed extract an biachemistry af animal madel
Hoang Anh Tuin, Hoang Gia Bao
83 U'ng dl:lng thang diem radnan cai tien trang danh gia ton thu'dng da b~nh xd cung 318
bi h~ thong
Using the madified radnan skin scare to assess skin lesians in patients with systemic sclerasis
Hoang Vi~t Tai, Bui Hai Binh
84 Tong ket cac baa caa lien quan den phan v~ cd so dCi'li~u baa caa W nguy~n 323
Vi~t Nam giai da~n 2010-2019
Anaphylactic reactians in spantaneaus reparting database af vietnam from 2010 to.2019
Truong Thi M§n, Nguy~n Phuong Thuy, Nguy~n Hoang Anh, D~ng Bieh Vi~t, Cao Thi Thu Huy~n, Nguy~n Hoang Anh, Vii Dinh Hoa, Nguy~n Van Dinh
85 B~c diem ngu'oi b~nh suy tim mi;ln,tinh tri;lng 10.au va ket qua cham soc ngu'oi b~nh 328
ti;li khaa tim mi;lch lao h9C - b~nh vi~n tim mi;lch an giang nam 2020
Characteristics af chronic heart failure and results take care patien at department tim mach lao hac - an giang cardiovascular haspital
Nguy~n Cong Thanh
86 Thl/c tr<;lngtuan thu quy trinh de thu'ong cua hQ sinh t~i khaa san B~nh vi~n San 333
- Nhi Tra Vinh nam 2020
The current situattian af camplying with narmal delivery pracedures af midwives at the department af abstetrics in Tra Vinh Obstetrics and Pediatrics Haspital, 2020
Huynh Thi Tuy~t Minh, Truong Quang Ti~n, T~ Van TrAm
87 Banh gia anh hu'ong tren huyet dQng cua phu'dng phap gay te song - ngaai 337
mang cung phoi hc;1pde mo lay thai tren sim phl,l c6 nguy cd caa tl,lt huyet ap
Hemadynamic effect af cambined spinal epidural anesthesia far cesarean delivery in patients with risk af hypatensian
Nguy~n Thi Thu Ba, Nguy~n Due Lam, Nguy~n Duy Anh
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 -562 - 2020
f>i;lihoc Y Ha NQi,Ha NQi,
2 K M Matsuda et al., 2019, Skin thickness score as a surrogate marker of organ involvements in systemic sclerosis: a retrospective observational
study, Arthritis research & therapy, 21, 1, 129-129
3 Varga, 2014, Overview of the clinical manifestations of systemic sclerosis (scleroderma)
in adults, UpToDate Waltham, MA Retrieved
August,4, 2014
4 V Leroy et al., 2019, Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: Analysis of a cohort of 239 patients,JAm Acad Dermatol,80, 2,478-484 S Amjadi et al., 2009, Course of the modified
Rodnan skin thickness score in systemic sclerosis
clinical trials: analysis of three large multicenter, double-blind, randomized controlled trials, Arthritis and rheumatism,60, 8, 2490-2498
6 T L Moore, M Lunt, B McManus, M E Anderson, and A.L.Herrick, 2003, Seventeen-point dermal ultrasound scoringsystem-a reliable measure of skin thickness in patients with systemic sclerosis, Rheumatolo~y (Oxford), 42, 12, 1559-63 L.P Lan, 2015, f>ac diem lam sang, can lam s,~ngv~ c~u'cDang t~on~ kh.iyh~i(1benh nhan xo cl1ng bl h~ thong, LUi;lnan tien Sly hoc, f>ai hoc Y
Ha NQi,
8 N.S.Gohet al., 2008, Interstitial lung disease in systemic sclerosis: a simple staging system, AmJ RespirCrit Care Med,177,11, 1248-54
, " "., , , ,, , ,? A'
TONG KET CAC BAO CAO LIEN QUAN DEN PHAN VE TRONG CO'sa
,nCr LIEU BAo cAo TU' NGUYEN VIET NAM GIAI DOAN 2010-2019. .
Truong Th] Mint, Nguy~n Phuong Thuy\ Nguy~n Hoang Anh2, D~ng Bieh Vi~t2,Cao Thj Thu Huy~n2, Nguy~n Hoang Anh',
, Vii Dlnh Hoa2, Nguy~n Van Dinh3
T6MTAT.
