of Pediatric Pathology Aliya N Husain, MD • J Thomas Stocker, MD The Color Atlas of Pediatric Pathology covers the broad range of pediatric diseases that a pathologist will likely encounter and is written by well-known leaders in this field Coverage includes both frequent and less commonly seen cases, and each discussion presents a concise summary of the salient features of the disease along with expertly selected, high-quality color images The Color Atlas of Pediatric Pathology is a practical working resource for every pathologist who sees pediatric cases as well as the pathology trainee The atlas features approximately 1,100 high-quality images as well as important staging and prognostic (including molecular) parameters Features of the Color Atlas of Pediatric Pathology include: omprehensive coverage of both common and uncommon diseases in pediatric C surgical pathology n Chapters presented by a recognized expert n Practical presentations: concise text highlights diagnostic features making the atlas an outstanding resource for the practitioner n n 1,100 full-color images A Look Inside the Book 10 Female and Male Reproductive Systems 11 Gastrointestinal Tract 12 Liver, Biliary Tract, and Pancreas 13 Thyroid, Parathyroid, and Adrenal Glands 14 Bone Marrow, Lymph Nodes, Spleen, and Thymus 15 Central Nervous System and Neuromuscular Diseases About the Editors Aliya N Husain, MD, Professor of Pathology, University of Chicago, Chicago, Illinois J Thomas Stocker, MD, Uniformed Services University of the Health Sciences, F Edward Hébert School of Medicine, Department of Pathology, Bethesda, Maryland Recommended Shelving Category: Pathology 11 W 42nd Street New York, NY 10036 www.demosmedpub.com Cover Design: Joe Tenerelli Husain Stocker Placenta Congenital Malformation Syndromes Infections The Skin Soft Tissue Lesions Bone and Joints The Heart The Lung and Mediastinum The Kidney Color Atlas of Pediatric Pathology Color Atlas Color Atlas of Pediatric Pathology Aliya N Husain J Thomas Stocker Color Atlas of Pediatric Pathology http://avaxho.me/blogs/ChrisRedfield Color Atlas of Pediatric Pathology EDITORS Aliya N Husain, MD Professor of Pathology university of Chicago Chicago, Illinois J Thomas Stocker, MD uniformed Services university of the Health Sciences F edward Hébert School of Medicine Department of Pathology Bethesda, Maryland NEW YORK Acquisitions Editor: Richard Winters Cover design: Joe Tenerelli Compositor: Absolute Service, Inc Visit our website at www.demosmedpub.com © 2011 Demos Medical Publishing, LLC All rights reserved ISBN 978-1-933864-57-0 eISBN 978-1-935281-40-5 This book is protected by copyright No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher Medicine is an ever-changing science Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, express or implied, with respect to the contents of the publication Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book Such examination is particularly important with drugs that are either rarely used or have been newly released on the market Library of Congress Cataloging-in-Publication Data Color atlas of pediatric pathology / editors, Aliya N Husain, J Thomas Stocker p ; cm Includes bibliographical references and index ISBN 978-1-933864-57-0 Pediatric pathology—Atlases I Husain, Aliya N II Stocker, J Thomas [DNLM: Pathologic Processes—Atlases Pediatrics—Atlases WS 17] RJ49.C65 2011 618.92’007—dc22 2010052842 11 12 13 14 Special discounts on bulk quantities of Demos Medical Publishing books are available to corporations, professional associations, pharmaceutical companies, health care organizations, and other qualifying groups For details, please contact: Special Sales Department Demos Medical Publishing 11 W 42nd Street, 15th Floor, New York, NY 10036 Phone: 800–532–8663 or 212–683–0072; Fax: 212–941–7842 E-mail: rsantana@demosmedpub.com Printed in the United States of America by Bang Printing For my family, Shaghil, Ameena, Ayesha, and Omar: Balancing work and home would not be possible without your understanding, support, and encouragement Aliya N Husain Contents Preface ix Contributors xi PlaCenTa raymond W redline ConGeniTal MalForMaTion syndroMes 29 nicole A Cipriani and Aliya n Husain inFeCTions 43 David M Parham The sKin 57 Vijaya B reddy soFT Tissue