Nghien oru du'gc tien hanh nham tong ket thong tin ve cac phanungphan v~ du'gc ghi nh~n tlt cac bao cao tlj nguy~n cd so dO'Ii~u canh giac du'dc t~i Vi~t Nam tlt nam 2010 den 2019 Cac bao cao tv' nguy~n du'gc sang IQ.cdu cac thong tin yeu cau cho qua trinh danh gia phim ung theo tieu chuan dinh tru'ck f>~cdiem cua hOi;ltdQng bao cao, d~c diem cua thuoc nghi ngo va phim ung phim v~ du'gc ghi nh~n cling voi t~o.ng tin ve xu tri ti;liddn vi dieu tri du'gc
tong ket va mo ta Ket qua cho thay phan v~ chiem 13,7%so bao cao tv' nguy~n ADR ti;li Vi~t Nam f>dn vi bao cao chu yeu thuQc khoi cong I~p(94,5%) Du'qc 59 la doi tu'gng bao cao phan v~ nhieu nhat(41,4%) Co81,8%bao cao ghi nh~n thong tin khai thac tien sU' diungtrong co 1,6%b~nh nhan co tien sU'di ((ng voi thuoc nghi ngo va 2,0% b~nh nhan co tien su di U'ngthuoc cling nhom vOi thuoc nghi n90 Khang sinh cephalosporinva carbapenem(51,5%tong so bao cao phan v~), khang sinh penicilin (9,5%), thuDc can quang(5,3°~o),N~,!\IDst5,oo/~}la.~hO'n~nhom}h~§c du'gc bao cao nhlE:~unhat Cac tn~u chl1ng bien nhat cua phan v~ la tren tuan hoan ~75,2%},ho hap (74,6%), da/niem mi;lc(55,6%) Co 38,4% tru'ong hgp co bieu hi~n hi;l huyet ap nghiem trQng, 67,9% tru'ong hqpdu'gccan bQy te danh gia la nghiem trQng va co1,6%tru'ong hgpt(tvong Corticoid(72,7%)va adrenalin(68,2%) la2thuDCdu'gc su dl,mg bien
) Tfllt7ng Cao Dang DI.I(fc7WHai Dl.ldng
2Trung tam DI&ADR QG, Trl.lt7ng D~i h9C DI.I(fc HaN9i
3Mnh v$nQuifcte'Vinmec TimesCity,D9it'9C VinUniversity
Chiu trach nhi~m chinh: Tru'dng Thi Man Email: vudinhhoa@gmail.com
Ngay nh~n bai:24.9.2020
Ngay phan bi~n khoa hQc:30.10.2020 Ngay duy~t bai:11.11.2020
nhat de xU'tri phan v~.Ket qua nghien ciru cung cap thong tin can thiet cho hoat dQng theo doi va xU' tri phan v~ ti;li cac don vi dieu tri cung nhu' gqi y cho cac giai phap can thi~p cua cac caccd quan quan Iy doi voi bien cO'y khoa nghiem trQng
Til'khoa: phan ung phan v~, bao cao ADR, ti Ie
bao cao, xII tri phan v~, adrenalin SUMMARY
ANAPHYLACTIC REACTIONS IN SPONTANEOUS REPORTING DATABASE OF
VIETNAM FROM 2010 TO 2019
The current study analyses information of anaphylatic reactions (AR) based on spontaneous reports to National Pharmacovigilance Center from 2010to 2019 Individual Case Safety Report (ICSR) were screened for essential information and the AR was assessed followed a prespecified criteria The characteristic of reporting activity, suspected medications and reported reactions were summarized and described The reported AR were in 13,7% of spontaneous ICSR in Vietnam The public sector had major contribution, accounting for94.5% Pharmacists were most active reporters contributing to 41,4% of ICSR.The history of allergy was reported in81,8%of cases Of those, allergic to suspected medications or allergiC to medications which might cross reactivity with the suspected one were 1,6%· and 2,0% respectively The leading suspected medications were cephalosporins and carbapenems (51,5%), penicilin (9,5%), contrast media agents (5,3%) and NSAIDs (5,O%).The manifestations of RA occurred mainly in cardiovascular, repiratory and subcutaneous systems with prevalence of 75,2%, 74,6% and 55,6%, respectively} Severe hypotension was reported in 38,4% of cases Servere reactions have been identified by reporters in 67,9% of reports, and the fatality rate was of1,6%.Adrenalin and corticoid were
323
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020
used to manage AR in 72,7% and 68,2% of patients, respectively), This study provides information for the management of anaphylatic reactions in healthcare centers and suggests for the intervention of authority,
Keywords: Anaphylactic reaction, ADR report,
reportingproportion,anaphylaxismanagement,adrenalin
v '" '"'
I £>AT VAN £>E
Philn v~ la mQt phan ((ng di ((ng toan than, cap tinh xily sau tiep xuc voi di nguyen Day du'qc coi la mQt nhG'ngphan ((ng nguy hiem nhat tren lam sang thai gian khoi phat nhanh, c6 the gayt((vong va khong the dl/ doan du'qc Trong cac nguon dG' Ii~u ve philn v~, bao cilO tl/ nguy~n ve philn ((ng co hc;licua thuoc (ADR) du'qc coi la n~uon thong tin quan trQng giup danh gia d~c diem cGng nhu' sl/ hinh tin hi~u philn v~.Ti;!i Vi~t Nam, theo nghien c((u cua Le Thi Thuy Linh, so Iu'qng bao cao philn v~ giai dOc;ln2010-2014 ta 2.161 ca, chiem 10,55% tong so bao cao ADR [2] Trong giai dOc;ln2010-2016, Nguyen Khac DGng va cQng sl/ ghi nh~n 55 bao cao philn v~ gU1ve Trung tam DI&ADR QUocgia la 4.873 ca, chiem 13,2% tong so bao cao ADR [4], co 111 ca t(( vong (chiem 82% so Iu'qng ca t(( vong nam cua toan bQcd so dG'Ii~u ADR), b~o cao lien quan den philn v~ chi chiem 0,9% tong so bao cao cd so dG' li~u bao cao ADR toan cau cua To ch((c Y te the gioi (Vigilyze) [5], Xuat phat tu thl/c te tren, nghien c((u du'qc thl/c hi~n nham tong ket d~c diem bao cao lien quan den philn ve cd so dG' li~u bao caotl/ nguy~n Vi~t Na'm giai dOc;ln2010-2019 de h~ tr$1cong tac bao cao,x((tri, dl/ phang va giilm thieu nguy co cua philn v~
11.001TlIQNG VA PHlfO'NG PHAp NGHIENc(J'u
1.D61tu'dng nghien cuu Tat cil cac bao cao tl/ nguy~j, ve philn ((ng co hc;licua thuoc (bao cao ADR) can bQ y te tren phc;lmvi cil nu'oc gU1ve Trung tam DI&ADR QUoc gia giai doan 2010-2019
'Du'a vao tieu chuan chan doan cac tru'ong hdp 'philn v~ du'qc quy dinh Thong tu' si/2017/TT-BYT [1], cac bao cao philn v~ du'qc du'a vao nghien c((u neu thea man dieu ki~n sau:
- £)u'qccan bQy te me til la soc philn v~ ho~c
philO ((ng philn v~
- ADRxuat hi~n yang tinh,tu Ian dung thu5c cu5i cung va co it nhat mQt bieu hi~n tren h~cd quan da/niem mc;lc-hohap -tieu hoa-tim mc;lchho~c co bieu hi~n hi;!huyet ap nghiem trQng
324
Tieuchuanloai tnn Cac bao cao ADR thieu
thong tin ve thucc'nghi ngo va bieu hi~n ADR Phu'dngphap nghh1!ncuu Mo ta thong qua hoi cuu cac tru'ong hop phan v~ du'qc bao cao ve Trung tam DI&,ADRQuoc gia giai doan 2010-2019 voi cac chi tieu: So IWng, tY I~ bao cao phan v~ cd so dG'Ii~u theo nam: thong tin hanhchinh ghi nhan tu baocao phan v~; D~c diem b~nh nhan ghi nhan tu bao cao phan v~;D~Cdiem cua thucc nghi ngo gay phan v~; D~c diem cua phan v~, cach xU' tri va ket qua sau xU'tri
Nhom thuoc c~a cac hOc;ltchat nghi ngo gay phan v~ du'qc phan 10c;lidl/a trencd so phan 10c;li rna ATC).Thai gian tiem tang xuat hi~n philn v~, bieu hi~n cua philn1~tren cac h~cd quan (phan 10i;!itheo Hu'ong dan WHO - ADR Terminology 2012) [6], m((c dQ nghiem trQng cua cac tru'ong hdp philn v~ phan10c;litheo Brown [3] va Hu'ong d§n QUocgia ve Cilnh giacDu'qc.