lesions 79 Zhongxin Yu and David M Parham Bone and JoinTs 103 Karen S thompson The hearT 123 Bahig M Shehata and Charlotte K Steelman The lunG and MediasTinuM 147 J thomas Stocker and Aliya n Husain The Kidney 177 Anthony Chang, neeraja Kambham, and elizabeth J Perlman 10 FeMale and Male reProduCTive sysTeMs 207 Michael K Fritsch and elizabeth J Perlman 11 GasTroinTesTinal TraCT 235 J thomas Stocker, Haresh Mani, and John Hart 12 liver, Biliary TraCT, and PanCreas 265 Haresh Mani and J thomas Stocker vii viiiâ•… Contents 13 Thyroid, ParaThyroid, and adrenal Glands 319 John Hicks 14 Bone Marrow, lyMPh nodes, sPleen, and ThyMus 373 Andrea M Sheehan 15 CenTral nervous sysTeM and neuroMusCular disease Peter Pytel Index 419 401 Preface Pediatric pathology is distinct from adult pathology in many ways: types of diseases, genetic and molecular defects, therapies (including side effects and long-term complications), and outcomes This is not only because of congenital malformations but also because infections and tumors that affect children are not the same as those seen in adults One example is Wilms tumor, which is relatively common in children but exceedingly rare in adults, with diagnostic and staging parameters distinct from adult renal tumors, and a cure rate of over 95% Thus, pediatric pathology has been a boarded subspecialty in the United States and Canada since 1991 The majority of pediatric pathologists work in children’s hospitals; however, more than half of the pediatric cases are being seen by “general pathologists” in various practice settings Thus, there continues to be a need for all pathologists to keep current in their diagnostic skills and knowledge of pediatric pathology and this atlas has been written with those residents, fellows, and general pathologists in mind It is meant to serve as a handy reference for people who see pediatric cases infrequently and may have no special expertise in the subject It cannot replace a comprehensive textbook; rather it should be used in addition to one For years, one of us (JTS) had wanted to use his extensive collection of photographs to illustrate an atlas of pediatric pathology You may wonder why such a book is needed in this age of “Google pictures.” We think there is considerable value to the student as well as the practicing pathologist to see illustrations selected by “experts,” such as the chapter authors in this book In addition, the accompanying text concisely summarizes the pertinent features of each disease Thus, rather than sifting through the thousands of items brought up in nanoseconds by any of the search engines, one can turn to an atlas such as this when faced with an uncommon or rare diagnostic specimen The Color Atlas of Pediatric Pathology is organized in a traditional manner with each chapter devoted to a specific organ system The authors for each chapter were chosen for their knowledge, and were asked to cover common as well as selected uncommon diseases that every pathologist would need to know about Because this is an atlas, the focus is on illustrations with supporting text; only selected references are given This book brings together the experience and expertise from many institutions, which add to its value As with any multi-author book, there is some variation in how each chapter is written and illustrated We hope our readers will find the Color Atlas of Pediatric Pathology to be a valuable resource in their diagnoses of pediatric cases Acknowledgments: Pictures are from the teaching collections of several pathologists and university hospitals; many are thanks to the diligence of past residents and fellows who are unnamed but not forgotten ix .. .Color Atlas of Pediatric Pathology http://avaxho.me/blogs/ChrisRedfield Color Atlas of Pediatric Pathology EDITORS Aliya N Husain, MD Professor of Pathology university of Chicago Chicago,... Library of Congress Cataloging-in-Publication Data Color atlas of pediatric pathology / editors, Aliya N Husain, J Thomas Stocker p ; cm Includes bibliographical references and index ISBN 97 8-1 -9 3386 4-5 7-0 ... www.demosmedpub.com © 2011 Demos Medical Publishing, LLC All rights reserved ISBN 97 8-1 -9 3386 4-5 7-0 eISBN 97 8-1 -9 3528 1-4 0-5 This book is protected by copyright No part of it may be reproduced, stored