3 xU' Iy dU' Ii~u.Toan bQ dG' Ii~u du'qc nh~p, xU'1'1'tren phan mem Microsoft Office Excel 2016 va SPSS22.0 Cac bien du'qc thong ke theo tan suat vatY I~ phan tram
III.KETQuANGHIEN CU'U
Tu73447 bao caotl/ nguy~n Iu'utrG'ti;!i trung tam 01 & ADR Quoc gia giai dOc;ln2010-2019, sau 10i;li1971 bao cao, co 10027 bao cao philn v~ da du'qc du'a vao nghien c((u
Sc)Iu'qng,tVI~ bao cao phim v~ thf!o nam
2500 20
18
,,po2000 16
>
c 14
-III
12'i
"E.1500
0 10
-III :!!'
u
o 1000
?:
-III
.0
~ 500
0
20102011 2012 2013 20142015 2016 20172018 2019
56bao,aoph"nv~ _ TVI~vOlt6ngsobaD cao nghlen c(I'U(%)
Hinh1:So'lutlng vatYI~ bao caophan v~
theo tung nam
So Iu'qng bao cao philO v~ tang aan qua cac namtlt 155 bao cao (nam 2010) len 2235 bao cao nam 2019 (hinh 1) T'1 I~ bao cao philn v~ tren tong 55 bao cao ADR cua tung nam dao dQng khoilng 9,1%-17,3% quanh gia tri trung binh la 13,7%
D~c diem cua ho~t dQng bao cao.Ddn vi bao cao chu yeu thuQc khoi cong I~p (94,5%)
(12)TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 -s62 - 2020
trong benh vi~n tuyen tinh/thanh la don
v] tham gia bao cao nhleu nhat (chiem 44,8%),
khoi benh vlen tu'nhan chi chiem 5,5% Ducc s9
va bac s9 la doi W<;1ngbao cao phan v~ nhieu
nhat, fan 1u'<;1tchlern 41,4% va 32,9%, dieu
du'ong (19,2%),cac doi tu'<;1ngkhac (3,0%)
Bang1:S~c diem thong tin hanh chinh
A • , , • A
ghi nhan tv bao cao phan ve
TYI~ Thong tin himh ehinh ghi Solu'qng (%)
nh~ntitbao efto phim v~~cphim v~ (n = 10027' Oan vi bao e,ao
Benh vien tuyen'Trung u'dng 1228 122 B~nh vi~n tuyen tinh/thanh 4493 44,8
pho
Benh vien tuyen quan/huyen 3317 33,1 Benh vien tu' nhan 552 55
Be'nh vien nganh 241 2,4 Tru'ong f)ai hoc Y Du'dc 196 2,0
001tu'ang bao eao
Bac Sy 3301 329
Du'dc Sy 4153 414
f)ieu dtiong 1923 19,2
Khac 296 3,0
Khong co thong tin 354 35
Thai gian bao eao
< tuan 2631 26,2
1 tuan - thanq 3688 36,8
> thang 3640 36,3
Khong co thong tin I 68 I 0,7 I
Cacbao cao phan v~duoc glri den Trunq tam vonq tuan chiem 26,2%, tu tuan -
thanq (36,8%), tren thang (36,3%) Co 0,7% bao cao khong xac dinh du'<;1ckhoimg thai gian bao cao Tronq 8205 bao cao (chlern 81,8% tong so bao cao phan v~) co ghi nh~n thong tin ve vi~c khai thac tien SlI d! lIng, co 162 benh nhan (1,6%) co tien SlI d! lIng vOi chfnh thuoc nghi ngo gay phim v~, 202 b~nh nhan (2,0%) co tien SlI d! lIng vOi thuoc cling nhom voi thuoc nghi ngo gay phim v~
f)~e diem ella thuoe nghi ngo gay phan
v~ Phim v~ du'<;1cghi nh~n vOi hau het cac nhom thuoc, nhG'ng nhom thuoc du'<;1Cbae cao nhieu nhat bao gem: nhom thuoc khang khuan tac dl:mg tean than (J) chiem 76,7%, nhom thuoc tac dl:mg tren h~ than kinh (N) chiem 8,82%, mau va cd quan t<;le mau (B) chiem 6,6%, h~ cd -xu'dng (M) chiem 6,28%, thuoc can quang chiem 5,3% (bang 3) NhG'ng hQ du'<;1cIy hay g~p cac bao cae phan v~ bao gem: khang khuan' nhom cephalosporin va carbapenem (chiem 51,5%), khang khuan nhom penicilin (chiem 9,5%), thuoc can quang (chiem 5,3%), NSAIDs (chiem 5,0%) Trong 566 thuOc nghi ngo khac da du'<;1cghi nh~n cac bao cae phan v~ co 10 thuoc nghi ngo co tan suat gay phan v~ cao nhat du'<;1ctrinh bay Bang
Bang2.Sac diem thuoc nghi ngtYgay phan ve
Nh6m thuoe - ma ATe Sobao eaophan ve (n=10027)Ty Ie0/0
Khang khuan tac dung toan than (J) 7687 76,7
1 J01D - khang khuan beta-Iactam khac 5166 515
2 J01C- khang khuan nhom beta-Iactam he penicilin 949 95 J01M- khang khuan nhom quinolon, khang khuan khac 1572 157
He than kinh (N) 884 88
1 N02-thuoc giam dau 338 3,4
2 N01-thuoc gay me va gay te 401 4,0
3 cae loai thuoc khac 145 1,5
Mau vacd quan tao mau (B) 665 66
1 B05-chat thay the mau va dich truyen 435 4,3
2 B02-thuoc cam mau, cae thuoc khac 230 23
He cd-xu'dnq (M) 630 6,3
1 M01A-NSAIDs 503 50
2 M03-thuoc qian cd 'M04-thuoc chonq qout 127 1,3
V08-thuoc can quanq 534 5,3
Cac nhom thuoc khac 1073 107
Mltai hoat chat nghi ngo gay phan ve nhieu nhat
1 Cefotaxim 1668 16,6
2 Ceftriaxon 955 9'5
3 Ceftazidim 720., 7,2
325
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020
4 Diclofenac 289 2,9
5 Cefuroxim 254 2,5
6 Iobitrldol 251 2,'5
7 Ciprofloxacin 247 2;5
8 Cefoperazon 241 2',4
9 Paracetamol 216 22
10 Cefoperazon/sulbactam 213 2,1 f)u'ong dung cua cac thuoe nghi ngo gay phan ve
1 Tinh mach 7850 78,3
2 Uong 1794 17,9
3 Tiem bap 1011 10,1
4 Du'ong dung khac 686 6,84
- , , A .- N , A , , - ,
Nhung du'ong dung bien nhat cac bao cao phanve la du'ong tmh mach (78,3%), du'ong uong (17,9%), du'ong tiem bap (10,1%) Cac du'ong dung khac (bao gam: gay te, tiem du'oi da, d~t h~u mon, khf dung, ng~m du'oi Iu'Oi,du'ong dQngmach, born vimtltcung, thuy cham, nho mat, nho
mUi) chiem 6,84%
f)ije diem ella phim v~ ghi nh~n bao cao Da so cat baocao phanv~ co thai gian tiem tang du'oi 10 phut (49,2%), 32,5% phan ltng xay yang tU' 10 phut den giO va chi co 7,7% cac tru'ong hcp xay sau gia Co 10,6% baocaokhong ghi r6 thai gian tiem tang xuat hi~n phan v~
B'ang3 8.. acv tlttemA' cuap, an• h' veAgjh'In an aocaohA b"
SoBC phan Ty I~(0/0)
NQidung (n=
v~ 10027)
Bieu hien eua phan ve
H~ tim m~eh: h~ huyet ap, m~ch nhanh, nhip tim nhanh, lo~n nhip, m~d 7542 75.2 cham khonQ bat du'dc, dai tieu tien khong tu' chu, nQat
H~ ho hap: suy ho hap, kho tho, co that phe quan, tho khe, tho rft, 7481 74.6 Quansu'ng, phu du'onQho hap
Da/niem mac: ban do, me day, phu mach, nglta da, va nglta mat 5576 55.6 He tieu h6a: dau thu'dng vi, tieu chay, non lien tuc, dau bl,lng dG'd6i 2729 27.2 Bieu hi~n khae: v~t va, va rna hoi, suy da t~ng, ret run, sot cao, hoa 2966 29.6
mat, chong mat, gong cltng ngu'ai
Mlte nghiem ella phim ve phan loai theo Brown [3]
Nghiem mlte do1 5376 53.6
Ha huyet ap nghiem trQng 3851 38.4 Bieu hien thieu oxY mau 1701 17.0 Bieu hien tren he TKTW 1367 13.6 Nghiem mlte do2 4632 46,2
Khong xae dinh du'de 19 0l_2
Mlte nghiem e(la phim ve phan loai theo bieu mau bao eao ADR
Tuvong 156 1,6
De doa tfnh mang 5069 50,6 Nhap vien/keo dai thoi Qian nam vien 1697 16,9 ran tat vinh vien/nanQ ne 43 0,4
Khong nghiem 2021 20,2
Khong r6 13 0,1
Kh6ng co thong tin 1028 10,3
. A , A A '" '" A A , ,. A
'"
Phan v~ thu'ong du'c;1cbleu hl~n bien nhat tren h~ tim m~ch (75,2%) va h~ ho hap (74,6%) Tri~u ch((ng tren da ho~c niem m~c du'c;1cghi nh~n tren 55,6% so bao cao, tren tieu hoa (27,2%),cac bieu hi~n khac (29,6%) Cac bao cao co bieu hi~n nghiem trQng mltc chiem 53,6% voi tl,lt huyet ap nghiem trQng 113bieu hi~n biet nhat, chiem 38,4% Bieu hi~n thieu oxy va thieu mau chiem ran 1u'c;1t17,0% va 13,6% Da so phan v~ du'c;1ccan bQy te danh gia la nghiem trQng, chi co 20,2% phan v~ du'c;1Ccoi 113kh6ng nghiem trQng
326
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
TAP CHi Y HOC VIET NAM TAp 496· THANG 11·562·2020
Bang4 Dac diem ve xu triphan ve ghi nhan trona baoceo
each xU'tri SaBe Ty I~(%) Kit qua sau xU'tri SaBe
jry I~(0/0
phi,"v~ (n= tOO27) phan v~ (n=
tOO27)
Corticoid 7294 72,7 TU'vong 163 f,6
Adrenalin 6834 68,2 Chua hoiphuc 253 2',5
Lieu phap oxy 4710 47,0 Dang hoi phuc 3203 31;9
Khang histamin Hl va H2 4658 46,4 Hoi phuc co di chunq 92 0,9
Truven dich 4159 41;5 Hoiphuc khong co di chung 5383 53,7
Thuoc khac 790 7,9 Khong 200 2,0
Kichthich beta 400 4;0 Khonocothong tin 733 7,3
Van mach, khac , 366 , 3,7
A .~ ~ A , , A ~ ~
C~rtlcold va,adrenal,1nI~ du'Q'c~udunq p~o bien nhe~dexu tnAphan,v~, la~ 1u'Q'tchlern72,7% va
68!! Vo.,K:t 9ua s~u~utn ch? thay ca~ tru'ong hop hOIphuc khong co di chung va dang hoi phuc
chiemtVI~ Ion nhat, Ian 1u'Q'tla 53,7% va 31,9% Co 163 ca ghinhantu vongungvai 1,6%
IV BAN LU~N cac tru'onghopnhi~m khuan n~ng Ngu'Q'clC;lithi
Nghien CtIUda cho thay so 1u'Q'ngbaocao lien penicilin la mQt thuoc da du'Q'ccanh baonhieu ve
quan den phsn v~ ghi nh~n du'Q'ctang theo thai c~c tru'ong hQ'pphsn v~ do ft du'Q'ccan be?y
gian 10 nam khso sat Khang sinh te h/a chQnsu dl,Jngtrong dieu trio
nhom cephalosporin va carbapenem du'Q'cghi Nhom thu5c co so bao cao phsn v~ CqOthu'
nh~n la cac thuOc bien nhat lien quan den hai cd so dCi' Ii~u la thu5c csn quang
phsn ung phsn v~ Bh~uhi~n cua phsn v~ da (5,3%)" dung dau la iobitridol (2,5%)
dC;lngva xuat hi~n chu yeu tren h~ ho hap va tim Theo ca:: nghien nay, iopromid la thuoc csn
mC;lch.Phan Ian cac phsn ung 0mucde?nghiem qu~ng lien quan den nhieu tru'ong hQ'pphsn v~
trQng va du'Q'CxU' trf bang adrenalin cung nhat, nghien cuu cua ch(mg toi
corticoid Da co 1,6% so bao cao ghi nhan benh iopromid chidung thu vai 1,1% Su' khac biet
nhan tU'vong nat co the den tlt vi~c iobitridol du'~c sU'dl,m'g
So 1u'Q'ngbao cao phsn v~ tang dan theo tltng nhieu hdn i<?promid.Nghien cuu cua ch(mg toi
nam, tY I~ bao cao phsn v~ cung co xu hu'ang cho thay, bieu hi~n tren tuan hoan la thu'ong g~p
tang va dao de?ng quanh gia tri trung binh nhat (75,2%) sau den bieu hi~n tren ho hap
13,7% TV l~nay cao hdn tY I~10,5% (74,6%), da/niem mC;lc (55,6%), tieu hoa
nghien cuu cua Le Thi Thuy Linh giai dOC;ln2010- (27,2~0).:.MQt nghien cuu hoi cuu thl/c hi~n tC;li
2015 [2] So sanh vai cd so dCi'lieu bao cao tu' An DQcung cho ket qus vai ket cau tu'dng tu'vai
nguy~n Vigilyze cua To chuc Y te the giai (2010~ bieu hi~n tren tuan hoan chiem 98,15%; ho
2019) thi tY I~ la 0,9%[5] Ket qus mQt h~p(81,48%), da (72,2%), tieu hoa (9,26%) [7]
m~t cho thay nh~n th((c cua can bQ y te Ty I~ ~ay cao hdn nghien cuu cua chung toi
vi~c phat hi~n va bao cao nhCi'ngphsn ung co the can be? y te thu'ong mo ts ngan gQn
tai Trung tam 01 & ADR Quac Gia da du'dc cai phan v~ chu khong mo tilchi tiet cac bieu hien
thi~n, m~t khac phsn anh thoi quen sU"dung tren tat ca cac h~cd quan
thuoc tren lam sang cua can bo y teo Nghien cU'Ucung ghi nh~n 53,6% phim v~
Cephalosporin va carbapenem (chu yeu la xay mucde?nghiem trQng va co 1,6% tru'ong
khang ~nh cephalosporin) c~tY I~ gay phsn v~ h9P t~ vo~g I~en9uan denAphanv~., syk~ac bi~t
cao nhat (51,52%) - cao gap hdn Ian nhom co the den tIf hOC;ltdQng canh bao tlch cl/c
penicillin (9,5%) nghien cuu cua chung toi h~ thong y te tru'ac ve h~u qua dang
Ket qua khac vai me?tsO'nghien cuu 0Chau ti~c cua phan v~ neu khong du'Q'cxU'trf kip thai
Au da du'Q'ccong b5 tru'ac ma khang sinh cung nhu' vi~c tang cu'ong cong tac quan IV,
penicillin luon du'Q'cghi nh~n la thu5c co tY Ie giam sat phan v~ caccd so y te nen cac
gay phan v~ cao nhat nhu'ng tu'dng tl/ vai mot can be?y te da V thU'c hdn vi~c dl/ phong
nghien cuu hoi cuu 0 Trung Quac vai 34,50/0 va xU' trf phan v~ Phan v~ Iii phan ung co the
cephalosporin va 7,9% penicillins Nguyen nhan phong tranh du'Q'cneu tim hieu ky tien sU'di ung
co the xu hu'ang va thoi quen sU'dl:mg khang c~a b~nh nhan nhu'ng tren thl/c te, can bo y te
sinh cua can bo y te 0 Viet Nam nhom van chu'a chu trQng den dieu do v§n co
cephalosporin dJQ'c dung ph6 bien hdn dOi vai mQttY I~nho b~nh nhan g~p phsn v~ vai thuoc
327
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và
VIETNAM MEDICAL JOURNAL N2 ã NOVEMBERÃ 2020
dĐ tung gay di ((ng (1,6%) ho~c thuoc cling
nhorn voi thuoc gay di ((ng (2,0%)
Nghien cuu cua chung toi cling ghi nhan 72,7% tnJ'ong hop str dunq corticoid, 68,2% sU'
dunq adrenalin.Con ket qua nghien cirua
Trung QUoc,tY I~benh nhan sU'dunq adrenalin la 59,5% Trong mQt so nqhlen cuu khac, bien phep dlJ'qc sU' dunq nhieu nha't la corticoid va khanq histamin Hl, nhien ngoai adrenalin cac bi~n phap tren phI,!thuQc vao bieu hi~n phan v~ va cach xU' tri clla bac si nen tY I~ giiIa cac nghien c((u chenh I~ch nhieu NhlJ'v®y, vi~c dao t~o dinh ky nham giup can bQ y te t~i caccd so
kham chiIa b~nh nam viIng kien th((c ve phat hien va xU'trf la van de can thiet neu muon tang
tY'I~ xU'trf phu h<;1ptren thl/c teo
v.KET LU~N
Nghien c((u d§ cho thay hinh imh ve thl/c hanh bao cao lien quan den cac trlJ'ong phan v~ ghi nh~n tls' h~ thong bao cao tl/ nguy~n clla Vi~t Nam giai do~n 2010-2019 ve d~c diem clla ho~t dQng baa cao, d~c diem clla thuoc nghi ngo va phan lfng phan v~ dlJ'<;1cghi nh~n cung voi thong tin ve xU'trf t~i ddn vi dieu trj Ket qua tls' nghien clfu d5 cung cap nhiIng thong tin hiIu fch giup cho vi~c dl/ phong va xU' trJ phan v~ tren lam sang, nhien day la cac bao eao tl/ nguy~n nen khong the tranh du'<;1ehi~n tu'gng bao ca,o du'oi mlfc thl/e teo Can tiep tl,!Cdjnh ky tong ket cae bao cao tl/ nguy~n de cung cap cae bang ch((ng cho thl/e hanh gii~mthieu nguycdtai bien
do phan v~ tat cac don vi dieu trio TAl LIEU THAM KHAo
1 BOYte(~017~,Thanatu'sO51/2017{1T-BYTve vi~
"HtJ'angdan phong,chandeanva xU'trlphan v~"
2 LeThj Thuy Linh (2015), "Danh gia sl/ hinh tin hi~\.Jva cacf xU'tn cac tnlonq hop phan v~ nr dO',li~l!,bao cao ADR tl/ nguy,~ntal Vi~t Nam", Luc;tnvanthac siduoc hoc,TrtJ'dngDc;tihoc
Duoc Ha Nai
3 Brown S: G (2004), "Clinical features and severity grading of anaphylaxis", J Allergy Clin Immunol, 114(2), pp 371-6
4 Nguyen K D., Nguyen H A.,et al (2019),
"Drug-Induced Anaphylaxis in a Vietnamese Pharmacovigilance Database: Trends and Specific Signals from a Disproportionality Analysis", Drug Saf, 42(5), pp.671-682
5 Uppsala Monitoring Center(2019), "Vigilyze -an inst-ant graphical overview of global data to support evaluation of domestic data (avaiable for National PharmacovigilanceCenters participating in WHO Programme for International Drug Monitoring) Retrieved in Oct 1st 2020 at https://vigilyze.who-umc.org/", pp
6 WHO/Uppsala Monitoring Center (2012),
"WHO Adverse reactions Terminology", pp 8-178
7 Patel Tejas K, Patel Parvati B,et al (2014),
"Drug-induced anaphylactic reactions in Indian population: A systematic review", Indian journal of critical care medicine: peer-reviewed, official publication of Indian Society of Critical Care Medicine,18(12), pp 796
8 Ye Young-Min, Kim Mi Kyeong, et al (2015),
"Predictors of the severity and serious outcomes of anaphylaxis in Korean adults: a multicenter retrospective case study", Allergy, asthma & immunology research, 7(1), pp 22-29
DAC DIEM NGUCYIB~NH SUY TIM M~N, TINH T~NG LOAu vA
KEi QuACHAM SOC NGUCrI B~NH T~I KHOA TIM M~CH LAo HQC
-BENH VIEN TIM MACH AN GIANG NAM 2020. . .
T6MTAT
Nghien cltu me ta cat ngang tren 209 ngtJ'oi~nh suy tim mc;tnnh~p vi~n tc;tiB~nh vi~D Tim mc;tchAn Giang (BVTMAG),tu thang 01/2020 den 06/2020 Ml,1c dfch cua nghien cU'utim hieu cac yeu to lien quan den
10au va danh gia ket qua cham soc cua b~nh nhan suy tim nh~ vien tai BVTMAG.Ketqua: Nhom tren 60 tuoi chiem (85,60/0),tuoi trung binh72 :I:: 12, nO'
*Tru'ifng Dai Hoc TMng Long
Chiu trach nhiem chinh: Nguy~n Ceng Thanh Email: thanhaglx@gmail.com
Ngay nh~n bai: 28.9.2020
Ngay phan bi~n khoa hQc: 30.10.2020 Ngayduy~t bai: 10.11.2020
328
Nguy~n Cong Thimh*
chiem (63,2%), trinh dQ hQc van < cap (59,8%), nghi htJ'u (85,6%), song nang then (74,6%), thu nh~p < tri~u dang/tnang (80,4%), tien sU'suy tim (60,8%) Tinh trc;tngnh~p vi~n co kho tho (54,1%1, nang ngtJ'c (44,5%), phu chi (22%), tinh mc;tchnoi (35,4%).' Hong cau (4,2 :I:: 0,7), Ure (6,8 :I:: 4,8) Creatinin (112,8 :I::156,9), Natri (135:I::5,3), Kali (3,4 :I::0,4), NT ProBNP(2721,7:I::384,5 Suy tim nh~ (I +
II) 68%, suy tim n~ng (III+ IV) 32% TV I~ngtJ'oi benh10au nghienCIIU55,5% Sau dfeu tri va cham soc diem trung binh cua tnang diem DASSgiam
tU' 9,1 :I::0,4 xuong 3,61 :I::0,2 (p < 0,001) Cac yeu to co anh htJ'ongden 10 au bao gam: thu nh~p thap (OR = 2,06; KTC95% = (1,0 - 4,0); P = 0,046), thai gian suy tim > nam {OR = 2,57; KTC95% = (1,4 -4,5); P= 0,001), co mOt dQST n~ng (OR=2,04;
Trung
tâm
DI&ADR
Qu
ố
c
gia
- Tài
li
ệ
u
chia
s
ẻ
t
ạ
i CANHGIACDUOC.ORG.VN
và